oxidopamine and Aura
oxidopamine has been researched along with Aura in 10 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study we analyzed the electrophysiological and clinical effects of selective removal of the forebrain noradrenergic projection from the locus coeruleus, induced by bilateral injections of 6-hydroxydopamine into the dorsal tegmental bundle on focal cobalt-induced epilepsy." | 7.67 | Facilitation of focal cobalt-induced epilepsy after lesions of the noradrenergic locus coeruleus system. ( Björklund, A; Chauvel, P; Lindvall, O; Trottier, S, 1988) |
| " In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy." | 4.12 | Dopamine depletion in wistar rats with epilepsy. ( Becker, EL; Biase, CLCL; Carvalho, EGA; Castro, DN; Cavalcante, JBN; Costa, AF; Costa, MV; Costa, PJMS; de Melo, MR; Félix, VB; Leão, SABF; Leite, ML; Lima, JA; Lino, ATS; Moura, IMFB; Mousinho, KC; Pai, JD; Quintella, GB; Saldanha-Filho, AJM; Santos, SDBD; Silva, ATMD; Silva, JCD; Tavares, MMA; Trindade-Filho, EM; Vieira, JSS; Zambrano, LI, 2022) |
| "In this study we analyzed the electrophysiological and clinical effects of selective removal of the forebrain noradrenergic projection from the locus coeruleus, induced by bilateral injections of 6-hydroxydopamine into the dorsal tegmental bundle on focal cobalt-induced epilepsy." | 3.67 | Facilitation of focal cobalt-induced epilepsy after lesions of the noradrenergic locus coeruleus system. ( Björklund, A; Chauvel, P; Lindvall, O; Trottier, S, 1988) |
| "Chronic sound or electroshock-induced seizures caused down regulation of beta-adrenoceptors in frontal cortex and in hippocampus from GEPR-9s." | 1.31 | Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats. ( Cheong, JH; Choi, CR; Dailey, JW; Jobe, PC; Ko, KH; Reith, ME; Ryu, JR; Seo, DO; Shin, CY, 2000) |
| "The development of seizures was significantly faster in the grafted and normal rats that had been given idazoxan than in the grafted rats that had not been subjected to alpha-2 receptor blockade." | 1.28 | Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism. ( Bengzon, J; Brundin, P; Kokaia, M; Lindvall, O, 1990) |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Trindade-Filho, EM | 1 |
| Pai, JD | 1 |
| Castro, DN | 1 |
| Silva, ATMD | 1 |
| Costa, AF | 1 |
| Vieira, JSS | 1 |
| Santos, SDBD | 1 |
| Félix, VB | 1 |
| Leão, SABF | 1 |
| Zambrano, LI | 1 |
| Saldanha-Filho, AJM | 1 |
| Carvalho, EGA | 1 |
| Cavalcante, JBN | 1 |
| Quintella, GB | 1 |
| Lino, ATS | 1 |
| Costa, MV | 1 |
| Lima, JA | 1 |
| Tavares, MMA | 1 |
| de Melo, MR | 1 |
| Mousinho, KC | 1 |
| Biase, CLCL | 1 |
| Leite, ML | 1 |
| Costa, PJMS | 1 |
| Becker, EL | 1 |
| Moura, IMFB | 1 |
| Silva, JCD | 1 |
| Bengzon, J | 2 |
| Kokaia, Z | 2 |
| Lindvall, O | 5 |
| Seo, DO | 1 |
| Shin, CY | 1 |
| Ryu, JR | 1 |
| Cheong, JH | 1 |
| Choi, CR | 1 |
| Dailey, JW | 1 |
| Reith, ME | 1 |
| Jobe, PC | 1 |
| Ko, KH | 1 |
| Ferencz, I | 1 |
| Leanza, G | 1 |
| Nanobashvili, A | 1 |
| Kokaia, M | 2 |
| Qiao, XX | 1 |
| Noebels, JL | 1 |
| Velísková, J | 1 |
| Velísek, L | 1 |
| Mares, P | 1 |
| Rokyta, R | 1 |
| Budko, KP | 1 |
| Brundin, P | 2 |
| Maurin, Y | 1 |
| Enz, A | 1 |
| Le Saux, F | 1 |
| Besson, MJ | 1 |
| Barry, DI | 1 |
| Kikvadze, I | 1 |
| Bolwig, TG | 1 |
| Björklund, A | 2 |
| Trottier, S | 1 |
| Chauvel, P | 1 |
Other Studies
10 other studies available for oxidopamine and Aura
| Article | Year |
|---|---|
Dopamine depletion in wistar rats with epilepsy.
Topics: Animals; Dopamine; Epilepsy; Male; Muscarinic Agonists; Oxidopamine; Pilocarpine; Rats; Rats, Wistar | 2022 |
Specific functions of grafted locus coeruleus neurons in the kindling model of epilepsy.
Topics: Animals; Brain; Epilepsy; Hippocampus; Injections; Injections, Intraventricular; Kindling, Neurologi | 1993 |
Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats.
Topics: Animals; Dihydroalprenolol; Electroshock; Epilepsy; Norepinephrine; Oxidopamine; Prazosin; Rats; Rat | 2000 |
Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: comparison with noradrenergic neurons.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Antibodies, Monoclonal; Basal Nucleus of Meynert; Chol | 2001 |
Genetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects.
Topics: Animals; Brain; Electroencephalography; Epilepsy; Female; Glyoxylates; Histocytochemistry; Locus Coe | 1991 |
Bicuculline-induced neocortical epileptiform foci and the effects of 6-hydroxydopamine in developing rats.
Topics: Animals; Bicuculline; Catecholamines; Cerebral Cortex; Electroencephalography; Epilepsy; Frontal Lob | 1991 |
Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism.
Topics: Adrenergic beta-Antagonists; Animals; Dioxanes; Dopamine beta-Hydroxylase; Epilepsy; Hippocampus; Hy | 1990 |
Supernumerary locus coeruleus neurons as a determinant of inherited epilepsy in the convulsive mutant mouse quaking.
Topics: Animals; Epilepsy; Hydroxydopamines; Locus Coeruleus; Mice; Mice, Inbred C57BL; Mice, Quaking; Norep | 1986 |
Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.
Topics: Adrenergic Fibers; Animals; Epilepsy; Hippocampus; Hydroxydopamines; Kindling, Neurologic; Male; Nor | 1987 |
Facilitation of focal cobalt-induced epilepsy after lesions of the noradrenergic locus coeruleus system.
Topics: Animals; Cerebral Cortex; Cobalt; Electroencephalography; Epilepsy; Female; Hydroxydopamines; Locus | 1988 |