oxidopamine has been researched along with Innate Inflammatory Response in 73 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral treatment with chrysin (10 mg/kg, 28 days), culminated with the prevention of these alterations occasioned by 6-OHDA." | 5.48 | Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins. ( Antunes, MS; Boeira, SP; Goes, ATR; Jesse, CR; Lobo Ladd, AAB; Lobo Ladd, FV; Luchese, C; Paroul, N, 2018) |
| "Posttreatment with paeonol also reduced inflammatory responses in LPS-activated microglia and increased cell viability in LPS-treated microglia culture medium-treated neurons." | 5.38 | Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons. ( Hsu, YY; Lo, YC; Shih, YT; Tseng, YT, 2012) |
| "Taken together, the present preclinical study showed that while morphine can attenuate lipopolysaccharide-induced inflammation and cell death, both naloxone and L-NAME can abolish this effect." | 4.31 | Regulation of the Endogenous Opiate Signaling Pathway against Oxidative Stress and Inflammation: A Considerable Approach for Exploring Preclinical Treatment of Parkinson's Disease. ( Cadet, P; Neuwirth, LS; Zhu, W, 2023) |
| " To investigate the causative relationship between neuro-inflammation and dyskinesias, we assessed if striatal M1 and M2 microglia numbers correlated with dyskinesia severity and whether the anti-inflammatories, minocycline and indomethacin, reverse these numbers and mitigate against dyskinesia." | 4.31 | The ratio of M1 to M2 microglia in the striatum determines the severity of L-Dopa-induced dyskinesias. ( Egan, T; Kuriakose, A; Rentsch, P; Stayte, S; Vissel, B, 2023) |
| " MATERIAL AND METHODS In the present study, we evaluated the beneficial effects and underlying mechanisms of punicalagin (PN) in human neuroblastoma SH-SY5Y cells treated with 6-hydroxydopamine (6-OHDA) to mimic PD in vitro." | 3.88 | Punicalagin Exerts Beneficial Functions in 6-Hydroxydopamine-Treated SH-SY5Y Cells by Attenuating Mitochondrial Dysfunction and Inflammatory Responses. ( Chu, J; Han, W, 2018) |
| " ALC (200mg/kg) lowered apomorphine-induced rotational asymmetry and reduced the latency to initiate and the total time in the narrow beam test, reduced striatal malondialdehyde (MDA), increased catalase activity and glutathione (GSH) level, prevented reduction of nigral tyrosine hydroxylase (TH)-positive neurons and striatal TH-immunoreactivity, and lowered striatal glial fibrillary acidic protein (GFAP) and its immunoreactivity as an indicator of astrogliosis, and nuclear factor NF-kappa B and Toll-like receptor 4 (TLR4) as reliable markers of neuroinflammation." | 3.85 | Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat. ( Afshin-Majd, S; Baluchnejadmojarad, T; Bashiri, K; Kiasalari, Z; Roghani, M; Sedaghat, R, 2017) |
| " Selective degeneration of either peripheral sensory or sympathetic nerve fibers by their respective neurotoxins, capsaicin or 6-hydroxydopamime, significantly reduced the subcutaneous immigration of β-endorphin- (END-) and met-enkephalin- (ENK-)-containing polymorphonuclear leukocytes (PMN) (in the early phase) and mononuclear cells (in the late phase) during painful Freund's complete adjuvant (FCA) rat hind paw inflammation." | 3.76 | Involvement of the peripheral sensory and sympathetic nervous system in the vascular endothelial expression of ICAM-1 and the recruitment of opioid-containing immune cells to inhibit inflammatory pain. ( Al-Khrasani, M; Brendl, U; Fürst, S; Mousa, SA; Schäfer, M; Shaqura, M, 2010) |
| "Rats with chemical sympathectomy, induced either at neonatal age (long-term sympathectomy) or in adult animals (short-term sympathectomy) by guanethidine or by 6-hydroxydopamine, were used to determine the contribution of sympathetic noradrenergic fibres to afferent neuron-mediated responses and to non-neurogenic inflammation in the rat." | 3.68 | Neurogenic and non-neurogenic inflammation in the rat paw following chemical sympathectomy. ( Amann, R; Donnerer, J; Lembeck, F, 1991) |
| "A blister model of inflammation in the rat hind footpad was used to study the possible interaction between noradrenergic sympathetic fibres and primary afferent unmyelinated fibres which contain substance P (SP), the putative mediator of neurogenic inflammation." | 3.67 | Sympathetic neurons modulate plasma extravasation in the rat through a non-adrenergic mechanism. ( Helme, RD; Khalil, Z, 1989) |
| "Of these, neuroinflammation is one candidate that appears to accumulate more support with each passing year." | 2.46 | Modeling neuroinflammatory pathogenesis of Parkinson's disease. ( Barnum, CJ; Tansey, MG, 2010) |
| "Recent evidence highlights Parkinson's disease (PD) initiation in the gut as the prodromal phase of neurodegeneration." | 1.72 | Dual-Hit Model of Parkinson's Disease: Impact of Dysbiosis on 6-Hydroxydopamine-Insulted Mice-Neuroprotective and Anti-Inflammatory Effects of Butyrate. ( Avagliano, C; Calignano, A; Coretti, L; De Biase, D; De Caro, C; Lama, A; Lembo, F; Mattace Raso, G; Meli, R; Mollica, MP; Paciello, O; Pirozzi, C; Turco, L, 2022) |
| "Cardiac dysautonomia is a common nonmotor symptom of Parkinson's disease (PD) associated with loss of sympathetic innervation to the heart and decreased plasma catecholamines." | 1.56 | Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration. ( Bondarenko, V; Emborg, ME; Fleddermann, RA; Matsoff, HN; Mejia, A; Metzger, JM; Moore, CF; Simmons, HA; Zinnen, AD, 2020) |
| "Hydroxysafflor yellow A (HSYA) has been shown to have neuroprotective effects in cerebral infarction." | 1.56 | Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways. ( Chen, L; Li, Y; Nel, D; Sun, B; Wu, J; Xu, M; Yang, X; Zhang, P, 2020) |
| "Oral treatment with chrysin (10 mg/kg, 28 days), culminated with the prevention of these alterations occasioned by 6-OHDA." | 1.48 | Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins. ( Antunes, MS; Boeira, SP; Goes, ATR; Jesse, CR; Lobo Ladd, AAB; Lobo Ladd, FV; Luchese, C; Paroul, N, 2018) |
| "Posttreatment with paeonol also reduced inflammatory responses in LPS-activated microglia and increased cell viability in LPS-treated microglia culture medium-treated neurons." | 1.38 | Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons. ( Hsu, YY; Lo, YC; Shih, YT; Tseng, YT, 2012) |
| "Rutin has been shown to have antioxidant and anti-inflammatory actions, and thus was tested for its beneficial effects using 6-OHDA-induced PD rat model." | 1.38 | Rutin protects dopaminergic neurons from oxidative stress in an animal model of Parkinson's disease. ( Ahmad, A; Islam, F; Javed, H; Khan, A; Khan, MM; Raza, SS; Safhi, MM, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (6.85) | 18.7374 |
| 1990's | 3 (4.11) | 18.2507 |
| 2000's | 11 (15.07) | 29.6817 |
| 2010's | 39 (53.42) | 24.3611 |
| 2020's | 15 (20.55) | 2.80 |
| Authors | Studies |
|---|---|
| Avagliano, C | 1 |
| Coretti, L | 1 |
| Lama, A | 1 |
| Pirozzi, C | 1 |
| De Caro, C | 1 |
| De Biase, D | 1 |
| Turco, L | 1 |
| Mollica, MP | 1 |
| Paciello, O | 1 |
| Calignano, A | 1 |
| Meli, R | 1 |
| Lembo, F | 1 |
| Mattace Raso, G | 1 |
| Thomasi, BBM | 1 |
| Valdetaro, L | 1 |
| Ricciardi, MCG | 1 |
| Hayashide, L | 1 |
| Fernandes, ACMN | 1 |
| Mussauer, A | 1 |
| da Silva, ML | 1 |
| da Cunha Faria-Melibeu, A | 1 |
| Ribeiro, MGL | 1 |
| de Mattos Coelho-Aguiar, J | 1 |
| Campello-Costa, P | 1 |
| Moura-Neto, V | 1 |
| Tavares-Gomes, AL | 1 |
| Mishra, I | 2 |
| Pullum, KB | 2 |
| Eads, KN | 1 |
| Strunjas, AR | 1 |
| Ashley, NT | 2 |
| Pinheiro Campos, AC | 1 |
| Martinez, RCR | 1 |
| Auada, AVV | 1 |
| Lebrun, I | 1 |
| Fonoff, ET | 1 |
| Hamani, C | 1 |
| Pagano, RL | 1 |
| Gao, X | 1 |
| He, D | 1 |
| Liu, Y | 1 |
| Cui, M | 1 |
| Li, Z | 1 |
| Li, J | 1 |
| He, Y | 1 |
| Wang, H | 1 |
| Ye, B | 1 |
| Fu, S | 1 |
| Liu, D | 1 |
| Zhu, W | 1 |
| Neuwirth, LS | 1 |
| Cadet, P | 1 |
| Rentsch, P | 1 |
| Egan, T | 1 |
| Kuriakose, A | 1 |
| Stayte, S | 1 |
| Vissel, B | 1 |
| Mei, M | 1 |
| Zhou, Y | 1 |
| Liu, M | 1 |
| Zhao, F | 1 |
| Wang, C | 1 |
| Ding, J | 1 |
| Lu, M | 1 |
| Hu, G | 1 |
| Xue, B | 1 |
| Xiao, W | 1 |
| Tian, H | 1 |
| Metzger, JM | 1 |
| Matsoff, HN | 1 |
| Zinnen, AD | 1 |
| Fleddermann, RA | 1 |
| Bondarenko, V | 1 |
| Simmons, HA | 1 |
| Mejia, A | 1 |
| Moore, CF | 1 |
| Emborg, ME | 1 |
| Thayer, DC | 1 |
| Plummer, ER | 1 |
| Conkright, BW | 1 |
| Morris, AJ | 1 |
| O'Hara, BF | 1 |
| Demas, GE | 1 |
| Park, HW | 1 |
| Park, CG | 1 |
| Park, M | 1 |
| Lee, SH | 2 |
| Park, HR | 1 |
| Lim, J | 1 |
| Paek, SH | 1 |
| Choy, YB | 1 |
| Zhuang, W | 1 |
| Cai, M | 1 |
| Li, W | 2 |
| Chen, C | 1 |
| Wang, Y | 2 |
| Lv, E | 1 |
| Fu, W | 1 |
| Yang, X | 1 |
| Li, Y | 1 |
| Chen, L | 1 |
| Xu, M | 1 |
| Wu, J | 1 |
| Zhang, P | 1 |
| Nel, D | 1 |
| Sun, B | 1 |
| Elmazoglu, Z | 1 |
| Prnova, MS | 1 |
| Santamaria, A | 2 |
| Stefek, M | 1 |
| Karasu, C | 1 |
| Lei, H | 1 |
| Ren, R | 1 |
| Sun, Y | 1 |
| Zhang, K | 1 |
| Zhao, X | 1 |
| Ablat, N | 1 |
| Pu, X | 1 |
| Romero, A | 2 |
| Parada, E | 1 |
| González-Lafuente, L | 1 |
| Farré-Alins, V | 1 |
| Ramos, E | 1 |
| Cacabelos, R | 1 |
| Egea, J | 1 |
| Pellegrini, C | 1 |
| Antonioli, L | 1 |
| Colucci, R | 1 |
| Tirotta, E | 1 |
| Gentile, D | 1 |
| Ippolito, C | 1 |
| Segnani, C | 1 |
| Levandis, G | 2 |
| Cerri, S | 1 |
| Blandini, F | 2 |
| Barocelli, E | 1 |
| Ballabeni, V | 1 |
| Bernardini, N | 1 |
| Blandizzi, C | 1 |
| Fornai, M | 1 |
| Lima, FAV | 1 |
| Joventino, IP | 1 |
| Joventino, FP | 1 |
| de Almeida, AC | 1 |
| Neves, KRT | 1 |
| do Carmo, MR | 1 |
| Leal, LKAM | 1 |
| de Andrade, GM | 1 |
| de Barros Viana, GS | 1 |
| Fu, Q | 1 |
| Song, R | 1 |
| Yang, Z | 1 |
| Shan, Q | 1 |
| Chen, W | 1 |
| Goes, ATR | 1 |
| Jesse, CR | 1 |
| Antunes, MS | 1 |
| Lobo Ladd, FV | 1 |
| Lobo Ladd, AAB | 1 |
| Luchese, C | 1 |
| Paroul, N | 1 |
| Boeira, SP | 1 |
| Garrido-Gil, P | 1 |
| Rodriguez-Perez, AI | 1 |
| Dominguez-Meijide, A | 1 |
| Guerra, MJ | 1 |
| Labandeira-Garcia, JL | 1 |
| Nascimento, GC | 1 |
| Bariotto-Dos-Santos, K | 1 |
| Leite-Panissi, CRA | 1 |
| Del-Bel, EA | 1 |
| Bortolanza, M | 1 |
| Sharma, S | 1 |
| Taliyan, R | 1 |
| Kim, HW | 4 |
| Lee, HS | 1 |
| Kang, JM | 1 |
| Bae, SH | 1 |
| Kim, C | 1 |
| Schwarz, J | 1 |
| Kim, GJ | 1 |
| Kim, JS | 1 |
| Cha, DH | 1 |
| Kim, J | 1 |
| Chang, SW | 1 |
| Lee, TH | 1 |
| Moon, J | 1 |
| Chu, J | 1 |
| Han, W | 1 |
| Singh, K | 1 |
| Han, K | 1 |
| Tilve, S | 1 |
| Wu, K | 1 |
| Geller, HM | 1 |
| Sack, MN | 1 |
| Pain, S | 1 |
| Vergote, J | 1 |
| Gulhan, Z | 1 |
| Bodard, S | 1 |
| Chalon, S | 1 |
| Gaillard, A | 1 |
| Lee, J | 1 |
| Pinares-Garcia, P | 1 |
| Loke, H | 1 |
| Ham, S | 1 |
| Vilain, E | 1 |
| Harley, VR | 1 |
| Chen, HS | 1 |
| Li, FP | 1 |
| Li, XQ | 1 |
| Liu, BJ | 1 |
| Qu, F | 1 |
| Wen, WW | 1 |
| Lin, Q | 1 |
| Shi, X | 1 |
| Wang, L | 1 |
| Guo, T | 1 |
| Wei, T | 1 |
| Cheng, K | 1 |
| Rice, KC | 1 |
| Kingery, WS | 1 |
| Clark, JD | 1 |
| Wang, HM | 1 |
| Zhang, T | 1 |
| Li, Q | 1 |
| Huang, JK | 1 |
| Chen, RF | 1 |
| Sun, XJ | 1 |
| Hernandes, MS | 1 |
| Santos, GD | 1 |
| Café-Mendes, CC | 1 |
| Lima, LS | 1 |
| Scavone, C | 1 |
| Munhoz, CD | 1 |
| Britto, LR | 1 |
| Espinosa-Oliva, AM | 1 |
| de Pablos, RM | 1 |
| Sarmiento, M | 1 |
| Villarán, RF | 1 |
| Carrillo-Jiménez, A | 1 |
| Santiago, M | 1 |
| Venero, JL | 2 |
| Herrera, AJ | 1 |
| Cano, J | 2 |
| Machado, A | 2 |
| Nadella, R | 1 |
| Voutilainen, MH | 1 |
| Saarma, M | 1 |
| Gonzalez-Barrios, JA | 1 |
| Leon-Chavez, BA | 1 |
| Jiménez, JM | 1 |
| Jiménez, SH | 1 |
| Escobedo, L | 1 |
| Martinez-Fong, D | 1 |
| Stojkovska, I | 1 |
| Wagner, BM | 1 |
| Morrison, BE | 1 |
| Smith, GA | 1 |
| Rocha, EM | 1 |
| Rooney, T | 1 |
| Barneoud, P | 1 |
| McLean, JR | 1 |
| Beagan, J | 1 |
| Osborn, T | 1 |
| Coimbra, M | 1 |
| Luo, Y | 1 |
| Hallett, PJ | 1 |
| Isacson, O | 1 |
| Wei, X | 1 |
| Gao, H | 1 |
| Zou, J | 1 |
| Liu, X | 1 |
| Chen, D | 1 |
| Liao, J | 1 |
| Xu, Y | 1 |
| Ma, L | 1 |
| Tang, B | 1 |
| Zhang, Z | 1 |
| Cai, X | 1 |
| Jin, K | 1 |
| Xia, Y | 1 |
| Wang, Q | 1 |
| Kheradmand, A | 1 |
| Nayebi, AM | 1 |
| Jorjani, M | 1 |
| Khalifeh, S | 1 |
| Haddadi, R | 1 |
| Afshin-Majd, S | 1 |
| Bashiri, K | 1 |
| Kiasalari, Z | 1 |
| Baluchnejadmojarad, T | 1 |
| Sedaghat, R | 1 |
| Roghani, M | 1 |
| Maeda, M | 1 |
| Tsuruoka, M | 1 |
| Hayashi, B | 1 |
| Nagasawa, I | 1 |
| Inoue, T | 1 |
| Huang, WH | 1 |
| Chang, WB | 1 |
| Liu, SP | 1 |
| Lin, JT | 1 |
| Fu, YS | 1 |
| Chang, MC | 1 |
| Huang, HT | 1 |
| Ambrosi, G | 1 |
| Armentero, MT | 1 |
| Bramanti, P | 1 |
| Nappi, G | 1 |
| Na, SJ | 1 |
| DiLella, AG | 1 |
| Lis, EV | 1 |
| Jones, K | 1 |
| Levine, DM | 1 |
| Stone, DJ | 1 |
| Hess, JF | 1 |
| Michel-Monigadon, D | 1 |
| Bonnamain, V | 1 |
| Nerrière-Daguin, V | 1 |
| Dugast, AS | 1 |
| Lévèque, X | 1 |
| Plat, M | 1 |
| Venturi, E | 1 |
| Brachet, P | 1 |
| Anegon, I | 1 |
| Vanhove, B | 1 |
| Neveu, I | 1 |
| Naveilhan, P | 1 |
| Whitaker, AM | 1 |
| Sulzer, J | 1 |
| Walker, E | 1 |
| Mathis, K | 1 |
| Molina, PE | 1 |
| Argüelles, S | 1 |
| García-Rodriguez, S | 1 |
| Tomas-Camardiel, M | 1 |
| Ayala, A | 1 |
| Mousa, SA | 1 |
| Shaqura, M | 1 |
| Brendl, U | 1 |
| Al-Khrasani, M | 1 |
| Fürst, S | 1 |
| Schäfer, M | 1 |
| Barnum, CJ | 1 |
| Tansey, MG | 1 |
| Walsh, S | 1 |
| Finn, DP | 1 |
| Dowd, E | 1 |
| Eto, K | 1 |
| Kim, SK | 1 |
| Nabekura, J | 1 |
| Ishibashi, H | 1 |
| Tseng, YT | 1 |
| Hsu, YY | 1 |
| Shih, YT | 1 |
| Lo, YC | 1 |
| Khan, MM | 1 |
| Raza, SS | 1 |
| Javed, H | 1 |
| Ahmad, A | 1 |
| Khan, A | 1 |
| Islam, F | 2 |
| Safhi, MM | 1 |
| Betts, MJ | 1 |
| O'Neill, MJ | 1 |
| Duty, S | 1 |
| Thornton, E | 1 |
| Vink, R | 1 |
| Tobón-Velasco, JC | 1 |
| Limón-Pacheco, JH | 1 |
| Orozco-Ibarra, M | 1 |
| Macías-Silva, M | 1 |
| Vázquez-Victorio, G | 1 |
| Cuevas, E | 1 |
| Ali, SF | 1 |
| Cuadrado, A | 1 |
| Pedraza-Chaverrí, J | 1 |
| Sorkin, LS | 1 |
| Moore, J | 1 |
| Boyle, DL | 1 |
| Yang, L | 1 |
| Firestein, GS | 1 |
| Depino, AM | 1 |
| Earl, C | 1 |
| Kaczmarczyk, E | 1 |
| Ferrari, C | 1 |
| Besedovsky, H | 1 |
| del Rey, A | 1 |
| Pitossi, FJ | 1 |
| Oertel, WH | 1 |
| Planas, E | 1 |
| Poveda, R | 1 |
| Sánchez, S | 1 |
| Pol, O | 1 |
| Puig, MM | 1 |
| Yoon, SY | 3 |
| Roh, DH | 3 |
| Kwon, YB | 3 |
| Jeong, TO | 1 |
| Han, HJ | 3 |
| Lee, HJ | 3 |
| Choi, SM | 2 |
| Ryu, YH | 2 |
| Beitz, AJ | 3 |
| Lee, JH | 3 |
| Kang, SY | 1 |
| Kim, KW | 1 |
| Seo, HS | 1 |
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| Miller, RL | 1 |
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| Helme, RD | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1 Open-Label Dose Escalation Safety Study of Convection Enhanced Delivery (CED) of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor (AAV2-GDNF) in Subjects With Advanced Parkinson's Disease[NCT01621581] | Phase 1 | 25 participants (Actual) | Interventional | 2013-03-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for oxidopamine and Innate Inflammatory Response
| Article | Year |
|---|---|
Parkinson's disease and enhanced inflammatory response.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyto | 2015 |
Modeling neuroinflammatory pathogenesis of Parkinson's disease.
Topics: Animals; Disease Models, Animal; Disease Progression; Dopamine; Humans; Inflammation; Lipopolysaccha | 2010 |
Oxidative and inflammatory pathways in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Herbicides; Humans; Inflammation; Lipopolysac | 2009 |
Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenoviridae; Animals; Cell Survival; Corpus Striatum; | 2000 |
69 other studies available for oxidopamine and Innate Inflammatory Response
| Article | Year |
|---|---|
Dual-Hit Model of Parkinson's Disease: Impact of Dysbiosis on 6-Hydroxydopamine-Insulted Mice-Neuroprotective and Anti-Inflammatory Effects of Butyrate.
Topics: Animals; Anti-Inflammatory Agents; Butyrates; Dysbiosis; Inflammation; Mice; Oxidopamine; Parkinson | 2022 |
Enteric glial cell reactivity in colonic layers and mucosal modulation in a mouse model of Parkinson's disease induced by 6-hydroxydopamine.
Topics: Animals; Disease Models, Animal; Enteric Nervous System; Inflammation; Male; Mice; Neuroglia; Occlud | 2022 |
Peripheral Sympathectomy Alters Neuroinflammatory and Microglial Responses to Sleep Fragmentation in Female Mice.
Topics: Animals; Cytokines; Female; Inflammation; Mice; Mice, Inbred C57BL; Microglia; Neuroinflammatory Dis | 2022 |
Effect of Subthalamic Stimulation and Electrode Implantation in the Striatal Microenvironment in a Parkinson's Disease Rat Model.
Topics: Amino Acid Transport Systems; Animals; Cytokines; Deep Brain Stimulation; Electrodes; gamma-Aminobut | 2022 |
Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats.
Topics: Administration, Oral; Aged; Animals; Autophagy; Humans; Inflammation; Limonins; Microglia; Middle Ag | 2023 |
Regulation of the Endogenous Opiate Signaling Pathway against Oxidative Stress and Inflammation: A Considerable Approach for Exploring Preclinical Treatment of Parkinson's Disease.
Topics: Animals; Dopaminergic Neurons; Humans; Inflammation; Morphine; Naloxone; Neuroprotective Agents; NG- | 2023 |
The ratio of M1 to M2 microglia in the striatum determines the severity of L-Dopa-induced dyskinesias.
Topics: Animals; Anti-Inflammatory Agents; Antiparkinson Agents; Corpus Striatum; Dyskinesias; Indomethacin; | 2023 |
Antioxidant and anti-inflammatory effects of dexrazoxane on dopaminergic neuron degeneration in rodent models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents; Antioxidants; Blood | 2019 |
Nei-like 1 inhibition results in motor dysfunction and promotes inflammation in Parkinson's disease mice model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apomorphine; Disease Models, Animal; DNA Glyc | 2020 |
Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration.
Topics: Animals; Autopsy; Biomarkers; CD36 Antigens; Disease Models, Animal; Heart; Inflammation; Macaca mul | 2020 |
Chemical sympathectomy reduces peripheral inflammatory responses to acute and chronic sleep fragmentation.
Topics: Animals; Cortisone; Female; Inflammation; Mice; Mice, Inbred C57BL; Norepinephrine; Oxidopamine; Sle | 2020 |
Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model.
Topics: Administration, Oral; Animals; Apomorphine; Corpus Striatum; Dopaminergic Neurons; Dose-Response Rel | 2020 |
Polyphenols from Toona sinensiss Seeds Alleviate Neuroinflammation Induced by 6-Hydroxydopamine Through Suppressing p38 MAPK Signaling Pathway in a Rat Model of Parkinson's Disease.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Cyclooxygenase 2; Dopaminergic Neurons; Inflammation; | 2020 |
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Topics: Animals; Apoptosis; Chalcone; Corpus Striatum; Dopamine; Dopaminergic Neurons; Dose-Response Relatio | 2020 |
Combatting Nitrosative Stress and Inflammation with Novel Substituted Triazinoindole Inhibitors of Aldose Reductase in PC12 Cells Exposed to 6-Hydroxydopamine Plus High Glucose.
Topics: Aldehyde Reductase; Animals; Antioxidants; Cell Survival; Glucose; Inflammation; Neuroprotective Age | 2021 |
Neuroprotective Effects of Safflower Flavonoid Extract in 6-Hydroxydopamine-Induced Model of Parkinson's Disease May Be Related to its Anti-Inflammatory Action.
Topics: Animals; Anti-Inflammatory Agents; Apomorphine; Apoptosis; Astrocytes; Behavior, Animal; Brain; Cart | 2020 |
Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cell Line, Tumor; Cell Survival; D | 2017 |
Effects of L-DOPA/benserazide co-treatment on colonic excitatory cholinergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration.
Topics: Acetylcholine; Administration, Oral; Animals; Antiparkinson Agents; Benserazide; Choline O-Acetyltra | 2017 |
Neuroprotective Activities of Spirulina platensis in the 6-OHDA Model of Parkinson's Disease Are Related to Its Anti-Inflammatory Effects.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Inflammation; Male; Neuroprotection; Neuroprotecti | 2017 |
6-Hydroxydopamine induces brain vascular endothelial inflammation.
Topics: Animals; Brain; Cell Adhesion; Coculture Techniques; Cyclooxygenase 2; Disease Models, Animal; E-Sel | 2017 |
Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Dopamine; Flavonoids; Gene Expression Regulatio | 2018 |
Bidirectional Neural Interaction Between Central Dopaminergic and Gut Lesions in Parkinson's Disease Models.
Topics: Animals; Colon; Disease Models, Animal; Dopamine; Gastrointestinal Tract; Inflammation; Male; Mice, | 2018 |
Nociceptive Response to L-DOPA-Induced Dyskinesia in Hemiparkinsonian Rats.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dyskinesia, Drug-Induced; Inflammation; Levodopa; Ma | 2018 |
High fat diet feeding induced insulin resistance exacerbates 6-OHDA mediated neurotoxicity and behavioral abnormalities in rats.
Topics: Animals; Corpus Striatum; Diabetes Mellitus, Experimental; Diet, High-Fat; Inflammation; Insulin Res | 2018 |
Dual Effects of Human Placenta-Derived Neural Cells on Neuroprotection and the Inhibition of Neuroinflammation in a Rodent Model of Parkinson's Disease.
Topics: Animals; Brain; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Cellular Microenvi | 2018 |
Punicalagin Exerts Beneficial Functions in 6-Hydroxydopamine-Treated SH-SY5Y Cells by Attenuating Mitochondrial Dysfunction and Inflammatory Responses.
Topics: AMP-Activated Protein Kinases; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Hydrolyzable Tann | 2018 |
Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Astrocytes; Cells, Cultured; Cytokines; Endop | 2018 |
Inflammatory process in Parkinson disease: neuroprotection by neuropeptide Y.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Prote | 2019 |
Sex-specific neuroprotection by inhibition of the Y-chromosome gene,
Topics: Animals; Disease Models, Animal; DNA Damage; Female; Genes, Y-Linked; Humans; Inflammation; Male; Mi | 2019 |
Acute stress regulates nociception and inflammatory response induced by bee venom in rats: possible mechanisms.
Topics: Animals; Bee Venoms; Capsaicin; Disease Models, Animal; Edema; Hindlimb; Hyperalgesia; Inflammation; | 2013 |
Epidermal adrenergic signaling contributes to inflammation and pain sensitization in a rat model of complex regional pain syndrome.
Topics: Adrenergic Agents; Animals; Bufanolides; Complex Regional Pain Syndromes; Disease Models, Animal; Do | 2013 |
Inhibition of glycogen synthase kinase-3β by lithium chloride suppresses 6-hydroxydopamine-induced inflammatory response in primary cultured astrocytes.
Topics: Aminophenols; Animals; Astrocytes; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Glial Fibrillary | 2013 |
Microglial cells are involved in the susceptibility of NADPH oxidase knockout mice to 6-hydroxy-dopamine-induced neurodegeneration.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Inflammation; M | 2013 |
Role of dopamine in the recruitment of immune cells to the nigro-striatal dopaminergic structures.
Topics: alpha-Methyltyrosine; Animals; Astrocytes; Cell Movement; Corpus Striatum; Dopamine; Enzyme Inhibito | 2014 |
Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra.
Topics: Animals; Humans; Inflammation; Injections, Intraventricular; Male; Nerve Growth Factors; Oxidopamine | 2014 |
A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Expression; Imidazoles; Inflam | 2015 |
Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.
Topics: Animals; Cell Survival; Cytochromes c; Dopamine Plasma Membrane Transport Proteins; Gene Knockdown T | 2016 |
Effects of WR1065 on 6-hydroxydopamine-induced motor imbalance: Possible involvement of oxidative stress and inflammatory cytokines.
Topics: Animals; Disease Models, Animal; Glutathione; Inflammation; Interleukin-1beta; Lipid Peroxidation; M | 2016 |
Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat.
Topics: Acetylcarnitine; Animals; Apomorphine; Behavior, Animal; Corpus Striatum; Dopamine Agonists; Dopamin | 2017 |
Descending pathways from activated locus coeruleus/subcoeruleus following unilateral hindpaw inflammation in the rat.
Topics: Animals; Carrageenan; Disease Models, Animal; Functional Laterality; Hindlimb; Hyperalgesia; Inflamm | 2009 |
Inhibitory effect of dimethylthiourea on rat urinary bladder inflammation produced by 6-hydroxydopamine application.
Topics: Animals; Capillary Leak Syndrome; Capillary Permeability; Cystitis; Dose-Response Relationship, Drug | 2009 |
Effects of early and delayed treatment with an mGluR5 antagonist on motor impairment, nigrostriatal damage and neuroinflammation in a rodent model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Excitatory Amino Acid | 2010 |
Molecular profiling of a 6-hydroxydopamine model of Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Gene Expression Profiling; Inflammation; | 2010 |
Trophic and immunoregulatory properties of neural precursor cells: benefit for intracerebral transplantation.
Topics: Animals; Cell Proliferation; Cell Transplantation; Cytokines; Disease Models, Animal; Embryo, Mammal | 2011 |
Sympathetic modulation of the host defense response to infectious challenge during recovery from hemorrhage.
Topics: Animals; Disease Models, Animal; Hemorrhage; Immune Tolerance; Immunity, Innate; Inflammation; Ketam | 2010 |
Use of haptoglobin and transthyretin as potential biomarkers for the preclinical diagnosis of Parkinson's disease.
Topics: Animals; Biomarkers; Dopamine; Early Diagnosis; Electrophoresis, Gel, Two-Dimensional; Functional La | 2010 |
Involvement of the peripheral sensory and sympathetic nervous system in the vascular endothelial expression of ICAM-1 and the recruitment of opioid-containing immune cells to inhibit inflammatory pain.
Topics: Animals; Arthritis, Experimental; Calcitonin Gene-Related Peptide; Capsaicin; Endorphins; Endotheliu | 2010 |
Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat.
Topics: Animals; Axons; Corpus Striatum; Disease Models, Animal; Inflammation; Male; Nerve Degeneration; Ner | 2011 |
Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain.
Topics: Adrenergic Agents; Animals; Biogenic Monoamines; Disease Models, Animal; Dose-Response Relationship, | 2011 |
Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons.
Topics: Acetophenones; Animals; Animals, Newborn; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; | 2012 |
Rutin protects dopaminergic neurons from oxidative stress in an animal model of Parkinson's disease.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Male; Neuropr | 2012 |
Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease.
Topics: Allosteric Regulation; Anilides; Animals; Biomarkers; Cyclohexanecarboxylic Acids; Dopamine; Inflamm | 2012 |
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Cells; Dopaminergic Neurons; Inflammation; M | 2012 |
RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Caspase 9; Corpus Striatum; Cytochromes c; | 2013 |
Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers.
Topics: Adenosine; Animals; Capsaicin; Feedback; Inflammation; Injections, Spinal; Male; Nerve Fibers; Neuro | 2003 |
Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Blotting, Northern; Bromodeoxyuridine; Corpus Striatum; Disease Models, | 2003 |
Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2005 |
The anti-inflammatory effect of peripheral bee venom stimulation is mediated by central muscarinic type 2 receptors and activation of sympathetic preganglionic neurons.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Atropine; Autonomic Fibers, Preganglionic; Bee | 2005 |
Substantial role of locus coeruleus-noradrenergic activation and capsaicin-insensitive primary afferent fibers in bee venom's anti-inflammatory effect.
Topics: Adrenergic Agents; Animals; Anti-Inflammatory Agents; Bee Venoms; Capsaicin; Disease Models, Animal; | 2006 |
Peripheral bee venom's anti-inflammatory effect involves activation of the coeruleospinal pathway and sympathetic preganglionic neurons.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bee Venoms; Choline O-Acetyltransferase; Disease M | 2007 |
Effects of peripheral antisympathetic treatments in the tail-flick, formalin and autotomy tests.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Formaldehyde; Guanethidine; Hot Tempe | 1984 |
Further substantiation of a significant role for the sympathetic nervous system in inflammation.
Topics: Animals; Arthritis; Bradykinin; Exudates and Transudates; Inflammation; Knee Joint; Lidocaine; Male; | 1993 |
Effects of neurotoxins and hindpaw inflammation on opioid receptor immunoreactivities in dorsal root ganglia.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Ganglia, Spinal; Hindlimb; Immunohistochemistry | 1998 |
The effects of chemical sympathectomy on T-cell cytokine responses are not mediated by altered peritoneal exudate cell function or an inflammatory response.
Topics: Animals; Cell Separation; Clone Cells; Cytokines; Enzyme-Linked Immunosorbent Assay; Exudates and Tr | 2002 |
Neurogenic and non-neurogenic inflammation in the rat paw following chemical sympathectomy.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Carrageenan; Edema; Foot; Guanethidine; | 1991 |
Sympathetic neurons modulate plasma extravasation in the rat through a non-adrenergic mechanism.
Topics: Alprostadil; Animals; Blister; Hydroxydopamines; Inflammation; Male; Neurons; Neurons, Afferent; Neu | 1989 |
Effect of pre-existing inflammation on carrageenan-induced paw oedema in rats.
Topics: Adrenalectomy; Animals; Carrageenan; Edema; Hydroxydopamines; Inflammation; Male; Metyrapone; Oxidop | 1987 |
Inhibition of carrageenin-induced pedal oedema in rats by immobilisation stress.
Topics: 5,6-Dihydroxytryptamine; Adrenalectomy; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Foot | 1987 |
The effect of nerve lesions on the inflammatory response to injury.
Topics: Animals; Blister; Capsaicin; Cell Count; Hydroxydopamines; Inflammation; Leukocytes; Oxidopamine; Pe | 1985 |