oxidopamine has been researched along with Aging in 154 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated the effects of aging-associated formaldehyde (FA) on the inactivation of NE in vitro and in vivo, and on memory behaviors in rodents." | 7.81 | Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline. ( Jia, J; Jiang, C; Lv, J; Mei, Y; Tong, Z; Wan, Y; Wang, X; Yang, X, 2015) |
| " In this study, we investigated the effects of aging-associated formaldehyde (FA) on the inactivation of NE in vitro and in vivo, and on memory behaviors in rodents." | 3.81 | Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline. ( Jia, J; Jiang, C; Lv, J; Mei, Y; Tong, Z; Wan, Y; Wang, X; Yang, X, 2015) |
| " The effects of isoproterenol (ISP) and chemical sympathectomy (6-hydroxydopamine treatment) on myocardial beta-receptors were also investigated in 10 and 24 week-old SHRS and WKY to examine the effects of hypertension and aging on receptor regulation." | 3.68 | Effects of aging and drugs on myocardial beta-adrenergic receptors in M-SHRSP and SHRSP. ( Ikawa, H; Suzuki, A, 1991) |
| " The effects of aging on the responsiveness of the isolated pacemaker of the rat to the chronotropic effect of norepinephrine, isoproterenol and soterenol were studied." | 3.68 | Subsensitivity to beta-adrenoceptor agonists in pacemakers isolated from senescent rats. ( de Moraes, S; Spadari, RC, 1991) |
| "The calcitriol treatments significantly increased evoked overflow of DA from the lesioned striatum in both the young adult and middle-aged rats." | 1.46 | Reduced ability of calcitriol to promote augmented dopamine release in the lesioned striatum of aged rats. ( Cass, WA; Peters, LE, 2017) |
| " Parkin is thought to be critical for protecting dopaminergic neurons from toxic insults by targeting misfolded or oxidatively damaged proteins for proteasomal degradation." | 1.33 | Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity. ( Curtis, WR; Palmiter, RD; Perez, FA, 2005) |
| "Desipramine pretreatment, to block 6-OHDA uptake and prevent sympathectomy, completely blocked the 6-OHDA-induced effects, demonstrating that the destruction of NA nerve fibers is required." | 1.31 | Alterations in T lymphocyte activity following chemical sympathectomy in young and old Fischer 344 rats. ( Bellinger, DL; Felten, DL; Madden, KS; Stevens, SY, 2000) |
| "Treatment with isoproterenol on PN2-5 did not result in any significant changes in G(s)alpha expression but robustly decreased G(i)alpha1,2." | 1.31 | Ontogeny of G-protein expression: control by beta-adrenoceptors. ( Seidler, FJ; Slotkin, TA; Zeiders, JL, 2000) |
| "Huntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss." | 1.31 | Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine. ( Brundin, P; Castilho, RF; DiFiglia, M; Hansson, O; Petersén, A; Przedborski, S; Puschban, Z; Rice, M; Romero, N; Sapp, E; Sulzer, D, 2001) |
| "Pretreatment with clonidine (100 micrograms/kg, i." | 1.29 | 6-Hydroxydopamine treatment of neonatal rats. II. Effects on the development of the hindlimb flexor reflex. ( Jones, DJ; Simmons, KE, 1993) |
| " Animals that were lesioned and treated with haloperidol chronically had longer durations of catalepsy at the first two dose-response determinations." | 1.29 | Partial 6-hydroxydopamine-induced lesions and haloperidol-induced catalepsy. ( Fisher, H; Johnson, SK; Wagner, GC, 1993) |
| "Selegiline pretreatment protected SCG neurons and their postganglionic nerve fibers in SMG against these changes in a dose-dependent manner." | 1.29 | Monoamine oxidase B inhibitor selegiline protects young and aged rat peripheral sympathetic neurons against 6-hydroxydopamine-induced neurotoxicity. ( Haapalinna, A; Heinonen, E; Hervonen, A; Salonen, T; Suhonen, J, 1996) |
| ") ameliorated all the memory impairments except those induced by cysteamine or fimbria fornix lesion, and the dose-response curves were bell shaped with maximal response at 1 to 3." | 1.29 | FK960 N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate ameliorates the memory deficits in rats through a novel mechanism of action. ( Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M, 1996) |
| " However, the dose-response curve for apomorphine discrimination after doses of 0." | 1.27 | Differential effects of apomorphine in 6-hydroxydopamine-treated and aged rats. ( Concannon, JT; Schechter, MD, 1984) |
| "A model of minimal brain dysfunction (MBD) in rats based on injection of 6-OH-dopamine (DA) intracisternally on the 5th day of life has been described previously." | 1.26 | Dopamine receptors in a rat model of minimal brain dysfunction. ( Belmaker, RH; Brecher-Fride, E; Ebstein, RP; Eisenberg, J; Weizman, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (25.97) | 18.7374 |
| 1990's | 62 (40.26) | 18.2507 |
| 2000's | 31 (20.13) | 29.6817 |
| 2010's | 19 (12.34) | 24.3611 |
| 2020's | 2 (1.30) | 2.80 |
| Authors | Studies |
|---|---|
| Kasanga, EA | 1 |
| Owens, CL | 1 |
| Cantu, MA | 1 |
| Richard, AD | 1 |
| Davis, RW | 1 |
| McDivitt, LM | 1 |
| Blancher, B | 1 |
| Pruett, BS | 1 |
| Tan, C | 1 |
| Gajewski, A | 1 |
| Manfredsson, FP | 1 |
| Nejtek, VA | 1 |
| Salvatore, MF | 1 |
| Liu, W | 1 |
| Fu, R | 1 |
| Wang, Z | 1 |
| Liu, S | 1 |
| Tang, C | 1 |
| Li, L | 1 |
| Yin, D | 1 |
| Barata-Antunes, S | 1 |
| Teixeira, FG | 1 |
| Mendes-Pinheiro, B | 1 |
| Domingues, AV | 1 |
| Vilaça-Faria, H | 1 |
| Marote, A | 1 |
| Silva, D | 1 |
| Sousa, RA | 1 |
| Salgado, AJ | 1 |
| Cass, WA | 6 |
| Peters, LE | 2 |
| Xia, Y | 1 |
| Chen, BY | 1 |
| Sun, XL | 1 |
| Duan, L | 1 |
| Gao, GD | 1 |
| Wang, JJ | 1 |
| Yung, KK | 1 |
| Chen, LW | 1 |
| Yurek, DM | 3 |
| Hasselrot, U | 1 |
| Sesenoglu-Laird, O | 1 |
| Padegimas, L | 1 |
| Cooper, MJ | 1 |
| Collier, TJ | 3 |
| O'Malley, J | 1 |
| Rademacher, DJ | 1 |
| Stancati, JA | 1 |
| Sisson, KA | 1 |
| Sortwell, CE | 2 |
| Paumier, KL | 1 |
| Gebremedhin, KG | 1 |
| Steece-Collier, K | 2 |
| Mei, Y | 1 |
| Jiang, C | 1 |
| Wan, Y | 1 |
| Lv, J | 1 |
| Jia, J | 1 |
| Wang, X | 1 |
| Yang, X | 1 |
| Tong, Z | 1 |
| Johnson, AM | 1 |
| Grant, LM | 1 |
| Schallert, T | 2 |
| Ciucci, MR | 1 |
| Clark, AR | 1 |
| Carter, AB | 1 |
| Hager, LE | 1 |
| Price, EM | 1 |
| Bez, F | 1 |
| Francardo, V | 1 |
| Cenci, MA | 1 |
| Tubert, C | 1 |
| Taravini, IRE | 1 |
| Flores-Barrera, E | 1 |
| Sánchez, GM | 1 |
| Prost, MA | 1 |
| Avale, ME | 1 |
| Tseng, KY | 1 |
| Rela, L | 1 |
| Murer, MG | 1 |
| Bérubé-Carrière, N | 1 |
| Riad, M | 1 |
| Dal Bo, G | 1 |
| Lévesque, D | 1 |
| Trudeau, LE | 1 |
| Descarries, L | 4 |
| Martínez-Cerdeño, V | 1 |
| Noctor, SC | 1 |
| Espinosa, A | 1 |
| Ariza, J | 1 |
| Parker, P | 1 |
| Orasji, S | 1 |
| Daadi, MM | 1 |
| Bankiewicz, K | 1 |
| Alvarez-Buylla, A | 1 |
| Kriegstein, AR | 1 |
| Li, CR | 1 |
| Huang, GB | 1 |
| Sui, ZY | 1 |
| Han, EH | 1 |
| Chung, YC | 1 |
| Villar-Cheda, B | 1 |
| Valenzuela, R | 1 |
| Rodriguez-Perez, AI | 1 |
| Guerra, MJ | 2 |
| Labandeira-Garcia, JL | 2 |
| Massie, A | 1 |
| Schallier, A | 1 |
| Kim, SW | 1 |
| Fernando, R | 1 |
| Kobayashi, S | 1 |
| Beck, H | 1 |
| De Bundel, D | 1 |
| Vermoesen, K | 1 |
| Bannai, S | 1 |
| Smolders, I | 1 |
| Conrad, M | 1 |
| Plesnila, N | 1 |
| Sato, H | 1 |
| Michotte, Y | 1 |
| Rodriguez-Pallares, J | 1 |
| Parga, JA | 1 |
| Joglar, B | 1 |
| Bethel-Brown, CS | 1 |
| Morris, JK | 2 |
| Stanford, JA | 2 |
| Seim, NB | 1 |
| Bomhoff, GL | 1 |
| Geiger, PC | 1 |
| Sui, Y | 1 |
| Horne, MK | 1 |
| Stanić, D | 1 |
| Lev, N | 1 |
| Barhum, Y | 1 |
| Pilosof, NS | 1 |
| Ickowicz, D | 1 |
| Cohen, HY | 1 |
| Melamed, E | 1 |
| Offen, D | 1 |
| Zhang, K | 1 |
| Davids, E | 1 |
| Tarazi, FI | 1 |
| Baldessarini, RJ | 1 |
| Kordower, JH | 1 |
| Chen, HL | 1 |
| Lein, PJ | 1 |
| Wang, JY | 1 |
| Gash, D | 1 |
| Hoffer, BJ | 2 |
| Chiang, YH | 1 |
| Brus, R | 2 |
| Kostrzewa, RM | 4 |
| Nowak, P | 1 |
| Perry, KW | 2 |
| Kostrzewa, JP | 1 |
| Tamás, A | 3 |
| Lubics, A | 3 |
| Szalontay, L | 2 |
| Lengvári, I | 3 |
| Reglodi, D | 3 |
| Smith, MP | 2 |
| Pezzi, S | 1 |
| Checa, N | 1 |
| Alberch, J | 1 |
| Bellinger, DL | 3 |
| Stevens, SY | 2 |
| Thyaga Rajan, S | 1 |
| Lorton, D | 1 |
| Madden, KS | 4 |
| Boyce, PJ | 1 |
| Finlay, JM | 1 |
| Meissner, KK | 1 |
| Kirkham, DL | 1 |
| Doering, LC | 1 |
| Perez, FA | 1 |
| Curtis, WR | 1 |
| Palmiter, RD | 1 |
| Carvey, PM | 2 |
| Punati, A | 1 |
| Newman, MB | 1 |
| Toth, G | 1 |
| Singh, S | 1 |
| Ahmad, R | 1 |
| Mathur, D | 1 |
| Sagar, RK | 1 |
| Krishana, B | 1 |
| Imamura, K | 2 |
| Kasamatsu, T | 2 |
| Tanaka, S | 1 |
| Švíglerová, J | 1 |
| Kuncová, J | 1 |
| Nalos, L | 1 |
| Slavíková, J | 1 |
| Stengl, M | 1 |
| Pappas, BA | 2 |
| Ings, R | 1 |
| Knehans, AW | 1 |
| Romsos, DR | 1 |
| Concannon, JT | 3 |
| Braughler, JM | 1 |
| Schechter, MD | 3 |
| Shaywitz, BA | 1 |
| Teicher, MH | 1 |
| Cohen, DJ | 1 |
| Anderson, GM | 1 |
| Young, JG | 1 |
| Levitt, P | 1 |
| Erinoff, L | 1 |
| Kelly, PH | 1 |
| Basura, M | 1 |
| Snodgrass, SR | 1 |
| Randall, PK | 1 |
| Ponzio, F | 1 |
| Hallman, H | 2 |
| Jonsson, G | 2 |
| Felten, DL | 5 |
| Eisenberg, J | 1 |
| Brecher-Fride, E | 1 |
| Weizman, R | 1 |
| Ebstein, RP | 1 |
| Belmaker, RH | 1 |
| Tabsh, K | 1 |
| Nuwayhid, B | 1 |
| Murad, S | 1 |
| Ushioda, E | 1 |
| Erkkola, R | 1 |
| Brinkman, CR | 1 |
| Assali, NS | 1 |
| Nagai, K | 1 |
| Murano, S | 1 |
| Minokoshi, Y | 1 |
| Okuda, H | 1 |
| Kinutani, M | 1 |
| Johansson, BB | 1 |
| Linder, LE | 1 |
| Frohna, PA | 1 |
| Neal-Beliveau, BS | 2 |
| Joyce, JN | 3 |
| Milner, P | 2 |
| Lincoln, J | 2 |
| Belai, A | 1 |
| Burnstock, G | 2 |
| Abelli, L | 1 |
| Geppetti, P | 2 |
| Maggi, CA | 2 |
| Ryu, JH | 1 |
| Yanai, K | 1 |
| Sakurai, E | 1 |
| Kim, CY | 1 |
| Watanabe, T | 1 |
| Ingham, CA | 2 |
| Hood, SH | 2 |
| van Maldegem, B | 1 |
| Weenink, A | 1 |
| Arbuthnott, GW | 2 |
| Simmons, KE | 2 |
| Jones, DJ | 2 |
| Beltramo, M | 1 |
| Calas, A | 1 |
| Chernigovskaya, E | 1 |
| Borisova, N | 1 |
| Polenova, O | 1 |
| Tillet, Y | 1 |
| Thibault, J | 1 |
| Ugrumov, M | 1 |
| Byrnes, EM | 2 |
| Johnson, BJ | 2 |
| Bruno, JP | 7 |
| Strömberg, I | 2 |
| Björklund, L | 1 |
| Johansson, M | 1 |
| Tomac, A | 1 |
| Collins, F | 1 |
| Olson, L | 1 |
| Hoffer, B | 1 |
| Humpel, C | 1 |
| Unnerstall, JR | 2 |
| Ladner, A | 1 |
| Abrams, D | 1 |
| Gong, L | 1 |
| Li, C | 1 |
| Soghomonian, JJ | 2 |
| Schwartz, JP | 1 |
| Sheng, JG | 1 |
| Mitsuo, K | 1 |
| Shirabe, S | 1 |
| Nishiyama, N | 1 |
| Fernandes Xavier, FG | 1 |
| Doucet, G | 2 |
| Geffard, M | 1 |
| Ackerman, KD | 1 |
| Livnat, S | 1 |
| Felten, SY | 3 |
| Fuller, RW | 1 |
| Abrous, DN | 2 |
| Torres, EM | 1 |
| Dunnett, SB | 1 |
| Itoh, H | 2 |
| Buñag, RD | 2 |
| Johnson, SK | 1 |
| Fisher, H | 1 |
| Wagner, GC | 1 |
| Radja, F | 1 |
| Dewar, KM | 2 |
| Reader, TA | 2 |
| Bickford, P | 1 |
| Salonen, T | 1 |
| Haapalinna, A | 1 |
| Heinonen, E | 1 |
| Suhonen, J | 1 |
| Hervonen, A | 1 |
| Saland, LC | 1 |
| Samora, A | 1 |
| Apodaca, A | 1 |
| Ramirez, D | 1 |
| Kaseloo, PA | 1 |
| Lis, A | 1 |
| Asada, H | 1 |
| Barone, TA | 1 |
| Plunkett, RJ | 1 |
| Chaudhry, A | 1 |
| Muffler, LA | 1 |
| Yao, R | 1 |
| Granneman, JG | 1 |
| Yamazaki, M | 1 |
| Matsuoka, N | 1 |
| Maeda, N | 1 |
| Ohkubo, Y | 1 |
| Yamaguchi, I | 1 |
| Penit-Soria, J | 1 |
| Durand, C | 1 |
| Herve, D | 1 |
| Besson, MJ | 1 |
| Sandstrom, MI | 1 |
| Paquet, M | 1 |
| Lee, JY | 1 |
| Djamgoz, MB | 1 |
| Gordon, MN | 1 |
| Schreier, WA | 1 |
| Ou, X | 1 |
| Holcomb, LA | 1 |
| Morgan, DG | 2 |
| Iarygin, VN | 1 |
| Bibaeva, LV | 1 |
| Malinina, IE | 1 |
| ThyagaRajan, S | 1 |
| Thomas, WS | 1 |
| Pasinetti, GM | 3 |
| Hassler, M | 1 |
| Stone, D | 1 |
| Finch, CE | 3 |
| Ling, ZD | 1 |
| Lipton, JW | 1 |
| Vu, TQ | 1 |
| Robie, HC | 1 |
| Fletcher-Turner, A | 2 |
| Zeiders, JL | 1 |
| Seidler, FJ | 2 |
| Slotkin, TA | 2 |
| Vaudano, E | 1 |
| Rosenblad, C | 1 |
| Björklund, A | 2 |
| Fox, CM | 1 |
| Gash, DM | 1 |
| Smoot, MK | 1 |
| Connor, B | 1 |
| Kozlowski, DA | 1 |
| Elsworth, JD | 1 |
| Tillerson, JL | 1 |
| Bohn, MC | 1 |
| Campbell, BM | 1 |
| Gresch, PJ | 1 |
| Walker, PD | 1 |
| Petersén, A | 1 |
| Hansson, O | 1 |
| Puschban, Z | 1 |
| Sapp, E | 1 |
| Romero, N | 1 |
| Castilho, RF | 1 |
| Sulzer, D | 1 |
| Rice, M | 1 |
| DiFiglia, M | 1 |
| Przedborski, S | 1 |
| Brundin, P | 1 |
| Harned, ME | 1 |
| Bailey, SL | 1 |
| Holm, PC | 1 |
| Akerud, P | 1 |
| Wagner, J | 1 |
| Arenas, E | 1 |
| Pickel, VM | 1 |
| Johnson, E | 1 |
| Carson, M | 1 |
| Chan, J | 1 |
| Osterburg, HH | 1 |
| Kelly, AB | 1 |
| Kohama, S | 1 |
| Reinhard, JF | 1 |
| Stellwagen, RH | 1 |
| Snyder, DL | 1 |
| Aloyo, VJ | 1 |
| McIlvain, HB | 1 |
| Johnson, MD | 1 |
| Roberts, J | 4 |
| Abrams, DR | 1 |
| Garcia, S | 1 |
| Riekkinen, P | 2 |
| Riekkinen, M | 1 |
| Valjakka, A | 1 |
| Sirviö, J | 1 |
| Kohama, SG | 1 |
| Wagner, JP | 1 |
| Ikawa, H | 1 |
| Suzuki, A | 1 |
| Spadari, RC | 1 |
| de Moraes, S | 1 |
| Castañeda, E | 1 |
| Whishaw, IQ | 1 |
| Lermer, L | 1 |
| Robinson, TE | 1 |
| Snyder-Keller, AM | 1 |
| Lorens, SA | 1 |
| Guschwan, M | 1 |
| Hata, N | 1 |
| van de Kar, LD | 1 |
| Walenga, JM | 1 |
| Fareed, J | 1 |
| Neal, BS | 1 |
| Hamdi, A | 1 |
| Corr, LA | 1 |
| Aberdeen, JA | 1 |
| Drucker-Colín, R | 1 |
| García-Hernández, F | 1 |
| Mendoza-Ramírez, JL | 1 |
| Pacheco-Cano, MT | 1 |
| Komisaruk, BR | 1 |
| Tumer, N | 3 |
| Houck, WT | 2 |
| Rivet, JM | 1 |
| Le Moal, M | 2 |
| Herman, JP | 2 |
| Onn, SP | 1 |
| Balzer, JR | 1 |
| Sidney, JP | 1 |
| Stricker, EM | 2 |
| Zigmond, MJ | 2 |
| Berger, TW | 1 |
| Kaakkola, S | 1 |
| Teräväinen, H | 1 |
| Tanaka, H | 1 |
| Ozawa, E | 1 |
| von Knebel Doeberitz, C | 2 |
| Sievers, J | 3 |
| Sadler, M | 1 |
| Pehlemann, FW | 3 |
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| Halliwell, P | 1 |
| Zecchi-Orlandini, S | 1 |
| Santicioli, P | 1 |
| Meli, A | 1 |
| Frilli, S | 1 |
| Spillantini, MG | 1 |
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| Jelinek, H | 1 |
| Hendry, IA | 1 |
| McLennan, IS | 1 |
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| Reichardt, LF | 1 |
| Reder, A | 1 |
| Checinski, M | 1 |
| Chelmicka-Schorr, E | 1 |
| Schneyer, CA | 1 |
| Humphreys-Beher, M | 1 |
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| Sivam, SP | 1 |
| Breese, GR | 1 |
| Krause, JE | 1 |
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| Smythe, JW | 1 |
| Gage, FH | 1 |
6 reviews available for oxidopamine and Aging
| Article | Year |
|---|---|
Changes in Rat 50-kHz Ultrasonic Vocalizations During Dopamine Denervation and Aging: Relevance to Neurodegeneration.
Topics: Adrenergic Agents; Aging; Animals; Denervation; Dopamine; Neurodegenerative Diseases; Oxidopamine; P | 2015 |
Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Disease Models, Animal; Disease Progre | 2006 |
Sympathetic nervous system--immune system interactions in young and old Fischer 344 rats.
Topics: Aging; Animals; Antibody Formation; CD5 Antigens; Immunity; Interleukin-2; Lymphocyte Activation; Ly | 1995 |
Ovarian steroid and neurotoxin models of brain aging in rodents.
Topics: Aging; Animals; Atrophy; Brain; Estrogens; Female; Mice; Mice, Inbred C57BL; Neurons; Neurotoxins; O | 1992 |
Animal models of parkinsonism.
Topics: Aging; Animals; Behavior, Animal; Disease Models, Animal; Hydroxydopamines; MPTP Poisoning; Oxidopam | 1990 |
Neural grafting in animal models of neurodegenerative diseases.
Topics: Aging; Animals; Behavior, Animal; Brain; Brain Diseases; Choline; Corpus Striatum; Denervation; Dise | 1985 |
148 other studies available for oxidopamine and Aging
| Article | Year |
|---|---|
GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion.
Topics: Aging; Animals; Dopamine; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neuro | 2019 |
Regular Aerobic Exercise-Alleviated Dysregulation of CAMKIIα Carbonylation to Mitigate Parkinsonism via Homeostasis of Apoptosis With Autophagy.
Topics: Aging; alpha-Synuclein; Animals; Apoptosis; Autophagy; Beclin-1; Behavior, Animal; Calcium-Binding P | 2020 |
Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson's Disease.
Topics: Aging; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; Hum | 2020 |
Reduced ability of calcitriol to promote augmented dopamine release in the lesioned striatum of aged rats.
Topics: Aging; Animals; Calcitriol; Corpus Striatum; Dopamine; Male; Microdialysis; Oxidopamine; Rats; Rats, | 2017 |
Presence of proNGF-sortilin signaling complex in nigral dopamine neurons and its variation in relation to aging, lactacystin and 6-OHDA insults.
Topics: Acetylcysteine; Adaptor Proteins, Vesicular Transport; Aging; Animals; Anti-Bacterial Agents; Apopto | 2013 |
Age and lesion-induced increases of GDNF transgene expression in brain following intracerebral injections of DNA nanoparticles.
Topics: Aging; Animals; Astrocytes; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Genetic Vector | 2015 |
Interrogating the aged striatum: robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration.
Topics: Aging; Amphetamine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine and cAMP-Regulated Ph | 2015 |
Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline.
Topics: Aging; Animals; Autonomic Nervous System Diseases; Dopamine beta-Hydroxylase; Formaldehyde; Hippocam | 2015 |
In Vivo Neural Tissue Engineering: Cylindrical Biocompatible Hydrogels That Create New Neural Tracts in the Adult Mammalian Brain.
Topics: Aging; Animals; Behavior, Animal; Biocompatible Materials; Brain; Cell Movement; Female; Fibrin; Hyd | 2016 |
Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Ind | 2016 |
Decrease of a Current Mediated by Kv1.3 Channels Causes Striatal Cholinergic Interneuron Hyperexcitability in Experimental Parkinsonism.
Topics: Aging; Animals; Cholinergic Agents; Interneurons; Ion Channel Gating; Kv1.3 Potassium Channel; Membr | 2016 |
The dual dopamine-glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain.
Topics: Adrenergic Agents; Aging; Animals; Axons; Cell Count; Dopamine; Glutamic Acid; Mesencephalon; Neuron | 2009 |
Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats.
Topics: Aging; Animals; Behavior, Animal; Cell Differentiation; Cell Movement; Cell Survival; Cell Transplan | 2010 |
Effects of 6-hydroxydopamine lesioning of the medial prefrontal cortex on social interactions in adolescent and adult rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Dopamine; Exploratory Behavior; Interpersonal Relati | 2010 |
Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degeneration.
Topics: Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Co | 2012 |
Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.
Topics: Aging; Amino Acid Transport System y+; Animals; Corpus Striatum; Cystine; Dopamine; Glioma; Glutamic | 2011 |
Mitochondrial ATP-sensitive potassium channels enhance angiotensin-induced oxidative damage and dopaminergic neuron degeneration. Relevance for aging-associated susceptibility to Parkinson's disease.
Topics: Aging; Angiotensin II; Animals; Cells, Cultured; Dopaminergic Neurons; Fluorescence; Humans; Immunoh | 2012 |
Young and middle-aged rats exhibit isometric forelimb force control deficits in a model of early-stage Parkinson's disease.
Topics: Adrenergic Agents; Aging; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Forelimb; Male | 2011 |
Effects of unilateral nigrostriatal dopamine depletion on peripheral glucose tolerance and insulin signaling in middle aged rats.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Dopamine Antagonists; Eating; Glucose Intolerance; Glucos | 2011 |
Reduced proliferation in the adult mouse subventricular zone increases survival of olfactory bulb interneurons.
Topics: Aging; Animals; Astrocytes; Bromodeoxyuridine; Cell Count; Cell Movement; Cell Proliferation; Cell S | 2012 |
DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.
Topics: Adrenergic Agents; Aging; Animals; Blotting, Western; Cell Line; Disease Models, Animal; Dopamine; I | 2013 |
Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity.
Topics: Aging; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Carrier Proteins; D | 2002 |
Primate models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Corpus Striatum; Disease Models, Anima | 2003 |
Expression of bone morphogenetic proteins in the brain during normal aging and in 6-hydroxydopamine-lesioned animals.
Topics: Aging; Animals; Bone Morphogenetic Proteins; Brain; Gene Expression Regulation; Male; Oxidopamine; R | 2003 |
Ontogenetic quinpirole treatments fail to prime for D2 agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Biogenic Monoamines; Den | 2003 |
Age and gender differences in behavioral and morphological outcome after 6-hydroxydopamine-induced lesion of the substantia nigra in rats.
Topics: Aging; Animals; Behavior, Animal; Dopamine; Functional Laterality; Motor Activity; Neurons; Oxidopam | 2005 |
Reductions in spontaneous locomotor activity in aged male, but not female, rats in a model of early Parkinson's disease.
Topics: Adaptation, Physiological; Adrenergic Agents; Age Factors; Aging; Animals; Corpus Striatum; Disease | 2005 |
The vulnerability of striatal projection neurons and interneurons to excitotoxicity is differentially regulated by dopamine during development.
Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Gene Expression Regu | 2005 |
Aging and sympathetic modulation of immune function in Fischer 344 rats: effects of chemical sympathectomy on primary antibody response.
Topics: Adrenergic beta-Agonists; Aging; Animals; Antibody Formation; Antibody-Producing Cells; Cell Prolife | 2005 |
Neonatal depletion of cortical dopamine: effects on dopamine turnover and motor behavior in juvenile and adult rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Aging; Analysis of Variance; Animals; Animals, Ne | 2005 |
Transplants of neurosphere cell suspensions from aged mice are functional in the mouse model of Parkinson's.
Topics: Aging; Amphetamine; Animals; Apomorphine; Astrocytes; Behavior, Animal; Behavioral Symptoms; Corpus | 2005 |
Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity.
Topics: Aging; Animals; Dopamine; Drug Resistance; Methamphetamine; Mice; Mice, Knockout; Nerve Degeneration | 2005 |
Effects of age, gender, and gonadectomy on neurochemistry and behavior in animal models of Parkinson's disease.
Topics: Aging; Animals; Behavior, Animal; Brain; Castration; Dopamine; Female; Gonads; Male; Motor Activity; | 2006 |
Comparative study of the effects of PACAP in young, aging, and castrated males in a rat model of Parkinson's disease.
Topics: Aging; Animals; Behavior, Animal; Disease Models, Animal; Male; Orchiectomy; Oxidopamine; Parkinson | 2006 |
Neuroprotective effect of BDNF in young and aged 6-OHDA treated rat model of Parkinson disease.
Topics: Aging; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corpus Striatum; Disease Models | 2006 |
Oxidative stress and dopamine depletion in an intrastriatal 6-hydroxydopamine model of Parkinson's disease.
Topics: Age Factors; Aging; Aldehydes; Animals; Corpus Striatum; Dopamine; Male; Oxidative Stress; Oxidopami | 2007 |
Neural plasticity maintained high by activation of cyclic AMP-dependent protein kinase: an age-independent, general mechanism in cat striate cortex.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Brain Mapping; Bucladesine; Cats; Cholera Toxin; Cyclic | 2007 |
Depressed cardiac contractility and its postnatal development in rats after chemical sympathectomy.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Animals, Newborn; Myocardial | 2008 |
The ontogeny of spinal cord monoamines and the post-decapitation reflex.
Topics: Aging; Animals; Dopamine; Female; Hydroxydopamines; Locus Coeruleus; Male; Muscle Contraction; Neura | 1982 |
Norepinephrine turnover in obese (ob/ob) mice: effects of age, fasting, and acute cold.
Topics: Adipose Tissue, Brown; Aging; Animals; Cold Temperature; Fasting; Female; Growth; Heart; Hexamethoni | 1983 |
The development of brain biogenic amines, cyclic nucleotides and hyperactivity in 6-OHDA-treated rat pups.
Topics: Aging; Animals; Biogenic Amines; Body Weight; Brain Chemistry; Cyclic AMP; Cyclic GMP; Dopamine; Hyd | 1983 |
Open-field behavior in dopamine-depleted rat pups and their mothers.
Topics: Aging; Animals; Body Weight; Brain Chemistry; Dopamine; Female; Hydroxydopamines; Male; Maternal Beh | 1983 |
Dopaminergic but not noradrenergic mediation of hyperactivity and performance deficits in the developing rat pup.
Topics: Aging; Animals; Avoidance Learning; Brain Chemistry; Catecholamines; Dopamine; Escape Reaction; Hydr | 1984 |
Six-hydroxydopamine induced hyperactivity: neither sex differences nor caffeine stimulation are found.
Topics: Aging; alpha-Methyltyrosine; Animals; Body Weight; Brain; Brain Chemistry; Caffeine; Catecholamines; | 1984 |
Differential effects of apomorphine in 6-hydroxydopamine-treated and aged rats.
Topics: Aging; Animals; Animals, Newborn; Apomorphine; Brain Chemistry; Catecholamines; Discrimination, Psyc | 1984 |
Lesion-induced DA supersensitivity in aging C57BL/6J mice.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Functional Laterality; Hydroxydopamines; Mice; Mice, Inbr | 1984 |
Noradrenaline and dopamine interaction in rat brain during development.
Topics: Adrenergic Fibers; Aging; Animals; Animals, Newborn; Benzylamines; Brain; Brain Stem; Cerebral Corte | 1981 |
Evidence for a neurotropic role of noradrenaline neurons in the postnatal development of rat cerebral cortex.
Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Dendrites; Hydroxydopamines; Neurons; Norepinephr | 1982 |
Dopamine receptors in a rat model of minimal brain dysfunction.
Topics: Aging; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Caudate Nucleus; Di | 1982 |
Circulatory effects of chemical sympathectomy in fetal, neonatal, and adult sheep.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Blood Pressure; Cardiovascular Physiological Phenom | 1982 |
Effects of denervation and local 6-hydroxydopamine injection on testicular growth in rats.
Topics: Aging; Animals; Denervation; Hydroxydopamines; Male; Organ Size; Oxidopamine; Rats; Rats, Inbred Str | 1982 |
Specific gravity of brain tissue during maturation.
Topics: Aging; Animals; Animals, Newborn; Body Water; Brain; Female; Hydroxydopamines; Male; Myelin Sheath; | 1982 |
Neonatal 6-hydroxydopamine lesions lead to opposing changes in the levels of dopamine receptors and their messenger RNAs.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Dopamine; In Situ Hybridization; Neostriatum; Oxi | 1995 |
Plasticity in the myenteric plexus of the rat ileum after long-term sympathectomy.
Topics: Adrenergic Fibers; Aging; Animals; Animals, Newborn; Guanethidine; Ileum; Immunohistochemistry; Musc | 1995 |
Relative contribution of sympathetic and sensory nerves to thermal nociception and tissue trophism in rats.
Topics: Aging; Animals; Animals, Newborn; Capsaicin; Female; Hot Temperature; Male; Nervous System Physiolog | 1993 |
Ontogenetic development of histamine receptor subtypes in rat brain demonstrated by quantitative autoradiography.
Topics: Aging; Animals; Autoradiography; Brain; Corpus Striatum; Histamine Agonists; Histidine Decarboxylase | 1995 |
Morphological changes in the rat neostriatum after unilateral 6-hydroxydopamine injections into the nigrostriatal pathway.
Topics: Aging; Animals; Corpus Striatum; Dendrites; Histocytochemistry; Injections; Male; Neostriatum; Neura | 1993 |
6-Hydroxydopamine treatment of neonatal rats. I. Effects on the development of the spinal cord noradrenergic system.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Animals, Newborn; Cyclic AMP; Dihydroalprenolol; In Vit | 1993 |
Postnatal development of the suprachiasmatic nucleus in the rat. Morpho-functional characteristics and time course of tyrosine hydroxylase immunopositive fibers.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Female; Immunohistochemistry; Injections; | 1994 |
D1- and D2-receptor mediation of motoric behavior in rats depleted of DA as neonates: effects of age and size of depletion.
Topics: Aging; Animals; Animals, Newborn; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; | 1994 |
Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo.
Topics: Aging; Animals; Biomarkers; Brain; Brain Tissue Transplantation; Cell Division; Corpus Striatum; Dop | 1993 |
Deficits in the activation and phosphorylation of hippocampal tyrosine hydroxylase in the aged Fischer 344 rat following intraventricular administration of 6-hydroxydopamine.
Topics: Aging; Animals; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Hippoca | 1994 |
Co-activation of D1- and D2-like receptors is unnecessary for stimulated motor behavior in rats depleted of dopamine during development.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Brain; Dopamine; Dopamin | 1994 |
Neonatal 6-hydroxydopamine and adult SKF 38393 treatments alter dopamine D1 receptor mRNA levels: absence of other neurochemical associations with the enhanced behavioral responses of lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Aging; Animals; Anima | 1994 |
Differential regulation of glutamate decarboxylase and preproenkephalin mRNA levels in the rat striatum.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Dopamine; Enkephalins; Female; Glutamate Decarbox | 1994 |
Trophic factor production by reactive astrocytes in injured brain.
Topics: Aging; Animals; Astrocytes; Biomarkers; Cells, Cultured; Cerebellum; Enkephalin, Methionine; Enkepha | 1993 |
Dopamine neoinnervation in the substantia nigra and hyperinnervation in the interpeduncular nucleus of adult rat following neonatal cerebroventricular administration of 6-hydroxydopamine.
Topics: Aging; Animals; Animals, Newborn; Dopamine; Female; Immunohistochemistry; Injections, Intraventricul | 1994 |
Neonatal sympathetic denervation alters development of natural killer (NK) cell activity in F344 rats.
Topics: Aging; Animals; Animals, Newborn; Cytotoxicity, Immunologic; Desipramine; Female; Killer Cells, Natu | 1993 |
Age-dependence of a 6-hydroxydopamine lesion on SKF 38393- and m-chlorophenylpiperazine-induced oral activity responses of rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Biogenic Monoamines; Cor | 1993 |
Dopaminergic grafts implanted into the neonatal or adult striatum: comparative effects on rotation and paw reaching deficits induced by subsequent unilateral nigrostriatal lesions in adulthood.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Brain Tissue Transplan | 1993 |
6-Hydroxydopamine treatment of neonatal rats. II. Effects on the development of the hindlimb flexor reflex.
Topics: Aging; Animals; Animals, Newborn; Clonidine; Electric Stimulation; Hindlimb; Motor Activity; Movemen | 1993 |
Age-related reduction of reflex bradycardia in conscious rats by catecholaminergic nucleus tractus solitarius lesions.
Topics: Aging; Animals; Blood Pressure; Bradycardia; Heart Rate; Male; Medulla Oblongata; Nitroprusside; Oxi | 1993 |
Partial 6-hydroxydopamine-induced lesions and haloperidol-induced catalepsy.
Topics: Aging; Animals; Apomorphine; Brain Chemistry; Catalepsy; Corpus Striatum; Dose-Response Relationship | 1993 |
Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Brain; Corpus Striatum; Denervation; Dopamine; Fe | 1993 |
Reduced ageing effects of striatal neuronal discharge rate by aged ventral mesencephalic grafts.
Topics: Aging; Animals; Apomorphine; Brain Tissue Transplantation; Dopamine Agonists; Electrophysiology; Fem | 1996 |
Monoamine oxidase B inhibitor selegiline protects young and aged rat peripheral sympathetic neurons against 6-hydroxydopamine-induced neurotoxicity.
Topics: Aging; Animals; Immunohistochemistry; Male; Microscopy, Fluorescence; Monoamine Oxidase Inhibitors; | 1996 |
Regulation of pituitary beta-endorphin secretion in aging rats: in vitro responsiveness to dopamine.
Topics: Aging; Animals; beta-Endorphin; Dopamine; Immunohistochemistry; In Vitro Techniques; Male; Oxidopami | 1995 |
In vitro assessment of neurotrophic activity from the striatum of aging rats.
Topics: 1-Methyl-4-phenylpyridinium; Aging; Animals; Cell Extracts; Cell Line; Cells, Cultured; Chick Embryo | 1996 |
Perinatal expression of adenylyl cyclase subtypes in rat brown adipose tissue.
Topics: Adenylyl Cyclases; Adipose Tissue, Brown; Aging; Animals; Animals, Newborn; Cell Differentiation; Ce | 1996 |
FK960 N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate ameliorates the memory deficits in rats through a novel mechanism of action.
Topics: Aging; Animals; Behavior, Animal; Benzamides; Brain; Cysteamine; Fenclonine; Male; Memory; Nootropic | 1996 |
Morphological and biochemical adaptations to unilateral dopamine denervation of the neostriatum in newborn rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Basal Ganglia; Denervation; Dopami | 1997 |
Sensitivity to the motoric effects of a dopamine receptor antagonist differs as a function of age at the time of dopamine depletion.
Topics: Aging; Animals; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Rela | 1997 |
Alterations in the turnover rate of dopamine D1 but not D2 receptors in the adult rat neostriatum after a neonatal dopamine denervation.
Topics: Aging; Animals; Animals, Newborn; Benzazepines; Denervation; Dopamine; Dopamine Antagonists; Female; | 1997 |
Retinal dopamine depletion in young quail mimics some of the effects of ageing on visual function.
Topics: Adrenergic Agents; Aging; Animals; Contrast Sensitivity; Coturnix; Dopamine; Electroretinography; Fe | 1997 |
Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat.
Topics: Afferent Pathways; Aging; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Brain Injurie | 1997 |
[Analysis of interaction between the central and peripheral noradrenergic structures in rat ontogenesis].
Topics: Aging; Animals; Chromatin; Female; Ganglia, Sympathetic; Locus Coeruleus; Neurons; Oxidopamine; Rats | 1997 |
Restoration of sympathetic noradrenergic nerve fibers in the spleen by low doses of L-deprenyl treatment in young sympathectomized and old Fischer 344 rats.
Topics: Adrenergic Fibers; Aging; Animals; Immunity, Cellular; Male; Monoamine Oxidase Inhibitors; Nerve Reg | 1998 |
There is a limited critical period for dopamine's effects on D1 receptor expression in the developing rat neostriatum.
Topics: Aging; Animals; Animals, Newborn; Benzazepines; Carrier Proteins; Corpus Striatum; Dopamine; Dopamin | 1998 |
Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesions.
Topics: Aging; Animals; Apolipoproteins E; Astrocytes; Clusterin; Gene Expression Regulation, Developmental; | 1999 |
Striatal trophic activity is reduced in the aged rat brain.
Topics: Aging; Animals; Brain; Cells, Cultured; Chromatography, High Pressure Liquid; Corpus Striatum; Dopam | 2000 |
Lesion-induced increase of BDNF is greater in the striatum of young versus old rat brain.
Topics: Aging; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corpus Striatum; Dopamine; Nerv | 2000 |
Alterations in T lymphocyte activity following chemical sympathectomy in young and old Fischer 344 rats.
Topics: Aging; Animals; Cell Division; Cells, Cultured; Concanavalin A; Desipramine; Dose-Response Relations | 2000 |
Ontogeny of G-protein expression: control by beta-adrenoceptors.
Topics: Adrenergic beta-Agonists; Aging; Animals; Colforsin; Drug Tolerance; Female; Fluorides; Gene Express | 2000 |
Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor.
Topics: Aging; Animals; Animals, Newborn; Brain Diseases; Cell Death; Dopamine; Female; Glial Cell Line-Deri | 2001 |
Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesion.
Topics: Aging; Animals; Brain-Derived Neurotrophic Factor; Denervation; Glial Cell Line-Derived Neurotrophic | 2001 |
Neuroprotective effects of GDNF against 6-OHDA in young and aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Cell Survival; Dopamine; Glial Cell Line-Derived Neu | 2001 |
Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects dopaminergic terminals from degeneration.
Topics: Aging; Animals; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Disease Models, Animal; | 2001 |
Neonatal dopamine depletion reveals a synergistic mechanism of mRNA regulation that is mediated by dopamine(D1) and serotonin(2) receptors and is targeted to tachykinin neurons of the dorsomedial striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Dopamine; Dopamine Agonists; Dopam | 2001 |
Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine.
Topics: Aging; Animals; Ascorbic Acid; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Respons | 2001 |
Enhanced effects of 6-hydroxydopamine on evoked overflow of striatal dopamine in aged rats.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Disease Models, Animal; Dopam | 2002 |
Neurturin is a neuritogenic but not a survival factor for developing and adult central noradrenergic neurons.
Topics: Aging; Animals; Brain; Cell Survival; Cells, Cultured; Drosophila Proteins; Embryo, Mammalian; Glial | 2002 |
Ultrastructure of spared dopamine terminals in caudate-putamen nuclei of adult rats neonatally treated with intranigral 6-hydroxydopamine.
Topics: Aging; Animals; Axons; Caudate Nucleus; Desipramine; Dopamine; Immunoenzyme Techniques; Immunohistoc | 1992 |
Slow changes of tyrosine hydroxylase gene expression in dopaminergic brain neurons after neurotoxin lesioning: a model for neuron aging.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Amino Acid Sequence; Animals; Biogenic Monoamines; Corpus Str | 1992 |
Effect of age on potassium- and tyramine-induced release of norepinephrine from cardiac synaptosomes in male F344 rats.
Topics: Adrenergic Fibers; Aging; Animals; Desipramine; Heart; Male; Myocardium; Norepinephrine; Oxidopamine | 1992 |
Ontogeny of apomorphine-induced stereotypy and its D1 and D2 receptor mediation in rats depleted of dopamine as neonates.
Topics: Aging; Animals; Apomorphine; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Oxidopa | 1992 |
D-1 and D-2 receptor mediation of sensorimotor behavior in rats depleted of dopamine during development.
Topics: Afferent Pathways; Aging; Animals; Attention; Corpus Striatum; Desipramine; Dopamine; Hippocampus; M | 1992 |
Ultrastructural analysis of the serotonin hyperinnervation in adult rat neostriatum following neonatal dopamine denervation with 6-hydroxydopamine.
Topics: Aging; Animals; Animals, Newborn; Corpus Striatum; Denervation; Dopamine; Immunohistochemistry; Micr | 1992 |
DSP-4, a noradrenergic neurotoxin, produces more severe biochemical and functional deficits in aged than young rats.
Topics: Aging; Animals; Benzylamines; Brain Chemistry; Choline O-Acetyltransferase; Dopamine; Electroencepha | 1992 |
Catecholaminergic nucleus tractus solitarius lesions in anesthetized rats alter baroreflexes differently with age.
Topics: Aging; Animals; Cardiovascular Physiological Phenomena; Catecholamines; Electric Stimulation; Male; | 1992 |
Presynaptic input regulates development of beta-adrenergic control of rat brain ornithine decarboxylase: effects of 6-hydroxydopamine or propranolol.
Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Dopamine; Neurotoxins; Norepinephrine; Ornithine | 1991 |
Effects of aging and drugs on myocardial beta-adrenergic receptors in M-SHRSP and SHRSP.
Topics: 5'-Nucleotidase; Aging; Animals; Cardiomegaly; Cerebrovascular Disorders; Disease Susceptibility; Do | 1991 |
Subsensitivity to beta-adrenoceptor agonists in pacemakers isolated from senescent rats.
Topics: Adrenergic beta-Agonists; Aging; Animals; Cocaine; Ethanolamines; Heart; Heart Rate; In Vitro Techni | 1991 |
Dopamine depletion in neonatal rats: effects on behavior and striatal dopamine release assessed by intracerebral microdialysis during adulthood.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Behavior, Animal; Corpus Striatum; | 1990 |
Development of striatal compartmentalization following pre- or postnatal dopamine depletion.
Topics: Acetylcholinesterase; Aging; Animals; Biomarkers; Corpus Striatum; Dopamine Antagonists; Female; Ges | 1991 |
Behavioral, endocrine, and neurochemical effects of sulfomucopolysaccharide treatment in the aged Fischer 344 male rat.
Topics: Aging; Animals; Avoidance Learning; Caudate Nucleus; Corticosterone; Dopamine; Exploratory Behavior; | 1991 |
Dopamine D1 receptor behavioral responsitivity following selective lesions of the striatal patch compartment during development.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Analysis of Variance; Animals; An | 1991 |
Ontogenic homologous supersensitization of dopamine D1 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Corpus | 1991 |
Neuropeptide Y in non-sympathetic nerves of the rat: changes during maturation but not after guanethidine sympathectomy.
Topics: Aging; Animals; Catecholamines; Guanethidine; Histocytochemistry; Immunohistochemistry; Microscopy, | 1991 |
Possible mechanisms of action of adrenal transplants in Parkinson's disease.
Topics: Adrenal Medulla; Aging; Animals; Apomorphine; Brain Tissue Transplantation; Bucladesine; Caudate Nuc | 1990 |
Effect of age on upregulation of the cardiac adrenergic beta receptors.
Topics: Adrenergic beta-Antagonists; Aging; Animals; Heart; Hydroxydopamines; Iodine Radioisotopes; Male; My | 1990 |
Similar post-lesion receptor readjustments following the unilateral 6-hydroxydopamine lesion of the dopaminergic mesotelencephalic system in neonatal and adult rats.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Dopamine Agents; Hydroxydopamines; | 1990 |
Lesions of the dopaminergic nigrostriatal system in neonatal rats: effects on the electrophysiological activity of striatal neurons recorded during adulthood.
Topics: Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Electric Stimulation; Electrophysiology | 1990 |
Developmental expression of dystrophin on the rat myocardial cell membrane.
Topics: Aging; Animals; Animals, Newborn; Cell Membrane; Dystrophin; Gene Expression; Heart; Hydroxydopamine | 1990 |
Destruction of meningeal cells over the newborn hamster cerebellum with 6-hydroxydopamine prevents foliation and lamination in the rostral cerebellum.
Topics: Aging; Animals; Animals, Newborn; Cerebellum; Cricetinae; Electronic Data Processing; Fluorescent An | 1986 |
Substance P-like immunoreactivity in capsaicin-sensitive structures of the rat thymus.
Topics: Aging; Animals; Capsaicin; Chromatography, High Pressure Liquid; Cricetinae; Female; Guinea Pigs; Hy | 1987 |
Effect of dopamine-depleting brain lesions in rat pups: role of striatal serotonergic neurons in behavior.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Corpus St | 1987 |
Destruction by anti-NGF of autonomic, sudomotor neurones and subsequent hyperinnervation of the foot pad by sensory fibres.
Topics: Adrenergic Fibers; Aging; Animals; Animals, Newborn; Hindlimb; Hydroxydopamines; Immune Sera; Nerve | 1988 |
Regulation of nerve growth factor mRNA levels in developing rat heart ventricle is not altered by sympathectomy.
Topics: Aging; Animals; Female; Heart; Heart Ventricles; Hydroxydopamines; Male; Nerve Growth Factors; Neuro | 1989 |
The effect of chemical sympathectomy on natural killer cells in mice.
Topics: Aging; Animals; Hydroxydopamines; Killer Cells, Natural; Mice; Mice, Inbred CBA; Oxidopamine; Spleen | 1989 |
Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age.
Topics: Aging; Animals; Corpus Striatum; Dendrites; Hydroxydopamines; Male; Medial Forebrain Bundle; Oxidopa | 1989 |
Upregulation of adrenergic beta receptor subtypes in the senescent rat heart.
Topics: Aging; Animals; Heart; Hydroxydopamines; In Vitro Techniques; Male; Oxidopamine; Rats; Rats, Inbred | 1989 |
Interaction of noradrenergic and cholinergic systems in regulation of ocular dominance plasticity.
Topics: Aging; Animals; Bethanechol; Bethanechol Compounds; Cats; Cholinergic Fibers; Dose-Response Relation | 1989 |
Comparison of effects of surgical and chemical sympathectomy on beta adrenergic and muscarinic receptors of parotid gland of young and adult rats.
Topics: Aging; Animals; Dihydroalprenolol; Hydroxydopamines; Oxidopamine; Parotid Gland; Quinuclidinyl Benzi | 1988 |
Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Benzaz | 1987 |
Distorted development of intracerebral grafts: long-term maintenance of tyrosine hydroxylase-containing neurons in grafts of cortical tissue.
Topics: Aging; Animals; Brain; Dopamine; Enkephalins; Frontal Lobe; Graft Survival; Hydroxydopamines; Immuno | 1988 |
Effect of aging on the response of the cerebral cortex to noradrenergic denervation.
Topics: Adenylyl Cyclases; Aging; Animals; Cerebral Cortex; Cyclic AMP; Dominance, Cerebral; Hydroxydopamine | 1985 |
Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates.
Topics: Aging; Animals; Cerebral Cortex; Clonidine; Cognition; Female; Hydroxydopamines; Macaca mulatta; Mem | 1985 |
Small vessel membrane potential, sympathetic input, and electrogenic pump rate in SHR.
Topics: Aging; Animals; Blood Pressure; Denervation; Heart Rate; Hydroxydopamines; Male; Membrane Potentials | 1986 |
Desipramine and noradrenergic neurotransmission in aging: failure to respond in aged laboratory animals.
Topics: Action Potentials; Aging; Animals; Desipramine; Electric Stimulation; Hydroxydopamines; Male; Norepi | 1987 |
Chemical sympathectomy decreases alveolar hypoxic vasoconstriction in lambs but not in sheep.
Topics: Aging; Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Dinoprost; Hydroxydopamines; Hypox | 1986 |
Influences of meningeal cells on brain development. Findings and hypothesis.
Topics: Aging; Animals; Ascorbic Acid; Brain; Cerebellum; Cricetinae; Hippocampus; Hydroxydopamines; Meninge | 1986 |
The pharmacology of (-)deprenyl.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcholine; Aging; Animals; Catecholamines; Corpus | 1986 |
Meningeal cells influence cerebellar development over a critical period.
Topics: Aging; Animals; Animals, Newborn; Cerebellum; Cricetinae; Hydroxydopamines; Meninges; Mesocricetus; | 1986 |
The influence of catecholamine systems and thyroid function on the actions of ethanol in long-sleep (LS) and short-sleep (SS) mice.
Topics: Aging; alpha-Methyltyrosine; Animals; Catecholamines; Ethanol; Hydroxydopamines; Methyltyrosines; Mi | 1987 |
The dopamine-depleting effect of 6-hydroxydopamine does not increase with aging.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Hydroxydopamines; Injections, Intraventricular; Male; Mic | 1988 |
Effect of increasing age on adrenergic control of heart rate in the rat.
Topics: Aging; Animals; Heart; Heart Block; Heart Conduction System; Heart Rate; Hydroxydopamines; Male; Oxi | 1988 |
"In situ" modulation of murine neuroblastoma growth and biochemical differentiation by the adrenergic nervous system and nerve growth factor.
Topics: Adrenergic Fibers; Aging; Animals; Catecholamines; Cell Transformation, Neoplastic; Hydroxydopamines | 1988 |
Neonatal 6-hydroxydopamine potentiates clonidine's locomotor effects throughout maturation in the rat.
Topics: Aging; Animals; Animals, Newborn; Catecholamines; Clonidine; Female; Hydroxydopamines; Motor Activit | 1985 |