oxidopamine has been researched along with Nerve Degeneration in 341 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, the intriguing ability of several anesthetics to readily inhibit GSK3β within the cortex and hippocampus led us to investigate the effects of brief isoflurane anesthesia on striatal GSK3β signaling in naïve rats and in a rat model of early-stage PD." | 7.85 | Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease. ( Forsberg, MM; Jalkanen, AJ; Kohtala, S; Leikas, JV; Rantamäki, T; Theilmann, W, 2017) |
| " The purpose of this study was to investigate the effects of glutathione on 3-hydroxykynurenine, 6-hydroxydopamine and salsolinol mediated neurotoxicity in the human neuroblastoma SH-SY5Y cell line in order to find a possible therapeutic application of this compound to neurodegenerative disorders." | 7.78 | Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line. ( Melzig, MF; Wszelaki, N, 2012) |
| "The influence of embryonic mesencephalic, striatal and mesencephalic/striatal co-grafts on amphetamine- and apomorphine-induced rotation behaviour was assessed in a rat model of multiple system atrophy/striatonigral degeneration type using dopamine D1 ([3H]SCH23390) and D2 ([3H]spiperone) receptor and dopamine re-uptake ([3H]mazindol) autoradiography." | 7.70 | Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc ( Granata, R; Jenner, P; Laboyrie, P; Poewe, W; Puschban, Z; Quinn, NP; Scherfler, C; Wenning, GK, 2000) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 5.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| "Riluzole is a neuroprotective drug used in the treatment of motor neurone disease." | 5.38 | Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. ( Carbone, M; Duty, S; Rattray, M, 2012) |
| "Riluzole was administered prior to and consecutively for ten days following double lesion placement in the left-sided medial forebrain bundle and ipsilateral striatum." | 5.33 | Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). ( Diguet, E; Poewe, W; Puschban, Z; Sather, T; Scherfler, C; Stefanova, N; Tison, F; Wenning, GK, 2005) |
| " Therefore, the intriguing ability of several anesthetics to readily inhibit GSK3β within the cortex and hippocampus led us to investigate the effects of brief isoflurane anesthesia on striatal GSK3β signaling in naïve rats and in a rat model of early-stage PD." | 3.85 | Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease. ( Forsberg, MM; Jalkanen, AJ; Kohtala, S; Leikas, JV; Rantamäki, T; Theilmann, W, 2017) |
| " The purpose of this study was to investigate the effects of glutathione on 3-hydroxykynurenine, 6-hydroxydopamine and salsolinol mediated neurotoxicity in the human neuroblastoma SH-SY5Y cell line in order to find a possible therapeutic application of this compound to neurodegenerative disorders." | 3.78 | Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line. ( Melzig, MF; Wszelaki, N, 2012) |
| "The influence of embryonic mesencephalic, striatal and mesencephalic/striatal co-grafts on amphetamine- and apomorphine-induced rotation behaviour was assessed in a rat model of multiple system atrophy/striatonigral degeneration type using dopamine D1 ([3H]SCH23390) and D2 ([3H]spiperone) receptor and dopamine re-uptake ([3H]mazindol) autoradiography." | 3.70 | Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc ( Granata, R; Jenner, P; Laboyrie, P; Poewe, W; Puschban, Z; Quinn, NP; Scherfler, C; Wenning, GK, 2000) |
| "Nonhuman primate models of Parkinson's disease (PD) have been invaluable to our understanding of the human disease and in the advancement of novel therapies for its treatment." | 2.43 | Neural repair strategies for Parkinson's disease: insights from primate models. ( Kordower, JH; O'Malley, J; Soderstrom, K; Steece-Collier, K, 2006) |
| "The development of animal models of Parkinson's disease is of great importance in order to test substitutive or neuroprotective strategies for Parkinson's disease." | 2.42 | Animal models of Parkinson's disease in rodents induced by toxins: an update. ( Breidert, T; Cohen-Salmon, C; Feger, J; Hirsch, EC; Höglinger, G; Launay, JM; Parain, K; Prigent, A; Rousselet, E; Ruberg, M, 2003) |
| "Determinations of dopamine (DA) neuron degeneration, food perception, and ROS content were performed in 6-OHDA-exposed BZ555 nematodes." | 1.91 | Chlorogenic acid delays the progression of Parkinson's disease via autophagy induction in ( He, CL; Long, T; Pan, R; Qin, DL; Qiu, WQ; Tang, Y; Teng, JF; Wu, AG; Wu, JM; Yu, CL; Yu, L; Zhou, XG, 2023) |
| "Cardiac dysautonomia is a common nonmotor symptom of Parkinson's disease (PD) associated with loss of sympathetic innervation to the heart and decreased plasma catecholamines." | 1.56 | Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration. ( Bondarenko, V; Emborg, ME; Fleddermann, RA; Matsoff, HN; Mejia, A; Metzger, JM; Moore, CF; Simmons, HA; Zinnen, AD, 2020) |
| "Current therapeutic strategies for Parkinson's disease (PD) aim to delay progression or replace damaged neurons by restoring the original neuronal structures." | 1.56 | A co-culture nanofibre scaffold model of neural cell degeneration in relevance to Parkinson's disease. ( Abeywickrama, N; Chemmarappally, JM; De Girolamo, LA; Fornari, E; Hargreaves, AJ; Pegram, HCN; Stevens, B, 2020) |
| "Parkinson's disease is a chronic neurodegenerative disorder characterized by cardinal motor features, such as bradykinesia, but also vocal deficits (e." | 1.48 | Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease. ( Andreatini, R; Bruginski, E; Campos, FR; de Almeida Soares Hocayen, P; Kanazawa, LKS; Miyoshi, E; Schwarting, RKW; Stern, CAJ; Vecchia, DD; Vital, MABF; Wendler, E; Wöhr, M, 2018) |
| "Rats treated with oleanolic acid 7 days pre- and 1 day post-lesion had more dopamine in the striatum than the non-treated or the 7 days after lesion rats." | 1.42 | Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration. ( Daniels, WM; Mabandla, MV; Nyoka, M, 2015) |
| " Our results confirm that systemic 6-OHDA dosing to nonhuman primates induces cardiac sympathetic neurodegeneration and loss of catecholaminergic enzymes in the adrenal medulla, and suggests that this model can be used as a platform to evaluate disease-modifying strategies aiming to induce peripheral neuroprotection." | 1.40 | Cardiac sympathetic denervation in 6-OHDA-treated nonhuman primates. ( Dilley, K; Emborg, ME; Joers, V; Jones, C; Rahman, S; Shultz, J; Simmons, H, 2014) |
| " The long-term use of LD is limited by the development of L-DOPA-induced dyskinesias and dystonia." | 1.39 | The combination of oral L-DOPA/rimonabant for effective dyskinesia treatment and cytological preservation in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia. ( Aley-Medina, P; Anaya-Martínez, V; Avila-Costa, MR; Espinosa-Villanueva, J; García-Ruiz, R; Gutiérrez-Valdez, AL; Montiel-Flores, E; Reynoso-Erazo, L; Sánchez-Betancourt, J; Torres-Esquivel, C; Tron-Alvarez, R, 2013) |
| "Riluzole is a neuroprotective drug used in the treatment of motor neurone disease." | 1.38 | Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation. ( Carbone, M; Duty, S; Rattray, M, 2012) |
| "Rosiglitazone is a commonly prescribed insulin-sensitizing drug with selective agonistic activity at the peroxisome proliferator-activated receptor-γ (PPARγ)." | 1.38 | Rosiglitazone, a PPAR-γ agonist, protects against striatal dopaminergic neurodegeneration induced by 6-OHDA lesions in the substantia nigra of rats. ( Koh, HC; Lee, EY; Lee, JE; Park, JH; Shin, IC, 2012) |
| "Studies on Parkinson's disease patients and dopamine-depleted animals indicate that dopaminergic neurons in the retina degenerate due to the genetic and environmental factors that cause dopaminergic neuron loss in the substantia nigra." | 1.37 | Minor retinal degeneration in Parkinson's disease. ( Huang, YM; Yin, ZQ, 2011) |
| "Parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the substantia nigra." | 1.37 | CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. ( Bachstetter, AD; Bickford, PC; Gemma, C; Hudson, CE; Pabon, MM, 2011) |
| "Patients with Parkinson's disease that receive transplants of foetal ventral mesencephalic tissue, the graft cell preparation is likely to contain, in addition to dopamine neurons, serotonin neurons that will vary in number depending on the landmarks used for dissection." | 1.35 | Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration. ( Björklund, A; Carlsson, T; Carta, M; Kirik, D; Mattsson, B; Muñoz, A; Winkler, C, 2009) |
| " The in vitro study showed that 1 microM OEA exerted a significantly neuroprotective effect on cultured nigral dopamine neurons, effects following U-shaped dose-response curves." | 1.35 | Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons. ( Bermudez-Silva, FJ; Fernandez-Espejo, E; Galan-Rodriguez, B; Gonzalez-Aparicio, R; Maldonado, R; Robledo, P; Rodriguez de Fonseca, F; Suarez, J, 2009) |
| "Parkinson's disease is a neurodegenerative disorder with uncertain aetiology and ill-defined pathophysiology." | 1.35 | Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. ( Ferrari, CC; Pitossi, FJ; Pott Godoy, MC; Sarchi, MI; Tarelli, R, 2008) |
| " However, angiotensin increased the toxic effect of 6-hydroxydopamine." | 1.34 | Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons. ( Labandeira-Garcia, JL; Lopez-Real, A; Muñoz, A; Rey, P; Sanchez-Iglesias, S; Soto-Otero, R, 2007) |
| "Depression is the most common psychiatric complication in Parkinson's disease (PD)." | 1.34 | Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats. ( Juckel, G; Klein, J; Kupsch, A; Lee, T; Morgenstern, R; Mundt, A; Petrus, D; von Rumohr, A; Winter, C, 2007) |
| "The causes of nigrostriatal neuron degeneration in Parkinson's disease (PD) are not known, but it has been suggested that exogenous or endogenous factors or neurotoxins may play a role." | 1.33 | An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate. ( Delville, Y; Fleming, SM; Schallert, T, 2005) |
| "Riluzole was administered prior to and consecutively for ten days following double lesion placement in the left-sided medial forebrain bundle and ipsilateral striatum." | 1.33 | Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). ( Diguet, E; Poewe, W; Puschban, Z; Sather, T; Scherfler, C; Stefanova, N; Tison, F; Wenning, GK, 2005) |
| " Parkin is thought to be critical for protecting dopaminergic neurons from toxic insults by targeting misfolded or oxidatively damaged proteins for proteasomal degradation." | 1.33 | Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity. ( Curtis, WR; Palmiter, RD; Perez, FA, 2005) |
| "An intensification of catalepsy has been observed upon repeated testing in rats with permanent neurodegeneration of substantia nigra." | 1.32 | Intensification of cataleptic response in 6-hydroxydopamine-induced neurodegeneration of substantia nigra is not dependent on the degree of dopamine depletion. ( Schmidt, WJ; Srinivasan, J, 2004) |
| "The causes of sporadic Parkinson's disease (PD) are poorly understood." | 1.32 | Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death. ( Bower, KA; Chen, G; Fang, S; Luo, J; Ma, C; Thiele, CJ, 2004) |
| "Behaviour was evaluated by catalepsy tests and activity box." | 1.32 | Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats. ( Schmidt, WJ; Srinivasan, J, 2003) |
| "Pramipexole treated animals exhibited a 29% and a 27% reduction in striatal dopamine and THir cell counts, respectively." | 1.31 | Pramipexole attenuates the dopaminergic cell loss induced by intraventricular 6-hydroxydopamine. ( Carvey, PM; Chen, EY; Ling, ZD; Lipton, JW; Ma, SY; Robie, HC; Tong, CW; Vu, TQ, 2000) |
| " Since both H(2)O(2) and 6-OHDA may injure cells via free radical and reactive oxygen species, the neuroprotection seen here may operate via a reversal of such a toxic mechanism." | 1.31 | Vitamin D(3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats. ( Borlongan, CV; Chen, HH; Cherng, TL; Hoffer, BJ; Wang, JY; Wang, Y; Wu, JN, 2001) |
| "Pretreatment with nimodipine failed to antagonize or to ameliorate any of the lesion-induced deficits." | 1.30 | Degeneration of pre-labelled nigral neurons induced by intrastriatal 6-hydroxydopamine in the rat: behavioural and biochemical changes and pretreatment with the calcium-entry blocker nimodipine. ( Earl, CD; Kupsch, A; Oertel, WH; Sautter, J, 1997) |
| "Adenosine A2 receptors were labeled and visualized by autoradiography in tissue sections of the human brain using the A2-selective agonist ligand [3H](2-p-(2-carboxyethyl)phenylamino)-5'-N-carboxamidoadenosine (CGS 21680)." | 1.28 | Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease. ( Martinez-Mir, MI; Palacios, JM; Probst, A, 1991) |
| "Treatment with propranolol enhanced open field performance 1 day after 6-OHDA injection but failed to enhance recovery of consummatory behaviour and body weight control." | 1.27 | Catecholamine-blocking drugs injected at sites of amine accumulation reverse catecholamine degeneration associated deficits. ( Smith, GC; Willis, GL, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (5.28) | 18.7374 |
| 1990's | 57 (16.72) | 18.2507 |
| 2000's | 152 (44.57) | 29.6817 |
| 2010's | 96 (28.15) | 24.3611 |
| 2020's | 18 (5.28) | 2.80 |
| Authors | Studies |
|---|---|
| Mendes-Pinheiro, B | 1 |
| Soares-Cunha, C | 1 |
| Marote, A | 1 |
| Loureiro-Campos, E | 1 |
| Campos, J | 1 |
| Barata-Antunes, S | 1 |
| Monteiro-Fernandes, D | 1 |
| Santos, D | 1 |
| Duarte-Silva, S | 1 |
| Pinto, L | 1 |
| José Salgado, A | 1 |
| Sato, F | 1 |
| Nakamura, Y | 1 |
| Ma, S | 1 |
| Kochi, T | 1 |
| Hisaoka-Nakashima, K | 1 |
| Wang, D | 1 |
| Liu, K | 1 |
| Wake, H | 1 |
| Nishibori, M | 1 |
| Morioka, N | 1 |
| He, CL | 1 |
| Tang, Y | 2 |
| Wu, JM | 1 |
| Long, T | 1 |
| Yu, L | 1 |
| Teng, JF | 1 |
| Qiu, WQ | 1 |
| Pan, R | 1 |
| Yu, CL | 1 |
| Qin, DL | 1 |
| Wu, AG | 1 |
| Zhou, XG | 1 |
| Palese, F | 1 |
| Pontis, S | 2 |
| Realini, N | 1 |
| Torrens, A | 1 |
| Ahmed, F | 1 |
| Assogna, F | 1 |
| Pellicano, C | 1 |
| Bossù, P | 1 |
| Spalletta, G | 1 |
| Green, K | 1 |
| Piomelli, D | 1 |
| Gan, X | 2 |
| Ren, J | 2 |
| Huang, T | 2 |
| Wu, K | 2 |
| Li, S | 3 |
| Duan, Y | 2 |
| Wang, Z | 2 |
| Si, W | 2 |
| Wei, J | 2 |
| Singh, A | 2 |
| Panhelainen, A | 1 |
| Voutilainen, MH | 2 |
| Morton, KS | 1 |
| Hartman, JH | 1 |
| Heffernan, N | 1 |
| Ryde, IT | 2 |
| Kenny-Ganzert, IW | 1 |
| Meng, L | 1 |
| Sherwood, DR | 1 |
| Meyer, JN | 2 |
| Oñate, M | 2 |
| Catenaccio, A | 1 |
| Salvadores, N | 1 |
| Saquel, C | 1 |
| Martinez, A | 2 |
| Moreno-Gonzalez, I | 1 |
| Gamez, N | 1 |
| Soto, P | 1 |
| Soto, C | 1 |
| Hetz, C | 3 |
| Court, FA | 3 |
| Pak, ME | 1 |
| Ahn, SM | 1 |
| Jung, DH | 1 |
| Lee, HJ | 1 |
| Ha, KT | 1 |
| Shin, HK | 1 |
| Choi, BT | 1 |
| Metzger, JM | 1 |
| Matsoff, HN | 1 |
| Zinnen, AD | 1 |
| Fleddermann, RA | 1 |
| Bondarenko, V | 1 |
| Simmons, HA | 1 |
| Mejia, A | 1 |
| Moore, CF | 1 |
| Emborg, ME | 2 |
| Chemmarappally, JM | 1 |
| Pegram, HCN | 1 |
| Abeywickrama, N | 1 |
| Fornari, E | 1 |
| Hargreaves, AJ | 1 |
| De Girolamo, LA | 1 |
| Stevens, B | 1 |
| Haddadi, R | 1 |
| Eyvari-Brooshghalan, S | 1 |
| Nayebi, AM | 1 |
| Sabahi, M | 1 |
| Ahmadi, SA | 1 |
| Biolchi, AM | 1 |
| de Oliveira, DGR | 1 |
| Amaral, HO | 1 |
| Campos, GAA | 1 |
| Gonçalves, JC | 1 |
| de Souza, ACB | 1 |
| Lima, MR | 1 |
| Silva, LP | 1 |
| Mortari, MR | 1 |
| Ma, Q | 1 |
| Wei, R | 1 |
| Zhang, X | 3 |
| Sang, Z | 1 |
| Dong, J | 1 |
| Peters, OM | 1 |
| Weiss, A | 1 |
| Metterville, J | 1 |
| Song, L | 1 |
| Logan, R | 1 |
| Smith, GA | 3 |
| Schwarzschild, MA | 1 |
| Mueller, C | 1 |
| Brown, RH | 1 |
| Freeman, M | 1 |
| Sikora, J | 1 |
| Ouagazzal, AM | 1 |
| Chalorak, P | 2 |
| Sanguanphun, T | 1 |
| Limboonreung, T | 1 |
| Meemon, K | 2 |
| Ay, M | 1 |
| Luo, J | 3 |
| Langley, M | 1 |
| Jin, H | 3 |
| Anantharam, V | 2 |
| Kanthasamy, A | 2 |
| Kanthasamy, AG | 2 |
| Kuter, K | 1 |
| Olech, Ł | 1 |
| Głowacka, U | 1 |
| Leikas, JV | 1 |
| Kohtala, S | 1 |
| Theilmann, W | 1 |
| Jalkanen, AJ | 1 |
| Forsberg, MM | 1 |
| Rantamäki, T | 1 |
| Becker, B | 1 |
| Demirbas, M | 1 |
| Johann, S | 1 |
| Zendedel, A | 1 |
| Beyer, C | 1 |
| Clusmann, H | 1 |
| Haas, SJ | 1 |
| Wree, A | 1 |
| Tan, SKH | 1 |
| Kipp, M | 1 |
| Vecchia, DD | 1 |
| Kanazawa, LKS | 1 |
| Wendler, E | 1 |
| de Almeida Soares Hocayen, P | 1 |
| Bruginski, E | 1 |
| Campos, FR | 1 |
| Stern, CAJ | 1 |
| Vital, MABF | 1 |
| Miyoshi, E | 1 |
| Wöhr, M | 1 |
| Schwarting, RKW | 1 |
| Andreatini, R | 1 |
| Offenburger, SL | 3 |
| Jongsma, E | 1 |
| Gartner, A | 3 |
| Ho, XY | 1 |
| Tachie-Menson, T | 1 |
| Coakley, S | 1 |
| Hilliard, MA | 1 |
| Tsai, CW | 1 |
| Tsai, RT | 2 |
| Liu, SP | 2 |
| Chen, CS | 2 |
| Tsai, MC | 1 |
| Chien, SH | 1 |
| Hung, HS | 1 |
| Lin, SZ | 2 |
| Shyu, WC | 2 |
| Fu, RH | 2 |
| Ermine, CM | 1 |
| Wright, JL | 1 |
| Frausin, S | 1 |
| Kauhausen, JA | 1 |
| Parish, CL | 1 |
| Stanic, D | 1 |
| Thompson, LH | 1 |
| Tamano, H | 1 |
| Nishio, R | 1 |
| Morioka, H | 1 |
| Takeda, A | 2 |
| Paliga, D | 1 |
| Raudzus, F | 1 |
| Leppla, SH | 1 |
| Heumann, R | 1 |
| Neumann, S | 1 |
| Cheng, L | 1 |
| Chen, L | 2 |
| Wei, X | 3 |
| Wang, Y | 6 |
| Ren, Z | 1 |
| Zeng, S | 1 |
| Wen, H | 1 |
| Gao, C | 1 |
| Liu, H | 1 |
| Chen, HH | 2 |
| Chang, PC | 1 |
| Wey, SP | 1 |
| Chen, PM | 1 |
| Chen, C | 2 |
| Chan, MH | 1 |
| Pain, S | 1 |
| Vergote, J | 1 |
| Gulhan, Z | 1 |
| Bodard, S | 1 |
| Chalon, S | 1 |
| Gaillard, A | 1 |
| Shan, C | 1 |
| Gong, YL | 1 |
| Zhuang, QQ | 1 |
| Hou, YF | 1 |
| Wang, SM | 1 |
| Zhu, Q | 1 |
| Huang, GR | 1 |
| Tao, B | 1 |
| Sun, LH | 1 |
| Zhao, HY | 1 |
| Li, ST | 1 |
| Liu, JM | 1 |
| Manouchehrabadi, M | 1 |
| Farhadi, M | 1 |
| Azizi, Z | 1 |
| Torkaman-Boutorabi, A | 1 |
| Löw, K | 1 |
| Aebischer, P | 1 |
| Schneider, BL | 2 |
| Li, R | 1 |
| Zheng, N | 1 |
| Liang, T | 1 |
| He, Q | 1 |
| Xu, L | 2 |
| Wang, YC | 1 |
| Chang, WL | 1 |
| Lin, HL | 1 |
| Lu, CH | 1 |
| Wei, JR | 1 |
| Wang, ZW | 1 |
| Hemmerle, AM | 1 |
| Dickerson, JW | 1 |
| Herman, JP | 1 |
| Seroogy, KB | 1 |
| Hernandes, MS | 2 |
| Santos, GD | 1 |
| Café-Mendes, CC | 2 |
| Lima, LS | 1 |
| Scavone, C | 1 |
| Munhoz, CD | 1 |
| Britto, LR | 2 |
| Gutiérrez-Valdez, AL | 1 |
| García-Ruiz, R | 1 |
| Anaya-Martínez, V | 1 |
| Torres-Esquivel, C | 1 |
| Espinosa-Villanueva, J | 1 |
| Reynoso-Erazo, L | 1 |
| Tron-Alvarez, R | 1 |
| Aley-Medina, P | 1 |
| Sánchez-Betancourt, J | 1 |
| Montiel-Flores, E | 1 |
| Avila-Costa, MR | 1 |
| Zhang, Q | 1 |
| Wang, S | 1 |
| Zhang, L | 3 |
| Zhang, H | 2 |
| Qiao, H | 1 |
| Niu, X | 1 |
| Liu, J | 1 |
| Shin, E | 1 |
| Rogers, JT | 1 |
| Devoto, P | 1 |
| Björklund, A | 9 |
| Carta, M | 2 |
| Valdés, P | 2 |
| Mercado, G | 2 |
| Vidal, RL | 2 |
| Molina, C | 1 |
| Parsons, G | 1 |
| Galleguillos, D | 1 |
| Armentano, D | 1 |
| Lu, X | 1 |
| Kim-Han, JS | 1 |
| Harmon, S | 1 |
| Sakiyama-Elbert, SE | 1 |
| O'Malley, KL | 1 |
| Zhang, Y | 1 |
| Dong, W | 1 |
| Guo, S | 1 |
| Zhao, S | 1 |
| He, S | 1 |
| Wang, H | 2 |
| Joers, V | 1 |
| Dilley, K | 1 |
| Rahman, S | 1 |
| Jones, C | 1 |
| Shultz, J | 1 |
| Simmons, H | 1 |
| Saal, KA | 1 |
| Koch, JC | 1 |
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| Szegő, EM | 1 |
| Ribas, VT | 1 |
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| Bähr, M | 1 |
| Tönges, L | 1 |
| Lingor, P | 1 |
| Rodriguez-Perez, AI | 3 |
| Borrajo, A | 1 |
| Valenzuela, R | 3 |
| Lanciego, JL | 1 |
| Labandeira-Garcia, JL | 7 |
| Suzuki, S | 1 |
| Kawamata, J | 1 |
| Iwahara, N | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Starving for Energy - A Pilot Study to Test Ketone Derived Energy in Eating Disorders[NCT05507008] | 40 participants (Anticipated) | Interventional | 2022-10-13 | Recruiting | |||
| Phase I Study of Subthalamic GAD Gene Transfer in Medically Refractory Parkinson's Disease Patients[NCT00195143] | Phase 1 | 12 participants | Interventional | 2003-08-31 | Completed | ||
| Effectiveness of a Probiotic K10 in Managing Health Outcomes in Parkinson's Disease and in Early Stage (Mild Cognitive Impairment to Mild Dementia) Alzheimer's Disease[NCT06019117] | 104 participants (Anticipated) | Interventional | 2023-08-10 | Active, not recruiting | |||
| Phase II Study to Assess Prevention of Oxaliplatin-induced Neurotoxicity Through the Vitamin D Pathway[NCT01499940] | Phase 2 | 9 participants (Actual) | Interventional | 2012-01-31 | Terminated (stopped due to Research cancelled - no funding identified.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
NCI CTCAE Version 4.0 (NCT01499940)
Timeframe: Up to 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin D3 2000 IU/Day | 5 |
13 reviews available for oxidopamine and Nerve Degeneration
| Article | Year |
|---|---|
Synaptic Zinc: An Emerging Player in Parkinson's Disease.
Topics: Animals; Basal Ganglia; Cation Transport Proteins; Cerebral Cortex; Chelating Agents; Corpus Striatu | 2021 |
The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration.
Topics: Animals; Biological Transport; Caenorhabditis elegans; Disease Models, Animal; Dopamine; Models, Ani | 2003 |
Animal models of Parkinson's disease in rodents induced by toxins: an update.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenergic Agents; Animals; Basal Ganglia; Brain Stem; | 2003 |
Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Disease Models, Animal; Disease Progre | 2006 |
Neural repair strategies for Parkinson's disease: insights from primate models.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Transplantation; Deep Brain Stimulation; | 2006 |
Controversies on new animal models of Parkinson's disease pro and con: the rotenone model of Parkinson's disease (PD).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; Dopamine Agents; Humans; Nerve Dege | 2006 |
Functional and molecular differentiation of the dopamine system induced by neonatal denervation.
Topics: Animals; Animals, Newborn; Dopamine; Locomotion; Nerve Degeneration; Oxidopamine; Receptors, Dopamin | 1996 |
Potential of neurotrophic factors in therapy of Parkinson's disease.
Topics: Adrenal Medulla; Animals; Cells, Cultured; Dopamine; Drug Evaluation, Preclinical; Drug Synergism; G | 1996 |
Mechanism of 6-hydroxydopamine neurotoxicity.
Topics: Animals; Brain; Chelating Agents; Free Radical Scavengers; Free Radicals; Humans; Mitochondria; Mode | 1997 |
Gene therapy for Parkinson's disease.
Topics: Adenoviruses, Human; Animals; Astrocytes; Cell Survival; Cell Transplantation; Cells, Cultured; Corp | 1997 |
MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: neuroprotective strategies.
Topics: Animals; Disease Models, Animal; Humans; Nerve Degeneration; Neuroprotective Agents; Oxidopamine; Pa | 2000 |
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease.
Topics: Animals; Apoptosis; Dopamine; Humans; MPTP Poisoning; Nerve Degeneration; Oxidopamine; Sympatholytic | 2001 |
Selective effects of DSP-4 on locus coeruleus axons: are there pharmacologically different types of noradrenergic axons in the central nervous system?
Topics: Adrenergic Agents; Adrenergic Fibers; Axons; Benzylamines; Cerebral Cortex; Dopamine beta-Hydroxylas | 1991 |
328 other studies available for oxidopamine and Nerve Degeneration
| Article | Year |
|---|---|
Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response.
Topics: Animals; Anxiety; Behavior, Animal; Corpus Striatum; Depressive Disorder; Disease Models, Animal; Fe | 2021 |
Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson's disease.
Topics: Alarmins; Animals; Antibodies, Neutralizing; Corpus Striatum; Disease Models, Animal; Dopaminergic N | 2022 |
Chlorogenic acid delays the progression of Parkinson's disease via autophagy induction in
Topics: Animals; Animals, Genetically Modified; Autophagy; Caenorhabditis elegans; Chlorogenic Acid; Disease | 2023 |
Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amidohydrolases; Animals; Disease Models, Animal; Dopa | 2022 |
Pathological α-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine.
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Macaca fasc | 2023 |
Pathological α-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine.
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Macaca fasc | 2023 |
Pathological α-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine.
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Macaca fasc | 2023 |
Pathological α-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine.
Topics: alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Macaca fasc | 2023 |
Feasibility of combining alpha-synuclein aggregation and 6-OHDA in embryonic midbrain culture for modeling dopamine neuron degeneration.
Topics: alpha-Synuclein; Animals; Dopamine; Feasibility Studies; Mesencephalon; Mice; Nerve Degeneration; Ox | 2023 |
Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration.
Topics: Adenosine Triphosphate; Animals; Caenorhabditis elegans; Disease Models, Animal; Dopamine; Dopaminer | 2023 |
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease.
Topics: Animals; Axons; Biomarkers; Disease Models, Animal; Dopaminergic Neurons; Humans; Mice, Inbred C57BL | 2020 |
Electroacupuncture Therapy Ameliorates Motor Dysfunction via Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor in a Mouse Model of Parkinson's Disease.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corpus Striatum; Disease Models, Animal; Dopaminergic Ne | 2020 |
Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration.
Topics: Animals; Autopsy; Biomarkers; CD36 Antigens; Disease Models, Animal; Heart; Inflammation; Macaca mul | 2020 |
A co-culture nanofibre scaffold model of neural cell degeneration in relevance to Parkinson's disease.
Topics: Acrylic Resins; Astrocytes; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cocul | 2020 |
Neuronal degeneration and oxidative stress in the SNc of 6-OHDA intoxicated rats; improving role of silymarin long-term treatment.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Nerve D | 2020 |
Fraternine, a Novel Wasp Peptide, Protects against Motor Impairments in 6-OHDA Model of Parkinsonism.
Topics: Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Female; Male; M | 2020 |
Structural elucidation and neuroprotective activities of lignans from the flower buds of
Topics: Cell Death; Cell Line; Flowers; Humans; Lignans; Magnetic Resonance Spectroscopy; Magnolia; Molecula | 2021 |
Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease.
Topics: Animals; Armadillo Domain Proteins; Axons; Cytoskeletal Proteins; Genetic Variation; Male; Mice; Mic | 2021 |
Neurorescue Effects of Frondoside A and Ginsenoside Rg3 in
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Apoptosis; Caenorhabditis elegans; Caenorha | 2021 |
Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease.
Topics: Adrenergic Agents; Animals; Antioxidants; Cell Line, Transformed; Cell Survival; DNA-Binding Protein | 2017 |
Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA.
Topics: Animals; Astrocytes; Behavior, Animal; Cell Death; Citrates; Dopamine; Dopaminergic Neurons; Glial F | 2018 |
Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease.
Topics: Anesthesia; Animals; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; | 2017 |
Effect of Intrastriatal 6-OHDA Lesions on Extrastriatal Brain Structures in the Mouse.
Topics: Animals; Astrocytes; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Injections; Male | 2018 |
Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: Therapeutic implications for Parkinson's disease.
Topics: Anhedonia; Animals; Depression; Disease Models, Animal; Gait; Imipramine; Ketamine; Male; Nerve Dege | 2018 |
Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment.
Topics: Animals; Animals, Genetically Modified; Apoptosis; Caenorhabditis elegans; Caenorhabditis elegans Pr | 2018 |
6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Car | 2018 |
Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson's Disease.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Disease Models, Animal; Dopaminergic | 2017 |
Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis.
Topics: Adrenergic Neurons; Animals; Brain; Bromodeoxyuridine; Cell Death; Dopamine; Dopamine beta-Hydroxyla | 2018 |
Extracellular Zn
Topics: Animals; Calcium; Chelating Agents; Disease Models, Animal; Dopaminergic Neurons; Ethylenediamines; | 2019 |
Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells.
Topics: Animals; Antigens, Bacterial; Bacterial Toxins; Base Sequence; Cell Line, Tumor; Dopaminergic Neuron | 2019 |
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Topics: Acetophenones; Animals; Apomorphine; Cell Line, Transformed; Corpus Striatum; Disease Models, Animal | 2018 |
Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation.
Topics: Animals; Biphenyl Compounds; Gliosis; Lignans; Longevity; Male; Mice; Motor Activity; NADPH Oxidases | 2018 |
Inflammatory process in Parkinson disease: neuroprotection by neuropeptide Y.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Prote | 2019 |
Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease.
Topics: Animals; Cell Survival; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopaminergic Neuro | 2019 |
Carvacrol Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in In Vivo and In Vitro Models of Parkinson's Disease.
Topics: Animals; Annexins; Behavior, Animal; Cell Survival; Corpus Striatum; Cymenes; Dose-Response Relation | 2020 |
Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles.
Topics: Animals; Axons; Biological Transport; Capsid; Cell Nucleus; Deoxyribonuclease I; Dependovirus; Dopam | 2013 |
Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Brain Injuries; Disease Models, Animal; Dose-Response Relat | 2013 |
Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Antiparkinson Agents; Appetitive Behavior; | 2014 |
Stress exacerbates experimental Parkinson's disease.
Topics: Animals; Antigens, Nuclear; Cell Count; Cell Survival; Chronic Disease; Depressive Disorder; Dopamin | 2014 |
Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Inflammation; M | 2013 |
The combination of oral L-DOPA/rimonabant for effective dyskinesia treatment and cytological preservation in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia.
Topics: Administration, Oral; Animals; Cannabinoid Receptor Antagonists; Corpus Striatum; Dihydroxyphenylala | 2013 |
NADPH oxidase and the degeneration of dopaminergic neurons in parkinsonian mice.
Topics: Animals; Apomorphine; CD11b Antigen; Dopaminergic Neurons; Enzyme Activation; Glial Fibrillary Acidi | 2013 |
Decreased response of interneurons in the medial prefrontal cortex to 5-HT₁A receptor activation in the rat 6-hydroxydopamine Parkinson model.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Dose-Response Relationship, Drug | 2014 |
Noradrenaline neuron degeneration contributes to motor impairments and development of L-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Adrenergic Neurons; Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Benz | 2014 |
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1.
Topics: Animals; Cell Survival; DNA-Binding Proteins; Dopaminergic Neurons; Endoplasmic Reticulum Stress; Ge | 2014 |
The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons.
Topics: Adrenergic Agents; Animals; Axonal Transport; Disease Models, Animal; Dopaminergic Neurons; Mice; Mi | 2014 |
Lentivirus-mediated delivery of sonic hedgehog into the striatum stimulates neuroregeneration in a rat model of Parkinson disease.
Topics: Adrenergic Agents; Animals; Corpus Striatum; Disease Models, Animal; Genetic Vectors; Glial Fibrilla | 2014 |
Cardiac sympathetic denervation in 6-OHDA-treated nonhuman primates.
Topics: Adrenal Medulla; alpha-Synuclein; Animals; Aromatic-L-Amino-Acid Decarboxylases; Autonomic Fibers, P | 2014 |
AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Dependovirus; Disease Models, Animal; Do | 2015 |
Critical period for dopaminergic neuroprotection by hormonal replacement in menopausal rats.
Topics: Angiotensin Receptor Antagonists; Animals; Cells, Cultured; Dopaminergic Neurons; Estrogen Receptor | 2015 |
Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats.
Topics: Animals; Dopaminergic Neurons; Female; Humans; Mesenchymal Stem Cell Transplantation; Methamphetamin | 2015 |
Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Caenorhabditis elegans; Cytoprotection; Dopaminergic | 2014 |
Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans.
Topics: Adrenergic Agents; Animals; Caenorhabditis elegans; DNA Damage; DNA, Mitochondrial; Dopamine; Dopami | 2014 |
The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity.
Topics: alpha-Synuclein; Animals; Cells, Cultured; Disease Models, Animal; Dopaminergic Neurons; Mesencephal | 2015 |
Pramipexole protects dopaminergic neurons through paraplegin against 6-hydroxydopamine.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Benzothiazoles; Cells, Cultured; Dopam | 2015 |
Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain Chemistry; Brain-Derived Neurotrophi | 2015 |
A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Expression; Imidazoles; Inflam | 2015 |
PET Imaging of Serotonin Transporters With 4-[(18)F]-ADAM in a Parkinsonian Rat Model With Porcine Neural Xenografts.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Male; | 2016 |
Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson's disease in rats.
Topics: Animals; Apomorphine; Benserazide; Combined Modality Therapy; Drug Combinations; Glial Fibrillary Ac | 2015 |
Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration.
Topics: Animals; Antiparkinson Agents; Apoptosis; Corpus Striatum; Dopamine; Forelimb; Functional Laterality | 2015 |
6-Hydroxydopamine as a tool to understand adaptive immune system-induced dopamine neurodegeneration in Parkinson's disease.
Topics: Adaptive Immunity; Animals; B-Lymphocytes; Calcium-Binding Proteins; CD3 Complex; Disease Models, An | 2015 |
Systemic human CD34(+) cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration.
Topics: Animals; Antigens, CD34; Brain; Cell Differentiation; Cell Line; Cell Movement; Cord Blood Stem Cell | 2015 |
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration.
Topics: Animals; Axons; Cell Survival; Corpus Striatum; Denervation; Dopaminergic Neurons; Female; Gene Expr | 2015 |
Novel Food Supplement "CP1" Improves Motor Deficit, Cognitive Function, and Neurodegeneration in Animal Model of Parkinson's Disease.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cholinergic Neurons; Cognition; Cyperus; Die | 2016 |
Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.
Topics: Animals; Cell Survival; Cytochromes c; Dopamine Plasma Membrane Transport Proteins; Gene Knockdown T | 2016 |
Combination of acamprosate and baclofen as a promising therapeutic approach for Parkinson's disease.
Topics: Acamprosate; Animals; Baclofen; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; | 2015 |
Intranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in rats.
Topics: Animals; Behavior, Animal; Corpus Striatum; Dopamine; Insulin; Male; Nerve Degeneration; Neuroprotec | 2016 |
Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo.
Topics: Acetylcysteine; Animals; Corpus Striatum; Male; Mice; Nerve Degeneration; Neuroprotective Agents; Ox | 2016 |
7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Dopaminergic Neurons; Flavo | 2016 |
Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures.
Topics: Animals; Axons; Brain; Cells, Cultured; Colchicine; Dependovirus; Disease Models, Animal; Genetic Ve | 2016 |
Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model.
Topics: Animals; Autophagy; Cell Death; Iridoid Glucosides; Iridoids; Mitochondria; Nerve Degeneration; Oxid | 2016 |
Topics: Acetylcholinesterase; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Astragalus pr | 2016 |
FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Dose-Response Relationship, Drug; Fingolimod | 2017 |
Cardiovascular dysfunction associated with neurodegeneration in an experimental model of Parkinson's disease.
Topics: Acetylcholine; Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Bradycardia; Brain Ste | 2017 |
Rat brain sagittal organotypic slice cultures as an ex vivo dopamine cell loss system.
Topics: Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Brain; Cell Death; Desipramine; Dopaminergi | 2017 |
Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Feeding Beha | 2017 |
Long-term protective effects of AAV9-mesencephalic astrocyte-derived neurotrophic factor gene transfer in parkinsonian rats.
Topics: Adenoviridae; Adrenergic Agents; Amphetamine; Animals; Cells, Cultured; Disease Models, Animal; Dopa | 2017 |
Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson's disease is mediated by a reduction of inducible nitric oxide synthase.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Astrocytes; Corpus Striatum; Disease Models, Animal | 2018 |
Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing.
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Biological Products; Caenorhabditis elegans; Disease | 2018 |
Dietary restriction does not prevent nigrostriatal degeneration in the 6-hydroxydopamine model of Parkinson's disease.
Topics: Animals; Corpus Striatum; Diet Therapy; Disease Models, Animal; Male; Nerve Degeneration; Oxidopamin | 2008 |
Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats.
Topics: Amphetamine; Animals; Behavior, Animal; Brain; Cell Nucleus; Cells, Cultured; Cytoplasm; Dependoviru | 2008 |
Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine.
Topics: Animals; Caspases; Cell Cycle; Cell Death; Cell Differentiation; Cyclin D1; Cyclin-Dependent Kinase | 2008 |
Enhanced glutamatergic phenotype of mesencephalic dopamine neurons after neonatal 6-hydroxydopamine lesion.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Glutamic Acid; Male; Mesencephalon; Ner | 2008 |
Unilateral axonal or terminal injection of 6-hydroxydopamine causes rapid-onset nigrostriatal degeneration and contralateral motor impairments in the rat.
Topics: Adrenergic Agents; Animals; Axons; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Humans | 2008 |
The footfault test as a screening tool in the 6-hydroxydopamine rat model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Behavioral Sciences; Disease Models, Animal; Dopamine; Dopamine Agonists; | 2009 |
Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration.
Topics: Animals; Corpus Striatum; Dopamine; Dyskinesia, Drug-Induced; Female; Immunohistochemistry; Levodopa | 2009 |
Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Endocannabinoid | 2009 |
Combined treatment of neurotrophin-3 gene and neural stem cells is ameliorative to behavior recovery of Parkinson's disease rat model.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Movement; Cells, Cultured; Disease Models, Animal; Dopa | 2009 |
Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro.
Topics: Animals; Apoptosis; Brain; Cell Line; Cell Survival; Flavanones; Glial Fibrillary Acidic Protein; Hu | 2009 |
Effect of unilateral lesion of the nigrostriatal dopamine pathway on survival and neurochemistry of parafascicular nucleus neurons in the rat--evaluation of time-course and LGR8 expression.
Topics: Animals; Cell Death; Cell Survival; Corpus Striatum; Disease Models, Animal; Functional Laterality; | 2009 |
Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.
Topics: Administration, Oral; Adrenergic Agents; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; | 2009 |
PET imaging in rats to discern temporal onset differences between 6-hydroxydopamine and tau gene vector neurodegeneration models.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Fluorine Radioisotopes; Genetic Vectors; Male; Ner | 2009 |
Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture.
Topics: Animals; Animals, Newborn; Cell Death; Cell Differentiation; Cells, Cultured; Dopamine; Dose-Respons | 2009 |
Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Brain; Brain Chemistry; Chromatography, | 2009 |
Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Glial Cell Line-Derived Neurotrophic Fac | 2009 |
Caffeine and CSC, adenosine A2A antagonists, offer neuroprotection against 6-OHDA-induced neurotoxicity in rat mesencephalic cells.
Topics: Adenosine A2 Receptor Agonists; Animals; Apoptosis; Caffeine; Cells, Cultured; Encephalitis; Female; | 2010 |
Kinetics of microglial activation and degeneration of dopamine-containing neurons in a rat model of Parkinson disease induced by 6-hydroxydopamine.
Topics: Animals; Cell Death; Corpus Striatum; Disease Models, Animal; Dopamine; Kinetics; Male; Mesencephalo | 2009 |
Biochemical alteration in cerebrospinal fluid precedes behavioral deficits in Parkinsonian rats induced by 6-hydroxydopamine.
Topics: Animals; Biomarkers; Cell Count; Cell Death; Disease Models, Animal; Dopamine; Homovanillic Acid; Hy | 2009 |
A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenine; Animals; Antiparkinson Agents; Autoradiograph | 2010 |
Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat.
Topics: Adrenergic Agents; Animals; Axons; Corpus Striatum; Disease Models, Animal; Gene Expression; Male; M | 2010 |
Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease.
Topics: Animals; Antioxidants; Disease Models, Animal; Dopamine; Enzymes; Free Radicals; Glutathione; Lipid | 2010 |
On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Analysis of Variance; Animals; Brain; Cell Count; | 2010 |
Intake of tomato-enriched diet protects from 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carotenoids; Disease Models, Animal; Dopamine; Functional L | 2009 |
Characterisation of behavioural and neurodegenerative changes induced by intranigral 6-hydroxydopamine lesions in a mouse model of Parkinson's disease.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agen | 2010 |
Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Chromatography, High Pressure Liquid; Dietary Fats | 2010 |
Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degeneration.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Co | 2012 |
Minor retinal degeneration in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; Hallucinations; Haplorhini; Humans; | 2011 |
Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Basal Ganglia; Behavior, Animal; Biomarkers; Brain; Deoxyguano | 2011 |
Neuroprotective effects of SCM198 on 6-hydroxydopamine-induced behavioral deficit in rats and cytotoxicity in neuronal SH-SY5Y cells.
Topics: Animals; Behavior, Animal; Cell Line, Tumor; Cell Survival; Gallic Acid; Humans; Leonurus; Male; Ner | 2011 |
Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat.
Topics: Animals; Axons; Corpus Striatum; Disease Models, Animal; Inflammation; Male; Nerve Degeneration; Ner | 2011 |
Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis.
Topics: Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Survival; Curcumin; Dopamine; Humans; | 2011 |
CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.
Topics: Animals; Chemokine CX3CL1; Corpus Striatum; Disease Models, Animal; Humans; Male; Microglia; Nerve D | 2011 |
Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells.
Topics: Adrenergic Agents; Apoptosis; Blotting, Western; Cathepsin L; Cell Line, Tumor; Fluorescent Antibody | 2011 |
Vascular endothelial growth factor-B is neuroprotective in an in vivo rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Behavioral Symptoms; Cell Count; Central Nervous System Stimulants; Disease Mo | 2011 |
Modifications of neuroactive steroid levels in an experimental model of nigrostriatal degeneration: potential relevance to the pathophysiology of Parkinson's disease.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Male; Nerve Degeneration; Oxidopa | 2012 |
Adhesion molecules as potential targets for neuroprotection in a rodent model of Parkinson's disease.
Topics: Animals; Cell Adhesion Molecules; Corpus Striatum; Disease Models, Animal; Freund's Adjuvant; Interc | 2011 |
Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses.
Topics: Animals; Anti-Inflammatory Agents; Anxiety; Apoptosis; Autoradiography; Cell Survival; Disease Model | 2011 |
Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans.
Topics: Animals; Animals, Genetically Modified; Blotting, Western; Caenorhabditis elegans; Caenorhabditis el | 2011 |
Microarray expression profiling in 6-hydroxydopamine-induced dopaminergic neuronal cell death.
Topics: Animals; Cell Death; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Gene Expression Profil | 2011 |
Lesions of the dopaminergic innervation of the nucleus accumbens medial shell delay the generation of preference for sucrose, but not of sexual pheromones.
Topics: Animals; Female; Food Preferences; Mice; Motor Activity; Nerve Degeneration; Nucleus Accumbens; Oxid | 2012 |
Ether-à-go-go 1 (Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion.
Topics: Animals; Basal Ganglia; Disease Models, Animal; Dopaminergic Neurons; Ether-A-Go-Go Potassium Channe | 2012 |
CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease.
Topics: Animals; Antibodies, Blocking; Antigens, CD; Behavior, Animal; Disease Models, Animal; Dopamine; Dop | 2011 |
Impaired hepatic function and central dopaminergic denervation in a rodent model of Parkinson's disease: a self-perpetuating crosstalk?
Topics: Adenosine Triphosphate; Animals; Cytokines; Dopamine; Dopaminergic Neurons; Liver; Male; Membrane Po | 2012 |
Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: motor impairments identify extent of dopamine depletion at three different lesion sites.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Male; Medial Forebrain Bundle; Mice; Mic | 2012 |
Dopaminergic neuroprotection of hormonal replacement therapy in young and aged menopausal rats: role of the brain angiotensin system.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Compounds; Corpus Striatu | 2012 |
Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Female; Medial | 2012 |
Riluzole neuroprotection in a Parkinson's disease model involves suppression of reactive astrocytosis but not GLT-1 regulation.
Topics: Animals; Astrocytes; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Excitatory Amino | 2012 |
Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line.
Topics: Adenosine Triphosphate; Apoptosis; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Dose-Response | 2012 |
Neurokinin receptor 3 peptide exacerbates 6-hydroxydopamine-induced dopaminergic degeneration in rats through JNK pathway.
Topics: Animals; Corpus Striatum; Dopaminergic Neurons; Male; MAP Kinase Signaling System; Nerve Degeneratio | 2012 |
Rosiglitazone, a PPAR-γ agonist, protects against striatal dopaminergic neurodegeneration induced by 6-OHDA lesions in the substantia nigra of rats.
Topics: Animals; Basal Ganglia; Calcium-Binding Proteins; Cyclooxygenase 2; Disease Models, Animal; Dopamine | 2012 |
Neurotrophic effects of serum- and glucocorticoid-inducible kinase on adult murine mesencephalic dopamine neurons.
Topics: Animals; Cell Count; Cell Death; Dopaminergic Neurons; Gene Expression Regulation, Enzymologic; Gene | 2012 |
The C-terminal domain of the heavy chain of tetanus toxin given by intramuscular injection causes neuroprotection and improves the motor behavior in rats treated with 6-hydroxydopamine.
Topics: Animals; Apoptosis; Astrocytes; Catecholamines; Chromatography, High Pressure Liquid; Corpus Striatu | 2012 |
Fibroblast growth factor-20 protects against dopamine neuron loss in vitro and provides functional protection in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
Topics: Animals; Corpus Striatum; Dopaminergic Neurons; Fibroblast Growth Factors; Male; Motor Activity; Ner | 2012 |
Proliferation of external globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons.
Topics: Animals; Carrier Proteins; Dopamine; Dopaminergic Neurons; Exploratory Behavior; Globus Pallidus; In | 2012 |
RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells.
Topics: Adrenergic Agents; Aged; Aged, 80 and over; Animals; Carrier Proteins; DNA-Binding Proteins; Dopamin | 2013 |
Functional and histochemical characterization of a uterine adrenergic denervation process in pregnant rats.
Topics: Animals; Blood Vessels; Electric Stimulation; Embryo Implantation; Female; Gestational Age; Histocyt | 2002 |
Asymmetrical changes of excitatory synaptic transmission in dopamine-denervated striatum after transient forebrain ischemia.
Topics: Animals; Brain Ischemia; Dopamine; Electric Stimulation; Excitatory Postsynaptic Potentials; Functio | 2002 |
Subthalamic GAD gene therapy in a Parkinson's disease rat model.
Topics: Animals; Dependovirus; Disease Models, Animal; Dopamine; Electric Stimulation; Electrophysiology; ga | 2002 |
Change in bi-directional plasticity at CA1 synapses in hippocampal slices taken from 6-hydroxydopamine-treated rats: the role of endogenous norepinephrine.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Animals, Newborn; Axons; Cyclic AMP-De | 2002 |
Catecholaminergic neuronal degeneration in rainbow trout assessed by skin color change: a model system for identification of environmental risk factors.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adaptation, Physiological; Animals; Catecholamines; Do | 2002 |
Susceptibility of ascending dopamine projections to 6-hydroxydopamine in rats: effect of hypothermia.
Topics: Animals; Body Temperature; Cell Survival; Cocaine; Disease Susceptibility; Dopamine; Efferent Pathwa | 2002 |
Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females.
Topics: Adrenergic Agents; Animals; Castration; Cell Survival; Chromatography, High Pressure Liquid; Corpus | 2003 |
Effects of basolateral amygdala dopamine depletion on the nucleus accumbens and medial prefrontal cortical dopamine responses to stress.
Topics: Amygdala; Animals; Dopamine; Electrochemistry; Functional Laterality; Male; Nerve Degeneration; Neur | 2003 |
Progressive and extensive dopaminergic degeneration induced by convection-enhanced delivery of 6-hydroxydopamine into the rat striatum: a novel rodent model of Parkinson disease.
Topics: Adrenergic Agents; Animals; Cardiotonic Agents; Convection; Corpus Striatum; Disease Models, Animal; | 2003 |
Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations.
Topics: Action Potentials; Animals; Dopamine; Electrophysiology; gamma-Aminobutyric Acid; Glutamate Decarbox | 2003 |
Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Behavior, Animal; Benzylamines; Cataleps | 2003 |
Implantation of human amniotic epithelial cells prevents the degeneration of nigral dopamine neurons in rats with 6-hydroxydopamine lesions.
Topics: Amnion; Animals; Cell Culture Techniques; Cell Survival; Dopamine; Epithelial Cells; Female; Fetal T | 2003 |
[Correlation between iron levels and degeneration of dopaminergic neurons in rat nigrostriatal system during the early 6-OHDA lesions in medial forebrain bundle].
Topics: Animals; Corpus Striatum; Dopamine; Female; Iron; Medial Forebrain Bundle; Nerve Degeneration; Neuro | 2003 |
Effects of orally administered levodopa on mesencephalic dopaminergic neurons undergoing a degenerative process.
Topics: Administration, Oral; Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine; Female; Immun | 2003 |
Intensification of cataleptic response in 6-hydroxydopamine-induced neurodegeneration of substantia nigra is not dependent on the degree of dopamine depletion.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Catalepsy; Dopamine; Dopamine Anta | 2004 |
6-Hydroxydopamine increases the level of TNFalpha and bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemiparkinsonian rats.
Topics: Adrenergic Agents; Animals; Apoptosis; bcl-2-Associated X Protein; Corpus Striatum; Dopamine; Functi | 2004 |
Combined toxicity of prenatal bacterial endotoxin exposure and postnatal 6-hydroxydopamine in the adult rat midbrain.
Topics: Animals; Animals, Newborn; Cell Death; Disease Models, Animal; Dopamine; Encephalitis; Endotoxins; F | 2004 |
Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; CCAAT-Enhancer-Binding Proteins; Cells, Cultu | 2004 |
6-hydroxydopamine lesions in anuran amphibians: a new model system for Parkinson's disease?
Topics: Acoustic Stimulation; Animals; Anura; Attention; Brain; Disease Models, Animal; Dopamine; Down-Regul | 2004 |
Alterations in the cellular distribution of bcl-2, bcl-x and bax in the adult rat substantia nigra following striatal 6-hydroxydopamine lesions.
Topics: Animals; Apoptosis; Astrocytes; bcl-2-Associated X Protein; bcl-X Protein; Disease Models, Animal; D | 2004 |
6-Hydroxydopamine induces dopaminergic cell degeneration via a caspase-9-mediated apoptotic pathway that is attenuated by caspase-9dn expression.
Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Survival; Cell | 2004 |
An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Carbidopa; Cell Count; Differential Threshold; Dise | 2005 |
Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy).
Topics: Animals; Biomarkers; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine and cAMP-Regulat | 2005 |
Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat.
Topics: Adenoviridae; Adrenergic Agents; Animals; Corpus Striatum; Dopamine; Genetic Vectors; Hedgehog Prote | 2005 |
Analysis of gene expression changes in a cellular model of Parkinson disease.
Topics: Animals; Cell Cycle; Cell Death; Cell Differentiation; Cell Survival; Dopamine; Gene Expression Prof | 2005 |
RA410/Sly1 suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells.
Topics: 1-Methyl-4-phenylpyridinium; Adaptation, Physiological; Animals; Apoptosis; Carrier Proteins; Caspas | 2005 |
Cystatin C prevents degeneration of rat nigral dopaminergic neurons: in vitro and in vivo studies.
Topics: Animals; Astrocytes; Cell Survival; Cells, Cultured; Cystatin C; Cystatins; Cysteine Proteinase Inhi | 2005 |
Glial overexpression of heme oxygenase-1: a histochemical marker for early stages of striatal damage.
Topics: 5,7-Dihydroxytryptamine; Afferent Pathways; Animals; Astrocytes; Basal Ganglia Diseases; Biomarkers; | 2005 |
The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model.
Topics: Amphetamine; Animals; Cell Survival; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Respons | 2005 |
Failure of FK506 (tacrolimus) to alleviate apomorphine-induced circling in rat Parkinson model in spite of some cytoprotective effects in SH-SY5Y dopaminergic cells.
Topics: Animals; Apomorphine; Behavior, Animal; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Disease M | 2005 |
Comparison of 6-hydroxydopamine-induced medial forebrain bundle and nigrostriatal terminal lesions in a lateralised nose-poking task in rats.
Topics: Adrenergic Agents; Animals; Behavioral Research; Dopamine; Exploratory Behavior; Functional Laterali | 2005 |
Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.
Topics: Adrenergic Agents; alpha-Synuclein; Analysis of Variance; Animals; Animals, Genetically Modified; Bl | 2005 |
Dopaminergic neurotoxicity by 6-OHDA and MPP+: differential requirement for neuronal cyclooxygenase activity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Death; Cells, Cultured; Cyclooxygenase Inhibitors; Dopami | 2005 |
Degeneration of dopaminergic neurons triggers an expression of individual enzymes of dopamine synthesis in non-dopaminergic neurons of the arcuate nucleus in adult rats.
Topics: Adrenergic Agents; Animals; Arcuate Nucleus of Hypothalamus; Aromatic-L-Amino-Acid Decarboxylases; D | 2005 |
Dopaminergic neurotoxins require excitotoxic stimulation in organotypic cultures.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Animals, Newborn; Brain; Cell Death; Cell Nucleus; Cerebral Co | 2005 |
Functional reinnervation from remaining DA terminals induced by GDNF lentivirus in a rat model of early Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Genetic Therapy; Glial Cell Line-Derived | 2006 |
Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system.
Topics: Animals; Bacterial Proteins; Blueberry Plants; Calcium-Binding Proteins; Cell Count; Corpus Striatum | 2005 |
Partial dopamine loss enhances activated caspase-3 activity: differential outcomes in striatal projection systems.
Topics: Animals; Apoptosis; Caspase 3; Caspases; Corpus Striatum; Disease Models, Animal; Disease Progressio | 2005 |
Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease.
Topics: Animals; Cell Survival; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Electron Trans | 2006 |
Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity.
Topics: Aging; Animals; Dopamine; Drug Resistance; Methamphetamine; Mice; Mice, Knockout; Nerve Degeneration | 2005 |
Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
Topics: Animals; Antioxidants; Brain; Cell Survival; Corpus Striatum; Cytoprotection; Disease Models, Animal | 2006 |
Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Topics: Cell Line, Tumor; Dopamine; Down-Regulation; Enzyme Inhibitors; Free Radical Scavengers; Gene Expres | 2006 |
Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons.
Topics: Adrenergic Agents; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Corpus St | 2007 |
Behavioral and morphological effects of minocycline in the 6-hydroxydopamine rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Behavior, Animal; Brain; Image Processing, Computer-Assisted; Immunohist | 2006 |
Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk.
Topics: Animals; Animals, Newborn; Antibodies; Astrocytes; Cell Communication; Cell Survival; Cells, Culture | 2006 |
KDI tripeptide of gamma1 laminin protects rat dopaminergic neurons from 6-OHDA induced toxicity.
Topics: Animals; Cell Count; Cell Death; Cytoprotection; Disease Models, Animal; Dopamine; Laminin; Male; Ne | 2006 |
Proliferation of neural precursors in the subventricular zone after chemical lesions of the nigrostriatal pathway in rat brain.
Topics: Animals; Biomarkers; Bromodeoxyuridine; Cell Movement; Cell Proliferation; Corpus Striatum; Denervat | 2006 |
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model.
Topics: Animals; Antibodies, Blocking; Behavior, Animal; Cell Death; Cells, Cultured; Dopamine; Dopamine Age | 2006 |
Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity.
Topics: Animals; Anthocyanins; Antioxidants; Ascorbic Acid; Cytochromes c; Dopamine; Flavonoids; Glucosides; | 2007 |
Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.
Topics: Amphetamine; Animals; Cell Death; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Dop | 2006 |
Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Cells, Cultured; Cerebellar Cortex; Cytoprotecti | 2006 |
Peripheral inflammation and neuroprotection: systemic pretreatment with complete Freund's adjuvant reduces 6-hydroxydopamine toxicity in a rodent model of Parkinson's disease.
Topics: Adjuvants, Immunologic; Analysis of Variance; Animals; Disease Models, Animal; Freund's Adjuvant; Ma | 2006 |
A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase Inhibitors; Cells, Cultured; Disease Models | 2006 |
Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition.
Topics: Anastrozole; Animals; Aromatase; Aromatase Inhibitors; Cell Survival; Corpus Striatum; Dopamine; Dop | 2007 |
Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection.
Topics: Animals; Binding, Competitive; Cell Survival; Cocaine; Corpus Striatum; Cytoprotection; Dopamine; Do | 2007 |
Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties.
Topics: Animals; Antioxidants; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid R | 2007 |
Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.
Topics: Adrenergic Agents; Animals; Autophagy; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Ion | 2007 |
Early inhibition of TNFalpha increases 6-hydroxydopamine-induced striatal degeneration.
Topics: Animals; Immunohistochemistry; Male; Neostriatum; Nerve Degeneration; Oligodeoxyribonucleotides, Ant | 2007 |
NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Benzothiazoles; DNA Fragmentation; Dopamine; Mal | 2007 |
Repetitive vibrissae-elicited forelimb placing before and immediately after unilateral 6-hydroxydopamine improves outcome in a model of Parkinson's disease.
Topics: Animals; Conditioning, Classical; Disease Models, Animal; Exercise Therapy; Exploratory Behavior; Fo | 2007 |
Protein tyrosine phosphatase inhibition reduces degeneration of dopaminergic substantia nigra neurons and projections in 6-OHDA treated adult rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhib | 2007 |
Nicotine induces tyrosine hydroxylase plasticity in the neurodegenerating striatum.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Axons; | 2007 |
Ferroportin1 and hephaestin are involved in the nigral iron accumulation of 6-OHDA-lesioned rats.
Topics: Animals; Cation Transport Proteins; Cell Death; Dopamine Agonists; Female; Fluorescent Antibody Tech | 2007 |
Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons.
Topics: Angiotensin II; Animals; Cells, Cultured; Corpus Striatum; Dopamine; Mesencephalon; Microglia; NADPH | 2007 |
Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats.
Topics: Animals; Carbon Radioisotopes; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins | 2007 |
Myricetin reduces 6-hydroxydopamine-induced dopamine neuron degeneration in rats.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; El | 2007 |
The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases.
Topics: Activins; Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cell Line, Tumor; Cell Survival; | 2007 |
Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats.
Topics: Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Anim | 2007 |
High frequency stimulation of the subthalamic nucleus improves speed of locomotion but impairs forelimb movement in Parkinsonian rats.
Topics: Animals; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine; Electric Stimulation Therap | 2007 |
Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo.
Topics: Animals; Benzoates; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Ac | 2007 |
Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of Parkinson's disease does not involve activation of caspase-9 and caspase-3.
Topics: Adrenergic Agents; Animals; Apoptosis; Brain; Caspase 3; Caspase 9; Caspases; Dopamine; Enzyme Activ | 2008 |
Brain-derived neurotrophic factor expression in the substantia nigra does not change after lesions of dopaminergic neurons.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain-Derived Neurotrophic Factor; Disease Mo | 2007 |
Moderate degeneration of nigral neurons after repeated but not after single intrastriatal injections of low doses of 6-hydroxydopamine in mice.
Topics: Animals; Cell Count; Disease Models, Animal; Disease Progression; Dopamine; Dose-Response Relationsh | 2008 |
Adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain.
Topics: Adrenalectomy; Adrenergic Agents; Animals; Astrocytes; Corticosterone; Dopamine; Fibroblast Growth F | 2008 |
Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-no
Topics: Aldehydes; Antioxidants; Cell Line, Tumor; Cells, Cultured; Dopamine; Glutathione; Humans; Hydrogen | 2008 |
Tyrosine hydroxylase cells appearing in the mouse striatum after dopamine denervation are likely to be projection neurones regulated by L-DOPA.
Topics: Animals; Biomarkers; Bromodeoxyuridine; Cell Count; Cell Proliferation; Corpus Striatum; Denervation | 2008 |
Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease.
Topics: Animals; Antirheumatic Agents; Disease Models, Animal; Disease Susceptibility; Dopamine; Female; Int | 2008 |
Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS.
Topics: Adrenergic Agents; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Re | 2008 |
Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease.
Topics: Animals; Cells, Cultured; Dexamethasone; Disease Models, Animal; Disease Progression; Enzyme-Linked | 2008 |
Deterioration of axonal membranes induced by phenolic pro-oxidants. Roles of superoxide radicals and hydrogen peroxide.
Topics: Animals; Astacoidea; Axons; Catalase; Electric Conductivity; Electric Stimulation; Hydrogen Peroxide | 1984 |
Long-lasting depletion of spinal cord 5-hydroxytryptamine or catecholamines after intraspinal injection of 5,7-dihydroxytryptamine or 6-hydroxydopamine to newborn rats.
Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Brain; Dihydroxytryptamines; Dopamine; Female; H | 1983 |
Effect of brain monoamines on the secretion of adrenocorticotrophic hormone.
Topics: 5,6-Dihydroxytryptamine; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Benztropine; Brain Ch | 1982 |
Ptosis in the rat following topically administered 2% epinephrine.
Topics: Administration, Topical; Animals; Blepharoptosis; Catecholamines; Epinephrine; Eyelids; Hydroxydopam | 1983 |
Lack of masticatory response to periodontal stimulation after degeneration of nigrostriatal dopamine neurons in the rat brain.
Topics: Animals; Hydroxydopamines; Male; Masseter Muscle; Masticatory Muscles; Nerve Degeneration; Neurons; | 1983 |
[Morphologic characteristics of locus coeruleus neurons after selective chemical damage to the catecholaminergic system of the brain].
Topics: Animals; Catecholamines; Hydroxydopamines; Locus Coeruleus; Male; Microscopy, Electron; Nerve Degene | 1984 |
The importance of the peripeduncular nucleus in the neuroendocrine control of sexual behavior and milk ejection in the rat.
Topics: Animals; Body Weight; Dopamine; Female; Hydroxydopamines; Ibotenic Acid; Lactation; Male; Milk Eject | 1984 |
A role for amine accumulation in the syndrome of ingestive deficits following lateral hypothalamic lesions.
Topics: Animals; Appetite; Body Weight; Brain; Catecholamines; Dopamine; Eating; Energy Intake; Hydroxydopam | 1984 |
Feeding behavior after hypothalamic 6-hydroxydopamine injections.
Topics: Animals; Catecholamines; Dopamine; Eating; Hydroxydopamines; Hypothalamic Area, Lateral; Nerve Degen | 1984 |
Ultrastructural changes after intracisternal injection of 6-hydroxydopamine in the intermediolateral nucleus of the monkey (Macaca fascicularis).
Topics: Animals; Female; Hydroxydopamines; Macaca fascicularis; Male; Microscopy, Electron; Nerve Degenerati | 1981 |
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat.
Topics: Animals; Axonal Transport; Corpus Striatum; Fluorescent Dyes; Functional Laterality; Immunohistochem | 1994 |
6-Hydroxydopamine lesion of the rat substantia nigra: time course and morphology of cell death.
Topics: Animals; Cell Death; Disease Models, Animal; Nerve Degeneration; Nerve Endings; Neurons; Oxidopamine | 1995 |
Stimulation of D1- or D2-receptors in drug-naive rats with different degrees of unilateral nigro-striatal dopamine lesions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Dopamine; Erg | 1995 |
Presence of somatostatin or neurotensin in lateral septal dopaminergic axon terminals of distinct hypothalamic and midbrain origins: convergence on the somatospiny neurons.
Topics: Animals; Axons; Desipramine; Dopamine; Female; Horseradish Peroxidase; Hypothalamus; Immunohistochem | 1993 |
Ultrastructural features of the choline acetyltransferase-containing neurons and relationships with nigral dopaminergic and cortical afferent pathways in the rat striatum.
Topics: Afferent Pathways; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Dopamine; | 1993 |
Adrenergic innervation of the urinary bladder body in the cat with special reference to structure of the detrusor muscle: an immunohistochemical study of noradrenaline and its synthesizing enzymes.
Topics: Adrenergic Fibers; Animals; Aromatic-L-Amino-Acid Decarboxylases; Cats; Dopamine; Dopamine beta-Hydr | 1994 |
Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study.
Topics: Amphetamine; Animals; Behavior, Animal; Corpus Striatum; Histocytochemistry; Iron; Male; Medial Fore | 1994 |
Temporal and spatial increase of astroglial basic fibroblast growth factor synthesis after 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine neurons.
Topics: Animals; Astrocytes; Blotting, Western; Dopamine; Fibroblast Growth Factor 2; Glial Fibrillary Acidi | 1994 |
Long-term induction of tyrosine hydroxylase expression: compensatory response to partial degeneration of the dopaminergic nigrostriatal system in the rat brain.
Topics: Adaptation, Physiological; Animals; Autoradiography; Corpus Striatum; Dopamine; Immunologic Techniqu | 1995 |
Re-expression of glia-derived nexin/protease nexin 1 depends on mode of lesion-induction or terminal degeneration: observations after excitotoxin or 6-hydroxydopamine lesions of rat substantia nigra.
Topics: Amyloid beta-Protein Precursor; Animals; Carrier Proteins; Glial Fibrillary Acidic Protein; Ibotenic | 1994 |
Alterations in striatal glial fibrillary acidic protein expression in response to 6-hydroxydopamine-induced denervation.
Topics: Animals; Astrocytes; Blotting, Western; Corpus Striatum; Dopamine; Glial Fibrillary Acidic Protein; | 1993 |
Ganglioside GM1 cooperates with brain-derived neurotrophic factor to protect dopaminergic neurons from 6-hydroxydopamine-induced degeneration.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Dopamine; Female; G(M1) Ganglioside; Ne | 1993 |
Influence of prelimbic and sensorimotor cortices on striatal neurons in the rat: electrophysiological evidence for converging inputs and the effects of 6-OHDA-induced degeneration of the substantia nigra.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Electric Stimulation; Limbic System; Male; Moto | 1993 |
Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease.
Topics: Animals; Autoradiography; Brain-Derived Neurotrophic Factor; Corpus Striatum; Dopamine; Fibroblasts; | 1995 |
Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: behavioural and immunohistochemical studies.
Topics: Animals; Dopamine; Drug Administration Schedule; Functional Laterality; Immunohistochemistry; Kainic | 1996 |
GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo.
Topics: Animals; Cell Line; Genetic Engineering; Glial Cell Line-Derived Neurotrophic Factor; Locus Coeruleu | 1995 |
Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration.
Topics: Amphetamines; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Fetal Tissue Transplantation; | 1996 |
Dopaminergic neurons protected from degeneration by GDNF gene therapy.
Topics: Adenoviridae; Animals; Corpus Striatum; Dopamine; Gene Expression; Genetic Therapy; Genetic Vectors; | 1997 |
Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by instrastriatal 6-hydroxydopamine in the rat.
Topics: Animals; Axons; Corpus Striatum; Dopamine; Female; Motor Activity; Nerve Degeneration; Oxidopamine; | 1996 |
Neurochemical responses to lesions of dopaminergic neurons: implications for compensation and neuropathology.
Topics: Animals; Corpus Striatum; Dopamine; Models, Neurological; Nerve Degeneration; Neurons; Oxidopamine; | 1998 |
Degeneration of pre-labelled nigral neurons induced by intrastriatal 6-hydroxydopamine in the rat: behavioural and biochemical changes and pretreatment with the calcium-entry blocker nimodipine.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Dopamine; Female; Immunohistochemistry; Injecti | 1997 |
Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats.
Topics: Animals; Dependovirus; Disease Models, Animal; Gene Expression; Genetic Therapy; Genetic Vectors; Gl | 1997 |
Distribution of zinc in the substantia nigra of rats treated with 6-hydroxydopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Autoradiography; Blood-Brain Barrier; Ch | 1998 |
Experiments in a Parkinson's rat model.
Topics: Animals; Dopamine; Fluorescent Dyes; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neuro | 1997 |
Progressive accumbens degeneration after neonatal striatal 6-hydroxydopamine in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Caudate Nucleus; Chromatography, High Pre | 1998 |
Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat.
Topics: Amphetamine; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Forelimb; Microinjections; Mot | 1998 |
Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Benzazepines; Corpus Striatum; Disease Models, A | 1998 |
6-OHDA denervation substantially decreases DCC mRNA levels in rat substantia nigra compacta.
Topics: Animals; Antisense Elements (Genetics); Behavior, Animal; Cell Adhesion Molecules; Cell Adhesion Mol | 1998 |
Synaptophysin immunoreactivity in the rat pituitary: alterations after 6-hydroxydopamine treatment.
Topics: Animals; Denervation; GAP-43 Protein; Immunohistochemistry; Male; Nerve Degeneration; Nerve Regenera | 1998 |
6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions.
Topics: Animals; Antihypertensive Agents; Corpus Striatum; Denervation; Male; Malonates; Mitochondria; Nerve | 1998 |
A novel neurotransmitter system involved in the control of motor behavior by the basal ganglia.
Topics: Action Potentials; Analgesics; Animals; Basal Ganglia; Benzoxazines; Bicuculline; Cannabinoids; Cycl | 1998 |
In vitro evidence for increased facilitation of striatal acetylcholine release via pre- and postsynaptic NMDA receptors in hemiparkinsonian rats.
Topics: Acetylcholine; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Ago | 1999 |
Scopolamine prevents tolerance to the effects of caffeine on rotational behavior in 6-hydroxydopamine-denervated rats.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Toleran | 1999 |
Effect of dopamine denervation and dopamine agonist administration on serine phosphorylation of striatal NMDA receptor subunits.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antibodies; Antiparkinson Agent | 1999 |
Expression and localisation of CYP2D enzymes in rat basal ganglia.
Topics: Animals; Antibody Specificity; Basal Ganglia; Brain Chemistry; Clozapine; Cytochrome P-450 Enzyme Sy | 1999 |
Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Embryo, Mammalian; Female | 1999 |
Role of high-affinity dopamine uptake and impulse activity in the appearance of extracellular dopamine in striatum after administration of exogenous L-DOPA: studies in intact and 6-hydroxydopamine-treated rats.
Topics: Animals; Biological Transport; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Uptake Inhibitor | 1999 |
Protection and regeneration of nigral dopaminergic neurons by neurturin or GDNF in a partial lesion model of Parkinson's disease after administration into the striatum or the lateral ventricle.
Topics: Amphetamine; Animals; Antibodies; Apomorphine; Atrophy; Body Weight; Cerebral Ventricles; Corpus Str | 1999 |
Time dependence and role of N-methyl-D-aspartate glutamate receptors in the priming of D2-mediated rotational behavior and striatal Fos expression in 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Corpus Striatum; Dizocilpine Maleate; Dopam | 1999 |
Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons.
Topics: Animals; Cell Division; Dopamine; Fibroblasts; Gene Expression Regulation, Developmental; Genetic En | 1999 |
Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Brain Mapping; Corpus Striatum; Dementia; Dopa | 1999 |
Caspase inhibition protects nigral neurons against 6-OHDA-induced retrograde degeneration.
Topics: Amino Acid Chloromethyl Ketones; Animals; Caspase Inhibitors; Corpus Striatum; Cysteine Proteinase I | 1999 |
Nitrite- and peroxide-dependent oxidation pathways of dopamine: 6-nitrodopamine and 6-hydroxydopamine formation as potential contributory mechanisms of oxidative stress- and nitric oxide-induced neurotoxicity in neuronal degeneration.
Topics: Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Dopamine; Male; Nerve Degene | 1999 |
Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease.
Topics: Animals; Cytomegalovirus; Dependovirus; Dopamine; Genes, Reporter; Genetic Therapy; Genetic Vectors; | 1999 |
Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesenc
Topics: Amphetamine; Animals; Apomorphine; Atrophy; Autoradiography; Behavior, Animal; Brain Tissue Transpla | 2000 |
The pivotal role of iron in NF-kappa B activation and nigrostriatal dopaminergic neurodegeneration. Prospects for neuroprotection in Parkinson's disease with iron chelators.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Ani | 1999 |
Dendrite loss is a characteristic early indicator of toxin-induced neurodegeneration in rat midbrain slices.
Topics: Animals; Benzoxazines; Biomarkers; Cell Death; Coloring Agents; Dendrites; Immunohistochemistry; Mal | 2000 |
Lesion-induced increase of BDNF is greater in the striatum of young versus old rat brain.
Topics: Aging; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corpus Striatum; Dopamine; Nerv | 2000 |
Sequential administration of GDNF into the substantia nigra and striatum promotes dopamine neuron survival and axonal sprouting but not striatal reinnervation or functional recovery in the partial 6-OHDA lesion model.
Topics: Animals; Axonal Transport; Axons; Body Weight; Cell Survival; Corpus Striatum; Dopamine; Female; For | 2000 |
N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats.
Topics: Animals; Cell Count; Denervation; Dopamine; Immunohistochemistry; Insulin-Like Growth Factor I; Male | 2000 |
Sequential changes of [H]forskolin, [H]cyclohexyladenosine and [H]PN200-110 binding sites in the brain of 6-hydroxydopamine-lesioned rats.
Topics: Adenosine; Animals; Autoradiography; Binding Sites; Brain Chemistry; Calcium Channel Blockers; Calci | 2000 |
Haloperidol reverses the changes in striatal glutamatergic immunolabeling following a 6-OHDA lesion.
Topics: Animals; Apomorphine; Denervation; Dopamine Agonists; Dopamine Antagonists; Glutamic Acid; Haloperid | 2000 |
The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic system in hemiparkinsonian rats: behavioral and histological studies using two different dosages.
Topics: Animals; Apomorphine; Axons; Behavior, Animal; Disease Models, Animal; Dopamine; Dopamine Agonists; | 2000 |
Metabolic activity of excitatory parafascicular and pedunculopontine inputs to the subthalamic nucleus in a rat model of Parkinson's disease.
Topics: Animals; Axonal Transport; Disease Models, Animal; Energy Metabolism; Excitatory Postsynaptic Potent | 2000 |
Treatment with delta opioid peptide enhances in vitro and in vivo survival of rat dopaminergic neurons.
Topics: Adrenergic Agents; Age Factors; Animals; Brain Tissue Transplantation; Cell Death; Cell Survival; Ce | 2000 |
Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion.
Topics: Animals; Axons; Calbindin 2; Calbindins; Dopamine; Drug Resistance; Female; Neostriatum; Nerve Degen | 2000 |
Pramipexole attenuates the dopaminergic cell loss induced by intraventricular 6-hydroxydopamine.
Topics: Animals; Benzothiazoles; Cell Count; Cell Death; Dopamine; Dopamine Agonists; Male; Neostriatum; Ner | 2000 |
Metabolic changes after injection of quinolinic acid or 6-hydroxydopamine in the rat striatum: a time-course study using cytochrome oxidase and glycogene phosphorylase a histochemistry.
Topics: Animals; Autoradiography; Benzazepines; Biomarkers; Corpus Striatum; Disease Models, Animal; Dopamin | 2000 |
Systemic administration of the propargylamine CGP 3466B prevents behavioural and morphological deficits in rats with 6-hydroxydopamine-induced lesions in the substantia nigra.
Topics: Animals; Antibodies; Apoptosis; Behavior, Animal; Body Weight; Denervation; Dopamine; Exploratory Be | 2000 |
L-DOPA produces strong induction of c-fos messenger RNA in dopamine-denervated cortical and striatal areas of the common marmoset.
Topics: Animals; Benzazepines; Blotting, Western; Callithrix; Cerebral Cortex; Corpus Striatum; Denervation; | 2000 |
Delivery of a GDNF gene into the substantia nigra after a progressive 6-OHDA lesion maintains functional nigrostriatal connections.
Topics: Animals; Dopamine; Fluorescent Dyes; Genetic Therapy; Glial Cell Line-Derived Neurotrophic Factor; M | 2000 |
Adenosine A2A receptor gene expression in the normal striatum and after 6-OH-dopamine lesion.
Topics: Aged; Aged, 80 and over; Animals; Autoradiography; Cats; Corpus Striatum; Gene Expression; Humans; I | 2000 |
Sequential changes of cholinergic and dopaminergic receptors in brains after 6-hydroxydopamine lesions of the medial forebrain bundle in rats.
Topics: Animals; Autoradiography; Choline; Cholinergic Agents; Corpus Striatum; Dopamine Antagonists; Hemich | 2000 |
Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion.
Topics: Animals; Cell Death; Dopamine; Fluorescent Dyes; Immunohistochemistry; In Situ Nick-End Labeling; Lo | 2000 |
Regulation of GAP-43 protein and mRNA in nigrostriatal dopaminergic neurons after the partial destruction of dopaminergic terminals with intrastriatal 6-hydroxydopamine.
Topics: Animals; Cell Count; Disease Models, Animal; Dopamine; GAP-43 Protein; Male; Neostriatum; Nerve Dege | 2001 |
The effects of ascorbic acid on dopamine-induced death of PC12 cells are dependent on exposure kinetics.
Topics: Animals; Ascorbic Acid; Buthionine Sulfoximine; Dopamine; Dose-Response Relationship, Drug; Drug Int | 2000 |
The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats.
Topics: Animals; Corpus Striatum; Ligands; Male; Nerve Degeneration; Nerve Fibers; Nerve Regeneration; Oxido | 2001 |
Changes in the firing pattern of globus pallidus neurons after the degeneration of nigrostriatal pathway are mediated by the subthalamic nucleus in the rat.
Topics: Animals; Corpus Striatum; Globus Pallidus; Male; Nerve Degeneration; Neurons; Oxidopamine; Rats; Rat | 2000 |
Regulation of EphB1 expression by dopamine signaling.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Newborn; Cerebral Cortex; Cocaine; Cocaine-Related | 2000 |
Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Brain Tissue Transplantation; Corpus S | 2001 |
Serotonergic heterotypic sprouting in the unilaterally dopamine-depleted mouse neostriatum.
Topics: Age Factors; Animals; Dopamine; Immunohistochemistry; Mice; Mice, Inbred ICR; Neostriatum; Nerve Deg | 2001 |
cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Gene Expres | 2000 |
Neuroprotective effects of GDNF against 6-OHDA in young and aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Cell Survival; Dopamine; Glial Cell Line-Derived Neu | 2001 |
Immunophilin ligands can prevent progressive dopaminergic degeneration in animal models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Progression; Dopamine; Dopamine Agent | 2001 |
Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat.
Topics: Animals; Apomorphine; Benzazepines; Dopamine; Dopamine Agonists; Dopamine Antagonists; gamma-Aminobu | 2001 |
Dopaminergic mRNA expression in the intact substantia nigra of unilaterally 6-OHDA-lesioned and grafted rats: an in situ hybridization study.
Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Carrier Proteins; Dopamine Plasma Membrane | 2001 |
Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease.
Topics: Amphetamine; Animals; Corpus Striatum; Dopamine; Female; Glial Cell Line-Derived Neurotrophic Factor | 2001 |
Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induced degeneration.
Topics: Animals; beta-Galactosidase; Corpus Striatum; Dextroamphetamine; Dopamine; Female; Functional Latera | 2001 |
Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain Injuries; Cells, Cultured; Dopamine; Immunophilins; Immu | 2001 |
Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo.
Topics: Animals; Antibodies; Apoptosis; Axotomy; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Epitop | 2001 |
6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.
Topics: Animals; Apoptosis; Drug Interactions; Minor Histocompatibility Antigens; Nerve Degeneration; NF-kap | 2001 |
Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum.
Topics: Animals; Anti-Bacterial Agents; Cell Death; Disease Models, Animal; Gliosis; Immunohistochemistry; M | 2001 |
Validity of a quantitative technique to study striatal dopaminergic neurodegeneration by in vivo microdialysis.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Chromatography, High Pressure Liquid; Dopamine; Dose-Response | 2001 |
Vitamin D(3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats.
Topics: Animals; Cells, Cultured; Cholecalciferol; Dopamine; Drug Interactions; Glial Cell Line-Derived Neur | 2001 |
Subthalamic nucleus lesions reduce low frequency oscillatory firing of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease.
Topics: Action Potentials; Animals; Biological Clocks; Disease Models, Animal; Excitatory Amino Acid Agonist | 2001 |
Medullary neurones regulate hypothalamic corticotropin-releasing factor cell responses to an emotional stressor.
Topics: Adrenocorticotropic Hormone; Amygdala; Animals; Catecholamines; Cell Count; Corticotropin-Releasing | 2001 |
NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease.
Topics: Amphetamine; Amyloid beta-Protein Precursor; Animals; Antibodies; Caspase 3; Caspases; Cell Survival | 2001 |
Astroglial and microglial reaction after a partial nigrostriatal degeneration induced by the striatal injection of different doses of 6-hydroxydopamine.
Topics: Animals; Astrocytes; Behavior, Animal; Corpus Striatum; Dose-Response Relationship, Drug; Glial Fibr | 2001 |
Prevention of neurotoxin damage of 6-OHDA to dopaminergic nigral neuron by subthalamic nucleus lesions.
Topics: Afferent Pathways; Animals; Biomarkers; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Kai | 2000 |
Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcium-Binding Proteins; Caspases | 2002 |
Neuroprotection by adenosine A2A receptor blockade in experimental models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antineoplastic A | 2002 |
Evaluation of the protective effect of oestradiol against toxicity induced by 6-hydroxydopamine and 1-methyl-4-phenylpyridinium ion (Mpp+) towards dopaminergic mesencephalic neurones in primary culture.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Antioxidants; Cell Death; Cells, Cultured; Dopamine; Estradiol | 2002 |
Selective subregional dopamine depletions in the rat caudate-putamen following nigrostriatal lesions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Homovanillic Ac | 1992 |
Degeneration of the nigral dopamine neurons after 6-hydroxydopamine injection into the rat striatum.
Topics: Animals; Corpus Striatum; Hydroxydopamines; Immunohistochemistry; Injections; Male; Microscopy, Elec | 1991 |
Organization of the projections from the ventral tegmental area of Tsai to the hippocampal formation in the rat.
Topics: Animals; Axons; Fluorescent Dyes; Hippocampus; Male; Microscopy, Electron; Nerve Degeneration; Neura | 1991 |
Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease.
Topics: Adenosine; Aged; Aged, 80 and over; Animals; Basal Ganglia; Corpus Striatum; Female; Guinea Pigs; Hu | 1991 |
Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid.
Topics: Animals; Corpus Striatum; Desipramine; Dopamine; Male; Nerve Degeneration; Neural Pathways; Oxidopam | 1991 |
The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Deferoxamine; Dopamine; Homovanillic Acid; Hydroxydopamines | 1991 |
L-dopa stimulates the release of [3H]gamma-aminobutyric acid in the basal ganglia of 6-hydroxydopamine lesioned rats.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Basal Ganglia; Benzazepines; Brain Chemistry; | 1991 |
Microglial response to 6-hydroxydopamine-induced substantia nigra lesions.
Topics: Animals; Histocompatibility Antigens; Hydroxydopamines; Male; Nerve Degeneration; Neuroglia; Oxidopa | 1989 |
Local mechanical effects and humoral factors evoke degeneration of guinea pig uterine innervation.
Topics: Animals; Female; Fluorescent Antibody Technique; Foreign Bodies; Guinea Pigs; Myometrium; Nerve Dege | 1989 |
Differential time-course of reaction time recovery depending on variations in the amplitude of a goal-directed movement after nigrostriatal lesion in monkeys.
Topics: Animals; Brain Diseases; Caudate Nucleus; Corpus Striatum; Dopamine; Hydroxydopamines; Motor Activit | 1986 |
Imaging of the degeneration of neurons and their processes in rat or cat brain by 45CaCl2 autoradiography or 55CoCl2 positron emission tomography.
Topics: Animals; Autoradiography; Brain; Brain Diseases; Calcium; Calcium Chloride; Calcium Radioisotopes; C | 1988 |
'Disengage' sensorimotor deficit following apparent recovery from unilateral dopamine depletion.
Topics: Animals; Arousal; Corpus Striatum; Dominance, Cerebral; Dopamine; Feeding Behavior; Female; Hydroxyd | 1988 |
Catecholamine-blocking drugs injected at sites of amine accumulation reverse catecholamine degeneration associated deficits.
Topics: Animals; Behavior, Animal; Dopamine; Dopamine Antagonists; Drinking; Eating; Haloperidol; Hydroxydop | 1985 |
Effects of intracerebral transplantation of immature substantia nigra in rats with experimentally induced Parkinson's disease. I Comparative evaluation of two models of Parkinson's disease induced by unilateral stereotaxic lesion of the substantia nigra w
Topics: Animals; Disease Models, Animal; Electrocoagulation; Hydroxydopamines; Nerve Degeneration; Oxidopami | 1985 |
Small lesions in the primary visual cortex of rats cause a specific reorganization of associational connections.
Topics: Afferent Pathways; Animals; Animals, Newborn; Female; Horseradish Peroxidase; Hydroxydopamines; Male | 1985 |