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oxidopamine and Anxiety

oxidopamine has been researched along with Anxiety in 30 studies

Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"Although we could not establish an association between the anxiety level of rats with either the onset or severity of LID, our results showed that citalopram was able to mediate a partial alleviation in LID after chronic treatment, and the extent of recovery was negatively correlated to the anxiety measures of individual animals."7.74The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram. ( Barker, RA; Kuan, WL; Zhao, JW, 2008)
"Hesperidin treatment was also capable to increase striatal levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid and protects against the impairment of dopaminergic neurons in the substantia nigra pars compacta (SNpc) (p < 0."5.56Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson's Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice. ( Antunes, MS; Araújo, SM; Boeira, SP; Bortolotto, VC; Cattelan Souza, L; Ladd, AABL; Ladd, FVL; Moreira, AL; Nogueira, CW; Prigol, M; Silva, MRP, 2020)
"Although we could not establish an association between the anxiety level of rats with either the onset or severity of LID, our results showed that citalopram was able to mediate a partial alleviation in LID after chronic treatment, and the extent of recovery was negatively correlated to the anxiety measures of individual animals."3.74The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram. ( Barker, RA; Kuan, WL; Zhao, JW, 2008)
"Hesperidin treatment was also capable to increase striatal levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid and protects against the impairment of dopaminergic neurons in the substantia nigra pars compacta (SNpc) (p < 0."1.56Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson's Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice. ( Antunes, MS; Araújo, SM; Boeira, SP; Bortolotto, VC; Cattelan Souza, L; Ladd, AABL; Ladd, FVL; Moreira, AL; Nogueira, CW; Prigol, M; Silva, MRP, 2020)
"Anxiety in Parkinson's disease may represent a physiological reaction to the development of other symptoms during disease progression."1.51Anxiety-like behavior induced by 6-OHDA animal model of Parkinson's disease may be related to a dysregulation of neurotransmitter systems in brain areas related to anxiety. ( Bassani, TB; da Cunha, C; de O Guaita, G; Santiago, RM; Vieira, JCF; Vital, MABF; Zanoveli, JM, 2019)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (10.00)18.2507
2000's3 (10.00)29.6817
2010's17 (56.67)24.3611
2020's7 (23.33)2.80

Authors

AuthorsStudies
Zarrindast, MR1
Fazli-Tabaei, S1
Khakpai, F1
Mendes-Pinheiro, B1
Soares-Cunha, C1
Marote, A1
Loureiro-Campos, E1
Campos, J1
Barata-Antunes, S1
Monteiro-Fernandes, D1
Santos, D1
Duarte-Silva, S1
Pinto, L1
José Salgado, A1
Abrishamdar, M1
Farbood, Y1
Sarkaki, A1
Rashno, M1
Badavi, M1
Li, R1
Wang, Y2
Yang, Y2
Wu, Z1
Wang, L1
Tang, G1
Yang, J1
Liu, J4
Cunha, AM1
Teixeira, FG1
Guimarães, MR1
Esteves, M1
Pereira-Mendes, J1
Soares, AR1
Almeida, A1
Sousa, N1
Salgado, AJ1
Leite-Almeida, H1
G, A1
O, P1
E, CM1
M, GR1
Antunes, MS1
Cattelan Souza, L1
Ladd, FVL1
Ladd, AABL1
Moreira, AL1
Bortolotto, VC1
Silva, MRP1
Araújo, SM1
Prigol, M1
Nogueira, CW1
Boeira, SP1
Slominsky, PA1
Shadrina, MI1
Kolomin, TA1
Stavrovskaya, AV1
Filatova, EV1
Andreeva, LA1
Illarioshkin, SN1
Myasoedov, NF1
Sun, YN1
Yao, L1
Li, LB1
Du, CX3
Guo, Y3
Zhang, QJ1
Zhang, J2
Lv, SX2
Zhang, YM1
Loiodice, S1
Wing Young, H1
Rion, B1
Méot, B1
Montagne, P1
Denibaud, AS1
Viel, R1
Drieu La Rochelle, C1
Ferrazzo, S1
Gunduz-Cinar, O1
Stefanova, N1
Pollack, GA1
Holmes, A1
Schmuckermair, C1
Ferraguti, F1
Ogata, M1
Akita, H1
Ishibashi, H1
Vieira, JCF1
Bassani, TB1
Santiago, RM1
de O Guaita, G1
Zanoveli, JM1
da Cunha, C1
Vital, MABF1
Feng, CW1
Wen, ZH1
Huang, SY1
Hung, HC1
Chen, CH1
Yang, SN1
Chen, NF1
Wang, HM1
Hsiao, CD1
Chen, WF1
Sullivan, RM1
Dufresne, MM1
Siontas, D1
Chehab, S1
Townsend, J1
Laplante, F1
Chiu, WH1
Depboylu, C1
Hermanns, G1
Maurer, L1
Windolph, A1
Oertel, WH1
Ries, V1
Höglinger, GU1
Silva, TP1
Poli, A1
Hara, DB1
Takahashi, RN1
Dallé, E1
Daniels, WMU1
Mabandla, MV1
Picazo, O1
Chuc-Meza, E1
Anaya-Martinez, V1
Jimenez, I1
Aceves, J1
Garcia-Ramirez, M1
Eskow Jaunarajs, KL2
Dupre, KB1
Ostock, CY1
Button, T1
Deak, T1
Bishop, C2
Yan, J1
Xu, Y1
Zhu, C1
Zhang, L1
Wu, A1
Xiong, Z1
Deng, C1
Huang, XF1
Yenari, MA1
Yang, YG1
Ying, W1
Wang, Q1
Furmaga, H1
Shah, A1
Frazer, A1
George, JA1
Kuan, WL1
Zhao, JW1
Barker, RA1
Espejo, EF2
Miñano, J1
Pappas, BA1
Murtha, SJ1
Park, GA1
Condon, KT1
Szirtes, RM1
Laventure, SI1
Ally, A1
Steketee, JD1
Silverman, PB1
Swann, AC1

Other Studies

30 other studies available for oxidopamine and Anxiety

ArticleYear
Synergistic effect between quinpirole and L-NAME as well as sulpiride and L-arginine on the modulation of anxiety and memory processes in the 6-OHDA mouse model of Parkinson's disease: An isobologram analysis.
    Neurobiology of learning and memory, 2021, Volume: 186

    Topics: Adrenergic Agents; Animals; Anxiety; Arginine; Disease Models, Animal; Dopamine Agonists; Dopamine A

2021
Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response.
    International journal of molecular sciences, 2021, Oct-26, Volume: 22, Issue:21

    Topics: Animals; Anxiety; Behavior, Animal; Corpus Striatum; Depressive Disorder; Disease Models, Animal; Fe

2021
Evaluation of betulinic acid effects on pain, memory, anxiety, catalepsy, and oxidative stress in animal model of Parkinson's disease.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Antioxidants; Anxiety; Betulinic Acid; Brain-Derived Neurotrophic Factor; Catalepsy; Diseas

2023
The α1 and γ2 subunit-containing GABA
    Neuropharmacology, 2023, 10-01, Volume: 237

    Topics: Animals; Anxiety; Dopamine; Dorsal Raphe Nucleus; gamma-Aminobutyric Acid; Oxidopamine; Parkinson Di

2023
Unilateral accumbal dopamine depletion affects decision-making in a side-specific manner.
    Experimental neurology, 2020, Volume: 327

    Topics: Animals; Anxiety; Behavior, Animal; Decision Making; Depression; Dopaminergic Neurons; Impulsive Beh

2020
Reduction of dopaminergic transmission in the globus pallidus increases anxiety-like behavior without altering motor activity.
    Behavioural brain research, 2020, 05-27, Volume: 386

    Topics: Animals; Anxiety; Brain; Depression; Dopamine; Dopamine Agonists; Globus Pallidus; Male; Motor Activ

2020
Hesperidin Ameliorates Anxiety-Depressive-Like Behavior in 6-OHDA Model of Parkinson's Disease by Regulating Striatal Cytokine and Neurotrophic Factors Levels and Dopaminergic Innervation Loss in the Striatum of Mice.
    Molecular neurobiology, 2020, Volume: 57, Issue:7

    Topics: Animals; Anxiety; Behavior, Animal; Corpus Striatum; Cytokines; Depression; Dopaminergic Neurons; He

2020
Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.
    Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2017, Volume: 474, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Disease Models, Animal; Dopaminergic Neurons; Male; O

2017
Activation and blockade of basolateral amygdala 5-HT
    Neuropharmacology, 2018, 07-15, Volume: 137

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Corpus Striatum; Dopamine; gamma

2018
Involvement of prelimbic 5-HT
    Neurological research, 2018, Volume: 40, Issue:10

    Topics: Animals; Anxiety; Apomorphine; Desipramine; Disease Models, Animal; Dopamine Agents; Enzyme Inhibito

2018
Serotonin₆ Receptors in the Prelimbic Cortex are Involved in the Regulation of Anxiety-Like Behaviors in the Rat 6-Hydroxydopamine Parkinson’s Disease Model.
    The Chinese journal of physiology, 2018, Aug-31, Volume: 61, Issue:4

    Topics: Animals; Anxiety; Oxidopamine; Parkinson Disease; Rats; Receptors, Serotonin; Serotonin

2018
Implication of nigral dopaminergic lesion and repeated L-dopa exposure in neuropsychiatric symptoms of Parkinson's disease.
    Behavioural brain research, 2019, 03-15, Volume: 360

    Topics: Amphetamine; Animals; Antiparkinson Agents; Anxiety; Benserazide; Disease Models, Animal; Dopamine;

2019
Increased anxiety-like behavior following circuit-specific catecholamine denervation in mice.
    Neurobiology of disease, 2019, Volume: 125

    Topics: Adrenergic Agents; Amygdala; Animals; Anxiety; Catecholamines; Male; Mice; Mice, Inbred C57BL; Oxido

2019
Behavioral responses to anxiogenic tasks in young adult rats with neonatal dopamine depletion.
    Physiology & behavior, 2019, 05-15, Volume: 204

    Topics: Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Anxiety; Atomoxetine Hydrochloride; Behavio

2019
Anxiety-like behavior induced by 6-OHDA animal model of Parkinson's disease may be related to a dysregulation of neurotransmitter systems in brain areas related to anxiety.
    Behavioural brain research, 2019, 10-03, Volume: 371

    Topics: Adrenergic Agents; Amygdala; Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Brain; Corpus St

2019
Effects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio rerio) larvae.
    Zebrafish, 2014, Volume: 11, Issue:3

    Topics: Animals; Antiparkinson Agents; Anxiety; Biomarkers; Blotting, Western; Carbidopa; Disease Models, An

2014
Mesocortical dopamine depletion and anxiety-related behavior in the rat: sex and hemisphere differences.
    Progress in neuro-psychopharmacology & biological psychiatry, 2014, Oct-03, Volume: 54

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Dietary Sucrose; Dopamine; Estrous Cycle; Exploratory

2014
Long-term treatment with L-DOPA or pramipexole affects adult neurogenesis and corresponding non-motor behavior in a mouse model of Parkinson's disease.
    Neuropharmacology, 2015, Volume: 95

    Topics: Animals; Antiparkinson Agents; Anxiety; Benzothiazoles; Depression; Hippocampus; Levodopa; Male; Mic

2015
Time course study of microglial and behavioral alterations induced by 6-hydroxydopamine in rats.
    Neuroscience letters, 2016, 05-27, Volume: 622

    Topics: Acetylglucosaminidase; Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Corpus Striatum; Dep

2016
Anti-parkinsonian effects of fluvoxamine maleate in maternally separated rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2016, Volume: 53

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antiparkinson Agents; Anxiety; Disease

2016
6-Hydroxydopamine lesion in thalamic reticular nucleus reduces anxiety behaviour in the rat.
    Behavioural brain research, 2009, Feb-11, Volume: 197, Issue:2

    Topics: Analysis of Variance; Animals; Anxiety; Cell Count; Exploratory Behavior; Fear; Immunohistochemistry

2009
Behavioral and neurochemical effects of chronic L-DOPA treatment on nonmotor sequelae in the hemiparkinsonian rat.
    Behavioural pharmacology, 2010, Volume: 21, Issue:7

    Topics: Amygdala; Animals; Anxiety; Behavioral Research; Biogenic Monoamines; Chromatography, High Pressure

2010
Simvastatin prevents dopaminergic neurodegeneration in experimental parkinsonian models: the association with anti-inflammatory responses.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Anxiety; Apoptosis; Autoradiography; Cell Survival; Disease Model

2011
Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats.
    Biological psychiatry, 2011, Nov-15, Volume: 70, Issue:10

    Topics: 5,7-Dihydroxytryptamine; Adrenergic Agents; Adrenergic Uptake Inhibitors; Analysis of Variance; Anim

2011
L-DOPA-induced dysregulation of extrastriatal dopamine and serotonin and affective symptoms in a bilateral rat model of Parkinson's disease.
    Neuroscience, 2012, Aug-30, Volume: 218

    Topics: Adrenergic Agents; Animals; Anxiety; Behavior, Animal; Brain; Chromatography, High Pressure Liquid;

2012
The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease, and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram.
    Psychopharmacology, 2008, Volume: 197, Issue:2

    Topics: Adrenal Cortex Hormones; Amphetamine; Animals; Anxiety; Blotting, Western; Body Weight; Central Nerv

2008
Selective dopamine depletion within the medial prefrontal cortex induces anxiogenic-like effects in rats placed on the elevated plus maze.
    Brain research, 1997, Jul-11, Volume: 762, Issue:1-2

    Topics: Animals; Anxiety; Behavior, Animal; Denervation; Dopamine; Male; Maze Learning; Microinjections; Oxi

1997
Adrenergic hyperactivity and metanephrine excess in the nucleus accumbens after prefrontocortical dopamine depletion.
    Journal of neurophysiology, 2001, Volume: 85, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anxiety; Behavior, Animal; Darkness; Dopamine; Epinephrine;

2001
Neonatal brain dopamine depletion and the cortical and behavioral consequences of enriched postweaning environment.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 42, Issue:4

    Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Body Weight; Brain Chemistry; Catecholamines;

1992
Noradrenergic receptor mechanisms in neophobia.
    Psychopharmacology, 1992, Volume: 106, Issue:1

    Topics: Adenylyl Cyclases; Animals; Anxiety; Behavior, Animal; Clonidine; Colforsin; Dopamine beta-Hydroxyla

1992