oxidopamine has been researched along with Multiple System Atrophy in 9 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Riluzole was administered prior to and consecutively for ten days following double lesion placement in the left-sided medial forebrain bundle and ipsilateral striatum." | 5.33 | Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). ( Diguet, E; Poewe, W; Puschban, Z; Sather, T; Scherfler, C; Stefanova, N; Tison, F; Wenning, GK, 2005) |
| "In the present experiment we studied the ability of embryonic striatal grafts to protect against striatal quinolinic acid (QA)-induced excitotoxicity in a previously established double lesion rat model of striatonigral degeneration (SND), the neuropathological substrate of parkinsonism associated with multiple system atrophy (MSA)." | 3.70 | Failure of neuroprotection by embryonic striatal grafts in a double lesion rat model of striatonigral degeneration (multiple system atrophy). ( Humpel, C; Levivier, M; Poewe, W; Puschban, Z; Scherfler, C; Seppi, K; Stefanova, N; Waldner, R; Wenning, GK, 2000) |
| "Riluzole was administered prior to and consecutively for ten days following double lesion placement in the left-sided medial forebrain bundle and ipsilateral striatum." | 1.33 | Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy). ( Diguet, E; Poewe, W; Puschban, Z; Sather, T; Scherfler, C; Stefanova, N; Tison, F; Wenning, GK, 2005) |
| "Levodopa-unresponsive parkinsonism is present in 80% of MSA cases, and this dominant clinical presentation (MSA-P) is associated with a combined degeneration of the substantia nigra pars compacta and the striatum in anatomically related areas." | 1.33 | In vivo models of multiple system atrophy. ( Diguet, E; Fernagut, PO; Ghorayeb, I; Tison, F, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (88.89) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaindlstorfer, C | 1 |
| García, J | 1 |
| Winkler, C | 2 |
| Wenning, GK | 8 |
| Nikkhah, G | 1 |
| Döbrössy, MD | 1 |
| Mantoan, L | 1 |
| Stefanova, N | 5 |
| Egger, KE | 1 |
| Jellinger, KA | 1 |
| Poewe, W | 6 |
| Scherfler, C | 4 |
| Sather, T | 1 |
| Diguet, E | 2 |
| Puschban, Z | 5 |
| Tison, F | 4 |
| Fernagut, PO | 2 |
| Ghorayeb, I | 3 |
| Petersén, A | 1 |
| Brundin, P | 1 |
| Köllensperger, M | 1 |
| Reindl, M | 1 |
| Waldner, R | 1 |
| Seppi, K | 1 |
| Humpel, C | 1 |
| Levivier, M | 1 |
| Goebel, GP | 1 |
| Jellinger, K | 1 |
| Rouland, R | 1 |
9 other studies available for oxidopamine and Multiple System Atrophy
| Article | Year |
|---|---|
Behavioral and histological analysis of a partial double-lesion model of parkinson-variant multiple system atrophy.
Topics: Animals; Apomorphine; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dopami | 2012 |
Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy).
Topics: Amino Acid Chloromethyl Ketones; Analysis of Variance; Animals; Basal Ganglia; Behavior, Animal; Cas | 2005 |
Riluzole improves motor deficits and attenuates loss of striatal neurons in a sequential double lesion rat model of striatonigral degeneration (parkinson variant of multiple system atrophy).
Topics: Animals; Biomarkers; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine and cAMP-Regulat | 2005 |
In vivo models of multiple system atrophy.
Topics: alpha-Synuclein; Animals; Antiparkinson Agents; Corpus Striatum; Levodopa; Macaca fascicularis; Mice | 2005 |
Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy.
Topics: Amphetamine; Animals; Disease Models, Animal; Dopamine; Female; Fetal Tissue Transplantation; Male; | 2005 |
Loss of dopaminergic responsiveness in a double lesion rat model of the Parkinson variant of multiple system atrophy.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Disease Models, Animal; Functional Lat | 2007 |
Failure of neuroprotection by embryonic striatal grafts in a double lesion rat model of striatonigral degeneration (multiple system atrophy).
Topics: Animals; Apomorphine; Autoradiography; Binding, Competitive; Brain Tissue Transplantation; Corpus St | 2000 |
Complex motor disturbances in a sequential double lesion rat model of striatonigral degeneration (multiple system atrophy).
Topics: Animals; Corpus Striatum; Disease Models, Animal; Glial Fibrillary Acidic Protein; Male; Motor Activ | 2000 |
Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: a model of early-stage striatonigral degeneration.
Topics: Animals; Behavior, Animal; Cell Count; Corpus Striatum; Disease Models, Animal; Forelimb; Male; Micr | 2001 |