oxidopamine has been researched along with Chronic Disease in 16 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic fatigue is a complex and little understood symptom for which there is no safe and effective pharmacotherapy." | 5.33 | Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity. ( Brown-Borg, HM; Dhanasekaran, M; Manyam, BV; Tharakan, B, 2006) |
| "Chronic fatigue is a complex and little understood symptom for which there is no safe and effective pharmacotherapy." | 1.33 | Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity. ( Brown-Borg, HM; Dhanasekaran, M; Manyam, BV; Tharakan, B, 2006) |
| "It has been suggested that phantom limb pain is a result of peripheral denervation leading to reorganization of somatosensory pathways, particularly in the cerebral cortex, which is shown to depend upon central noradrenergic activity." | 1.31 | Central noradrenergic blockade prevents autotomy in rat: implication for pharmacological prevention of postdenervation pain syndrome. ( Al-Adawi, S; Bonner, A; Dawe, GS; Stephenson, JD; Zarei, M, 2002) |
| "Our data imply that repetitive hypoxemia in SAS is probably the cause of the high prevalence of systemic hypertension in this population and that peripheral chemoreceptors and the sympathetic nervous system play important roles in this pathophysiologic process." | 1.30 | Hypertension caused by chronic intermittent hypoxia--influence of chemoreceptors and sympathetic nervous system. ( Bao, G; Fletcher, EC; Lesske, J; Unger, T, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Hyland, BI | 1 |
| Seeger-Armbruster, S | 1 |
| Smither, RA | 1 |
| Parr-Brownlie, LC | 1 |
| McQuade, RM | 1 |
| Singleton, LM | 1 |
| Wu, H | 1 |
| Lee, S | 1 |
| Constable, R | 1 |
| Di Natale, M | 1 |
| Ringuet, MT | 1 |
| Berger, JP | 1 |
| Kauhausen, J | 1 |
| Parish, CL | 1 |
| Finkelstein, DI | 1 |
| Furness, JB | 1 |
| Diwakarla, S | 1 |
| Hemmerle, AM | 1 |
| Dickerson, JW | 1 |
| Herman, JP | 2 |
| Seroogy, KB | 1 |
| Yadav, AP | 1 |
| Fuentes, R | 1 |
| Zhang, H | 1 |
| Vinholo, T | 1 |
| Wang, CH | 1 |
| Freire, MA | 1 |
| Nicolelis, MA | 1 |
| Chaswal, M | 1 |
| Das, S | 1 |
| Prasad, J | 1 |
| Katyal, A | 1 |
| Fahim, M | 1 |
| Grant, LM | 1 |
| Barnett, DG | 1 |
| Doll, EJ | 1 |
| Leverson, G | 1 |
| Ciucci, M | 1 |
| Varcin, M | 1 |
| Bentea, E | 1 |
| Mertens, B | 1 |
| Haute, CV | 1 |
| Baekelandt, V | 1 |
| Michotte, Y | 1 |
| Sarre, S | 1 |
| Obuchowicz, R | 1 |
| Sendur, R | 1 |
| Pawlik, M | 1 |
| Biernat, J | 1 |
| Koprowska, B | 1 |
| Jaworek, J | 1 |
| Thor, PJ | 1 |
| Woodlee, MT | 1 |
| Asseo-García, AM | 1 |
| Zhao, X | 1 |
| Liu, SJ | 1 |
| Jones, TA | 1 |
| Schallert, T | 1 |
| Tharakan, B | 1 |
| Dhanasekaran, M | 1 |
| Brown-Borg, HM | 1 |
| Manyam, BV | 1 |
| Saadé, NE | 1 |
| Atweh, SF | 1 |
| Bahuth, NB | 1 |
| Jabbur, SJ | 1 |
| Lesske, J | 1 |
| Fletcher, EC | 1 |
| Bao, G | 1 |
| Unger, T | 1 |
| Ziegler, DR | 1 |
| Cass, WA | 1 |
| Sahach, VF | 1 |
| Baziliuk, OV | 1 |
| Oleshko, MM | 1 |
| Kotsiuruba, OV | 1 |
| Bukhanevych, OM | 1 |
| Appenzeller, O | 1 |
| Al-Adawi, S | 1 |
| Dawe, GS | 1 |
| Bonner, A | 1 |
| Stephenson, JD | 1 |
| Zarei, M | 1 |
| Nakamura, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Thoracic Dorsal Spinal Cord Stimulation for the Treatment of Gait and Balance Impairments in Parkinson Disease[NCT03079310] | 15 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for oxidopamine and Chronic Disease
| Article | Year |
|---|---|
[Myoelectric function, metabolism, intestinal circulation and vagal activity after chemical sympathectomy].
Topics: Acute Disease; Animals; Chronic Disease; Female; Intestines; Male; Myoelectric Complex, Migrating; O | 2002 |
Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment.
Topics: Animals; Antidepressive Agents; Axons; Chronic Disease; Desipramine; Electroconvulsive Therapy; Elec | 1991 |
14 other studies available for oxidopamine and Chronic Disease
| Article | Year |
|---|---|
Altered Recruitment of Motor Cortex Neuronal Activity During the Grasping Phase of Skilled Reaching in a Chronic Rat Model of Unilateral Parkinsonism.
Topics: Animals; Chronic Disease; Disease Models, Animal; Hand Strength; Male; Motor Cortex; Motor Skills; N | 2019 |
The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acute Disease; Animals; Cell Count; Chronic Disease; C | 2021 |
Stress exacerbates experimental Parkinson's disease.
Topics: Animals; Antigens, Nuclear; Cell Count; Cell Survival; Chronic Disease; Depressive Disorder; Dopamin | 2014 |
Chronic spinal cord electrical stimulation protects against 6-hydroxydopamine lesions.
Topics: Adrenergic Agents; Animals; Behavior, Animal; Chronic Disease; Deep Brain Stimulation; Disease Model | 2014 |
Chemical sympathectomy restores baroreceptor-heart rate reflex and heart rate variability in rats with chronic nitric oxide deficiency.
Topics: Animals; Blood Pressure; Chronic Disease; Heart Rate; Male; Nitric Oxide; Oxidopamine; Pressorecepto | 2015 |
Relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion.
Topics: Acute Disease; Animals; Apomorphine; Chronic Disease; Corpus Striatum; Dopamine; Dopamine Agonists; | 2015 |
Acute versus long-term effects of 6-hydroxydopamine on oxidative stress and dopamine depletion in the striatum of mice.
Topics: Acute Disease; Animals; Chronic Disease; Corpus Striatum; Dopamine; Female; Mice; Mice, Inbred C57BL | 2011 |
Testing forelimb placing "across the midline" reveals distinct, lesion-dependent patterns of recovery in rats.
Topics: Animals; Behavior, Animal; Cerebral Decortication; Chronic Disease; Diagnosis, Differential; Disease | 2005 |
Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Chronic Disease; Dioscoreaceae; Fatigu | 2006 |
Augmentation of nociceptive reflexes and chronic deafferentation pain by chemical lesions of either dopaminergic terminals or midbrain dopaminergic neurons.
Topics: Animals; Behavior, Animal; Chronic Disease; Denervation; Dopamine; Excitatory Amino Acid Agonists; F | 1997 |
Hypertension caused by chronic intermittent hypoxia--influence of chemoreceptors and sympathetic nervous system.
Topics: Adrenal Medulla; Animals; Blood Pressure; Carotid Body; Catecholamines; Chemoreceptor Cells; Chronic | 1997 |
Excitatory influence of the locus coeruleus in hypothalamic-pituitary-adrenocortical axis responses to stress.
Topics: Acute Disease; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Chronic Disease; Corticosterone | 1999 |
[The nitric oxide system in a chronic deficiency of mesostriatal dopamine: the action of nitroglycerin].
Topics: Animals; Chronic Disease; Dopamine; Male; Muscle, Smooth, Vascular; Neostriatum; Neurotoxins; Nitric | 2000 |
Central noradrenergic blockade prevents autotomy in rat: implication for pharmacological prevention of postdenervation pain syndrome.
Topics: Afferent Pathways; Animals; Chronic Disease; Denervation; Immunohistochemistry; Locus Coeruleus; Mal | 2002 |