oxidopamine has been researched along with Epilepsy in 10 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study we analyzed the electrophysiological and clinical effects of selective removal of the forebrain noradrenergic projection from the locus coeruleus, induced by bilateral injections of 6-hydroxydopamine into the dorsal tegmental bundle on focal cobalt-induced epilepsy." | 7.67 | Facilitation of focal cobalt-induced epilepsy after lesions of the noradrenergic locus coeruleus system. ( Björklund, A; Chauvel, P; Lindvall, O; Trottier, S, 1988) |
| " In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy." | 4.12 | Dopamine depletion in wistar rats with epilepsy. ( Becker, EL; Biase, CLCL; Carvalho, EGA; Castro, DN; Cavalcante, JBN; Costa, AF; Costa, MV; Costa, PJMS; de Melo, MR; Félix, VB; Leão, SABF; Leite, ML; Lima, JA; Lino, ATS; Moura, IMFB; Mousinho, KC; Pai, JD; Quintella, GB; Saldanha-Filho, AJM; Santos, SDBD; Silva, ATMD; Silva, JCD; Tavares, MMA; Trindade-Filho, EM; Vieira, JSS; Zambrano, LI, 2022) |
| "In this study we analyzed the electrophysiological and clinical effects of selective removal of the forebrain noradrenergic projection from the locus coeruleus, induced by bilateral injections of 6-hydroxydopamine into the dorsal tegmental bundle on focal cobalt-induced epilepsy." | 3.67 | Facilitation of focal cobalt-induced epilepsy after lesions of the noradrenergic locus coeruleus system. ( Björklund, A; Chauvel, P; Lindvall, O; Trottier, S, 1988) |
| "Chronic sound or electroshock-induced seizures caused down regulation of beta-adrenoceptors in frontal cortex and in hippocampus from GEPR-9s." | 1.31 | Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats. ( Cheong, JH; Choi, CR; Dailey, JW; Jobe, PC; Ko, KH; Reith, ME; Ryu, JR; Seo, DO; Shin, CY, 2000) |
| "The development of seizures was significantly faster in the grafted and normal rats that had been given idazoxan than in the grafted rats that had not been subjected to alpha-2 receptor blockade." | 1.28 | Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism. ( Bengzon, J; Brundin, P; Kokaia, M; Lindvall, O, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trindade-Filho, EM | 1 |
| Pai, JD | 1 |
| Castro, DN | 1 |
| Silva, ATMD | 1 |
| Costa, AF | 1 |
| Vieira, JSS | 1 |
| Santos, SDBD | 1 |
| Félix, VB | 1 |
| Leão, SABF | 1 |
| Zambrano, LI | 1 |
| Saldanha-Filho, AJM | 1 |
| Carvalho, EGA | 1 |
| Cavalcante, JBN | 1 |
| Quintella, GB | 1 |
| Lino, ATS | 1 |
| Costa, MV | 1 |
| Lima, JA | 1 |
| Tavares, MMA | 1 |
| de Melo, MR | 1 |
| Mousinho, KC | 1 |
| Biase, CLCL | 1 |
| Leite, ML | 1 |
| Costa, PJMS | 1 |
| Becker, EL | 1 |
| Moura, IMFB | 1 |
| Silva, JCD | 1 |
| Bengzon, J | 2 |
| Kokaia, Z | 2 |
| Lindvall, O | 5 |
| Seo, DO | 1 |
| Shin, CY | 1 |
| Ryu, JR | 1 |
| Cheong, JH | 1 |
| Choi, CR | 1 |
| Dailey, JW | 1 |
| Reith, ME | 1 |
| Jobe, PC | 1 |
| Ko, KH | 1 |
| Ferencz, I | 1 |
| Leanza, G | 1 |
| Nanobashvili, A | 1 |
| Kokaia, M | 2 |
| Qiao, XX | 1 |
| Noebels, JL | 1 |
| Velísková, J | 1 |
| Velísek, L | 1 |
| Mares, P | 1 |
| Rokyta, R | 1 |
| Budko, KP | 1 |
| Brundin, P | 2 |
| Maurin, Y | 1 |
| Enz, A | 1 |
| Le Saux, F | 1 |
| Besson, MJ | 1 |
| Barry, DI | 1 |
| Kikvadze, I | 1 |
| Bolwig, TG | 1 |
| Björklund, A | 2 |
| Trottier, S | 1 |
| Chauvel, P | 1 |
10 other studies available for oxidopamine and Epilepsy
| Article | Year |
|---|---|
Dopamine depletion in wistar rats with epilepsy.
Topics: Animals; Dopamine; Epilepsy; Male; Muscarinic Agonists; Oxidopamine; Pilocarpine; Rats; Rats, Wistar | 2022 |
Specific functions of grafted locus coeruleus neurons in the kindling model of epilepsy.
Topics: Animals; Brain; Epilepsy; Hippocampus; Injections; Injections, Intraventricular; Kindling, Neurologi | 1993 |
Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats.
Topics: Animals; Dihydroalprenolol; Electroshock; Epilepsy; Norepinephrine; Oxidopamine; Prazosin; Rats; Rat | 2000 |
Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Antibodies, Monoclonal; Basal Nucleus of Meynert; Chol | 2001 |
Genetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects.
Topics: Animals; Brain; Electroencephalography; Epilepsy; Female; Glyoxylates; Histocytochemistry; Locus Coe | 1991 |
Bicuculline-induced neocortical epileptiform foci and the effects of 6-hydroxydopamine in developing rats.
Topics: Animals; Bicuculline; Catecholamines; Cerebral Cortex; Electroencephalography; Epilepsy; Frontal Lob | 1991 |
Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism.
Topics: Adrenergic beta-Antagonists; Animals; Dioxanes; Dopamine beta-Hydroxylase; Epilepsy; Hippocampus; Hy | 1990 |
Supernumerary locus coeruleus neurons as a determinant of inherited epilepsy in the convulsive mutant mouse quaking.
Topics: Animals; Epilepsy; Hydroxydopamines; Locus Coeruleus; Mice; Mice, Inbred C57BL; Mice, Quaking; Norep | 1986 |
Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.
Topics: Adrenergic Fibers; Animals; Epilepsy; Hippocampus; Hydroxydopamines; Kindling, Neurologic; Male; Nor | 1987 |
Facilitation of focal cobalt-induced epilepsy after lesions of the noradrenergic locus coeruleus system.
Topics: Animals; Cerebral Cortex; Cobalt; Electroencephalography; Epilepsy; Female; Hydroxydopamines; Locus | 1988 |