oxidopamine has been researched along with Motor Disorders in 13 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Motor Disorders: Motor skills deficits that significantly and persistently interfere with ACTIVITIES OF DAILY LIVING appropriate to chronological age. (from DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this model of 6-OHDA-induced parkinsonism, Gst treatment in all three doses showed a dose dependent symptomatic improvement in motor imbalance (P < 0." | 5.72 | Post treatment with Gastrodin suppresses oxidative stress and attenuates motor disorders following 6-OHDA induced Parkinson disease. ( Eyvari-Brooshghalan, S; Haddadi, R; Nourouzi, N; Sabahi, M; Sadeghian, Z, 2022) |
| " After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using beam traversal test 10, 30 and 60 minutes after intraperitoneal injections of the drugs (caffeine, SCH58261)." | 3.83 | Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat. ( Mahmoudi, J; Reyhani-Rad, S, 2016) |
| "In this model of 6-OHDA-induced parkinsonism, Gst treatment in all three doses showed a dose dependent symptomatic improvement in motor imbalance (P < 0." | 1.72 | Post treatment with Gastrodin suppresses oxidative stress and attenuates motor disorders following 6-OHDA induced Parkinson disease. ( Eyvari-Brooshghalan, S; Haddadi, R; Nourouzi, N; Sabahi, M; Sadeghian, Z, 2022) |
| "Many patients of advanced Parkinson's disease (PD) suffer from intractable axial symptoms (severe gait and postural impairments), which were recently speculated to be more relevant to cholinergic degeneration in the brainstem than dopaminergic degeneration in the substantia nigra compacta (SNc)." | 1.46 | Selective cholinergic depletion of pedunculopontine tegmental nucleus aggravates freezing of gait in parkinsonian rats. ( Cai, J; Chang, J; Li, M; Li, N; Wang, Q; Wen, P; Xiao, H; Xie, Z; Zhang, W; Zhou, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 8 (61.54) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, X | 1 |
| Liang, P | 1 |
| Wang, K | 1 |
| Jia, J | 1 |
| Wang, X | 1 |
| Sadeghian, Z | 1 |
| Eyvari-Brooshghalan, S | 1 |
| Sabahi, M | 1 |
| Nourouzi, N | 1 |
| Haddadi, R | 1 |
| Pereira, CPM | 1 |
| Francis-Oliveira, J | 1 |
| Singulani, MP | 1 |
| Ferreira, AFF | 1 |
| Britto, LRG | 1 |
| Vaz, RL | 1 |
| Chapela, D | 1 |
| Coelho, JE | 1 |
| Lopes, LV | 1 |
| Ferreira, JJ | 1 |
| Afonso, ND | 1 |
| Sousa, S | 1 |
| Outeiro, TF | 1 |
| Barata-Antunes, S | 1 |
| Teixeira, FG | 1 |
| Mendes-Pinheiro, B | 1 |
| Domingues, AV | 1 |
| Vilaça-Faria, H | 1 |
| Marote, A | 1 |
| Silva, D | 1 |
| Sousa, RA | 1 |
| Salgado, AJ | 1 |
| Sitzia, G | 1 |
| Mantas, I | 1 |
| Zhang, X | 1 |
| Svenningsson, P | 1 |
| Chergui, K | 1 |
| Iravanpour, F | 1 |
| Dargahi, L | 1 |
| Rezaei, M | 1 |
| Haghani, M | 1 |
| Heidari, R | 1 |
| Valian, N | 1 |
| Ahmadiani, A | 1 |
| Brazhnik, E | 1 |
| Novikov, N | 1 |
| McCoy, AJ | 1 |
| Ilieva, NM | 1 |
| Ghraib, MW | 1 |
| Walters, JR | 1 |
| Xiao, H | 1 |
| Li, M | 1 |
| Cai, J | 1 |
| Li, N | 1 |
| Zhou, M | 1 |
| Wen, P | 1 |
| Xie, Z | 1 |
| Wang, Q | 1 |
| Chang, J | 1 |
| Zhang, W | 1 |
| Zhou, B | 1 |
| Wen, M | 1 |
| Lin, X | 1 |
| Chen, YH | 1 |
| Gou, Y | 1 |
| Li, Y | 1 |
| Zhang, Y | 1 |
| Li, HW | 1 |
| Tang, L | 1 |
| Haghparast, E | 1 |
| Sheibani, V | 1 |
| Abbasnejad, M | 1 |
| Esmaeili-Mahani, S | 1 |
| Reyhani-Rad, S | 1 |
| Mahmoudi, J | 1 |
| Leikas, JV | 1 |
| Kääriäinen, TM | 1 |
| Jalkanen, AJ | 1 |
| Lehtonen, M | 1 |
| Rantamäki, T | 1 |
| Forsberg, MM | 1 |
13 other studies available for oxidopamine and Motor Disorders
| Article | Year |
|---|---|
Serotonin 1A receptor agonist modulation of motor deficits and cortical oscillations by NMDA receptor interaction in parkinsonian rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Beta Rhythm; Locomotion; Male; Motor Cortex; Motor | 2022 |
Post treatment with Gastrodin suppresses oxidative stress and attenuates motor disorders following 6-OHDA induced Parkinson disease.
Topics: Animals; Disease Models, Animal; Humans; Motor Disorders; Oxidative Stress; Oxidopamine; Parkinson D | 2022 |
Microglial depletion exacerbates motor impairment and dopaminergic neuron loss in a 6-OHDA model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Mice; Microglia; Motor Disorders; O | 2023 |
Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia.
Topics: Adrenergic Uptake Inhibitors; Animals; Disease Models, Animal; Dyskinesia, Drug-Induced; Levodopa; M | 2020 |
Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson's Disease.
Topics: Aging; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; Hum | 2020 |
NMDA receptors are altered in the substantia nigra pars reticulata and their blockade ameliorates motor deficits in experimental parkinsonism.
Topics: Animals; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred C57BL; Motor Disorders; Oxidopa | 2020 |
Intranasal insulin improves mitochondrial function and attenuates motor deficits in a rat 6-OHDA model of Parkinson's disease.
Topics: Administration, Intranasal; Animals; Humans; Insulin; Male; Mitochondria; Motor Disorders; Oxidopami | 2021 |
Early decreases in cortical mid-gamma peaks coincide with the onset of motor deficits and precede exaggerated beta build-up in rat models for Parkinson's disease.
Topics: Animals; Beta Rhythm; Dopamine D2 Receptor Antagonists; Exercise Test; Gamma Rhythm; Male; Motor Cor | 2021 |
Selective cholinergic depletion of pedunculopontine tegmental nucleus aggravates freezing of gait in parkinsonian rats.
Topics: Acetylcholine; Animals; Choline O-Acetyltransferase; Cholinergic Neurons; Dopamine; Gait; Immunotoxi | 2017 |
Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson's Disease Model Induced by 6-Hydroxydopamine.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apomorphine; Cell Death; Disease Models, Animal; Dopa | 2018 |
Apelin-13 attenuates motor impairments and prevents the changes in synaptic plasticity-related molecules in the striatum of Parkinsonism rats.
Topics: Animals; Corpus Striatum; Intercellular Signaling Peptides and Proteins; Male; Motor Disorders; Neur | 2019 |
Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat.
Topics: Adenosine A2 Receptor Antagonists; Animals; Caffeine; Disease Models, Animal; Hypokinesia; Male; Mot | 2016 |
Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats.
Topics: Animals; Behavior, Animal; Brain; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Moto | 2017 |