oxepins and Malaria--Falciparum

oxepins has been researched along with Malaria--Falciparum* in 1 studies

Other Studies

1 other study(ies) available for oxepins and Malaria--Falciparum

Article	Year
Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina. Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2 Mass-directed isolation of the CH(2)Cl(2)/CH(3)OH extract from a marine sponge of the genus Pseudoceratina resulted in the purification of a new antimalarial bromotyrosine alkaloid, psammaplysin H (1), along with the previously isolated analogs psammaplysins G (2) and F (3). The structure of 1 was elucidated following 1D and 2D NMR, and MS data analysis. All compounds were tested in vitro against the 3D7 line of Plasmodium falciparum and mammalian cell lines (HEK293 and HepG2), with 1 having the most potent (IC(50) 0.41μM) and selective (>97-fold) antimalarial activity. Topics: Alkaloids; Animals; Antimalarials; Cell Line; Humans; Isoxazoles; Malaria, Falciparum; Oxepins; Plasmodium falciparum; Porifera; Tyrosine	2011

Article

Year

Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina.

Bioorganic & medicinal chemistry letters, 2011, Jan-15, Volume: 21, Issue:2

Mass-directed isolation of the CH(2)Cl(2)/CH(3)OH extract from a marine sponge of the genus Pseudoceratina resulted in the purification of a new antimalarial bromotyrosine alkaloid, psammaplysin H (1), along with the previously isolated analogs psammaplysins G (2) and F (3). The structure of 1 was elucidated following 1D and 2D NMR, and MS data analysis. All compounds were tested in vitro against the 3D7 line of Plasmodium falciparum and mammalian cell lines (HEK293 and HepG2), with 1 having the most potent (IC(50) 0.41μM) and selective (>97-fold) antimalarial activity.

Topics: Alkaloids; Animals; Antimalarials; Cell Line; Humans; Isoxazoles; Malaria, Falciparum; Oxepins; Plasmodium falciparum; Porifera; Tyrosine

2011