oxepins and Chemical-and-Drug-Induced-Liver-Injury

oxepins has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 2 studies

Other Studies

2 other study(ies) available for oxepins and Chemical-and-Drug-Induced-Liver-Injury

Article	Year
Discovery of an Oxepine-Containing Diketopiperazine Derivative Active against Concanavalin A-Induced Hepatitis. Journal of natural products, 2020, 09-25, Volume: 83, Issue:9 Topics: Animals; Aspergillus; CD28 Antigens; CD3 Complex; Cell Proliferation; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Diketopiperazines; Humans; Liver; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Oxepins; Piperazines; Spleen; T-Lymphocytes; X-Ray Diffraction	2020
Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH. PloS one, 2016, Volume: 11, Issue:8 The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) signals during cellular stress via several post-translational modifications that change its folding properties, protein-protein interactions and sub-cellular localization. We examined GAPDH properties in acute mouse liver injury due to ethanol and/or acetaminophen (APAP) treatment. Synergistic robust and time-dependent nuclear accumulation and aggregation of GAPDH were observed only in combined, but not individual, ethanol/APAP treatments. The small molecule GAPDH-targeting compound TCH346 partially attenuated liver damage possibly via mitochondrial mechanisms, and independent of nuclear accumulation and aggregation of GAPDH. These findings provide a novel potential mechanism for hepatotoxicity caused by combined alcohol and acetaminophen exposure. Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Nucleus; Central Nervous System Depressants; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethanol; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Liver; Mice; Mice, Inbred C57BL; Oxepins; Protein Transport	2016

Article

Year

Discovery of an Oxepine-Containing Diketopiperazine Derivative Active against Concanavalin A-Induced Hepatitis.

Journal of natural products, 2020, 09-25, Volume: 83, Issue:9

Topics: Animals; Aspergillus; CD28 Antigens; CD3 Complex; Cell Proliferation; Chemical and Drug Induced Liver Injury; Concanavalin A; Cytokines; Diketopiperazines; Humans; Liver; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Oxepins; Piperazines; Spleen; T-Lymphocytes; X-Ray Diffraction

2020

Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH.

PloS one, 2016, Volume: 11, Issue:8

The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) signals during cellular stress via several post-translational modifications that change its folding properties, protein-protein interactions and sub-cellular localization. We examined GAPDH properties in acute mouse liver injury due to ethanol and/or acetaminophen (APAP) treatment. Synergistic robust and time-dependent nuclear accumulation and aggregation of GAPDH were observed only in combined, but not individual, ethanol/APAP treatments. The small molecule GAPDH-targeting compound TCH346 partially attenuated liver damage possibly via mitochondrial mechanisms, and independent of nuclear accumulation and aggregation of GAPDH. These findings provide a novel potential mechanism for hepatotoxicity caused by combined alcohol and acetaminophen exposure.

Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Nucleus; Central Nervous System Depressants; Chemical and Drug Induced Liver Injury; Drug Synergism; Ethanol; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Liver; Mice; Mice, Inbred C57BL; Oxepins; Protein Transport

2016