oxidopamine has been researched along with Restless Leg Syndrome in 4 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pursuant to the clinical suspicion that restless legs syndrome (RLS) may involve dopaminergic diencephalic spinal neurons (A11), we performed stereotaxic bilateral 6-hydroxydopamine (6-OHDA) lesions into the A11 nucleus to observe for any behavioral correlates similar to this clinical condition." | 1.31 | Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome. ( He, Y; Le, WD; Ondo, WG; Rajasekaran, S, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lopes, C | 1 |
| Esteves, AM | 1 |
| Frussa-Filho, R | 1 |
| Tufik, S | 1 |
| de Mello, MT | 1 |
| Zhao, H | 1 |
| Zhu, W | 1 |
| Pan, T | 1 |
| Xie, W | 2 |
| Zhang, A | 2 |
| Ondo, WG | 3 |
| Le, W | 2 |
| Qu, S | 1 |
| Zhang, X | 1 |
| He, Y | 1 |
| Rajasekaran, S | 1 |
| Le, WD | 1 |
4 other studies available for oxidopamine and Restless Leg Syndrome
| Article | Year |
|---|---|
Evaluation of periodic limb movements in a putative animal model of restless leg syndrome.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Benzothiazoles; Disease Models, Animal; Electro | 2012 |
Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation.
Topics: Animals; Binding, Competitive; Circadian Rhythm; Denervation; Disease Models, Animal; Dopamine; Dors | 2007 |
Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome.
Topics: Animals; Brain Injuries; Diencephalon; Disease Models, Animal; Dopamine Agonists; Indoles; Iron; Iro | 2007 |
Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome.
Topics: Adrenergic Agents; Animals; Brain Mapping; Diencephalon; Disease Models, Animal; Female; Neural Path | 2000 |