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oxidopamine and Hypotension

oxidopamine has been researched along with Hypotension in 12 studies

Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"The present study sought to determine whether chemical destruction of peripheral catecholaminergic fibers with 6-hydroxydopamine (6OHDA) attenuates vasopressin (VP) and oxytocin (OT) secretion stimulated by hemorrhage, hypotension, and hyperosmolality."7.73Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats. ( Lone, U; Madden, CJ; Stocker, SD; Sved, AF; Wilson, ME, 2006)
"choline can increase blood pressure in rats made hypotensive by acute chemical sympathectomy through the activation of central nicotinic receptors by presynaptic mechanisms."5.30Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy. ( Gürün, MS; Savci, V; Ulus, IH, 1997)
"The present study sought to determine whether chemical destruction of peripheral catecholaminergic fibers with 6-hydroxydopamine (6OHDA) attenuates vasopressin (VP) and oxytocin (OT) secretion stimulated by hemorrhage, hypotension, and hyperosmolality."3.73Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats. ( Lone, U; Madden, CJ; Stocker, SD; Sved, AF; Wilson, ME, 2006)
"Intracerebroventricular injections of nicardipine (10 micrograms/kg) to SHR induced hypotension which was suppressed by pretreatment with 6-OHDA."3.67Endogenous opiate system and dihydropyridine-induced central regulation of sympathetic tone in rats. ( Brisac, AM; Champeroux, P; Laurent, S; Schmitt, H, 1988)
"Anaphylactic shock is sometimes life-threatening, and it is accompanied by hepatic venoconstriction in animals, which, in part, accounts for anaphylactic hypotension."1.39Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats. ( Kurata, Y; Shibamoto, T; Tanida, M; Wang, M, 2013)
"The early stress responses to hemorrhagic shock, trauma and endotoxicosis are associated with an early proinflammatory response characterized by increased gene expression of proinflammatory cytokines, PMN influx and accumulation in the lung and apoptosis."1.31Noradrenergic inhibition of TNF upregulation in hemorrhagic shock. ( Molina, PE, 2001)
"choline can increase blood pressure in rats made hypotensive by acute chemical sympathectomy through the activation of central nicotinic receptors by presynaptic mechanisms."1.30Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy. ( Gürün, MS; Savci, V; Ulus, IH, 1997)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19905 (41.67)18.7374
1990's3 (25.00)18.2507
2000's3 (25.00)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, M1
Tanida, M1
Shibamoto, T1
Kurata, Y1
Chan, CK1
Burke, SL1
Zhu, H1
Piletz, JE1
Head, GA1
Stocker, SD1
Wilson, ME1
Madden, CJ1
Lone, U1
Sved, AF1
Livingston, A1
Oner, G1
Lederis, K1
Nandiwada, PA1
Hyman, AL1
Kadowitz, PJ1
Kiang-Ulrich, M1
Horvath, SM1
Gürün, MS1
Savci, V1
Ulus, IH1
Kawahara, Y1
Kawahara, H1
Westerink, BH1
Molina, PE1
Waxman, MB1
Asta, JA1
Cameron, DA1
Endrenyi, L1
Champeroux, P1
Brisac, AM1
Laurent, S1
Schmitt, H1
Daugirdas, JT1
Nawab, ZM1
Hayashi, JA1

Other Studies

12 other studies available for oxidopamine and Hypotension

ArticleYear
Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Oct-15, Volume: 305, Issue:8

    Topics: Adrenergic alpha-1 Receptor Antagonists; Anaphylaxis; Animals; Hypertension, Portal; Hypotension; Li

2013
Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine.
    Neuroscience, 2005, Volume: 132, Issue:4

    Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Animals; Antihypertensive Agents; Blotting, Western; Bra

2005
Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 291, Issue:1

    Topics: Animals; Diazoxide; Dopamine beta-Hydroxylase; Hemorrhage; Hypotension; Hypothalamus; Injections, In

2006
Reversal of 6-hydroxydopamine-induced hypotension in Long Evans and diabetes insipidus (Brattleboro) rats.
    Pharmacology, 1983, Volume: 26, Issue:4

    Topics: Animals; Arginine Vasopressin; Blood Pressure; Diabetes Insipidus; Heart Rate; Hematocrit; Hydroxydo

1983
Pulmonary vasodilator responses to vagal stimulation and acetylcholine in the cat.
    Circulation research, 1983, Volume: 53, Issue:1

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetylcholine; Airway Obstruction; Animals; Autonomic Nervous Syste

1983
Food intake following systemic 6-hydroxydopamine injection.
    Medical biology, 1982, Volume: 60, Issue:1

    Topics: Acclimatization; Adrenal Medulla; Animals; Cold Temperature; Eating; Hydroxydopamines; Hypotension;

1982
Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy.
    Journal of autonomic pharmacology, 1997, Volume: 17, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Choline; Cholinergic Antagonists; Dose-Respon

1997
Comparison of effects of hypotension and handling stress on the release of noradrenaline and dopamine in the locus coeruleus and medial prefrontal cortex of the rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthesia; Animals; Antihypertensive Agents; Dopamine; Handling, Ps

1999
Noradrenergic inhibition of TNF upregulation in hemorrhagic shock.
    Neuroimmunomodulation, 2001, Volume: 9, Issue:3

    Topics: Animals; Apoptosis; beta-Endorphin; Catecholamines; Corticosterone; Hypotension; Lung; Male; Neuroim

2001
Vasodepressor reaction induced by inferior vena caval occlusion and isoproterenol.
    Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:6

    Topics: Animals; Atropine; Disease Models, Animal; Drug Administration Routes; Heart Rate; Hypotension; Infu

1992
Endogenous opiate system and dihydropyridine-induced central regulation of sympathetic tone in rats.
    European journal of pharmacology, 1988, Dec-06, Volume: 158, Issue:1-2

    Topics: Animals; Blood Pressure; Dihydropyridines; Endorphins; Hydroxydopamines; Hypotension; Male; Naloxone

1988
Hemodialysis hemodynamics in an animal model: effect of using an acetate-buffered dialysate.
    The Journal of laboratory and clinical medicine, 1986, Volume: 107, Issue:6

    Topics: Acetates; Animals; Bicarbonates; Blood Pressure; Buffers; Cardiac Output; Dogs; Hemodynamics; Hydrox

1986