oxidopamine has been researched along with Muscle Rigidity in 7 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has previously been reported that intracerebroventricular administration of neurotensin (30 micrograms) reduced muscular rigidity and tremors, induced by a neurochemical lesion with 6-hydroxydopamine in the posterolateral hypothalamus of rats." | 7.68 | Structure-activity studies of neurotensin on muscular rigidity and tremors induced by 6-hydroxydopamine lesions in the posterolateral hypothalamus of the rat. ( Jolicoeur, FB; Rivest, R; St-Pierre, S, 1991) |
| " Moreover, XE991 decreased apomorphine (APO)-induced contralateral rotations, enhanced balance and coordination, and attenuated muscle rigidity in 6-OHDA-treated rats." | 3.88 | The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat model of Parkinson's disease. ( Chen, X; Jia, L; Liu, H; Shi, L; Xie, J, 2018) |
| "It has previously been reported that intracerebroventricular administration of neurotensin (30 micrograms) reduced muscular rigidity and tremors, induced by a neurochemical lesion with 6-hydroxydopamine in the posterolateral hypothalamus of rats." | 3.68 | Structure-activity studies of neurotensin on muscular rigidity and tremors induced by 6-hydroxydopamine lesions in the posterolateral hypothalamus of the rat. ( Jolicoeur, FB; Rivest, R; St-Pierre, S, 1991) |
| "The loss of this action would cause muscular rigidity and motor asymmetry." | 1.29 | Appearance of EMG activity and motor asymmetry after unilateral lesions of the dopaminergic innervation to the subthalamic nucleus in the rat. ( Aceves, J; Flores, G; Rosales, MG; Sierra, A; Valencia, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Jia, L | 1 |
| Chen, X | 1 |
| Shi, L | 1 |
| Xie, J | 1 |
| Lin, JW | 1 |
| Shih, CM | 1 |
| Chen, YC | 1 |
| Lin, CM | 1 |
| Tsai, JT | 1 |
| Chiang, YH | 1 |
| Shih, R | 1 |
| Chiu, PL | 1 |
| Hung, KS | 1 |
| Yeh, YS | 1 |
| Wei, L | 1 |
| Chiu, WT | 1 |
| Yang, LY | 1 |
| Carey, RJ | 1 |
| Flores, G | 1 |
| Valencia, J | 1 |
| Rosales, MG | 1 |
| Sierra, A | 1 |
| Aceves, J | 1 |
| Lindner, MD | 1 |
| Cain, CK | 1 |
| Plone, MA | 1 |
| Frydel, BR | 1 |
| Blaney, TJ | 1 |
| Emerich, DF | 1 |
| Hoane, MR | 1 |
| Jolicoeur, FB | 2 |
| Rivest, R | 2 |
| Drumheller, A | 1 |
| St-Pierre, S | 1 |
7 other studies available for oxidopamine and Muscle Rigidity
| Article | Year |
|---|---|
The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat model of Parkinson's disease.
Topics: Animals; Anthracenes; Apomorphine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopaminergic Neuron | 2018 |
Biochemical alteration in cerebrospinal fluid precedes behavioral deficits in Parkinsonian rats induced by 6-hydroxydopamine.
Topics: Animals; Biomarkers; Cell Count; Cell Death; Disease Models, Animal; Dopamine; Homovanillic Acid; Hy | 2009 |
Differential effects of limbic versus striatal dopamine loss on motoric function.
Topics: Animals; Catalepsy; Corpus Striatum; Dextroamphetamine; Dopamine; Humans; Hydroxydopamines; Limbic S | 1983 |
Appearance of EMG activity and motor asymmetry after unilateral lesions of the dopaminergic innervation to the subthalamic nucleus in the rat.
Topics: Animals; Bicuculline; Dopamine; Electromyography; gamma-Aminobutyric Acid; Male; Methamphetamine; Mo | 1993 |
Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Brain Mapping; Corpus Striatum; Dementia; Dopa | 1999 |
Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Dyskinesia, Drug-Induced; Homovanillic Aci | 1991 |
Structure-activity studies of neurotensin on muscular rigidity and tremors induced by 6-hydroxydopamine lesions in the posterolateral hypothalamus of the rat.
Topics: Animals; Cerebral Ventricles; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxydopam | 1991 |