oxidopamine has been researched along with Encephalopathy, Toxic in 77 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Animal models have been invaluable to Parkinson's disease (PD) research." | 2.46 | Neurotoxic in vivo models of Parkinson's disease recent advances. ( Cannon, JR; Greenamyre, JT, 2010) |
| " Oxidative stress is regarded as an important starting factor for neuronal cell loss and necrosis, is one of the causes of Parkinson's disease (PD), and is considered to be the cause of adverse reactions caused by the current PD commonly used treatment drug levodopa (l-DA)." | 1.72 | Fucoxanthin Prevents Long-Term Administration l-DOPA-Induced Neurotoxicity through the ERK/JNK-c-Jun System in 6-OHDA-Lesioned Mice and PC12 Cells. ( Chen, H; Chen, J; Chen, S; Li, Q; Liu, J; Lu, Y; Shao, F; Tang, M; Wu, W; Xu, Z; Yang, D; Zhai, L, 2022) |
| "Baicalin was reported to have neuroprotective effects." | 1.51 | Baicalin alleviates 6-hydroxydopamine-induced neurotoxicity in PC12 cells by down-regulation of microRNA-192-5p. ( Fu, Y; Gao, J; Kang, C; Kang, M; Liu, X; Wang, L, 2019) |
| "Ferulic acid (FA) is a phenolic compound possessing antioxidant and cytoprotective properties." | 1.48 | Comparing the Effects of Ferulic Acid and Sugarcane Aqueous Extract in In Vitro and In Vivo Neurotoxic Models. ( Aschner, M; Colonnello, A; de Lima, ME; García-Contreras, R; Kotlar, I; Ortíz-Plata, A; Santamaría, A; Soares, FAA, 2018) |
| "The effects of berberine on long-term administration of L-DOPA in 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease (PD) were investigated." | 1.39 | Neurotoxic effects of berberine on long-term L-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. ( Choi, HS; Choi, SO; Kwon, IH; Lee, MK; Shin, KS; Suh, KH; Zhao, TT, 2013) |
| " It is, therefore, suggested that the use of long-term l-DOPA therapy with isoquinoline derivatives including berberine may need to be examined for the presence of adverse symptoms." | 1.36 | Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease. ( Choi, HS; Hwang, BY; Kwon, IH; Lee, BK; Lee, CK; Lee, MK; Lim, SC; Shin, KS, 2010) |
| "Rosmarinic acid (RA) is a naturally occurring polyphenolic compound." | 1.35 | Rosmarinic acid inhibits 6-OHDA-induced neurotoxicity by anti-oxidation in MES23.5 cells. ( Jiang, H; Li, R; Ren, P; Song, N; Wang, J; Xie, JX; Xu, HM, 2009) |
| "Nicotine pre-treatment attenuated behavioral deficits and lessened lesion-induced losses of the striatal dopamine transporter, and alpha6beta2* and alpha4beta2* nicotinic receptors (nAChRs)." | 1.35 | Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys. ( Bordia, T; Huang, LZ; Michael McIntosh, J; Parameswaran, N; Quik, M, 2009) |
| " Following recovery, the phencyclidine dose-response curve was repeated in the fixed-interval paradigm." | 1.33 | Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum. ( Carlson, KM; Wagner, GC, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 18 (23.38) | 29.6817 |
| 2010's | 42 (54.55) | 24.3611 |
| 2020's | 17 (22.08) | 2.80 |
| Authors | Studies |
|---|---|
| Simões, RF | 1 |
| Oliveira, PJ | 1 |
| Cunha-Oliveira, T | 1 |
| Pereira, FB | 1 |
| Estrada-Valencia, R | 1 |
| Hurtado-Díaz, ME | 1 |
| Rangel-López, E | 2 |
| Retana-Márquez, S | 1 |
| Túnez, I | 1 |
| Tinkov, A | 1 |
| Karasu, C | 1 |
| Ferrer, B | 1 |
| Pedraza-Chaverri, J | 3 |
| Aschner, M | 2 |
| Santamaría, A | 5 |
| Liu, J | 4 |
| Lu, Y | 2 |
| Tang, M | 2 |
| Shao, F | 1 |
| Yang, D | 1 |
| Chen, S | 1 |
| Xu, Z | 1 |
| Zhai, L | 1 |
| Chen, J | 2 |
| Li, Q | 1 |
| Wu, W | 2 |
| Chen, H | 2 |
| Chen, CH | 1 |
| Hsu, PC | 2 |
| Hsu, SW | 2 |
| Hong, KT | 1 |
| Chen, KY | 2 |
| He, JL | 1 |
| Cho, DY | 1 |
| Wang, YC | 2 |
| Chang, WS | 2 |
| Bau, DT | 2 |
| Tsai, CW | 3 |
| Sokouti, H | 1 |
| Mohajeri, D | 1 |
| Nourazar, MA | 1 |
| Guo, SY | 1 |
| Guan, RX | 1 |
| Chi, XD | 1 |
| Sui, AR | 1 |
| Zhao, W | 2 |
| Supratik, K | 1 |
| Yang, JY | 1 |
| Zhao, J | 1 |
| Li, S | 3 |
| Perlikowska, R | 1 |
| Silva, J | 2 |
| Alves, C | 2 |
| Susano, P | 1 |
| Pedrosa, R | 2 |
| Luo, Y | 2 |
| Sakamoto, K | 1 |
| Fu, RH | 2 |
| Hong, SY | 1 |
| Chen, HJ | 1 |
| Sun, L | 1 |
| Zhang, T | 1 |
| Xiu, W | 1 |
| Cao, W | 1 |
| He, M | 1 |
| Sun, W | 1 |
| Yu, CC | 1 |
| Yang, JS | 1 |
| Tsai, FJ | 1 |
| Monzel, AS | 1 |
| Hemmer, K | 1 |
| Kaoma, T | 1 |
| Smits, LM | 1 |
| Bolognin, S | 1 |
| Lucarelli, P | 1 |
| Rosety, I | 1 |
| Zagare, A | 1 |
| Antony, P | 1 |
| Nickels, SL | 1 |
| Krueger, R | 1 |
| Azuaje, F | 1 |
| Schwamborn, JC | 1 |
| Wasel, O | 1 |
| Freeman, JL | 1 |
| Dong, Y | 1 |
| Xiong, J | 1 |
| Ji, L | 2 |
| Xue, X | 1 |
| Ma, L | 1 |
| Zhang, B | 1 |
| Qiao, C | 1 |
| Liu, Y | 1 |
| Lv, H | 1 |
| Jiang, Y | 1 |
| He, Y | 1 |
| Shen, T | 1 |
| Li, F | 1 |
| Hu, W | 1 |
| Han, H | 1 |
| Wu, X | 1 |
| Cao, X | 1 |
| Zhao, T | 1 |
| Niu, T | 1 |
| Kao, CJ | 1 |
| Chen, WF | 1 |
| Guo, BL | 1 |
| Feng, CW | 1 |
| Hung, HC | 1 |
| Yang, WY | 1 |
| Sung, CS | 1 |
| Tsui, KH | 1 |
| Chu, H | 1 |
| Chen, NF | 1 |
| Wen, ZH | 1 |
| He, X | 1 |
| Yuan, W | 1 |
| Li, Z | 1 |
| Hou, Y | 1 |
| Liu, F | 1 |
| Feng, J | 1 |
| Huang, C | 1 |
| Lin, F | 1 |
| Wang, G | 1 |
| Lu, D | 1 |
| Wu, Q | 1 |
| Shi, J | 1 |
| Zhang, F | 1 |
| Colonnello, A | 1 |
| Kotlar, I | 1 |
| de Lima, ME | 1 |
| Ortíz-Plata, A | 1 |
| García-Contreras, R | 1 |
| Soares, FAA | 1 |
| Rafiepour, K | 1 |
| Esmaeili-Mahani, S | 1 |
| Salehzadeh, A | 1 |
| Sheibani, V | 1 |
| Kang, C | 1 |
| Wang, L | 1 |
| Kang, M | 1 |
| Liu, X | 1 |
| Fu, Y | 1 |
| Gao, J | 1 |
| Ren, J | 1 |
| Yuan, L | 1 |
| Wang, W | 1 |
| Zhang, M | 1 |
| Wang, Q | 1 |
| Zhang, L | 1 |
| Hu, K | 1 |
| Iglesias González, PA | 1 |
| Conde, MA | 1 |
| González-Pardo, V | 1 |
| Uranga, RM | 1 |
| Salvador, GA | 1 |
| Eo, H | 1 |
| Kwon, Y | 1 |
| Huh, E | 1 |
| Sim, Y | 1 |
| Choi, JG | 1 |
| Jeong, JS | 1 |
| Du, XF | 1 |
| Soh, HY | 1 |
| Hong, SP | 1 |
| Kim Pak, Y | 1 |
| Oh, MS | 2 |
| Liu, TW | 1 |
| Ma, ZG | 1 |
| Zhou, Y | 2 |
| Xie, JX | 2 |
| Shin, KS | 2 |
| Choi, HS | 2 |
| Zhao, TT | 1 |
| Suh, KH | 1 |
| Kwon, IH | 2 |
| Choi, SO | 1 |
| Lee, MK | 2 |
| Oliva, I | 1 |
| Fernández, M | 1 |
| Martín, ED | 1 |
| Carmo, MR | 1 |
| Menezes, AP | 1 |
| Nunes, AC | 1 |
| Pliássova, A | 1 |
| Rolo, AP | 1 |
| Palmeira, CM | 1 |
| Cunha, RA | 1 |
| Canas, PM | 1 |
| Andrade, GM | 1 |
| Lin, CY | 1 |
| Chen, JH | 1 |
| Zhang, XS | 1 |
| Ha, S | 1 |
| Wang, XL | 1 |
| Shi, YL | 1 |
| Duan, SS | 1 |
| Li, ZA | 1 |
| Sagarduy, A | 1 |
| Llorente, J | 1 |
| Miguelez, C | 1 |
| Morera-Herreras, T | 1 |
| Ruiz-Ortega, JA | 1 |
| Ugedo, L | 1 |
| Avagliano, C | 1 |
| Russo, R | 1 |
| De Caro, C | 1 |
| Cristiano, C | 1 |
| La Rana, G | 1 |
| Piegari, G | 1 |
| Paciello, O | 1 |
| Citraro, R | 1 |
| Russo, E | 1 |
| De Sarro, G | 1 |
| Meli, R | 1 |
| Mattace Raso, G | 1 |
| Calignano, A | 1 |
| Kich, DM | 1 |
| Bitencourt, S | 1 |
| Pinteus, S | 1 |
| Laufer, S | 1 |
| de Souza, CFV | 1 |
| Goettert, MI | 1 |
| Li, H | 1 |
| Shi, R | 1 |
| Ding, F | 1 |
| Wang, H | 1 |
| Han, W | 1 |
| Ma, F | 1 |
| Hu, M | 1 |
| Ma, CW | 1 |
| Huang, Z | 1 |
| Maya-López, M | 1 |
| Ruiz-Contreras, HA | 1 |
| de Jesús Negrete-Ruíz, M | 1 |
| Martínez-Sánchez, JE | 1 |
| Benítez-Valenzuela, J | 1 |
| Colín-González, AL | 1 |
| Villeda-Hernández, J | 1 |
| Sánchez-Chapul, L | 1 |
| Parra-Cid, C | 1 |
| de Oliveira, PA | 1 |
| Ben, J | 1 |
| Matheus, FC | 1 |
| Schwarzbold, ML | 1 |
| Moreira, ELG | 1 |
| Rial, D | 1 |
| Walz, R | 1 |
| Prediger, RD | 1 |
| Avila-Costa, M | 1 |
| Gutierrez-Valdez, A | 1 |
| Ordoñez-Librado, J | 1 |
| Martinez, V | 1 |
| Colin-Barenque, L | 1 |
| Espinosa-Villanueva, J | 1 |
| Aley-Medina, P | 1 |
| Montiel-Flores, E | 1 |
| Velazquz-Mata, A | 1 |
| Machado-Salas, JP | 1 |
| Garcia, E | 1 |
| Limon, D | 1 |
| Perez-De La Cruz, V | 1 |
| Giordano, M | 1 |
| Diaz-Muñoz, M | 1 |
| Maldonado, PD | 1 |
| Herrera-Mundo, MN | 1 |
| Ji, B | 1 |
| Maeda, J | 1 |
| Sawada, M | 1 |
| Ono, M | 1 |
| Okauchi, T | 1 |
| Inaji, M | 1 |
| Zhang, MR | 1 |
| Suzuki, K | 1 |
| Ando, K | 1 |
| Staufenbiel, M | 1 |
| Trojanowski, JQ | 1 |
| Lee, VM | 1 |
| Higuchi, M | 1 |
| Suhara, T | 1 |
| Jadavji, NM | 1 |
| Metz, GA | 1 |
| Ren, P | 1 |
| Jiang, H | 1 |
| Li, R | 1 |
| Wang, J | 1 |
| Song, N | 1 |
| Xu, HM | 1 |
| Huang, LZ | 1 |
| Parameswaran, N | 1 |
| Bordia, T | 1 |
| Michael McIntosh, J | 1 |
| Quik, M | 1 |
| Buck, K | 1 |
| Voehringer, P | 1 |
| Ferger, B | 1 |
| Ju, MS | 1 |
| Lee, P | 1 |
| Kim, HG | 1 |
| Lee, KY | 2 |
| Hur, J | 1 |
| Cho, SH | 1 |
| Sung, SH | 2 |
| Michel-Monigadon, D | 1 |
| Bonnamain, V | 1 |
| Nerrière-Daguin, V | 1 |
| Dugast, AS | 1 |
| Lévèque, X | 1 |
| Plat, M | 1 |
| Venturi, E | 1 |
| Brachet, P | 1 |
| Anegon, I | 1 |
| Vanhove, B | 1 |
| Neveu, I | 1 |
| Naveilhan, P | 1 |
| Li, CR | 1 |
| Huang, GB | 1 |
| Sui, ZY | 1 |
| Han, EH | 1 |
| Chung, YC | 1 |
| Walker, RH | 1 |
| Davies, G | 1 |
| Koch, RJ | 1 |
| Haack, AK | 1 |
| Moore, C | 1 |
| Meshul, CK | 2 |
| Zou, Z | 1 |
| Jiang, X | 1 |
| Zhang, W | 1 |
| Ke, Y | 1 |
| Zhang, S | 1 |
| Xu, R | 1 |
| Lee, BK | 1 |
| Lee, CK | 1 |
| Hwang, BY | 1 |
| Lim, SC | 1 |
| Cannon, JR | 1 |
| Greenamyre, JT | 1 |
| Dunnett, SB | 1 |
| Lelos, M | 1 |
| Howard, CD | 1 |
| Keefe, KA | 1 |
| Garris, PA | 1 |
| Daberkow, DP | 1 |
| Chu, JM | 1 |
| Chen, LW | 1 |
| Chan, YS | 1 |
| Yung, KK | 1 |
| Alam, M | 1 |
| Heissler, HE | 1 |
| Schwabe, K | 1 |
| Krauss, JK | 1 |
| Subramaniam, S | 1 |
| Napolitano, F | 1 |
| Mealer, RG | 1 |
| Kim, S | 1 |
| Errico, F | 1 |
| Barrow, R | 1 |
| Shahani, N | 1 |
| Tyagi, R | 1 |
| Snyder, SH | 1 |
| Usiello, A | 1 |
| Lopes, FM | 1 |
| Londero, GF | 1 |
| de Medeiros, LM | 1 |
| da Motta, LL | 1 |
| Behr, GA | 1 |
| de Oliveira, VA | 1 |
| Ibrahim, M | 1 |
| Moreira, JC | 1 |
| Porciúncula, LO | 1 |
| da Rocha, JB | 1 |
| Klamt, F | 1 |
| Healy-Stoffel, M | 1 |
| Ahmad, SO | 1 |
| Stanford, JA | 1 |
| Levant, B | 1 |
| Fainstein, N | 1 |
| Einstein, O | 1 |
| Cohen, ME | 1 |
| Brill, L | 1 |
| Lavon, I | 1 |
| Ben-Hur, T | 1 |
| Rui, G | 1 |
| Guangjian, Z | 1 |
| Yong, W | 1 |
| Jie, F | 1 |
| Yanchao, C | 1 |
| Xi, J | 1 |
| Fen, L | 1 |
| Kopalli, SR | 1 |
| Noh, SJ | 1 |
| Koppula, S | 1 |
| Suh, YH | 1 |
| Khudoerkov, RM | 1 |
| Voronkov, DN | 1 |
| Yamshchikova, NG | 1 |
| Tobón-Velasco, JC | 1 |
| Limón-Pacheco, JH | 1 |
| Orozco-Ibarra, M | 1 |
| Macías-Silva, M | 1 |
| Vázquez-Victorio, G | 1 |
| Cuevas, E | 1 |
| Ali, SF | 1 |
| Cuadrado, A | 1 |
| Haleagrahara, N | 1 |
| Siew, CJ | 1 |
| Ponnusamy, K | 1 |
| Grant, RJ | 1 |
| Clarke, PB | 1 |
| De Yébenes, JG | 1 |
| Sánchez, M | 1 |
| Mena, MA | 1 |
| Schlegel, J | 1 |
| Neff, F | 1 |
| Piontek, G | 1 |
| Tanaka, K | 1 |
| Ogawa, N | 1 |
| Aguiar, LM | 1 |
| Macedo, DS | 1 |
| de Freitas, RM | 1 |
| de Albuquerque Oliveira, A | 1 |
| Vasconcelos, SM | 1 |
| de Sousa, FC | 1 |
| de Barros Viana, GS | 1 |
| Carlson, KM | 1 |
| Wagner, GC | 1 |
| Kim, YC | 1 |
| Ma, Z | 1 |
| Wei, X | 1 |
| Fontanilla, C | 1 |
| Noelker, C | 1 |
| Dodel, R | 1 |
| Hampel, H | 1 |
| Du, Y | 1 |
| Yao, Y | 1 |
| Vieira, A | 1 |
| Paquette, MA | 1 |
| Brudney, EG | 1 |
| Putterman, DB | 1 |
| Johnson, SW | 1 |
| Berger, SP | 1 |
| Pienaar, IS | 1 |
| Schallert, T | 1 |
| Russell, VA | 1 |
| Kellaway, LA | 1 |
| Carr, JA | 1 |
| Daniels, WM | 1 |
| Soto-Otero, R | 1 |
| Méndez-Alvarez, E | 1 |
| Hermida-Ameijeiras, A | 1 |
| López-Real, AM | 1 |
| Labandeira-García, JL | 1 |
4 reviews available for oxidopamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Chemical and Genetic Zebrafish Models to Define Mechanisms of and Treatments for Dopaminergic Neurodegeneration.
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Knockdown Techniques; Neurotox | 2020 |
Neurotoxic in vivo models of Parkinson's disease recent advances.
Topics: Animals; Disease Models, Animal; Dopamine; Humans; MPTP Poisoning; Neurotoxicity Syndromes; Neurotox | 2010 |
Behavioral analysis of motor and non-motor symptoms in rodent models of Parkinson's disease.
Topics: Animals; Cognition Disorders; Corpus Striatum; Disease Models, Animal; Dopamine; Humans; Learning; M | 2010 |
Neurotrophic factors for the investigation and treatment of movement disorders.
Topics: Animals; Animals, Newborn; Dopamine; Nerve Fibers; Neurotoxicity Syndromes; Oxidopamine; Rats; Recep | 2003 |
73 other studies available for oxidopamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational Statistics.
Topics: Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Neuroprotective Agents; Neurotoxicit | 2022 |
Alpha-Mangostin Alleviates the Short-term 6-Hydroxydopamine-Induced Neurotoxicity and Oxidative Damage in Rat Cortical Slices and in Caenorhabditis elegans.
Topics: Animals; Animals, Genetically Modified; Antioxidants; Caenorhabditis elegans; Caenorhabditis elegans | 2022 |
Fucoxanthin Prevents Long-Term Administration l-DOPA-Induced Neurotoxicity through the ERK/JNK-c-Jun System in 6-OHDA-Lesioned Mice and PC12 Cells.
Topics: Animals; Antioxidants; Humans; Levodopa; Mice; Neurotoxicity Syndromes; Oxidopamine; Parkinson Disea | 2022 |
Protective Effects of Jujubosides on 6-OHDA-Induced Neurotoxicity in SH-SY5Y and SK-N-SH Cells.
Topics: Apoptosis; Cell Line, Tumor; Humans; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; | 2022 |
6-Hydroxydopamine-Induced Neurotoxicity in Rat Model of Parkinson's Disease: Is Reversed via Anti-Oxidative Activities of Curcumin and Aerobic Exercise Therapy.
Topics: alpha-Synuclein; Animals; Antioxidants; Apomorphine; Curcumin; Disease Models, Animal; Glutathione P | 2022 |
Scorpion venom heat-resistant synthetic peptide protects dopamine neurons against 6-hydroxydopamine neurotoxicity in C. elegans.
Topics: Animals; Caenorhabditis elegans; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Hot Tempera | 2022 |
The Therapeutic Potential of Naturally Occurring Peptides in Counteracting SH-SY5Y Cells Injury.
Topics: Antioxidants; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Humans; Neuroblastoma; Neuropro | 2022 |
Ethyl pyruvate protects SHSY5Y cells against 6-hydroxydopamine-induced neurotoxicity by upregulating autophagy.
Topics: Apoptosis; Autophagy; Cell Line, Tumor; Humans; Neuroblastoma; Neuroprotective Agents; Neurotoxicity | 2023 |
Syringin Prevents 6-Hydroxydopamine Neurotoxicity by Mediating the MiR-34a/SIRT1/Beclin-1 Pathway and Activating Autophagy in SH-SY5Y Cells and the
Topics: alpha-Synuclein; Animals; Autophagy; Beclin-1; Caenorhabditis elegans; Humans; MicroRNAs; Neuroblast | 2023 |
MiR-107 overexpression attenuates neurotoxicity induced by 6-hydroxydopamine both in vitro and in vivo.
Topics: Alzheimer Disease; Animals; Apoptosis Regulatory Proteins; Brain; Cell Death; Cell Line, Tumor; Dise | 2020 |
Protective effects of valproic acid on 6-hydroxydopamine-induced neuroinjury.
Topics: Animals; Apoptosis; Caspase 3; Cell Death; Cell Line, Tumor; Cell Survival; Dopamine; Humans; Mice; | 2020 |
Machine learning-assisted neurotoxicity prediction in human midbrain organoids.
Topics: Dopaminergic Neurons; Flow Cytometry; Humans; Induced Pluripotent Stem Cells; Machine Learning; Mese | 2020 |
MiR-421 Aggravates Neurotoxicity and Promotes Cell Death in Parkinson's Disease Models by Directly Targeting MEF2D.
Topics: Animals; bcl-2-Associated X Protein; Binding Sites; Cell Death; Cell Line; Dopaminergic Neurons; MEF | 2021 |
Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway.
Topics: AMP-Activated Protein Kinases; Antioxidants; Apoptosis; Cell Line; Humans; Kelch-Like ECH-Associated | 2020 |
Vina-Ginsenoside R4 from
Topics: Animals; Drugs, Chinese Herbal; Ginsenosides; Glycogen Synthase Kinase 3 beta; Humans; Neuroprotecti | 2020 |
Fucoxanthin Prevents 6-OHDA-Induced Neurotoxicity by Targeting Keap1.
Topics: Animals; Carrier Proteins; Kelch-Like ECH-Associated Protein 1; Neurotoxicity Syndromes; Oxidopamine | 2021 |
The 1-Tosylpentan-3-one Protects against 6-Hydroxydopamine-Induced Neurotoxicity.
Topics: Animals; Anthozoa; Apoptosis; Caspase 3; Cell Line; Cell Survival; Heme Oxygenase-1; Humans; Neurons | 2017 |
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.
Topics: Animals; Apoptosis; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Lin | 2018 |
Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity.
Topics: Animals; Dopamine; Glucosides; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidopamine; P | 2018 |
Comparing the Effects of Ferulic Acid and Sugarcane Aqueous Extract in In Vitro and In Vivo Neurotoxic Models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Birth Rate; Caenorhabditis elegans; Ca | 2018 |
Phytohormone Abscisic Acid Protects Human Neuroblastoma SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity Through Its Antioxidant and Antiapoptotic Properties.
Topics: Abscisic Acid; Anilides; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, | 2019 |
Baicalin alleviates 6-hydroxydopamine-induced neurotoxicity in PC12 cells by down-regulation of microRNA-192-5p.
Topics: Animals; Apoptosis; Autophagy; Cell Survival; Flavonoids; MicroRNAs; Neurotoxicity Syndromes; Oxidop | 2019 |
Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway.
Topics: Animals; Antioxidant Response Elements; Apoptosis; Caenorhabditis elegans; Cell Line, Tumor; Chromon | 2019 |
In vitro 6-hydroxydopamine-induced neurotoxicity: New insights on NFκB modulation.
Topics: Adrenergic Agents; Cell Line; Cell Survival; Cyclooxygenase 2; Dopamine; Humans; Neurons; Neurotoxic | 2019 |
Protective effects of DA-9805 on dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity in the models of Parkinson's disease.
Topics: Animals; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dopamine; | 2019 |
Transplantation of mouse CGR8 embryonic stem cells producing GDNF and TH protects against 6-hydroxydopamine neurotoxicity in the rat.
Topics: Animals; Cell Line; Cell Survival; Corpus Striatum; Disease Models, Animal; Embryonic Stem Cells; Fe | 2013 |
Neurotoxic effects of berberine on long-term L-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Berberine; Dopamine; Dose-Response Relationship, Drug; Drug Therapy, | 2013 |
Dopamine release regulation by astrocytes during cerebral ischemia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Astrocytes; Calcium; Corpus Striatum; | 2013 |
The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis.
Topics: Animals; Avoidance Learning; Brain; Cell Line, Tumor; Disease Models, Animal; Exploratory Behavior; | 2014 |
Induction of Pi form of glutathione S-transferase by carnosic acid is mediated through PI3K/Akt/NF-κB pathway and protects against neurotoxicity.
Topics: Abietanes; Animals; Blotting, Western; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, | 2014 |
Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway.
Topics: Abietanes; Animals; Apomorphine; Apoptosis; Cell Survival; Disease Models, Animal; Dopamine; Dopamin | 2015 |
Buspirone requires the intact nigrostriatal pathway to reduce the activity of the subthalamic nucleus via 5-HT1A receptors.
Topics: Action Potentials; Adrenergic Agents; Adrenergic Uptake Inhibitors; Animals; Buspirone; Desipramine; | 2016 |
Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: In vivo and in vitro evidence.
Topics: Amides; Animals; Apoptosis; Cell Death; Cyclooxygenase 2; Disease Models, Animal; Dopamine; Dopamine | 2016 |
Neuromodulatory effects of Calyptranthes grandifolia extracts against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.
Topics: Acetylcholinesterase; Caspase 3; Cell Line, Tumor; Cell Survival; Ethanol; Hexanes; Humans; Hydrogen | 2016 |
Topics: Acetylcholinesterase; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Astragalus pr | 2016 |
URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats.
Topics: Amidohydrolases; Animals; Apomorphine; Behavior, Animal; Benzamides; Body Weight; Carbamates; Inject | 2017 |
Moderate traumatic brain injury increases the vulnerability to neurotoxicity induced by systemic administration of 6-hydroxydopamine in mice.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Injuries; Brain Injuries, Traumatic; Co | 2017 |
Time course changes of the striatum neuropil after unilateral dopamine depletion and the usefulness of the contralateral striatum as a control structure.
Topics: Adrenergic Agents; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Functional Laterality | 2008 |
Lipid peroxidation, mitochondrial dysfunction and neurochemical and behavioural deficits in different neurotoxic models: protective role of S-allylcysteine.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants; Basal Ganglia; Behavior, Animal | 2008 |
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
Topics: Acetamides; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Cell L | 2008 |
Both pre- and post-lesion experiential therapy is beneficial in 6-hydroxydopamine dopamine-depleted female rats.
Topics: Animals; Apomorphine; Corticosterone; Disease Models, Animal; Dopamine; Environment; Exploratory Beh | 2009 |
Rosmarinic acid inhibits 6-OHDA-induced neurotoxicity by anti-oxidation in MES23.5 cells.
Topics: Adrenergic Agents; Animals; Antioxidants; Cell Line; Cinnamates; Depsides; Humans; Lamiaceae; Mice; | 2009 |
Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Analysis of Variance; Animals; Autoradiog | 2009 |
The alpha(2) adrenoceptor antagonist idazoxan alleviates L-DOPA-induced dyskinesia by reduction of striatal dopamine levels: an in vivo microdialysis study in 6-hydroxydopamine-lesioned rats.
Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antiparkinson Agents | 2010 |
Protective effects of standardized Thuja orientalis leaves against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.
Topics: Antioxidants; Apoptosis; Benzothiazoles; Biphenyl Compounds; Caspase 3; Cell Line, Tumor; Cell Nucle | 2010 |
Trophic and immunoregulatory properties of neural precursor cells: benefit for intracerebral transplantation.
Topics: Animals; Cell Proliferation; Cell Transplantation; Cytokines; Disease Models, Animal; Embryo, Mammal | 2011 |
Effects of 6-hydroxydopamine lesioning of the medial prefrontal cortex on social interactions in adolescent and adult rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Dopamine; Exploratory Behavior; Interpersonal Relati | 2010 |
Effects of zona incerta lesions on striatal neurochemistry and behavioral asymmetry in 6-hydroxydopamine-lesioned rats.
Topics: Adrenergic Agents; Animals; Behavioral Symptoms; Corpus Striatum; Disease Models, Animal; Dopamine; | 2010 |
Efficacy of Tyrosine Hydroxylase gene modified neural stem cells derived from bone marrow on Parkinson's disease--a rat model study.
Topics: Animals; Behavior, Animal; Bone Marrow Transplantation; Brain Chemistry; Cell Differentiation; Dopam | 2010 |
Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease.
Topics: Animals; Berberine; Cell Death; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rel | 2010 |
Methamphetamine neurotoxicity decreases phasic, but not tonic, dopaminergic signaling in the rat striatum.
Topics: Algorithms; Animals; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Electric Stimulat | 2011 |
Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway.
Topics: Analysis of Variance; Animals; Apomorphine; bcl-Associated Death Protein; Caspase 3; Cell Death; Cel | 2011 |
Deep brain stimulation of the pedunculopontine tegmental nucleus modulates neuronal hyperactivity and enhanced beta oscillatory activity of the subthalamic nucleus in the rat 6-hydroxydopamine model.
Topics: Action Potentials; Adrenergic Agents; Animals; Beta Rhythm; Deep Brain Stimulation; Disease Models, | 2012 |
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.
Topics: Adaptor Proteins, Signal Transducing; Adrenergic Agents; Animals; Antiparkinson Agents; Cell Line, T | 2011 |
Evaluation of the neurotoxic/neuroprotective role of organoselenides using differentiated human neuroblastoma SH-SY5Y cell line challenged with 6-hydroxydopamine.
Topics: Antioxidants; Antiparkinson Agents; Cell Differentiation; Cell Line, Tumor; Cell Survival; Coloring | 2012 |
A novel use of combined tyrosine hydroxylase and silver nucleolar staining to determine the effects of a unilateral intrastriatal 6-hydroxydopamine lesion in the substantia nigra: a stereological study.
Topics: Adrenergic Agents; Amphetamine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Function | 2012 |
Time limited immunomodulatory functions of transplanted neural precursor cells.
Topics: Adrenergic Agents; Animals; Cell Proliferation; Corpus Striatum; Cytokines; Disease Models, Animal; | 2013 |
High frequency electro-acupuncture enhances striatum DAT and D1 receptor expression, but decreases D2 receptor level in 6-OHDA lesioned rats.
Topics: Acupuncture Points; Acupuncture Therapy; Analysis of Variance; Animals; Apomorphine; Biophysical Phe | 2013 |
Methylparaben protects 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells and improved behavioral impairments in mouse model of Parkinson's disease.
Topics: Animals; Antioxidants; Avoidance Learning; Behavior, Animal; Cell Line, Tumor; Cognition; Cytoprotec | 2013 |
Immunohistochemical and morphological changes in neurons and neuroglia in the cerebral nigrostriatal structures under conditions of experimental nigral neurodegeneration.
Topics: Animals; Caudate Nucleus; Cell Count; Cell Proliferation; Cerebrum; Immunohistochemistry; Injections | 2012 |
RETRACTED: 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Caspase 9; Corpus Striatum; Cytochromes c; | 2013 |
Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of rats.
Topics: Animals; Behavior, Animal; Corpus Striatum; Deferoxamine; Disease Models, Animal; Dopamine; Drug The | 2013 |
Susceptibility of ascending dopamine projections to 6-hydroxydopamine in rats: effect of hypothermia.
Topics: Animals; Body Temperature; Cell Survival; Cocaine; Disease Susceptibility; Dopamine; Efferent Pathwa | 2002 |
Serial induction of mutations by ethylnitrosourea in PC12 cells: a new model for a phenotypical characterization of the neurotoxic response to 6-hydroxydopamine.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Ethylnitrosourea; Europ | 2004 |
Dopamine agonist cabergoline inhibits levodopa-induced caspase activation in 6-OHDA-lesioned mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Cabergoline; Carbidopa; Caspases; Dis | 2005 |
Protective effects of N-acetylserotonin against 6-hydroxydopamine-induced neurotoxicity.
Topics: Animals; Apomorphine; Benzazepines; Binding, Competitive; Biogenic Monoamines; Cell Count; Dopamine; | 2005 |
Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum.
Topics: Animals; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rel | 2005 |
Neuroprotective bibenzyl glycosides of Stemona tuberosa roots.
Topics: Bibenzyls; Glycosides; Humans; Korea; Molecular Structure; Neuroprotective Agents; Neurotoxicity Syn | 2006 |
Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity.
Topics: Animals; Animals, Newborn; Antioxidants; Caffeic Acids; Cell Death; Cerebellum; Free Radicals; Immun | 2006 |
Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity.
Topics: Animals; Anthocyanins; Antioxidants; Ascorbic Acid; Cytochromes c; Dopamine; Flavonoids; Glucosides; | 2007 |
Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias.
Topics: Adrenergic Agents; Amphetamine; Animals; Anti-Anxiety Agents; Behavior, Animal; Dextromethorphan; Di | 2008 |
Early pubertal female rats are more resistant than males to 6-hydroxydopamine neurotoxicity and behavioural deficits: a possible role for trophic factors.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2007 |
Effects of (-)-nicotine and (-)-cotinine on 6-hydroxydopamine-induced oxidative stress and neurotoxicity: relevance for Parkinson's disease.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Corpus Striatum; Cotinine; Disease Models, Animal; | 2002 |