Page last updated: 2024-11-02

oxidopamine and Autoimmune Diabetes

oxidopamine has been researched along with Autoimmune Diabetes in 5 studies

Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).

Research Excerpts

ExcerptRelevanceReference
"During the early phase of scar formation/healing, the density of GAP43/nestin(+) fibres innervating the peri-infarct/infarct region was significantly increased, whereas neurofilament-M/nestin(+) fibres were absent."1.39The neurogenic response of cardiac resident nestin(+) cells was associated with GAP43 upregulation and abrogated in a setting of type I diabetes. ( Calderone, A; Chabot, A; Duquette, N; Hertig, V; Meus, MA, 2013)
"Mice with autoimmune diabetes had an impaired glucagon response to sympathetic nerve activation, whereas those with non-autoimmune diabetes did not."1.35Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: relationship to invasive insulitis. ( Figlewicz, DP; Hackney, DJ; LeBoeuf, R; Mei, Q; Mundinger, TO; Taborsky, GJ, 2009)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chabot, A1
Meus, MA1
Hertig, V1
Duquette, N1
Calderone, A1
Taborsky, GJ4
Mei, Q4
Hackney, DJ1
Figlewicz, DP2
LeBoeuf, R1
Mundinger, TO4
Lernmark, A2
Lernmark, K1

Other Studies

5 other studies available for oxidopamine and Autoimmune Diabetes

ArticleYear
The neurogenic response of cardiac resident nestin(+) cells was associated with GAP43 upregulation and abrogated in a setting of type I diabetes.
    Cardiovascular diabetology, 2013, Aug-12, Volume: 12

    Topics: Animals; Cicatrix; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fibrosis; GAP-43 Prot

2013
Loss of islet sympathetic nerves and impairment of glucagon secretion in the NOD mouse: relationship to invasive insulitis.
    Diabetologia, 2009, Volume: 52, Issue:12

    Topics: Animals; Cyclophosphamide; Diabetes Mellitus, Type 1; Female; Glucagon; Hyperinsulinism; Islets of L

2009
Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.
    Diabetes, 2002, Volume: 51, Issue:10

    Topics: Animals; Antibodies; Diabetes Mellitus, Type 1; Female; Islets of Langerhans; Male; Membrane Glycopr

2002
Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy.
    American journal of physiology. Endocrinology and metabolism, 2003, Volume: 285, Issue:5

    Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Electric Stimulation; Epinephrine; Female

2003
Increased galanin expression in the celiac ganglion of BB diabetic rats.
    Neuropeptides, 2006, Volume: 40, Issue:1

    Topics: Animals; Diabetes Mellitus, Type 1; Disease Models, Animal; Galanin; Ganglia, Sympathetic; Gene Expr

2006