oxidopamine has been researched along with Cardiomegaly in 6 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of isoproterenol (ISP) and chemical sympathectomy (6-hydroxydopamine treatment) on myocardial beta-receptors were also investigated in 10 and 24 week-old SHRS and WKY to examine the effects of hypertension and aging on receptor regulation." | 3.68 | Effects of aging and drugs on myocardial beta-adrenergic receptors in M-SHRSP and SHRSP. ( Ikawa, H; Suzuki, A, 1991) |
| "Metoprolol-treated SHR showed a trend toward higher capillary numerical densities consistent with their attenuation of hypertrophy." | 1.28 | Sympathetic nerves modify mitochondrial and capillary growth in normotensive and hypertensive rats. ( Tomanek, RJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tucker, A | 1 |
| Bryant, SE | 1 |
| Frost, HH | 1 |
| Migally, N | 1 |
| Ho, AK | 1 |
| Duffield, R | 1 |
| Ikawa, H | 1 |
| Suzuki, A | 1 |
| Tomanek, RJ | 1 |
| Hou, QC | 1 |
| Seidler, FJ | 1 |
| Slotkin, TA | 1 |
| Siri, FM | 1 |
| McNamara, JJ | 1 |
6 other studies available for oxidopamine and Cardiomegaly
| Article | Year |
|---|---|
Chemical sympathectomy and serotonin inhibition reduce monocrotaline-induced right ventricular hypertrophy in rats.
Topics: Animals; Cardiomegaly; Fenclonine; Hydroxydopamines; Hypertension, Pulmonary; Lung; Male; Monocrotal | 1983 |
6-Hydroxydopamine-induced developmental cardiac alterations in morphology, calmodulin content, and K(2+)-mediated [Ca(2+)](i)Transient of chicken cardiomyocytes.
Topics: Abnormalities, Drug-Induced; Adenosine Triphosphatases; Animals; Autonomic Nervous System; Brain; Ca | 2000 |
Effects of aging and drugs on myocardial beta-adrenergic receptors in M-SHRSP and SHRSP.
Topics: 5'-Nucleotidase; Aging; Animals; Cardiomegaly; Cerebrovascular Disorders; Disease Susceptibility; Do | 1991 |
Sympathetic nerves modify mitochondrial and capillary growth in normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Capillaries; Cardiomegaly; Coronary Circulation; Heart Rate; Heart Ventricl | 1989 |
Development of the linkage of beta-adrenergic receptors to cardiac hypertrophy and heart rate control: neonatal sympathectomy with 6-hydroxydopamine.
Topics: Animals; Animals, Newborn; Body Weight; Cardiomegaly; Heart Rate; Hydroxydopamines; Isoproterenol; O | 1989 |
Effects of sympathectomy on heart size and function in aortic-constricted rats.
Topics: Animals; Aorta; Cardiomegaly; Hydroxydopamines; Male; Myocardium; Organ Size; Oxidopamine; Rats; Rat | 1987 |