oxidopamine has been researched along with Brain Injuries in 44 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rats treated with bromocriptine exhibited rotational sensitisation but no AIMs." | 1.34 | The "motor complication syndrome" in rats with 6-OHDA lesions treated chronically with L-DOPA: relation to dose and route of administration. ( Cenci, MA; Lindgren, HS; Lundblad, M; Ohlin, KE; Rylander, D, 2007) |
| "Treatment with nicotine (0." | 1.33 | Nicotine, but neither the alpha4beta2 ligand RJR2403 nor an alpha7 nAChR subtype selective agonist, protects against a partial 6-hydroxydopamine lesion of the rat median forebrain bundle. ( Duty, S; O'Neill, MJ; Visanji, NP, 2006) |
| "[3H]Vesamicol binding was characterized in human brain post mortem." | 1.28 | Choline acetyltransferase activity and [3H]vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions. ( Agid, Y; Brice, A; Duyckaerts, C; Hauw, JJ; LeMoal, M; Mayo, W; Ruberg, M; Simon, H, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.82) | 18.7374 |
| 1990's | 3 (6.82) | 18.2507 |
| 2000's | 24 (54.55) | 29.6817 |
| 2010's | 14 (31.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, R | 1 |
| Zheng, N | 1 |
| Liang, T | 1 |
| He, Q | 1 |
| Xu, L | 2 |
| Lindemann, C | 1 |
| Alam, M | 1 |
| Krauss, JK | 1 |
| Schwabe, K | 1 |
| Retailleau, A | 1 |
| Dejean, C | 1 |
| Fourneaux, B | 1 |
| Leinekugel, X | 1 |
| Boraud, T | 1 |
| Lindgren, HS | 2 |
| Demirbugen, M | 1 |
| Bergqvist, F | 1 |
| Lane, EL | 1 |
| Dunnett, SB | 1 |
| Zhang, X | 2 |
| Chergui, K | 1 |
| Heuer, A | 1 |
| Kirkeby, A | 1 |
| Pfisterer, U | 1 |
| Jönsson, ME | 1 |
| Parmar, M | 1 |
| Liang, C | 1 |
| Xu, Y | 1 |
| Zheng, D | 1 |
| Sun, X | 1 |
| Xu, Q | 1 |
| Duan, D | 1 |
| de Oliveira, PA | 1 |
| Ben, J | 1 |
| Matheus, FC | 1 |
| Schwarzbold, ML | 1 |
| Moreira, ELG | 1 |
| Rial, D | 1 |
| Walz, R | 1 |
| Prediger, RD | 1 |
| Gleason, D | 1 |
| Fallon, JH | 1 |
| Guerra, M | 1 |
| Liu, JC | 1 |
| Bryant, PJ | 1 |
| Andersson, DR | 1 |
| Björnsson, E | 1 |
| Bergquist, F | 1 |
| Nissbrandt, H | 1 |
| Dzahini, K | 1 |
| Dentresangle, C | 1 |
| Le Cavorsin, M | 1 |
| Bertrand, A | 1 |
| Detraz, I | 1 |
| Savasta, M | 1 |
| Leviel, V | 1 |
| Lex, B | 1 |
| Hauber, W | 1 |
| Somoza, R | 1 |
| Juri, C | 1 |
| Baes, M | 1 |
| Wyneken, U | 1 |
| Rubio, FJ | 1 |
| Nishimura, K | 1 |
| Inoue, T | 1 |
| Yoshimoto, K | 1 |
| Taniguchi, T | 1 |
| Kitamura, Y | 1 |
| Agata, K | 1 |
| Seeger-Armbruster, S | 1 |
| von Ameln-Mayerhofer, A | 1 |
| Sheng, J | 1 |
| Yang, S | 1 |
| Wu, C | 1 |
| Wu, X | 1 |
| Li, A | 1 |
| Yu, Y | 1 |
| Ni, H | 1 |
| Fukuda, M | 1 |
| Zhou, J | 1 |
| Brecht, S | 1 |
| Kirchhof, R | 1 |
| Chromik, A | 1 |
| Willesen, M | 1 |
| Nicolaus, T | 1 |
| Raivich, G | 1 |
| Wessig, J | 1 |
| Waetzig, V | 1 |
| Goetz, M | 1 |
| Claussen, M | 1 |
| Pearse, D | 1 |
| Kuan, CY | 1 |
| Vaudano, E | 1 |
| Behrens, A | 1 |
| Wagner, E | 1 |
| Flavell, RA | 1 |
| Davis, RJ | 1 |
| Herdegen, T | 1 |
| Wilson, MS | 1 |
| Chen, X | 1 |
| Ma, X | 1 |
| Ren, D | 1 |
| Wagner, AK | 1 |
| Reynolds, IJ | 1 |
| Dixon, CE | 1 |
| Courtière, A | 1 |
| Hardouin, J | 1 |
| Locatelli, V | 1 |
| Turle-Lorenzo, N | 1 |
| Amalric, M | 1 |
| Vidal, F | 1 |
| Hasbroucq, T | 1 |
| Shabanov, PD | 1 |
| Lebedev, AA | 1 |
| Meshcherov, ShK | 1 |
| Strel'tsov, VF | 1 |
| Ridley, RM | 1 |
| Cummings, RM | 1 |
| Leow-Dyke, A | 1 |
| Baker, HF | 1 |
| Bilbao, G | 1 |
| Ruiz-Ortega, JA | 1 |
| Miguens, N | 1 |
| Ulibarri, I | 1 |
| Linazasoro, G | 1 |
| Gómez-Urquijo, S | 1 |
| Garibi, J | 1 |
| Ugedo, L | 1 |
| Jakobsson, J | 1 |
| Rosenqvist, N | 1 |
| Mårild, K | 1 |
| V Agoston, D | 1 |
| Lundberg, C | 1 |
| Kloth, V | 1 |
| Klein, A | 1 |
| Loettrich, D | 1 |
| Nikkhah, G | 1 |
| Visanji, NP | 1 |
| O'Neill, MJ | 1 |
| Duty, S | 1 |
| Matsubara, K | 1 |
| Shimizu, K | 1 |
| Suno, M | 1 |
| Ogawa, K | 1 |
| Awaya, T | 1 |
| Yamada, T | 1 |
| Noda, T | 1 |
| Satomi, M | 1 |
| Ohtaki, K | 1 |
| Chiba, K | 1 |
| Tasaki, Y | 1 |
| Shiono, H | 1 |
| Arias-Carrión, O | 1 |
| Hernández-López, S | 1 |
| Ibañez-Sandoval, O | 1 |
| Bargas, J | 1 |
| Hernández-Cruz, A | 1 |
| Drucker-Colín, R | 1 |
| Ferrari, D | 1 |
| Sanchez-Pernaute, R | 1 |
| Lee, H | 1 |
| Studer, L | 1 |
| Isacson, O | 1 |
| Rylander, D | 1 |
| Ohlin, KE | 1 |
| Lundblad, M | 1 |
| Cenci, MA | 1 |
| Faraji, J | 1 |
| Metz, GA | 1 |
| Marin, C | 1 |
| Aguilar, E | 1 |
| Mengod, G | 1 |
| Cortés, R | 1 |
| Obeso, JA | 1 |
| Jabourian, M | 1 |
| Pérez, S | 1 |
| Ezan, P | 1 |
| Glowinski, J | 1 |
| Deniau, JM | 1 |
| Kemel, ML | 1 |
| Qu, S | 1 |
| Le, W | 1 |
| Xie, W | 1 |
| Zhang, A | 1 |
| Ondo, WG | 1 |
| Tait, DS | 1 |
| Brown, VJ | 1 |
| Farovik, A | 1 |
| Theobald, DE | 1 |
| Dalley, JW | 1 |
| Robbins, TW | 1 |
| Buck, K | 1 |
| Ferger, B | 1 |
| Bergstrom, BP | 1 |
| Cummings, DR | 1 |
| Skaggs, TA | 1 |
| Winner, B | 1 |
| Couillard-Despres, S | 1 |
| Geyer, M | 1 |
| Aigner, R | 1 |
| Bogdahn, U | 1 |
| Aigner, L | 1 |
| Kuhn, HG | 1 |
| Winkler, J | 1 |
| Gordon, MN | 1 |
| Schreier, WA | 1 |
| Ou, X | 1 |
| Holcomb, LA | 1 |
| Morgan, DG | 1 |
| Vizuete, ML | 1 |
| Venero, JL | 1 |
| Vargas, C | 1 |
| Ilundáin, AA | 1 |
| Echevarría, M | 1 |
| Machado, A | 1 |
| Cano, J | 1 |
| Guo, X | 1 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Ruberg, M | 1 |
| Mayo, W | 1 |
| Brice, A | 1 |
| Duyckaerts, C | 1 |
| Hauw, JJ | 1 |
| Simon, H | 1 |
| LeMoal, M | 1 |
| Agid, Y | 1 |
| Abercrombie, ED | 1 |
| Zigmond, MJ | 1 |
| Archer, T | 1 |
| Danysz, W | 1 |
| Fredriksson, A | 1 |
| Jonsson, G | 1 |
| Luthman, J | 1 |
| Sundström, E | 1 |
| Teiling, A | 1 |
| Hashimoto-Kitsukawa, S | 1 |
| Okuyama, S | 1 |
| Aihara, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| STEM-PD Trial: A Multicentre, Single Arm, First in Human, Dose-escalation Trial, Investigating the Safety and Tolerability of Intraputamenal Transplantation of Human Embryonic Stem Cell Derived Dopaminergic Cells for Parkinson's Disease (STEM-PD Product)[NCT05635409] | Phase 1 | 8 participants (Anticipated) | Interventional | 2022-11-30 | Recruiting | ||
| PhaseⅠ/ⅡTrial of Autologous Bone Marrow Derived Mesenchymal Stem Cells to Patients With Parkinson's Disease.[NCT01446614] | Phase 1/Phase 2 | 20 participants (Anticipated) | Interventional | 2011-10-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
44 other studies available for oxidopamine and Brain Injuries
| Article | Year |
|---|---|
Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Brain Injuries; Disease Models, Animal; Dose-Response Relat | 2013 |
Neuronal activity in the medial associative-limbic and lateral motor part of the rat subthalamic nucleus and the effect of 6-hydroxydopamine-induced lesions of the dorsolateral striatum.
Topics: Action Potentials; Adrenergic Agents; Algorithms; Analysis of Variance; Animals; Biological Clocks; | 2013 |
Why am I lost without dopamine? Effects of 6-OHDA lesion on the encoding of reward and decision process in CA3.
Topics: Action Potentials; Adrenergic Agents; Animals; Brain Injuries; CA3 Region, Hippocampal; Decision Mak | 2013 |
The effect of additional noradrenergic and serotonergic depletion on a lateralised choice reaction time task in rats with nigral 6-OHDA lesions.
Topics: Adrenergic Uptake Inhibitors; Animals; Brain Injuries; Cell Count; Desipramine; Dopamine; Dopamine b | 2014 |
Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B- and GluN2D-containing NMDA receptors.
Topics: Adrenergic Agents; Animals; Antioxidants; Ascorbic Acid; Brain Injuries; Corpus Striatum; Disease Mo | 2015 |
hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation.
Topics: Animals; Animals, Newborn; Antigens, CD; Blood-Brain Barrier; Brain Injuries; Cell Line, Transformed | 2016 |
RNAi-mediated silencing of HLA A2 suppressed acute rejection against human fibroblast xenografts in the striatum of 6-OHDA lesioned rats.
Topics: Adrenergic Agents; Animals; Antigens, CD; Brain Injuries; Corpus Striatum; Disease Models, Animal; F | 2016 |
Moderate traumatic brain injury increases the vulnerability to neurotoxicity induced by systemic administration of 6-hydroxydopamine in mice.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Injuries; Brain Injuries, Traumatic; Co | 2017 |
Ependymal stem cells divide asymmetrically and transfer progeny into the subventricular zone when activated by injury.
Topics: Animals; Biomarkers; Brain Injuries; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Mo | 2008 |
Motor activity-induced dopamine release in the substantia nigra is regulated by muscarinic receptors.
Topics: Analysis of Variance; Animals; Area Under Curve; Brain Injuries; Chromatography, High Pressure Liqui | 2010 |
Pre-synaptic glutamate-induced activation of DA release in the striatum after partial nigral lesion.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Animals; Brain Injuries; Chromatography, High Pressure | 2010 |
Disconnection of the entorhinal cortex and dorsomedial striatum impairs the sensitivity to instrumental contingency degradation.
Topics: Analysis of Variance; Animals; Brain Injuries; Choice Behavior; Conditioning, Operant; Corpus Striat | 2010 |
Intranigral transplantation of epigenetically induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson's disease.
Topics: Actins; Animals; Brain Injuries; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Proli | 2010 |
Regeneration of dopaminergic neurons after 6-hydroxydopamine-induced lesion in planarian brain.
Topics: Analysis of Variance; Animals; Brain Injuries; Bromodeoxyuridine; Cell Cycle; Cell Movement; Cell Pr | 2011 |
Short- and long-term unilateral 6-hydroxydopamine lesions in rats show different changes in characteristics of spontaneous firing of substantia nigra pars reticulata neurons.
Topics: Action Potentials; Adrenergic Agents; Animals; Brain Injuries; Dyskinesia, Drug-Induced; Forelimb; F | 2013 |
Bystin as a novel marker for reactive astrocytes in the adult rat brain following injury.
Topics: Animals; Astrocytes; Biomarkers; Brain Injuries; Cell Adhesion Molecules; Cell Differentiation; Cell | 2004 |
Specific pathophysiological functions of JNK isoforms in the brain.
Topics: Animals; Autonomic Denervation; Behavior, Animal; Blotting, Western; Brain; Brain Injuries; Cell Cou | 2005 |
Synaptosomal dopamine uptake in rat striatum following controlled cortical impact.
Topics: Adrenergic Agents; Animals; Blotting, Western; Brain Injuries; Corpus Striatum; Dopamine; Dopamine P | 2005 |
Selective effects of partial striatal 6-OHDA lesions on information processing in the rat.
Topics: Adrenergic Agents; Animals; Behavior, Animal; Brain Chemistry; Brain Diseases; Brain Injuries; Choic | 2005 |
The effects of neurochemical lesioning of dopaminergic terminals in early ontogenesis on behavior in adult rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Brain Injuries; Conditioning, Operant; Dop | 2005 |
Neglect of memory after dopaminergic lesions in monkeys.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Injuries; Callithrix; Catheter Ablation; Disc | 2006 |
Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: effects of subthalamotomy and levodopa treatment.
Topics: Action Potentials; Adrenergic Agents; Animals; Apomorphine; Brain Injuries; Dopamine; Dopamine Agent | 2006 |
Evidence for disease-regulated transgene expression in the brain with use of lentiviral vectors.
Topics: Animals; Animals, Genetically Modified; beta-Galactosidase; Brain; Brain Injuries; Functional Latera | 2006 |
Colour-coded pellets increase the sensitivity of the staircase test to differentiate skilled forelimb performances of control and 6-hydroxydopamine lesioned rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Apomorphine; Appetitive Behavior; Behavior, Ani | 2006 |
Nicotine, but neither the alpha4beta2 ligand RJR2403 nor an alpha7 nAChR subtype selective agonist, protects against a partial 6-hydroxydopamine lesion of the rat median forebrain bundle.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Brain Injuries; Cell Count; Dose-Response Re | 2006 |
Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Benzazepines; Brain Injuries; Dopamine | 2006 |
Neuronal precursors within the adult rat subventricular zone differentiate into dopaminergic neurons after substantia nigra lesion and chromaffin cell transplant.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Injuries; Cell Differentiation; Cerebral Vent | 2006 |
Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft.
Topics: Animals; Behavior, Animal; Brain Injuries; Cell Count; Cell Differentiation; Corpus Striatum; DNA-Bi | 2006 |
The "motor complication syndrome" in rats with 6-OHDA lesions treated chronically with L-DOPA: relation to dose and route of administration.
Topics: Analysis of Variance; Animals; Brain Injuries; Bromocriptine; Cell Count; Dopamine Agents; Dose-Resp | 2007 |
Sequential bilateral striatal lesions have additive effects on single skilled limb use in rats.
Topics: Adrenergic Agents; Animals; Apomorphine; Behavior, Animal; Brain Injuries; Corpus Striatum; Dopamine | 2007 |
Concomitant short- and long-duration response to levodopa in the 6-OHDA-lesioned rat: a behavioural and molecular study.
Topics: Animals; Behavior, Animal; Brain Injuries; Corpus Striatum; Dopamine Agents; Dopamine Plasma Membran | 2007 |
Impact of 6-hydroxydopamine lesions and cocaine exposure on mu-opioid receptor expression and regulation of cholinergic transmission in the limbic-prefrontal territory of the rat dorsal striatum.
Topics: Acetylcholine; Animals; Behavior, Animal; Brain Injuries; Circadian Rhythm; Cocaine; Corpus Striatum | 2007 |
Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome.
Topics: Animals; Brain Injuries; Diencephalon; Disease Models, Animal; Dopamine Agonists; Indoles; Iron; Iro | 2007 |
Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat.
Topics: Analysis of Variance; Animals; Association Learning; Attention; Behavior, Animal; Brain Injuries; Di | 2007 |
Intrastriatal inhibition of aromatic amino acid decarboxylase prevents l-DOPA-induced dyskinesia: a bilateral reverse in vivo microdialysis study in 6-hydroxydopamine lesioned rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic-L-Amino-Acid Decarboxylases; Behavior, Animal; Ben | 2008 |
Aspartame decreases evoked extracellular dopamine levels in the rat brain: an in vivo voltammetry study.
Topics: Analysis of Variance; Animals; Aspartame; Brain Injuries; Chromatography, High Pressure Liquid; Corp | 2007 |
Dopaminergic lesion enhances growth factor-induced striatal neuroblast migration.
Topics: Animals; Brain Injuries; Cell Count; Cell Differentiation; Cell Movement; Cell Proliferation; Corpus | 2008 |
Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat.
Topics: Afferent Pathways; Aging; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Brain Injurie | 1997 |
Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema.
Topics: Animals; Aquaporin 4; Aquaporins; Astrocytes; Axotomy; Blood-Brain Barrier; Brain Edema; Brain Injur | 1999 |
Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain Injuries; Cells, Cultured; Dopamine; Immunophilins; Immu | 2001 |
Choline acetyltransferase activity and [3H]vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain Injuries; Choline O-Acetyltransferase; Fe | 1990 |
Partial injury to central noradrenergic neurons: reduction of tissue norepinephrine content is greater than reduction of extracellular norepinephrine measured by microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Injuries; Electroshock; Hippocampus; Hydroxydopamines | 1989 |
Neonatal 6-hydroxydopamine-induced dopamine depletions: motor activity and performance in maze learning.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain Chemistry; Brain Injuries; Dopamine; Hydroxydopam | 1988 |
Enhancing effect of taurine in the rat caudate spindle. II. Effect of bilateral 6-hydroxydopamine lesions of the nigro-striatal dopamine system.
Topics: Animals; Behavior, Animal; Brain Chemistry; Brain Injuries; Caudate Nucleus; Corpus Striatum; Dopami | 1988 |