oxidopamine has been researched along with Brain Inflammation in 17 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Parkinson's disease is a slowly progressing neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra (SN), leading to severe impairment in motor and non-motor functions." | 1.43 | 6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis. ( Collmann, FM; Dollé, F; Faber, C; Faust, A; Fricke, IB; Hermann, S; Jacobs, AH; Kuhlmann, MT; Schäfers, K; Schwamborn, JC; Viel, T; Vrachimis, A; Wachsmuth, L; Worlitzer, MM, 2016) |
| " Three or 14 days after lesion, rats were dosed with XPro®1595 (10 mg/kg in saline, subcutaneous) every third day for 35 days." | 1.40 | Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats. ( Barnum, CJ; Chang, J; Chen, X; Chung, J; Grigoryan, N; Tansey, MG; Tesi, RJ; Williams, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lima, LAR | 1 |
| Lopes, MJP | 1 |
| Costa, RO | 1 |
| Lima, FAV | 1 |
| Neves, KRT | 1 |
| Calou, IBF | 1 |
| Andrade, GM | 1 |
| Viana, GSB | 1 |
| Barnum, CJ | 2 |
| Chen, X | 1 |
| Chung, J | 1 |
| Chang, J | 1 |
| Williams, M | 1 |
| Grigoryan, N | 1 |
| Tesi, RJ | 1 |
| Tansey, MG | 1 |
| Segura-Aguilar, J | 1 |
| Kostrzewa, RM | 1 |
| Panicker, N | 1 |
| Saminathan, H | 1 |
| Jin, H | 1 |
| Neal, M | 1 |
| Harischandra, DS | 1 |
| Gordon, R | 1 |
| Kanthasamy, K | 1 |
| Lawana, V | 1 |
| Sarkar, S | 1 |
| Luo, J | 1 |
| Anantharam, V | 1 |
| Kanthasamy, AG | 1 |
| Kanthasamy, A | 1 |
| Virel, A | 1 |
| Rehnmark, A | 1 |
| Orädd, G | 1 |
| Olmedo-Díaz, S | 1 |
| Faergemann, E | 1 |
| Strömberg, I | 1 |
| Tristão, FS | 1 |
| Lazzarini, M | 1 |
| Martin, S | 1 |
| Amar, M | 1 |
| Stühmer, W | 1 |
| Kirchhoff, F | 1 |
| Gomes, LA | 1 |
| Lanfumey, L | 1 |
| Prediger, RD | 1 |
| Sepulveda, JE | 1 |
| Del-Bel, EA | 1 |
| Raisman-Vozari, R | 1 |
| Fricke, IB | 1 |
| Viel, T | 1 |
| Worlitzer, MM | 1 |
| Collmann, FM | 1 |
| Vrachimis, A | 1 |
| Faust, A | 1 |
| Wachsmuth, L | 1 |
| Faber, C | 1 |
| Dollé, F | 1 |
| Kuhlmann, MT | 1 |
| Schäfers, K | 1 |
| Hermann, S | 1 |
| Schwamborn, JC | 1 |
| Jacobs, AH | 1 |
| Mulas, G | 1 |
| Espa, E | 1 |
| Fenu, S | 1 |
| Spiga, S | 1 |
| Cossu, G | 1 |
| Pillai, E | 1 |
| Carboni, E | 1 |
| Simbula, G | 1 |
| Jadžić, D | 1 |
| Angius, F | 1 |
| Spolitu, S | 1 |
| Batetta, B | 1 |
| Lecca, D | 1 |
| Giuffrida, A | 1 |
| Carta, AR | 1 |
| Ambrosi, G | 1 |
| Kustrimovic, N | 1 |
| Siani, F | 1 |
| Rasini, E | 1 |
| Cerri, S | 1 |
| Ghezzi, C | 1 |
| Dicorato, G | 1 |
| Caputo, S | 1 |
| Marino, F | 1 |
| Cosentino, M | 1 |
| Blandini, F | 1 |
| Lane, EL | 1 |
| Soulet, D | 1 |
| Vercammen, L | 1 |
| Cenci, MA | 1 |
| Brundin, P | 1 |
| Eskow, KL | 1 |
| Dupre, K | 1 |
| Blandino, P | 1 |
| Deak, T | 1 |
| Bishop, C | 1 |
| Nobre, HV | 1 |
| Cunha, GM | 1 |
| de Vasconcelos, LM | 1 |
| Magalhães, HI | 1 |
| Oliveira Neto, RN | 1 |
| Maia, FD | 1 |
| de Moraes, MO | 1 |
| Leal, LK | 1 |
| Viana, GS | 1 |
| Fainstein, N | 1 |
| Einstein, O | 1 |
| Cohen, ME | 1 |
| Brill, L | 1 |
| Lavon, I | 1 |
| Ben-Hur, T | 1 |
| Ling, ZD | 1 |
| Chang, Q | 1 |
| Lipton, JW | 1 |
| Tong, CW | 1 |
| Landers, TM | 1 |
| Carvey, PM | 1 |
| Venneti, S | 1 |
| Lopresti, BJ | 1 |
| Wang, G | 1 |
| Slagel, SL | 1 |
| Mason, NS | 1 |
| Mathis, CA | 1 |
| Fischer, ML | 1 |
| Larsen, NJ | 1 |
| Mortimer, AD | 1 |
| Hastings, TG | 1 |
| Smith, AD | 1 |
| Zigmond, MJ | 1 |
| Suhara, T | 1 |
| Higuchi, M | 1 |
| Wiley, CA | 1 |
| Gómez-Santos, C | 1 |
| Francisco, R | 1 |
| Giménez-Xavier, P | 1 |
| Ambrosio, S | 1 |
| Cicchetti, F | 1 |
| Brownell, AL | 1 |
| Williams, K | 1 |
| Chen, YI | 1 |
| Livni, E | 1 |
| Isacson, O | 1 |
17 other studies available for oxidopamine and Brain Inflammation
| Article | Year |
|---|---|
Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Tr | 2018 |
Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats.
Topics: Animals; Blood-Brain Barrier; Cell Count; Disease Models, Animal; Dopaminergic Neurons; Encephalitis | 2014 |
Neurotoxin mechanisms and processes relevant to Parkinson's disease: an update.
Topics: Animals; Brain; Dopaminergic Neurons; Encephalitis; Humans; Mitochondria; MPTP Poisoning; Neurons; O | 2015 |
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.
Topics: Animals; Cell Fractionation; Cells, Cultured; Cytokines; Disease Models, Animal; Encephalitis; Lipop | 2015 |
Magnetic resonance imaging as a tool to image neuroinflammation in a rat model of Parkinson's disease--phagocyte influx to the brain is promoted by bilberry-enriched diet.
Topics: Animals; Blood-Brain Barrier; Contrast Media; Disease Models, Animal; Encephalitis; Female; Magnetic | 2015 |
CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration.
Topics: Administration, Intranasal; Animals; Astrocytes; Corpus Striatum; CX3C Chemokine Receptor 1; Dopamin | 2016 |
6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis.
Topics: Animals; Astrocytes; Cell Proliferation; Corpus Striatum; Disease Models, Animal; Dopaminergic Neuro | 2016 |
Differential induction of dyskinesia and neuroinflammation by pulsatile versus continuous l-DOPA delivery in the 6-OHDA model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Cytokines; Disease Models, Animal; Drug Delivery Sys | 2016 |
Complex Changes in the Innate and Adaptive Immunity Accompany Progressive Degeneration of the Nigrostriatal Pathway Induced by Intrastriatal Injection of 6-Hydroxydopamine in the Rat.
Topics: Adaptive Immunity; Animals; Antigens, CD; Astrocytes; Corpus Striatum; Disease Models, Animal; Disea | 2017 |
Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease.
Topics: Adrenergic Agents; Amphetamine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Antiparkins | 2008 |
Exogenous corticosterone reduces L-DOPA-induced dyskinesia in the hemi-parkinsonian rat: role for interleukin-1beta.
Topics: Animals; Anti-Inflammatory Agents; Corpus Striatum; Corticosterone; Disease Models, Animal; Dose-Res | 2008 |
Caffeine and CSC, adenosine A2A antagonists, offer neuroprotection against 6-OHDA-induced neurotoxicity in rat mesencephalic cells.
Topics: Adenosine A2 Receptor Agonists; Animals; Apoptosis; Caffeine; Cells, Cultured; Encephalitis; Female; | 2010 |
Time limited immunomodulatory functions of transplanted neural precursor cells.
Topics: Adrenergic Agents; Animals; Cell Proliferation; Corpus Striatum; Cytokines; Disease Models, Animal; | 2013 |
Combined toxicity of prenatal bacterial endotoxin exposure and postnatal 6-hydroxydopamine in the adult rat midbrain.
Topics: Animals; Animals, Newborn; Cell Death; Disease Models, Animal; Dopamine; Encephalitis; Endotoxins; F | 2004 |
A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation.
Topics: Acetamides; Animals; Binding, Competitive; Brain; Disease Models, Animal; Encephalitis; Gliosis; Iso | 2007 |
Dopamine induces TNFalpha and TNF-R1 expression in SH-SY5Y human neuroblastoma cells.
Topics: 1-Methyl-4-phenylpyridinium; Antibodies; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Sur | 2007 |
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Agents; Avian Proteins; | 2002 |