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oxidopamine and Epilepsy

oxidopamine has been researched along with Epilepsy in 10 studies

Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"In this study we analyzed the electrophysiological and clinical effects of selective removal of the forebrain noradrenergic projection from the locus coeruleus, induced by bilateral injections of 6-hydroxydopamine into the dorsal tegmental bundle on focal cobalt-induced epilepsy."7.67Facilitation of focal cobalt-induced epilepsy after lesions of the noradrenergic locus coeruleus system. ( Björklund, A; Chauvel, P; Lindvall, O; Trottier, S, 1988)
" In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy."4.12Dopamine depletion in wistar rats with epilepsy. ( Becker, EL; Biase, CLCL; Carvalho, EGA; Castro, DN; Cavalcante, JBN; Costa, AF; Costa, MV; Costa, PJMS; de Melo, MR; Félix, VB; Leão, SABF; Leite, ML; Lima, JA; Lino, ATS; Moura, IMFB; Mousinho, KC; Pai, JD; Quintella, GB; Saldanha-Filho, AJM; Santos, SDBD; Silva, ATMD; Silva, JCD; Tavares, MMA; Trindade-Filho, EM; Vieira, JSS; Zambrano, LI, 2022)
"In this study we analyzed the electrophysiological and clinical effects of selective removal of the forebrain noradrenergic projection from the locus coeruleus, induced by bilateral injections of 6-hydroxydopamine into the dorsal tegmental bundle on focal cobalt-induced epilepsy."3.67Facilitation of focal cobalt-induced epilepsy after lesions of the noradrenergic locus coeruleus system. ( Björklund, A; Chauvel, P; Lindvall, O; Trottier, S, 1988)
"Chronic sound or electroshock-induced seizures caused down regulation of beta-adrenoceptors in frontal cortex and in hippocampus from GEPR-9s."1.31Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats. ( Cheong, JH; Choi, CR; Dailey, JW; Jobe, PC; Ko, KH; Reith, ME; Ryu, JR; Seo, DO; Shin, CY, 2000)
"The development of seizures was significantly faster in the grafted and normal rats that had been given idazoxan than in the grafted rats that had not been subjected to alpha-2 receptor blockade."1.28Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism. ( Bengzon, J; Brundin, P; Kokaia, M; Lindvall, O, 1990)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19903 (30.00)18.7374
1990's4 (40.00)18.2507
2000's2 (20.00)29.6817
2010's0 (0.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Trindade-Filho, EM1
Pai, JD1
Castro, DN1
Silva, ATMD1
Costa, AF1
Vieira, JSS1
Santos, SDBD1
Félix, VB1
Leão, SABF1
Zambrano, LI1
Saldanha-Filho, AJM1
Carvalho, EGA1
Cavalcante, JBN1
Quintella, GB1
Lino, ATS1
Costa, MV1
Lima, JA1
Tavares, MMA1
de Melo, MR1
Mousinho, KC1
Biase, CLCL1
Leite, ML1
Costa, PJMS1
Becker, EL1
Moura, IMFB1
Silva, JCD1
Bengzon, J2
Kokaia, Z2
Lindvall, O5
Seo, DO1
Shin, CY1
Ryu, JR1
Cheong, JH1
Choi, CR1
Dailey, JW1
Reith, ME1
Jobe, PC1
Ko, KH1
Ferencz, I1
Leanza, G1
Nanobashvili, A1
Kokaia, M2
Qiao, XX1
Noebels, JL1
Velísková, J1
Velísek, L1
Mares, P1
Rokyta, R1
Budko, KP1
Brundin, P2
Maurin, Y1
Enz, A1
Le Saux, F1
Besson, MJ1
Barry, DI1
Kikvadze, I1
Bolwig, TG1
Björklund, A2
Trottier, S1
Chauvel, P1

Other Studies

10 other studies available for oxidopamine and Epilepsy

ArticleYear
Dopamine depletion in wistar rats with epilepsy.
    Brazilian journal of biology = Revista brasleira de biologia, 2022, Volume: 84

    Topics: Animals; Dopamine; Epilepsy; Male; Muscarinic Agonists; Oxidopamine; Pilocarpine; Rats; Rats, Wistar

2022
Specific functions of grafted locus coeruleus neurons in the kindling model of epilepsy.
    Experimental neurology, 1993, Volume: 122, Issue:1

    Topics: Animals; Brain; Epilepsy; Hippocampus; Injections; Injections, Intraventricular; Kindling, Neurologi

1993
Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats.
    European journal of pharmacology, 2000, May-19, Volume: 396, Issue:2-3

    Topics: Animals; Dihydroalprenolol; Electroshock; Epilepsy; Norepinephrine; Oxidopamine; Prazosin; Rats; Rat

2000
Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons.
    Neuroscience, 2001, Volume: 102, Issue:4

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Antibodies, Monoclonal; Basal Nucleus of Meynert; Chol

2001
Genetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects.
    Brain research, 1991, Jul-26, Volume: 555, Issue:1

    Topics: Animals; Brain; Electroencephalography; Epilepsy; Female; Glyoxylates; Histocytochemistry; Locus Coe

1991
Bicuculline-induced neocortical epileptiform foci and the effects of 6-hydroxydopamine in developing rats.
    Brain research bulletin, 1991, Volume: 26, Issue:5

    Topics: Animals; Bicuculline; Catecholamines; Cerebral Cortex; Electroencephalography; Epilepsy; Frontal Lob

1991
Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism.
    Experimental brain research, 1990, Volume: 81, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Dioxanes; Dopamine beta-Hydroxylase; Epilepsy; Hippocampus; Hy

1990
Supernumerary locus coeruleus neurons as a determinant of inherited epilepsy in the convulsive mutant mouse quaking.
    Brain research, 1986, Feb-26, Volume: 366, Issue:1-2

    Topics: Animals; Epilepsy; Hydroxydopamines; Locus Coeruleus; Mice; Mice, Inbred C57BL; Mice, Quaking; Norep

1986
Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:23

    Topics: Adrenergic Fibers; Animals; Epilepsy; Hippocampus; Hydroxydopamines; Kindling, Neurologic; Male; Nor

1987
Facilitation of focal cobalt-induced epilepsy after lesions of the noradrenergic locus coeruleus system.
    Brain research, 1988, Jun-28, Volume: 454, Issue:1-2

    Topics: Animals; Cerebral Cortex; Cobalt; Electroencephalography; Epilepsy; Female; Hydroxydopamines; Locus

1988