oxidopamine has been researched along with Lesch-Nyhan Syndrome in 12 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of footshock sensitization (priming), apomorphine (APO) priming and their combination on behavior and neostriatal and cortical catecholamines were examined in adult rats which had neonatally received bilateral intracerebroventricular injections with 6-hydroxydopamine (6-OHDA; a model of Lesch-Nyhan syndrome (LNS)) or vehicle (unlesioned rats)." | 7.70 | Cross-sensitization between footshock stress and apomorphine on self-injurious behavior and neostriatal catecholamines in a rat model of Lesch-Nyhan syndrome. ( Loupe, PS; Schroeder, SR; Stodgell, CJ; Tessel, RE, 1998) |
| "The effects of footshock sensitization (priming), apomorphine (APO) priming and their combination on behavior and neostriatal and cortical catecholamines were examined in adult rats which had neonatally received bilateral intracerebroventricular injections with 6-hydroxydopamine (6-OHDA; a model of Lesch-Nyhan syndrome (LNS)) or vehicle (unlesioned rats)." | 3.70 | Cross-sensitization between footshock stress and apomorphine on self-injurious behavior and neostriatal catecholamines in a rat model of Lesch-Nyhan syndrome. ( Loupe, PS; Schroeder, SR; Stodgell, CJ; Tessel, RE, 1998) |
| "Lesch-Nyhan syndrome involves disorders of both purine and dopamine metabolism." | 3.67 | Assessment of purine-dopamine interactions in 6-hydroxydopamine-lesioned rats: evidence for pre- and postsynaptic influences by adenosine. ( Breese, GR; Criswell, H; Mueller, RA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Breese, GR | 6 |
| Baumeister, AA | 3 |
| McCown, TJ | 2 |
| Emerick, SG | 2 |
| Frye, GD | 3 |
| Crotty, K | 1 |
| Mueller, RA | 5 |
| Pickel, VM | 1 |
| Chan, J | 1 |
| Pierce, JP | 1 |
| Stodgell, CJ | 2 |
| Schroeder, SR | 2 |
| Tessel, RE | 2 |
| Allen, SM | 2 |
| Freeman, JN | 1 |
| Davis, WM | 2 |
| Loupe, PS | 1 |
| Visser, JE | 1 |
| Smith, DW | 1 |
| Moy, SS | 1 |
| Friedmann, T | 1 |
| Rothstein, JD | 1 |
| Jinnah, HA | 1 |
| Criswell, HE | 1 |
| Duncan, GE | 2 |
| Napier, TC | 1 |
| Criswell, H | 1 |
3 reviews available for oxidopamine and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
A dopamine deficiency model of Lesch-Nyhan disease--the neonatal-6-OHDA-lesioned rat.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Hydroxydopamines; Lesch-Nyhan Syndrome; | 1990 |
Neurobiology of D1 dopamine receptors after neonatal-6-OHDA treatment: relevance to Lesch-Nyhan disease.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani | 1986 |
The biochemical basis of the behavioral disorder in the Lesch-Nyhan syndrome.
Topics: Adenine Nucleotides; Animals; Central Nervous System; Child; Child, Preschool; Clonidine; Corpus Str | 1985 |
9 other studies available for oxidopamine and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Behavioral differences between neonatal and adult 6-hydroxydopamine-treated rats to dopamine agonists: relevance to neurological symptoms in clinical syndromes with reduced brain dopamine.
Topics: Age Factors; Animals; Antipsychotic Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, | 1984 |
Neonatal-6-hydroxydopamine treatment: model of susceptibility for self-mutilation in the Lesch-Nyhan syndrome.
Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Humans; Hydroxydopamines; Lesch-Nyha | 1984 |
Ultrastructure of Met5-enkephalin terminals in the caudate-putamen nuclei of adult rats receiving neonatal intranigral 6-hydroxydopamine.
Topics: Animals; Autoradiography; Dopamine; Enkephalin, Methionine; Enkephalins; Immunohistochemistry; Lesch | 1994 |
FR discrimination training reverses 6-hydroxydopamine-induced striatal dopamine depletion in a rat model of Lesch-Nyhan syndrome.
Topics: Animals; Corpus Striatum; Discrimination, Psychological; Disease Models, Animal; Dopamine; Lesch-Nyh | 1996 |
Evaluation of risperidone in the neonatal 6-hydroxydopamine model of Lesch-Nyhan syndrome.
Topics: Animals; Animals, Newborn; Behavior, Animal; Benzazepines; Disease Models, Animal; Dopamine Agents; | 1998 |
Cross-sensitization between footshock stress and apomorphine on self-injurious behavior and neostriatal catecholamines in a rat model of Lesch-Nyhan syndrome.
Topics: Animals; Animals, Newborn; Apomorphine; Catecholamines; Disease Models, Animal; Dopamine Agonists; E | 1998 |
Relationship of dopamine to serotonin in the neonatal 6-OHDA rat model of Lesch-Nyhan syndrome.
Topics: Adrenergic Agents; Animals; Animals, Newborn; Brain Mapping; Disease Models, Animal; Dopamine; Femal | 1999 |
Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aconitate Hydratase; Animals; Cell Death; Disease Models, Animal; Do | 2002 |
Assessment of purine-dopamine interactions in 6-hydroxydopamine-lesioned rats: evidence for pre- and postsynaptic influences by adenosine.
Topics: Adenosine; Animals; Female; Hydroxydopamines; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Sy | 1988 |