Page last updated: 2024-11-02

oxidopamine and Pain, Intractable

oxidopamine has been researched along with Pain, Intractable in 1 studies

Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).

Pain, Intractable: Persistent pain that is refractory to some or all forms of treatment.

Research Excerpts

ExcerptRelevanceReference
"It has been suggested that phantom limb pain is a result of peripheral denervation leading to reorganization of somatosensory pathways, particularly in the cerebral cortex, which is shown to depend upon central noradrenergic activity."1.31Central noradrenergic blockade prevents autotomy in rat: implication for pharmacological prevention of postdenervation pain syndrome. ( Al-Adawi, S; Bonner, A; Dawe, GS; Stephenson, JD; Zarei, M, 2002)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Al-Adawi, S1
Dawe, GS1
Bonner, A1
Stephenson, JD1
Zarei, M1

Other Studies

1 other study available for oxidopamine and Pain, Intractable

ArticleYear
Central noradrenergic blockade prevents autotomy in rat: implication for pharmacological prevention of postdenervation pain syndrome.
    Brain research bulletin, 2002, Mar-15, Volume: 57, Issue:5

    Topics: Afferent Pathways; Animals; Chronic Disease; Denervation; Immunohistochemistry; Locus Coeruleus; Mal

2002