oxidopamine has been researched along with Hyperactivity, Motor in 27 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Involuntary movements were assessed by two blinded raters prior and every 30 min after drug dosing using the Clinical Dyskinesia Rating Scale (CDRS)." | 1.91 | Comparison of dyskinesia profiles after L-DOPA dose challenges with or without dopamine agonist coadministration. ( Cenci, MA; Espa, E; Grigoriou, S; Jakobsson, A; Odin, P; Timpka, J; von Grothusen, G, 2023) |
| "Atomoxetine greatly reduced motor hyperactivity in 6-OHDA-lesioned rats while exhibiting transient sedative effects in sham controls." | 1.33 | Atomoxetine blocks motor hyperactivity in neonatal 6-hydroxydopamine-lesioned rats: implications for treatment of attention-deficit hyperactivity disorder. ( Baldessarini, RJ; Moran-Gates, T; Tarazi, FI; Zhang, K, 2005) |
| "Ritanserin pretreatment blunted systemic SKF 82958-induced hyperlocomotion and returned intrastriatal D1-mediated hyperactivity to sham lesion levels." | 1.32 | Intrastriatal serotonin 5-HT2 receptors mediate dopamine D1-induced hyperlocomotion in 6-hydroxydopamine-lesioned rats. ( Bishop, C; Kamdar, DP; Walker, PD, 2003) |
| "Autoradiographic analysis indicated that motor hyperactivity in lesioned rats was closely correlated with increases in D(4) but not D(2) receptor levels in caudate-putamen." | 1.31 | Role of dopamine D(4) receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats. ( Baldessarini, RJ; Tarazi, FI; Zhang, K, 2001) |
| "We recently reported that motor hyperactivity in juvenile male rats with neonatal 6-hydroxydopamine lesions of the central dopamine system can be reversed by dopamine D(4) receptor-selective antagonists." | 1.31 | Plasticity of dopamine D4 receptors in rat forebrain: temporal association with motor hyperactivity following neonatal 6-hydroxydopamine lesioning. ( Baldessarini, RJ; Davids, E; Tarazi, FI; Zhang, K, 2002) |
| " Following chronic administration of clenbuterol (5 mg/kg daily for 14 days), a procedure resulting in down-regulation of central beta-adrenoceptors, a larger dose of clenbuterol was necessary to enhance the quipazine-induced hyperactivity, suggesting that the mechanism of enhancement involved central post-synaptic beta-adrenoceptors." | 1.27 | Studies on the mechanisms by which clenbuterol, a beta-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat. ( Cowen, PJ; Deakin, JF; Grahame-Smith, DG; Green, AR; Heal, DJ; Nimgaonkar, VL, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 14 (51.85) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Grigoriou, S | 1 |
| Espa, E | 1 |
| Odin, P | 1 |
| Timpka, J | 1 |
| von Grothusen, G | 1 |
| Jakobsson, A | 1 |
| Cenci, MA | 1 |
| Charles, KA | 1 |
| Naudet, F | 1 |
| Bouali-Benazzouz, R | 1 |
| Landry, M | 1 |
| De Deurwaerdère, P | 1 |
| Fossat, P | 1 |
| Benazzouz, A | 1 |
| Tanaka, T | 1 |
| Ago, Y | 1 |
| Umehara, C | 1 |
| Imoto, E | 1 |
| Hasebe, S | 1 |
| Hashimoto, H | 1 |
| Takuma, K | 1 |
| Matsuda, T | 1 |
| Galiñanes, GL | 1 |
| Taravini, IR | 1 |
| Murer, MG | 1 |
| de Azeredo, LA | 1 |
| Marquardt, AR | 1 |
| Frazzon, AP | 1 |
| Barros, HM | 1 |
| McFarland, K | 1 |
| Price, DL | 1 |
| Bonhaus, DW | 1 |
| Masuo, Y | 4 |
| Shibato, J | 1 |
| Rakwal, R | 1 |
| Zhang, K | 5 |
| Davids, E | 3 |
| Tarazi, FI | 5 |
| Baldessarini, RJ | 5 |
| Ishido, M | 3 |
| Morita, M | 3 |
| Oka, S | 2 |
| Bishop, C | 1 |
| Kamdar, DP | 1 |
| Walker, PD | 1 |
| Villégier, AS | 1 |
| Drouin, C | 1 |
| Bizot, JC | 1 |
| Marien, M | 1 |
| Glowinski, J | 1 |
| Colpaërt, F | 1 |
| Tassin, JP | 1 |
| Niki, E | 2 |
| Rex, A | 1 |
| Fink, H | 1 |
| Moran-Gates, T | 1 |
| Inden, M | 1 |
| Kim, DH | 1 |
| Qi, M | 1 |
| Kitamura, Y | 1 |
| Yanagisawa, D | 1 |
| Nishimura, K | 1 |
| Tsuchiya, D | 1 |
| Takata, K | 1 |
| Hayashi, K | 1 |
| Taniguchi, T | 1 |
| Yoshimoto, K | 1 |
| Shimohama, S | 1 |
| Sumi, S | 1 |
| Inoue, K | 1 |
| Sawa, H | 1 |
| Nagashima, K | 1 |
| Archer, T | 1 |
| Fredriksson, A | 1 |
| Nimgaonkar, VL | 1 |
| Green, AR | 1 |
| Cowen, PJ | 1 |
| Heal, DJ | 1 |
| Grahame-Smith, DG | 1 |
| Deakin, JF | 1 |
| Heffner, TG | 1 |
| Heller, A | 1 |
| Miller, FE | 1 |
| Kotake, C | 1 |
| Seiden, LS | 1 |
| Goldenring, JR | 1 |
| Shaywitz, BA | 1 |
| Wool, RS | 1 |
| Batter, DK | 1 |
| Anderson, GM | 1 |
| Cohen, DJ | 1 |
| Duty, S | 1 |
| Brotchie, JM | 1 |
| Phillips, JM | 1 |
| Brown, VJ | 1 |
| Kula, NS | 1 |
| McMahon, FJ | 1 |
| Moran, TH | 1 |
| Robinson, RG | 1 |
| Olds, ME | 1 |
| Yuwiler, A | 1 |
27 other studies available for oxidopamine and Hyperactivity, Motor
| Article | Year |
|---|---|
Comparison of dyskinesia profiles after L-DOPA dose challenges with or without dopamine agonist coadministration.
Topics: Antiparkinson Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Dystonia; Humans; Hyperkinesis; L | 2023 |
Alteration of nociceptive integration in the spinal cord of a rat model of Parkinson's disease.
Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine; Functional Laterality; Hyperalgesia; H | 2018 |
Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice.
Topics: 5,7-Dihydroxytryptamine; Animals; Central Nervous System Stimulants; Desipramine; Dopamine; Dopamine | 2017 |
Dopamine-dependent periadolescent maturation of corticostriatal functional connectivity in mouse.
Topics: Action Potentials; Age Factors; Amphetamine; Animals; Animals, Newborn; Cerebral Cortex; Corpus Stri | 2009 |
Cocaine reverses the changes in GABAA subunits and in glutamic acid decarboxylase isoenzymes mRNA expression induced by neonatal 6-hydroxydopamine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Cocaine; Corpus Striatum; Glutamate Decarboxylase; Hipp | 2010 |
Pimavanserin, a 5-HT2A inverse agonist, reverses psychosis-like behaviors in a rodent model of Parkinson's disease.
Topics: Amphetamine; Amphetamines; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System S | 2011 |
ADHD animal model characterization: transcriptomics and proteomics analyses.
Topics: Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Brain; D | 2012 |
Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity.
Topics: Aging; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Carrier Proteins; D | 2002 |
Effects of neonatal 6-hydroxydopamine lesion on the gene expression profile in young adult rats.
Topics: Animals; Animals, Newborn; Catecholamines; Corpus Striatum; Disease Models, Animal; Dopamine; Female | 2002 |
Intrastriatal serotonin 5-HT2 receptors mediate dopamine D1-induced hyperlocomotion in 6-hydroxydopamine-lesioned rats.
Topics: Animals; Benzazepines; Denervation; Dopamine; Dopamine Agonists; Drug Interactions; Dyskinesia, Drug | 2003 |
Stimulation of postsynaptic alpha1b- and alpha2-adrenergic receptors amplifies dopamine-mediated locomotor activity in both rats and mice.
Topics: Adrenergic Agents; Amphetamine; Animals; Behavior, Animal; Benzopyrans; Cerebellum; Dopamine; Dopami | 2003 |
Motor activity and gene expression in rats with neonatal 6-hydroxydopamine lesions.
Topics: Animals; Animals, Newborn; Brain Chemistry; Catecholamines; Central Nervous System Stimulants; Chrom | 2004 |
Cholecystokinin tetrapeptide improves water maze performance of neonatally 6-hydroxydopamine-lesioned young rats.
Topics: Animals; Animals, Newborn; Body Weight; Brain Chemistry; Dopamine; Female; Hyperkinesis; Maze Learni | 2004 |
Atomoxetine blocks motor hyperactivity in neonatal 6-hydroxydopamine-lesioned rats: implications for treatment of attention-deficit hyperactivity disorder.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Animals, Newborn; At | 2005 |
Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats.
Topics: Animals; Basal Ganglia; Behavior, Animal; Brain Tissue Transplantation; Cell Count; Corpus Striatum; | 2005 |
Behavioural characteristics and gene expression in the hyperactive wiggling (Wig) rat.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Animals, Congenic; Animals, Newborn; Behavior, Ani | 2007 |
Behavioural supersensitivity following neonatal 6-hydroxydopamine: attenuation by MK-801.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Brain Chemistry; Dizocilpine Male | 2007 |
Studies on the mechanisms by which clenbuterol, a beta-adrenoceptor agonist, enhances 5-HT-mediated behaviour and increases metabolism of 5-HT in the brain of the rat.
Topics: Animals; Behavior, Animal; Brain; Carbidopa; Clenbuterol; Ethanolamines; Fenclonine; Humans; Hydroxy | 1983 |
Locomotor hyperactivity in neonatal rats following electrolytic lesions of mesocortical dopamine neurons.
Topics: Animals; Brain Chemistry; Catecholamines; Cerebral Cortex; Corpus Striatum; Dopamine; Humans; Hydrox | 1983 |
Environmental and biologic interactions on behavior: effects of artificial rearing in rat pups treated with 6-hydroxydopamine.
Topics: Animals; Arousal; Avoidance Learning; Body Weight; Brain Chemistry; Dopamine; Escape Reaction; Habit | 1982 |
Enhancement of the behavioral response to apomorphine administration following repeated treatment in the 6-hydroxydopamine-lesioned rat is temporally correlated with a rise in striatal preproenkephalin-B, but not preproenkephalin-A, gene expression.
Topics: Adrenergic Agents; Animals; Apomorphine; Caudate Nucleus; Corpus Striatum; Enkephalins; Gene Express | 1997 |
Reaction time performance following unilateral striatal dopamine depletion and lesions of the subthalamic nucleus in the rat.
Topics: Animals; Behavior, Animal; Corpus Striatum; Discrimination Learning; Dopamine; Hyperkinesis; Male; O | 1999 |
Role of dopamine D(4) receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats.
Topics: Animals; Animals, Newborn; Autoradiography; Central Nervous System Stimulants; Dopamine Agonists; Do | 2001 |
Plasticity of dopamine D4 receptors in rat forebrain: temporal association with motor hyperactivity following neonatal 6-hydroxydopamine lesioning.
Topics: Adrenergic Agents; Animals; Animals, Newborn; Dopamine D2 Receptor Antagonists; Female; Hyperkinesis | 2002 |
Effects of norepinephrine and serotonin transporter inhibitors on hyperactivity induced by neonatal 6-hydroxydopamine lesioning in rats.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Carrier Proteins; Hyperk | 2002 |
Hyperactivity following posterior cortical injury is lateralized, sensitive to lesion size and independent of the nigrostriatal dopamine system.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Dopamine; Functional Laterality; Hydroxydopamines; Hyperk | 1989 |
Comparison of hyperactivity in adult rats induced by neonatal intraventricular 6-hydroxydopamine following pargyline or desmethylimipramine treatment.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Desipramine; Dopamine; Female; Hydroxydopamines; Hype | 1985 |