oxazoles has been researched along with Disease Models, Animal in 160 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (10.00) | 18.7374 |
| 1990's | 13 (8.13) | 18.2507 |
| 2000's | 28 (17.50) | 29.6817 |
| 2010's | 92 (57.50) | 24.3611 |
| 2020's | 11 (6.88) | 2.80 |
| Authors | Studies |
|---|---|
| Carr, W; Converse, PJ; Dartois, V; Dooley, KE; Garcia, A; Kurbatova, E; Nuermberger, EL; Stout, JE; Tasneen, R; Vernon, AA; Zimmerman, MD | 1 |
| Amato, CM; Bereman, M; Fricke, A; Marella, S; McCoy, KA; Mogus, JP | 1 |
| Beohar, M; Ganeshpurkar, A; Gutti, G; Kakarla, R; Krishnamurthy, S; Kumar, A; Kumar, D; Singh, SK | 1 |
| Liu, S; Pan, J; Ye, Q; Zhang, J | 1 |
| Atkinson, JB; Carrier, EJ; Galindo, CL; Kim, K; Knollmann, BC; Macias-Perez, I; Markham, LW; Pavliv, L; Shin, JJ; Soslow, JH; West, JD | 1 |
| Qi, JS; Wang, CF; Wang, ZJ; Wu, MN; Xiao, Y; Yang, W; Zhang, J; Zhang, XM; Zhao, F; Zhou, F | 1 |
| Aoyama, K; Erion, DM; Kaneko, M; Matsumoto, M; Nakamura, S; Nambu, T; Nishida, M; Ogino, H; Wang, X; Yashiro, H | 1 |
| Huang, Y; Li, JX; Liu, J; Wang, K; Wu, R; Zhang, Y | 1 |
| Cardoso Santos, C; Inam Ullah, A; Meuser Batista, M; Rama Krishna Reddy, T; Soeiro, MNC | 1 |
| Galabov, AS; Stoyanova, A | 1 |
| Cai, D; Guo, F; Holm, L; Li, Y; Liu, HY; Zhang, K; Zhou, B | 1 |
| Dismuke, T; Gershon, TR; Hwang, D; Kabanov, AV; Kagel, JR; Lim, C; Ramsey, JD; Rosen, EP; Sokolsky-Papkov PhD, M; Tikunov, A; Zamboni, W | 1 |
| Bax, HI; de Steenwinkel, JEM; Keutzer, L; Pieterman, ED; Simonsson, USH; van den Berg, S; van der Meijden, A; Wang, H; Zimmerman, MD | 1 |
| Ardizzone, A; Campolo, M; Casili, G; Cuzzocrea, S; Esposito, E; Filippone, A; Lanza, M; Mare, M; Memeo, L; Paterniti, I; Puglisi, C; Scuderi, SA | 1 |
| Kaji, C; Kikuchi, C; Kubota-Ishida, N; Matsuhira, T; Tabata, Y | 1 |
| Asai, N; Hagihara, M; Kato, H; Koizumi, Y; Matsuura, K; Mikamo, H; Nishiyama, N; Sakanashi, D; Suematsu, H; Yamagishi, Y | 1 |
| Chen, X; Ge, Y; He, X; Lei, W; Ma, Y; Mou, X; Ru, G; Wang, S; Wang, Y; Wei, B | 1 |
| Anderson, RF; Blaser, A; Chatelain, E; Denny, WA; Franzblau, SG; Launay, D; Ma, Z; Maes, L; Palmer, BD; Shinde, SS; Thompson, AM; Wan, B; Wang, Y | 1 |
| Ochani, M; Sharma, A; Wang, P; Yang, WL | 1 |
| Chen, Y; Fillmore, N; Gao, S; Harrington, J; Liu, P; Murphy, E; Springer, D; Stoehr, A; Wang, X; Yang, Y; Zhang, X; Zhu, J | 1 |
| Cho, SJ; Miranda, CJ; N'Gouemo, P; Vaca, MA | 1 |
| Johnson, BN; Li, JX; Siemian, JN; Xue, Z; Zhang, Y | 1 |
| Ha, H; Jin, WJ; Kim, B; Kim, HH; Lee, JH; Lee, ZH | 1 |
| Chen, X; Ji, M; Jin, J; Lai, F; Wang, Y; Xue, N; Zhang, S; Zhang, X | 1 |
| Cordaro, M; Crupi, R; Cuzzocrea, S; D'Amico, R; Di Paola, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Siracusa, R | 1 |
| Besra, G; Blumberg, RS; Collin, F; de Silva, PSA; Gandhi, A; Gensollen, T; Glickman, J; Hauser, R; Iyer, SS; Lavin, R; Llebaria, A; Maxwell, A; Neves, JF; Oh, SF; Sartor, RB; Serra, C | 1 |
| Qi, X; Wang, L; Xu, H; Zhang, Z | 1 |
| Antoni, FA; Gacsályi, I; Gigler, G; Machado, P; Megyeri, K; Móricz, K | 1 |
| Dong, T; Fukunaga, K; Ibata, T; Imachi, H; Iwama, H; Kobayashi, T; Lyu, J; Murao, K; Sato, S; Yonezaki, K; Yoshimoto, T; Zhang, G | 1 |
| Asta, J; Azam, MA; Bokhari, MM; Kichigina, G; Labos, C; Lai, PFH; Massé, S; Nanthakumar, K; Porta-Sánchez, A; Si, D; Sun, H; Yang, P; Zamiri, N | 1 |
| Cordaro, M; Crupi, R; Cuzzocrea, S; D'amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Siracusa, R | 1 |
| Campos, C; Contreras-Ferrat, A; Diaz-Vegas, A; Jaimovich, E; Lavandero, S; Marchi, S; Morales, C; Pinton, P; Utreras-Mendoza, Y; Valladares, D; Westermeier, F | 1 |
| Bespalov, AY; Dolgorukova, A; Dorotenko, A; Gainetdinov, RR; Hoener, MC; Sukhanov, I | 1 |
| Feng, HP; Flanagan, S; Flattery, A; Gill, C; Liang, L; Liu, J; Tan, C; Wu, J; Xiao, J | 1 |
| Just, S; Köhler, D; Pott, A; Pylatiuk, C; Rottbauer, W; Shahid, M; Weinmann, K | 1 |
| Jiao, S; Li, Q; Pan, M; Qu, J; Reinach, PS; Srinivasalu, N; Yan, J; Yang, Y; Zhou, X | 1 |
| Cordaro, M; Crupi, R; Cuzzocrea, S; D'Amico, R; Di Paola, R; Evangelista, M; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Petrosino, S; Siracusa, R | 1 |
| Aplin, AE; Chervoneva, I; Erkes, DA; Nikbakht, N; Tiago, M | 1 |
| Jiang, Y; Liu, R; Men, H; Shao, W; Shu, S; Zhang, W | 1 |
| Ambhore, NS; Kalidhindi, RSR; Loganathan, J; Sathish, V | 1 |
| Boujon, V; Endres, M; Gertz, K; Kronenberg, G; Laufs, U; Uhlemann, R; Wegner, S; Wright, MB | 1 |
| Baccelli, I; Bertomeu, T; Blouin-Chagnon, V; Boivin, I; Bordeleau, ME; Boucher, G; Corneau, S; Coulombe-Huntington, J; Frechette, M; Gareau, Y; Gingras, S; Girard, S; Hébert, J; Kanshin, E; Krosl, J; Lavallée, VP; Lehnertz, B; Lemieux, S; Leveillé, K; MacRae, T; Marinier, A; Mayotte, N; Roux, PP; Sauvageau, G; Spinella, JF; St-Denis, C; Thibault, P; Thiollier, C; Tyers, M | 1 |
| Choi, JY; Gi, M; Han, G; Jeon, DK; Jo, S; Kim, B; Lee, H; Lee, HJ; Namkung, W; Park, J; Seo, Y; Song, D | 1 |
| Cornet, M; De Ron, P; Dedoncker, P; Delaunois, A; Depelchin, BO; Guyaux, M; Hanon, E; Jnoff, E; Rosseels, ML | 1 |
| Dirksen, RT; Protasi, F; Yarotskyy, V | 1 |
| Dhandapani, KM; Fessler, RD; Kimbler, DE; Laird, MD; Shakir, B; Shields, JS; Sukumari-Ramesh, S; Vender, JR; Yanasak, N; Youssef, P | 1 |
| Drusano, GL; Lodise, TP | 1 |
| Das, D; Fang, E; Mehra, P; Prokocimer, P; Tulkens, PM | 1 |
| Böhm, M; Gensch, C; Laufs, U; Pavlickova, V; Pöss, J; Schirmer, SH; Werner, CM; Wright, MB | 1 |
| Amaro, C; Hor, LI; Lee, CT; Lemos, ML; Pajuelo, D; Roig, FJ | 1 |
| Fagone, P; Kim, JJ; Magro, G; Mangano, K; Meroni, PL; Muthumani, K; Nicoletti, F; Sardesai, NY; Weiner, DB | 1 |
| Fukui, M; Hinoi, E; Ito, Y; Kitao, T; Kubo, M; Shirahase, H; Yoneda, Y | 1 |
| Bergès, R; Brouland, JP; Canivenc-Lavier, MC; Perrot-Applanat, M; Phrakonkham, P; Pimpie, C; Pocard, M; Saad, Hel S | 1 |
| Cho, S; Franzblau, SG; Kim, Y; Lu, Y; Ma, Z; Mdluli, K; Upton, AM; Wang, B; Wang, Y; Xu, J; Yang, TJ | 1 |
| Amoabeng, O; Mdluli, KE; Minkowski, A; Nuermberger, EL; Tasneen, R; Upton, AM; Williams, K | 1 |
| Aghaei, HN; Dehpour, AR; Ebrahimi, A; Gholizadeh, R; Gooshe, M; Mousavizadeh, K; Payandemehr, B; Rahimian, R; Varastehmoradi, B | 1 |
| Chen, S; Huang, J; Huang, Q; Liu, B; Liu, P; Luo, J; Pan, X; Zang, L; Zeng, Z; Zhou, S | 1 |
| Kalia, NP; Khan, IA; Kumar, S; Munagala, G; Rajput, VS; Sawant, SD; Sharma, S; Singh, PP; Singh, S; Vishwakarma, RA; Yempalla, KR | 1 |
| Han, JW; Jang, CH; Ji, YE; Kang, TB; Koppula, S; Lee, KH; Shim, DW; Shin, HJ | 1 |
| Blaser, A; Denny, WA; Franzblau, SG; Kmentova, I; Ma, Z; Palmer, BD; Sutherland, HS; Thompson, AM; Wan, B; Wang, Y | 1 |
| Han, JW; Kang, TB; Kim, TJ; Lee, KH; Shim, DW; Shim, EJ; Shin, HJ; Shin, WY; Sun, X | 1 |
| Arnold, B; Bald, T; Bestvater, F; Gaffal, E; Hämmerling, GJ; Klotz, L; Ludwig, J; Meister, M; Moldenhauer, G; Oelert, T; Papatriantafyllou, M; Pougialis, G; Tounsi, A; Tüting, T | 1 |
| Chaki, S; Hikichi, H; Hiyoshi, T; Iida, I; Kaku, A; Karasawa, J; Marumo, T; Tamita, T; Tomishima, Y; Urabe, H; Yasuhara, A | 1 |
| Baram, SM; Dehpour, AR; Rahimian, R; Rahmatollahi, M; Saeedi Saravi, SS | 1 |
| Galabov, AS; Nikolova, I; Stoyanova, A | 1 |
| Geng, L; Guo, F; Li, Y; Ye, D; Zhang, Q; Zhang, X; Zhang, Z | 1 |
| Nandicoori, VK; Samla, G; Singh, A; Soni, V; Sriram, D; Suryadevara, P; Upadhayay, S; Yogeeswari, P | 1 |
| Betoudji, F; Converse, PJ; Dartois, V; Li, SY; Mdluli, KE; Mendel, CM; Nuermberger, EL; Tasneen, R; Tyagi, S; Williams, K; Yang, T | 1 |
| Jiang, Q; Li, X; Yang, T; Yang, Y; Zhang, H | 1 |
| Balu, DT; Bolshakov, VY; Conn, PJ; Coyle, JT; Jones, CK; Li, Y; Lindsley, CW; Presti, KT; Ramikie, TS; Rook, JM; Takagi, S | 1 |
| Alfonsi, D; Bruschetta, G; Cordaro, M; Crupi, R; Cuzzocrea, S; Impellizzeri, D; Marcolongo, G; Pascali, J | 1 |
| Auer, JL; Fairlamb, AH; Norval, S; Osuna-Cabello, M; Patterson, S; Read, KD; Simeons, FR; Stojanovski, L; Wyllie, S | 1 |
| Hasegawa, H; Izumikawa, K; Kaku, N; Kosai, K; Miyazaki, T; Morinaga, Y; Mukae, H; Takeda, K; Uno, N; Yanagihara, K | 1 |
| Abbadi, BL; Basso, LA; Campos, MM; de Souza, MV; Gonçalves, RS; González-Martín, J; López-Gavín, A; Rodrigues-Junior, VS; Santos, DS; Trindade, RV; Tudó, G; Villela, AD | 1 |
| Esmaeilkhani, H; Nazarian, S; Rasooli, I; Sefid, F | 1 |
| Amato, CM; McCoy, KA | 1 |
| Greenwood-Quaintance, KE; Mandrekar, J; Park, KH; Patel, R | 1 |
| Cruz, HG; Dingemanse, J; Groenen, PM; Krause, A; Lott, D; Stalder, AK; Strasser, DS | 1 |
| Kim, J; Lee, H; Lim, J; Shin, SS; Yang, H; Yoon, M; Yoon, S | 1 |
| Black, SW; Chen, TM; Hoener, MC; Kilduff, TS; Schwartz, MD | 1 |
| Bogdán, D; Borbély, É; Botz, B; Csepregi, JZ; Helyes, Z; Horváth, Á; Juhász, T; Keeble, J; Kemény, Á; Mátyus, P; Menghis, A; Mócsai, A; Pintér, E; Tékus, V; Zákány, R | 1 |
| Araldi, D; Ferrari, LF; Khomula, EV; Levine, JD | 1 |
| Bagdas, D; Carroll, FI; Damaj, MI; Greenwald, M; Jackson, A; Lichtman, AH; Miles, MF; Muldoon, PP | 1 |
| Arora, P; Barman, TK; Bhadauriya, T; Rao, M; Upadhyay, DJ | 1 |
| Fukumoto, Y; Ito, K; Nawata, J; Onoue, N; Shimokawa, H; Sugimura, K; Tada, T; Wang, H; Zhulanqiqige, D | 1 |
| Chapman, V; Kendall, DA; Sagar, DR | 1 |
| Bendtzen, K; Cuzzocrea, S; Kim, JJ; Mangano, K; Mazzon, E; Meroni, PL; Nicoletti, F; Quattrocchi, C; Sardesai, NY | 1 |
| Al-Khrasani, M; Gyires, K; Mátyus, P; Mózes, MM; Pap, B; Shujaa, N; Zádori, ZS | 1 |
| Bousquet, P; Lessa, MA; Nascimento, AR; Sabino, B; Tibiriçá, E | 1 |
| Chang, M; Franzblau, SG; Miller, MJ; Möllmann, U; Moraski, GC; Villegas-Estrada, A | 1 |
| Christaki, E; Harris, HA; Keith, JC; Kessinian, N; Lavallie, E; Malamas, MS; Mewshaw, RE; Mounts, W; Opal, SM; Palardy, JE; Parejo, NA; Racie, L; Vlasuk, GP | 1 |
| Choi, SH; Espinoza-Gonzalez, NA; Lozano-Garza, G; Ocampo-Candiani, J; Said-Fernandez, S; Vera-Cabrera, L; Welsh, O | 1 |
| Feng, J; Fu, Z; Li, Y; Luo, J; Tian, Q; Wang, Q; Yang, X; Yang, Y; Zhang, Q | 1 |
| Ham, SW; Li, M; Lim, DH; Lim, KM; Seo, JA | 1 |
| Harvala, H; Pajkrt, D; Wildenbeest, JG; Wolthers, KC | 1 |
| Bénardeau, A; Hansen, BC; Meyer, M; Mizrahi, J; Sebokova, E; Tigno, XT | 1 |
| Ahn, DS; Cho, YE; Lee, YH; Morgan, KG | 1 |
| Han, SH; Kim, HS; Lee, GH; Lee, S; Moon, EY; Oh, JM; Yang, Y; Yi, KY; Yoon, WK | 1 |
| Azuma, YT; Morioka, A; Nakajima, H; Nishiyama, K; Takeuchi, T | 1 |
| Abdul-Ghani, AA; Dashwood, RH; Eklof, B; Hasaniya, NW; McNamara, JJ; Premaratne, S; Razzuk, A; Tinsley, L; Zhang, WW | 1 |
| Ahmad, M; Bolin, D; Chen, Y; Conde-Knape, K; Gillespie, P; Kazmer, S; Li, S; Qian, Y; Taub, R; Wertheimer, SJ; Whittard, T; Yun, W | 1 |
| Actis, LA; Arivett, BA; Gaddy, JA; López-Rojas, R; McConnell, MJ; Pachón, J | 1 |
| Cao, Q; Deng, Y; Ding, C; Feng, D; Gu, B; Hu, W; Wang, J; Xie, F; Yao, K; Zhang, C; Zhang, G; Zhou, F | 1 |
| Bradaia, A; Bruns, A; Buchy, D; Chaboz, S; Galley, G; Groebke Zbinden, K; Hoener, MC; Kilduff, TS; Metzler, V; Morairty, SR; Moreau, JL; Mory, R; Norcross, RD; Pouzet, B; Revel, FG; Risterucci, C; Tuerck, D; Wallace, TL; Wettstein, JG | 1 |
| Chen, MF; Cheng, JT; Chou, MT; Chung, HH; Yang, TT | 1 |
| Cao, DY; Ji, Y; Tang, B; Traub, RJ | 1 |
| Andes, DR; Craig, WA; Lepak, AJ; Marchillo, K; Pichereau, S | 1 |
| Gyires, K; Mátyus, P; Mérey, A; Szökő, E; Tábi, T; Tóth, V | 1 |
| Amat, M; Banoglu, E; Caturla, JF; Kupeli, E; Okçelik, B; Sahin, MF; Unlü, S; Yeşilada, E | 1 |
| Albert, LM; Frail, DE; Harris, HA; Henderson, RA; Keith, JC; Kharode, YP; Komm, BS; Leathurby, Y; Malamas, MS; Marzolf, J; Mewshaw, RE; Miller, CP; Winneker, RC; Zhu, Y | 1 |
| Amano, H; Hayashi, I; Inukai, M; Kamata, M; Kitasato, H; Majima, M; Yoshida, S; Yoshimura, H | 1 |
| Gulcan, HO; Kupeli, E; Sahin, MF; Unlu, S; Yesilada, E | 1 |
| Arthur, S; Barrish, J; Baska, RA; Baumann, J; Beyer, S; Bird, E; Carlson, K; Dickinson, K; Fadnis, L; Ferrer, P; Giancarli, M; Gu, Z; Kane, B; Kowala, MC; Macor, JE; Monshizadegan, H; Murugesan, N; Panchal, B; Perrone, M; Ryan, C; Tellew, J; Trippodo, N; Yang, Y; Zhang, D | 1 |
| Ernsberger, P; Koletsky, RJ; Velliquette, RA | 1 |
| Blum, E; Buhl, T; Di Padova, FE; Feifel, R; Gram, H; Hiestand, P; Manning, U; Revesz, L; Rucklin, G | 1 |
| Aubin, N; Barneoud, P; Burnier, P; Caille, D; Carter, C; Charieras, T; Curet, O; Gardes, A; George, P; Jegham, S; Le Kim, A; Lolivier, J; Marc, C; Pandini, M; Perron, C; Puech, F; Scatton, B; Sontag, N | 1 |
| Hashiguchi, S; Iizawa, Y; Ishikawa, T; Miyake, A; Nagai, J; Nakao, M; Okonogi, K | 1 |
| Bruner-Tran, KL; Harris, HA; Lyttle, CR; Osteen, KG; Zhang, X | 1 |
| Adrogue, JV; Brown, KK; Burgmaier, M; Golfman, LS; Guthrie, PH; Sharma, S; Taegtmeyer, H; Van Arsdall, M; Wilson, CR; Young, ME | 1 |
| Dakshinamurti, S; Gutsol, A; Halayko, AJ; Hinton, M; Mellow, L | 1 |
| Ernsberger, P; Kossover, R; Previs, SF; Velliquette, RA | 1 |
| Esumi, H; Ikeda, D; Kawada, M; Kunimoto, S; Masuda, T; Ohba, S; Osono, M | 1 |
| Fisher, CF; Leimbach, A; Mey, AR; Payne, SM; Wyckoff, EE | 1 |
| Bousquet, PP; Monassier, LJ; Signolet, IL | 1 |
| Cavazos-Rocha, N; Choi, SH; de Torres, NW; Espinoza-González, NA; Lozano-Garza, G; Ocampo-Candiani, J; Said-Fernandez, S; Vera-Cabrera, L; Welsh, O | 1 |
| Moseley, RH | 1 |
| Aoki, T; Asaki, T; Hamamoto, T; Kuwabara, K; Murakami, K; Ohmachi, S; Sugiyama, Y; Todo, M | 1 |
| Day, M; Dwyer, JM; Hughes, ZA; Liu, F; Platt, BJ; Pulicicchio, CM; Rosenzweig-Lipson, S; Schechter, LE; Zhang, G | 1 |
| Bennett, DA; Brugger, S; Dutta, P; Fielding, S; Geyer, H; Lal, H | 1 |
| Breddin, HK; Pauliks, V; Weichert, W | 1 |
| Heran, CL; Ogletree, ML; Schumacher, WA; Steinbacher, TE; Youssef, S | 1 |
| Grover, GJ; Ogletree, ML; Schumacher, WA | 1 |
| Blank, M; Shoenfeld, Y | 1 |
| Buchanan, JO; Fleming, JS; Gamberdella, M; Meanwell, NA; Schumacher, WA; Seiler, SM; Zavoico, GB | 1 |
| Dabire, H; Levy, BI; Poitevin, P; Safar, ME | 1 |
| Durham, SK; Megill, JR; Schumacher, WA; Steinbacher, TE | 1 |
| Berthault, MF; Dubar, M; Ferré, P; Ktorza, A; Morin, J; Pénicaud, L | 1 |
| Asai, H; Endo, T; Iwata, H; Katayama, T; Kato, M; Narita, H | 1 |
| Griebel, G; Perrault, G; Sanger, DJ | 1 |
| Masaki, M; Matsushita, M; Tanaka, T; Wakitani, K; Yagi, Y | 1 |
| Cambridge, D; MacLennan, SJ; Marston, C; Martin, GR; Whiting, MV | 1 |
| Hatano, K; Ishihara, S; Kitayama, J; Muto, T; Nagawa, H; Nita, ME; Osada, T; Shibata, Y; Sunami, E; Tomozawa, S; Tsuno, N; Tsuruo, T; Yano, H | 1 |
| Albut, R; Figueira, M; Pelton, SI; Stalker, D | 1 |
| Aragoncillo, P; Cachofeiro, V; Cediel, E; de Las Heras, N; Díaz, C; Hernández, G; Lahera, V; Navarro-Cid, J; Ruilope, LM; Sanz-Rosa, D; Vázquez-Pérez, S | 1 |
| Akimitsu, N; Kaito, C; Sekimizu, K; Watanabe, H | 1 |
| Béládi, I; Dzeguse, D; Indulen, MK; Mécs, I; Veckenstedt, A; Zgórniak-Nowosielska, I | 1 |
| Kobayakawa, T; Osuga, K; Yasuda, H | 1 |
| Bogden, AE; Houchens, DP; Johnson, RK; Neil, GL; Ovejera, AA; Sheridan, MA | 1 |
| Dulaney, EL; Frost, BM; Valiant, ME | 1 |
| Schneider, GB | 1 |
| Buzsaki, G; Gage, FH; Mandel, RJ; Terry, RD; Thal, LJ | 1 |
| Guidinger, PL; Jubelt, B; McKinlay, MA; Ropka, SL; Wilson, AK | 1 |
| Callens-el Amrani, F; Paolaggi, F; Swynghedauw, B | 1 |
| Daly, JS; Eliopoulos, GM; Moellering, RC; Willey, S | 1 |
| Allen, SD; Kinsolving, CR; Mullen, GB; Ordy, JM; Palmer, GC; Simmons, RD; St Georgiev, V; Strand, JC | 1 |
| Goldman, AS | 2 |
| Stepanek, J | 1 |
| Parkinson, TM; Schultz, JR; Schurr, PE | 1 |
| Blickens, DA; Riggi, SJ | 1 |
4 review(s) available for oxazoles and Disease Models, Animal
| Article | Year |
|---|---|
Use of pharmacokinetic/pharmacodynamic systems analyses to inform dose selection of tedizolid phosphate.
Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Disease Models, Animal; Humans; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Pneumonia, Staphylococcal; Staphylococcal Skin Infections; Staphylococcus aureus | 2014 |
Tedizolid phosphate for the management of acute bacterial skin and skin structure infections: safety summary.
Topics: Animals; Anti-Bacterial Agents; Clinical Trials as Topic; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Humans; Organophosphates; Oxazoles; Staphylococcal Skin Infections | 2014 |
The need for treatment against human parechoviruses: how, why and when?
Topics: Animals; Antiviral Agents; Central Nervous System Infections; Disease Models, Animal; Humans; Infant, Newborn; Oxadiazoles; Oxazoles; Parechovirus; Picornaviridae Infections; Sepsis | 2010 |
Inhibition of 3 -hydroxy- 5 -steroid dehydrogenase.
Topics: Adrenal Hyperplasia, Congenital; Androstenes; Animals; Antibodies; Cell Differentiation; Dehydroepiandrosterone; Disease Models, Animal; Female; Genitalia, Female; Genitalia, Male; Humans; Hydroxysteroid Dehydrogenases; Hydroxysteroids; Male; Mammary Glands, Animal; Nitriles; Oxazoles; Pregnancy; Progesterone; Rats; Testosterone; Wolffian Ducts | 1971 |
1 trial(s) available for oxazoles and Disease Models, Animal
| Article | Year |
|---|---|
Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949.
Topics: Adolescent; Adult; Animals; Biomarkers; Cell Migration Assays; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Inflammation; Lipopolysaccharides; Male; Middle Aged; Neutrophils; Oxazoles; Receptors, Formyl Peptide; Receptors, Lipoxin; Triazoles; Young Adult | 2017 |
155 other study(ies) available for oxazoles and Disease Models, Animal
| Article | Year |
|---|---|
Novel Regimens of Bedaquiline-Pyrazinamide Combined with Moxifloxacin, Rifabutin, Delamanid and/or OPC-167832 in Murine Tuberculosis Models.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Diarylquinolines; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Isoniazid; Mice; Mice, Inbred BALB C; Moxifloxacin; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Pyrazinamide; Rifabutin; Tuberculosis | 2022 |
An experimental evaluation of the efficacy of perinatal sulforaphane supplementation to decrease the incidence and severity of vinclozolin-induced hypospadias in the mouse model.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Environmental Pollutants; Female; Humans; Hypospadias; Incidence; Isothiocyanates; Male; Mice; NF-E2-Related Factor 2; Oxazoles; Pregnancy; Sulfoxides | 2022 |
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amnesia; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Eels; Female; Horses; Humans; Ligands; Male; Mice; Molecular Structure; Neuroprotective Agents; Oxazoles; Rats; Rats, Wistar; Scopolamine; Structure-Activity Relationship | 2019 |
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Liver Neoplasms; Male; Melanoma; Mice; Oncogene Addiction; Oxazoles; Signal Transduction; Thiazoles; Transcription Factors; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2019 |
Antagonism of the Thromboxane-Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cardiomyopathies; Disease Models, Animal; Female; Male; Mice; Mice, Inbred mdx; Mice, Knockout; Muscular Dystrophy, Duchenne; Oxazoles; Prostaglandin Antagonists; Random Allocation; Receptors, Thromboxane | 2019 |
Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Cognition; Disease Models, Animal; Hippocampus; Macrocyclic Compounds; Male; Maze Learning; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Nootropic Agents; Oxazoles; Plaque, Amyloid | 2019 |
Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.
Topics: Acetyl-CoA Carboxylase; Animals; Disease Models, Animal; Enzyme Inhibitors; Gene Knockout Techniques; Isobutyrates; Liver; Liver Cirrhosis; Mice; Non-alcoholic Fatty Liver Disease; Organ Size; Oxazoles; Pyrimidines; Receptor, Melanocortin, Type 4; Triglycerides | 2020 |
Effects of a trace amine-associated receptor 1 agonist RO 5263397 on ethanol-induced behavioral sensitization.
Topics: Alcoholism; Animals; Behavior, Animal; Central Nervous System Depressants; Central Nervous System Sensitization; Disease Models, Animal; Ethanol; Female; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxazoles; Receptors, G-Protein-Coupled | 2020 |
Drug screening using shape-based virtual screening and
Topics: Animals; Antiprotozoal Agents; Benzimidazoles; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; In Vitro Techniques; Inhibitory Concentration 50; Leishmania; Leishmaniasis, Cutaneous; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Oxazoles; Pentamidine; Pyridones | 2021 |
Effect of Consecutive Alternating Administration of a Triple Combination of Anti-Enteroviral Compounds in Mice Infected with Coxsackievirus B3.
Topics: Animals; Antiviral Agents; Apomorphine; Cell Line; Coxsackievirus Infections; Disease Models, Animal; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Enterovirus B, Human; Humans; Mice; Nitriles; Oxadiazoles; Oxazoles; Virus Replication | 2020 |
Co-option of PPARα in the regulation of lipogenesis and fatty acid oxidation in CLA-induced hepatic steatosis.
Topics: Acetyl-CoA Carboxylase; Acyl-CoA Dehydrogenase; Animals; Cells, Cultured; Disease Models, Animal; Fatty Acids; Gene Expression Regulation, Enzymologic; Hepatocytes; Histones; Insulin Resistance; Linoleic Acids, Conjugated; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxazoles; Oxidation-Reduction; PPAR alpha; Signal Transduction; Transcriptional Activation; Tyrosine | 2021 |
Poly(2-oxazoline) nanoparticle delivery enhances the therapeutic potential of vismodegib for medulloblastoma by improving CNS pharmacokinetics and reducing systemic toxicity.
Topics: Anilides; Animals; Biological Availability; Central Nervous System; Cerebellar Neoplasms; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Medulloblastoma; Mice; Micelles; Nanoparticles; Oxazoles; Particle Size; Protein Binding; Pyridines; Serum Albumin | 2021 |
Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model.
Topics: Animals; Antitubercular Agents; Diarylquinolines; Disease Models, Animal; Drug Therapy, Combination; Linezolid; Mice; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Pyrazinamide; Recurrence; Tuberculosis | 2021 |
PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis.
Topics: Animals; Disease Models, Animal; Ganglia, Spinal; Humans; Mice; Neoplasms; NF-E2-Related Factor 2; NF-kappa B; Oxaliplatin; Oxazoles; Pain; Peripheral Nervous System Diseases; Rats; Signal Transduction | 2021 |
Anti-inflammatory effects of a novel phosphodiesterase-4 inhibitor, AA6216, in mouse dermatitis models.
Topics: Animals; Anti-Inflammatory Agents; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dermatitis, Atopic; Dermatophagoides farinae; Disease Models, Animal; Female; Humans; Leukocytes, Mononuclear; Mice; Oxazoles; Oxazolone; Phosphodiesterase 4 Inhibitors; Piperazines; Severity of Illness Index; Skin; Thiazoles | 2021 |
Efficacy of tedizolid against methicillin-resistant Staphylococcus aureus and Peptostreptococcus anaerobius in thigh mixed-infection mouse model.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Female; Gram-Positive Bacterial Infections; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Peptostreptococcus; Staphylococcal Infections; Thigh | 2017 |
Synergistic antitumor effects of CDK inhibitor SNS‑032 and an oncolytic adenovirus co‑expressing TRAIL and Smac in pancreatic cancer.
Topics: Adenoviridae; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Gene Expression; Genetic Therapy; Genetic Vectors; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mitochondrial Proteins; Oncolytic Virotherapy; Oncolytic Viruses; Oxazoles; Pancreatic Neoplasms; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2017 |
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.
Topics: Animals; Antitubercular Agents; Chagas Disease; Disease Models, Animal; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Structure-Activity Relationship; Thiazoles; Tuberculosis | 2017 |
Mitigation of sepsis-induced inflammatory responses and organ injury through targeting Wnt/β-catenin signaling.
Topics: Animals; Apoptosis; Cytokines; Disease Models, Animal; Inflammation; Inflammation Mediators; Lipopolysaccharides; Lung; Macrophage Activation; Macrophages; Mice; Neutrophil Infiltration; Oxazoles; RAW 264.7 Cells; Sepsis; Wnt Signaling Pathway | 2017 |
A Systems Biology Approach to Investigating Sex Differences in Cardiac Hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Female; Gene Expression Regulation; Gene Regulatory Networks; Male; Mice, Inbred C57BL; MicroRNAs; Myocardium; Oxazoles; PPAR alpha; Protein Interaction Maps; RNA, Messenger; Sex Characteristics; Sex Factors; Signal Transduction; Systems Biology; Time Factors; Tyrosine | 2017 |
Inhibition of transient potential receptor vanilloid type 1 suppresses seizure susceptibility in the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anticonvulsants; Benzoates; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Kindling, Neurologic; Male; Oxazoles; Rats; Rats, Mutant Strains; Sex Factors; Time Factors; TRPV Cation Channels | 2018 |
Methamphetamine-induced impulsivity during chronic methamphetamine treatment in rats: Effects of the TAAR 1 agonist RO5263397.
Topics: Animals; Central Nervous System Stimulants; Choice Behavior; Disease Models, Animal; Dose-Response Relationship, Drug; Impulsive Behavior; Locomotion; Male; Methamphetamine; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Substance-Related Disorders; Time Factors | 2018 |
JN-2, a C-X-C motif chemokine receptor 3 antagonist, ameliorates arthritis progression in an animal model.
Topics: Animals; Arthritis, Rheumatoid; Cell Movement; Chemokine CXCL10; Chemokines, CXC; Cytokines; Disease Models, Animal; Disease Progression; Male; Mice; Oxazoles; Transcription Factor RelA | 2018 |
Validating a Selective S1P
Topics: Administration, Oral; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fingolimod Hydrochloride; Guinea Pigs; Mice; Mitotic Index; Mucous Membrane; Oxazoles; Propanolamines; Psoriasis; Random Allocation; Receptors, Lysosphingolipid; Reproducibility of Results; Skin; Specific Pathogen-Free Organisms; Sphingosine-1-Phosphate Receptors; Vagina | 2018 |
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; Astrocytes; Behavior, Animal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; DNA Damage; Dopamine Plasma Membrane Transport Proteins; Inflammation; Mice, Inbred C57BL; Microglia; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nitrosative Stress; Oxazoles; Oxidative Stress; Parkinson Disease; Poly Adenosine Diphosphate Ribose; Transcription Factor RelA; Tyrosine; Tyrosine 3-Monooxygenase | 2018 |
Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses.
Topics: Animals; Antigens, CD1d; Colitis; Diet; Disease Models, Animal; Epithelial Cells; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-10; Intestines; Mice; Mice, Inbred C57BL; Mice, Knockout; Natural Killer T-Cells; Oxazoles; Receptors, Aryl Hydrocarbon; RNA Interference; RNA, Small Interfering; Signal Transduction; Tryptophan | 2018 |
Comparison of Therapeutic Effects of TREK1 Blockers and Fluoxetine on Chronic Unpredicted Mild Stress Sensitive Rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Apoptosis; Behavior, Animal; Bridged Bicyclo Compounds; Cell Proliferation; Dentate Gyrus; Depression; Disease Models, Animal; Fluoxetine; Neurogenesis; Oxazoles; Peptides; Potassium Channels, Tandem Pore Domain; Rats; Stress, Psychological | 2018 |
Persistent therapeutic effect of a novel α5-GABA
Topics: Animals; Benzodiazepines; Cognition; Dementia, Vascular; Disease Models, Animal; GABA-A Receptor Antagonists; Male; Mice; Oxazoles; Rats; Receptors, GABA-A; Recognition, Psychology | 2018 |
Selective peroxisome proliferator-activated receptor-α modulator K-877 regulates the expression of ATP-binding cassette transporter A1 in pancreatic beta cells.
Topics: Animals; ATP Binding Cassette Transporter 1; Benzoxazoles; Butyrates; Cell Line, Tumor; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Glucose; Glucose Intolerance; Humans; Hypolipidemic Agents; Insulin; Insulin-Secreting Cells; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Rats; RNA, Messenger; Tyrosine | 2018 |
Essential role of ryanodine receptor 2 phosphorylation in the effect of azumolene on ventricular arrhythmia vulnerability in a rabbit heart model.
Topics: Animals; Disease Models, Animal; Imidazoles; Isolated Heart Preparation; Male; Oxazoles; Phosphorylation; Rabbits; Ryanodine Receptor Calcium Release Channel; Treatment Outcome; Ventricular Fibrillation | 2018 |
Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Carboxymethylcellulose Sodium; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; I-kappa B Proteins; Male; Mast Cells; Mice; Nerve Growth Factor; Neuralgia; Neuroglia; Oxazoles; Pain Threshold; Psychomotor Performance; Recovery of Function; Sciatic Neuropathy; Tubulin | 2018 |
IP
Topics: Animals; Autophagy; Calcium; Disease Models, Animal; Down-Regulation; Gene Knockdown Techniques; Humans; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred mdx; Mitochondria; Mitochondrial Dynamics; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Oxazoles; RNA, Small Interfering | 2018 |
Activation of trace amine-associated receptor 1 attenuates schedule-induced polydipsia in rats.
Topics: Animals; Appetitive Behavior; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Feeding Behavior; Male; Motor Activity; Neurotransmitter Agents; Oxazoles; Polydipsia; Rats, Wistar; Receptors, G-Protein-Coupled; Time Factors | 2019 |
Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Neutropenia; Organophosphates; Oxazoles; Staphylococcal Skin Infections | 2019 |
Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish.
Topics: Animals; Apoptosis; Cardiomyopathies; Disease Models, Animal; Enzyme Inhibitors; Humans; Marine Toxins; Myocardial Contraction; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Zebrafish; Zebrafish Proteins | 2018 |
Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.
Topics: Animals; Apolipoprotein A-II; Bezafibrate; Biometry; Blotting, Western; Butyrates; Clofibrate; Collagen Type I; Disease Models, Animal; Electroretinography; Fluorescent Antibody Technique, Indirect; Guinea Pigs; Intraocular Pressure; Malate Dehydrogenase; Myopia; Oxazoles; Phenylurea Compounds; PPAR alpha; Refraction, Ocular; Sensory Deprivation; Tyrosine | 2018 |
N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents; Apoptosis; Carotid Stenosis; Dementia, Vascular; Disease Models, Animal; Inflammation; Male; Mice; Neuroprotective Agents; Oxazoles; Oxidative Stress | 2019 |
BET Inhibition Modifies Melanoma Infiltrating T Cells and Enhances Response to PD-L1 Blockade.
Topics: Animals; Antineoplastic Agents, Immunological; CD8-Positive T-Lymphocytes; Cell Growth Processes; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Forkhead Transcription Factors; Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Melanoma; Mice; Nerve Tissue Proteins; Oxazoles; Programmed Cell Death 1 Receptor; Pyridines; Pyrroles; Receptors, Cell Surface; Skin Neoplasms; T-Lymphocytes, Regulatory; Tumor Burden | 2019 |
Monoamine oxidase inhibitors protect against coronary heart disease in rodent rat models: A pilot study.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Hemodynamics; Male; Monoamine Oxidase Inhibitors; Myocardium; Oxazoles; Rats, Wistar | 2019 |
Role of Differential Estrogen Receptor Activation in Airway Hyperreactivity and Remodeling in a Murine Model of Asthma.
Topics: Airway Remodeling; Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Drug Implants; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Laser Capture Microdissection; Male; Mice; Mice, Inbred C57BL; Ovariectomy; Oxazoles; Phenols; Pyrazoles; Sex Characteristics | 2019 |
Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Mice; Oxazoles; PPAR alpha; PPAR gamma; Stroke; Thiophenes | 2019 |
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.
Topics: Animals; Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Electron Transport Complex I; Female; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Mice; Models, Biological; Oxazoles; Oxidative Phosphorylation; Protein Kinase Inhibitors; Receptor, ErbB-2; Triazoles | 2019 |
Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma.
Topics: Animals; Asthma; Disease Models, Animal; Dual Oxidases; Eosinophils; Gene Expression Regulation; Goblet Cells; Humans; Hyperplasia; Mice; Mucin 5AC; Mucins; Nasal Mucosa; Neutrophils; NIH 3T3 Cells; Oxazoles; Respiratory Hypersensitivity; Sulfate Transporters | 2019 |
Advantageous safety profile of a dual selective alpha(2C) agonist/alpha(2A) antagonist antinociceptive agent.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Clonidine; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Male; Mice; Oxazoles; Pain; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 2014 |
Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death.
Topics: Acceleration; Anesthetics; Animals; Calcium; Calcium Channels; Calcium-Binding Proteins; Calsequestrin; Death, Sudden; Disease Models, Animal; Electrophysiological Phenomena; Gene Knock-In Techniques; Gene Knockout Techniques; Hot Temperature; Imidazoles; Mice; Muscle Fibers, Skeletal; Oxazoles; Ryanodine Receptor Calcium Release Channel | 2013 |
High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4.
Topics: Acetates; Animals; Brain Edema; Brain Injuries; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gene Expression Regulation; HMGB1 Protein; Humans; Immunologic Factors; Male; Mice; Mice, Inbred C3H; Microglia; Neurons; Oxazoles; Ribosomal Proteins; Toll-Like Receptor 4 | 2014 |
The dual PPARα/γ agonist aleglitazar increases the number and function of endothelial progenitor cells: implications for vascular function and atherogenesis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Case-Control Studies; Cell Movement; Cell Proliferation; Cells, Cultured; Coronary Artery Disease; Disease Models, Animal; Endothelial Cells; Hindlimb; Humans; Ischemia; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Oxazoles; PPAR alpha; PPAR gamma; Signal Transduction; Stem Cells; Thiophenes | 2014 |
Host-nonspecific iron acquisition systems and virulence in the zoonotic serovar of Vibrio vulnificus.
Topics: Amides; Animals; Disease Models, Animal; Gene Knockout Techniques; Genetic Complementation Test; Hemin; Iron; Membrane Transport Proteins; Mice; Mice, Inbred BALB C; Oxazoles; Vibrio Infections; Vibrio vulnificus; Virulence; Virulence Factors | 2014 |
VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus.
Topics: Acetates; Animals; Disease Models, Animal; Female; Humans; Immunologic Factors; Lipopolysaccharides; Lupus Erythematosus, Systemic; Male; Mice; Oxazoles; Toll-Like Receptor 4 | 2014 |
Insulin sensitization by a novel partial peroxisome proliferator-activated receptor γ agonist with protein tyrosine phosphatase 1B inhibitory activity in experimental osteoporotic rats.
Topics: Adipocytes; Animals; Bone Density; Cell Differentiation; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Isoquinolines; Osteoblasts; Osteoporosis, Postmenopausal; Ovariectomy; Oxazoles; PPAR gamma; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Rats, Inbred F344; Receptor, Insulin; Risk; Rosiglitazone; Thiazolidinediones; Triglycerides | 2014 |
Dietary exposure in utero and during lactation to a mixture of genistein and an anti-androgen fungicide in a rat mammary carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Androgen Antagonists; Animals; Breast Neoplasms; Carcinoma in Situ; Cell Proliferation; Diet; Disease Models, Animal; Endocrine Disruptors; Epithelial Cells; Female; Fungicides, Industrial; Genistein; Gestational Age; Mammary Glands, Animal; Maternal Exposure; Oxazoles; Pregnancy; Prenatal Education; Rats, Wistar; Receptors, Estrogen; Receptors, Progesterone; Risk Assessment; Risk Factors; Tumor Burden | 2015 |
In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.
Topics: Animals; Antitubercular Agents; Caco-2 Cells; Cell Line, Tumor; Disease Models, Animal; Drug Interactions; Drug Resistance, Bacterial; Female; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazines; Oxazoles; Tuberculosis | 2015 |
Contribution of the nitroimidazoles PA-824 and TBA-354 to the activity of novel regimens in murine models of tuberculosis.
Topics: Animals; Antitubercular Agents; Clofazimine; Diarylquinolines; Disease Models, Animal; Drug Therapy, Combination; Female; Fluoroquinolones; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Moxifloxacin; Mycobacterium tuberculosis; Nitroimidazoles; Oxazines; Oxazoles; Pyrazinamide; Random Allocation; Tuberculosis | 2015 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morpholines; Naphthalenes; Oxazoles; Pentylenetetrazole; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Thiazolidinediones; Tyrosine | 2015 |
Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Topics: Animals; Animals, Newborn; Butyryl-CoA Dehydrogenase; Cardiomegaly; Disease Models, Animal; Fatty Acids; Fenofibrate; Flavonoids; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Myocytes, Cardiac; Oxazoles; Phenylephrine; Phosphorylation; PPAR alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2015 |
Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation.
Topics: Administration, Intranasal; Animals; Antitubercular Agents; Cell Death; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Therapy, Combination; Hep G2 Cells; Humans; Isoenzymes; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazoles; Structure-Activity Relationship | 2015 |
A novel synthetic derivative of melatonin, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation.
Topics: Acute Lung Injury; Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Female; Indoles; Inflammasomes; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Melatonin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitochondria; Nitric Oxide; Oxazoles; Random Allocation; Reactive Oxygen Species; Shock, Septic; Signal Transduction; Tumor Necrosis Factor-alpha | 2015 |
Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Topics: Administration, Oral; Animals; Antitubercular Agents; Biological Availability; Chemistry Techniques, Synthetic; Chronic Disease; Disease Models, Animal; Humans; Male; Mice, Inbred BALB C; Mice, Inbred Strains; Microbial Sensitivity Tests; Microsomes, Liver; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Rats, Sprague-Dawley; Structure-Activity Relationship; Tuberculosis | 2015 |
Anti-inflammatory effect of Streptochlorin via TRIF-dependent signaling pathways in cellular and mouse models.
Topics: Acute Lung Injury; Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Disease Models, Animal; Female; Indoles; Lipopolysaccharides; Macrophages; Mice; Oxazoles; Signal Transduction | 2015 |
Self-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T-Cell Auto-Reactivity.
Topics: Adaptor Proteins, Signal Transducing; Animals; Autoantigens; CD4-Positive T-Lymphocytes; Cyclopropanes; Dermatitis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Genes, MHC Class II; Intercellular Signaling Peptides and Proteins; Keratinocytes; Mice; Mice, Knockout; Mice, Transgenic; Myelin Basic Protein; Oxazoles; Skin | 2015 |
Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor.
Topics: Administration, Oral; Allosteric Regulation; Animals; Antipsychotic Agents; Cells, Cultured; Disease Models, Animal; Electroencephalography; Humans; Imidazoles; Male; Motor Activity; Oxazoles; Prefrontal Cortex; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Metabotropic Glutamate; Schizophrenia; Sleep, REM; Stimulation, Chemical | 2015 |
Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin-Induced Cardiotoxicity in Mice.
Topics: Animals; Atrial Function, Left; Benzoxazines; Cannabinoid Receptor Agonists; Cardiotonic Agents; Cardiotoxicity; Cytoprotection; Disease Models, Animal; Doxorubicin; Heart Diseases; Male; Malondialdehyde; Mice, Inbred BALB C; Morpholines; Myocardial Contraction; Myocytes, Cardiac; Naphthalenes; Oxazoles; PPAR alpha; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2016 |
Effect of consecutive alternating administration (CAA) of a triple anti-enteroviral combination on Coxsackievirus B1 neuroinfection in mice.
Topics: Animals; Antiviral Agents; Apomorphine; Brain; Central Nervous System Infections; Coxsackievirus Infections; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Enterovirus B, Human; Guanidine; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Survival Analysis; Treatment Outcome | 2015 |
TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling.
Topics: Action Potentials; Animals; Antidepressive Agents; Brain; Bridged Bicyclo Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Gene Expression Regulation; HEK293 Cells; Humans; Male; Oxazoles; Patch-Clamp Techniques; Peptides; Potassium Channels, Tandem Pore Domain; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Agents; Signal Transduction; Stress, Psychological; Transfection | 2015 |
Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen.
Topics: Animals; Bacterial Proteins; Benzylidene Compounds; Blotting, Western; Disease Models, Animal; Guinea Pigs; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Mutagenesis, Site-Directed; Mycobacterium tuberculosis; Naphthalenes; Oxazoles; Tuberculosis | 2015 |
Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis.
Topics: Animals; Antitubercular Agents; Bacterial Load; Diarylquinolines; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Synergism; Female; Linezolid; Lung; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Nitroimidazoles; Organophosphates; Oxazoles; Oxazolidinones; Pyrazinamide; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary | 2016 |
Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Biomarkers; Cell Proliferation; Disease Models, Animal; Doxorubicin; Energy Metabolism; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucose; Humans; Mice; Mitochondria; Myocytes, Cardiac; Oxazoles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Pyrimidines; Reactive Oxygen Species; Tyrosine; Up-Regulation | 2015 |
An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia.
Topics: Allosteric Regulation; Animals; Disease Models, Animal; Hippocampus; Male; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Oxazoles; Proto-Oncogene Proteins c-akt; Pyridines; Racemases and Epimerases; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2016 |
2-pentadecyl-2-oxazoline: Identification in coffee, synthesis and activity in a rat model of carrageenan-induced hindpaw inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Coffee; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Oxazoles; Peroxidase; Rats; Rats, Sprague-Dawley | 2016 |
The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Antitubercular Agents; Biotransformation; Disease Models, Animal; Drug Administration Schedule; Drug Dosage Calculations; Drug Repositioning; Female; Hormesis; Leishmania donovani; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oxazoles; Parasitic Sensitivity Tests; Treatment Outcome | 2016 |
Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Cytokines; Disease Models, Animal; Immunologic Factors; Lung; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Organophosphates; Oxazoles; Plasma; Pneumonia, Staphylococcal; Survival Analysis; Treatment Outcome | 2016 |
Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection.
Topics: Animals; Antitubercular Agents; Bacterial Load; Disease Models, Animal; Drug Interactions; Drug Repositioning; Male; Mefloquine; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazoles; Tuberculosis, Multidrug-Resistant | 2016 |
In vivo validation of the immunogenicity of recombinant Baumannii Acinetobactin Utilization A protein (rBauA).
Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Antibodies, Bacterial; Antigens, Bacterial; Chromatography, Affinity; Cloning, Molecular; Disease Models, Animal; Escherichia coli; Gene Expression; Genetic Vectors; Imidazoles; Immunization, Passive; Membrane Transport Proteins; Mice, Inbred BALB C; Oxazoles; Recombinant Proteins; Survival Analysis; Treatment Outcome | 2016 |
A validated protocol to quantify severity of male urogenital feminization using the MOUSE (Mouse objective urethral severity evaluation).
Topics: Androgen Antagonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Feminization; Gestational Age; Humans; Hypospadias; Male; Mice; Oxazoles; Pregnancy; Translational Research, Biomedical; Urethra | 2016 |
Activity of Tedizolid in Methicillin-Resistant Staphylococcus aureus Experimental Foreign Body-Associated Osteomyelitis.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Bone Wires; Disease Models, Animal; Drug Combinations; Drug Resistance, Bacterial; Foreign Bodies; Injections, Intraperitoneal; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Organophosphates; Osteomyelitis; Oxazoles; Rats; Rats, Wistar; Rifampin; Staphylococcal Infections; Tibia; Vancomycin | 2016 |
The effects of herbal composition Gambigyeongsinhwan (4) on hepatic steatosis and inflammation in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, Animal; Fenofibrate; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatitis; Hepatocytes; Humans; Hypolipidemic Agents; Inflammation Mediators; Lipids; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Oxazoles; Plant Extracts; PPAR alpha; Rats, Inbred OLETF; RNA, Messenger; Transfection; Tyrosine | 2017 |
Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Electromyography; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Motor Activity; Narcolepsy; Oxazoles; Rare Diseases; Receptors, G-Protein-Coupled; Sleep, REM; Wakefulness-Promoting Agents | 2017 |
Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse.
Topics: Amine Oxidase (Copper-Containing); Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Arthritis; Cells, Cultured; Chronic Disease; Disease Models, Animal; Disease Progression; Freund's Adjuvant; Humans; Hydrazines; Joints; Mice; Mice, Inbred Strains; Mice, Transgenic; Oxazoles; Oximes | 2017 |
Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP
Topics: Animals; Cells, Cultured; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Female; Ganglia, Spinal; Hyperalgesia; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Male; Oligodeoxyribonucleotides, Antisense; Oxazoles; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sensory Receptor Cells; Sex Characteristics; Thapsigargin | 2017 |
In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Local; Animals; Benzamides; Bridged Bicyclo Compounds; Cocaine; Conditioning, Operant; Disease Models, Animal; Fenofibrate; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Oxazoles; PPAR alpha; Pyrimidines; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2017 |
Utilization of Bombyx mori larvae as a surrogate animal model for evaluation of the anti-infective potential of oxazolidinones.
Topics: Animals; Anti-Infective Agents; Bombyx; Disease Models, Animal; Furans; Humans; Larva; Methicillin Resistance; Mice; Oxazoles; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome | 2008 |
Enhanced pulsatile pressure accelerates vascular smooth muscle migration: implications for atherogenesis of hypertension.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Atherosclerosis; Azetidinecarboxylic Acid; Blood Pressure; Calcium Channel Blockers; Calcium Signaling; Cell Movement; Cells, Cultured; Dihydropyridines; Disease Models, Animal; Equipment and Supplies; Estrenes; Hypertension; Imidazoles; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Muscle, Smooth, Vascular; Oxazoles; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Tetrazoles; Type C Phospholipases | 2008 |
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; Inflammation; Oxazoles; Pain; Piperidines; PPAR gamma; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Tyrosine | 2008 |
Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats.
Topics: Acetates; Animals; Aqueous Humor; Ciliary Body; Disease Models, Animal; Eye Proteins; Immunohistochemistry; Immunologic Factors; Iris; Lipopolysaccharides; Male; Oxazoles; Rats; Rats, Inbred Lew; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Uveitis | 2008 |
Pharmacological analysis of alpha(2)-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Clonidine; Disease Models, Animal; Edema; Gastrointestinal Motility; Hyperalgesia; Male; Oxazoles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rilmenidine; Stomach Ulcer | 2009 |
Microvascular effects of centrally acting antihypertensive drugs in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Clonidine; Disease Models, Animal; Hypertension; Imidazoles; Male; Microcirculation; Microscopy, Video; Muscle, Skeletal; Oxazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rilmenidine; Skin; Time Factors | 2010 |
Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Esters; Mice; Mice, Inbred BALB C; Molecular Conformation; Mycobacterium tuberculosis; Oxazoles; Stereoisomerism; Structure-Activity Relationship; Tuberculosis | 2010 |
Estrogen receptor beta agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: a pharmacogenomic study.
Topics: Animals; Disease Models, Animal; Estrogen Receptor beta; Female; Gene Expression Profiling; Male; Mice; Mice, Inbred BALB C; Naphthols; Oxazoles; Pneumonia, Pneumococcal; Sepsis; Transcription, Genetic | 2010 |
Evaluation of the Combined Therapy of DA-7218, a New Oxazolidinone, and Trimethoprim/ Sulfamethoxazole in the Treatment of Experimental Actinomycetoma by Nocardia brasiliensis.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Disease Models, Animal; Drug Therapy, Combination; Female; Mice, Inbred BALB C; Nocardia; Nocardia Infections; Organophosphates; Oxazoles; Trimethoprim, Sulfamethoxazole Drug Combination | 2010 |
Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A.
Topics: Alzheimer Disease; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Male; Malondialdehyde; Marine Toxins; Melatonin; Memory Disorders; Oxazoles; Oxidative Stress; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; tau Proteins | 2011 |
A novel organogermanium protected atopic dermatitis induced by oxazolone.
Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Germanium; Mice; Organometallic Compounds; Oxazoles | 2010 |
Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome.
Topics: Administration, Oral; Animals; Apolipoprotein A-I; Apolipoprotein A-II; Biomarkers; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Eating; Glycated Hemoglobin; Hypertriglyceridemia; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Macaca mulatta; Male; Metabolic Syndrome; Obesity; Oxazoles; PPAR alpha; PPAR gamma; Prediabetic State; Thiophenes; Time Factors; Triglycerides; Weight Loss | 2011 |
Enhanced contractility and myosin phosphorylation induced by Ca(2+)-independent MLCK activity in hypertensive rats.
Topics: Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Death-Associated Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Male; Marine Toxins; Mesenteric Arteries; Muscle Proteins; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Phosphatase 1; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents | 2011 |
KR33426, [2-(2,5-dichlorophenyl)-5-methyloxazol-4yl]carbonylguanidine, is a novel compound to be effective on mouse systemic lupus erythematosus.
Topics: Animals; Apoptosis; B-Cell Activating Factor; B-Cell Activation Factor Receptor; B-Lymphocytes; Cell Proliferation; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Guanidines; Lupus Erythematosus, Systemic; Mice; Oxazoles; Spleen | 2011 |
Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery.
Topics: Anilides; Animals; Anticholesteremic Agents; Benzamides; Calcium; Clofibrate; Colon; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Evaluation, Preclinical; Guanylate Cyclase; Male; Marine Toxins; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Nitric Oxide Synthase; Oxazoles; Potassium Channel Blockers; PPAR alpha; Pyridines; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Sodium Channel Blockers; Soluble Guanylyl Cyclase | 2011 |
Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH.
Topics: Animals; Antioxidants; Catalase; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Lung; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Oxazoles; Oxypurinol; Rabbits; Reactive Oxygen Species; Reperfusion Injury; Spin Labels; Superoxide Dismutase; Time Factors | 2011 |
Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors.
Topics: Administration, Oral; Animals; Body Weight; Diacylglycerol O-Acyltransferase; Disease Models, Animal; Drug Discovery; Enzyme Activation; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Mice; Molecular Structure; Obesity; Oxazoles; Rats; Solubility; Structure-Activity Relationship | 2011 |
Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice.
Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Cell Line; Disease Models, Animal; Epithelial Cells; Female; Humans; Imidazoles; Iron; Larva; Lepidoptera; Mice; Mice, Inbred C57BL; Oxazoles; Sepsis; Survival Analysis; Virulence Factors | 2012 |
In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection.
Topics: Animals; Animals, Newborn; Antiviral Agents; Cell Line, Tumor; Cell Survival; Child, Preschool; Disease Models, Animal; Enterovirus A, Human; Enterovirus Infections; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Ribavirin; Survival Analysis | 2012 |
A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Attention; Benzodiazepines; Body Weight; Cocaine; Conditioning, Operant; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Electroencephalography; Hallucinogens; Haloperidol; Humans; Macaca fascicularis; Magnetic Resonance Imaging; Male; Mental Recall; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microinjections; Motor Activity; Mutation; Olanzapine; Oocytes; Oxazoles; Phencyclidine; Phenethylamines; Protein Binding; Pyrrolidinones; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reinforcement, Psychology; Schizophrenia; Swimming; Telemetry; Tritium; Xenopus | 2013 |
Improvement of hyperphagia by activation of cerebral I(1)-imidazoline receptors in streptozotocin-induced diabetic mice.
Topics: Animals; Benzofurans; Cerebrum; Diabetes Mellitus, Type 1; Disease Models, Animal; Eating; Female; Humans; Hyperphagia; Hypothalamus; Imidazoles; Imidazoline Receptors; Male; Mice; Mice, Inbred BALB C; Neuropeptide Y; Oxazoles; Rilmenidine; Streptozocin | 2012 |
Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat.
Topics: Animals; Disease Models, Animal; Estradiol; Estrogen Receptor beta; Female; Fulvestrant; Nitriles; Nociception; Oxazoles; Phenols; Posterior Horn Cells; Propionates; Rats; Rats, Sprague-Dawley; Visceral Pain | 2012 |
Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Area Under Curve; Blood Proteins; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Neutropenia; Organophosphates; Oxazoles; Oxazolidinones; Pneumonia, Staphylococcal; Prodrugs; Protein Binding; Staphylococcus aureus | 2012 |
Study on SSAO enzyme activity and anti-inflammatory effect of SSAO inhibitors in animal model of inflammation.
Topics: Amine Oxidase (Copper-Containing); Animals; Arthritis, Experimental; Carrageenan; Disease Models, Animal; Enzyme Inhibitors; Functional Laterality; Gene Expression Regulation, Enzymologic; Hydrazines; Inflammation; Male; Oxazoles; Oximes; Rats; Rats, Wistar; Time Factors | 2013 |
Amide derivatives of [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl]acetic acids as potential analgesic and anti-inflammatory compounds.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Humans; In Vitro Techniques; Isoenzymes; Lethal Dose 50; Male; Membrane Proteins; Mice; Oxazoles; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Stomach Ulcer; Structure-Activity Relationship | 2003 |
Evaluation of an estrogen receptor-beta agonist in animal models of human disease.
Topics: Animals; Animals, Genetically Modified; Arthritis, Experimental; beta 2-Microglobulin; Bone Density; Bone Diseases, Metabolic; Cell Line; Disease Models, Animal; Estrogen Receptor beta; Female; HLA-B27 Antigen; Humans; Inflammatory Bowel Diseases; Mammary Glands, Animal; Mice; Ovariectomy; Oxazoles; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Estrogen; Uterus; Weight Gain | 2003 |
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelial Growth Factors; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lymphokines; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Nitrobenzenes; Oxazoles; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcoma 180; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
4-(5-chloro-2(3H)-benzoxazolon-3-yl) butanoic acid derivatives: synthesis, antinociceptive and anti-inflammatory properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Disease Models, Animal; Edema; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Oxazoles; Pain; Structure-Activity Relationship | 2003 |
Novel dual action AT1 and ETA receptor antagonists reduce blood pressure in experimental hypertension.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Calcium; Desoxycorticosterone; Disease Models, Animal; Endothelin A Receptor Antagonists; Humans; Hypertension; Irbesartan; Losartan; Male; Oxazoles; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Endothelin A; Sodium; Sulfonamides; Tetrazoles | 2004 |
The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Disease Models, Animal; Female; Glucagon; Glucose; Glucose Tolerance Test; Humans; Imidazoles; Imidazoline Receptors; Lipid Metabolism; Male; Metabolic Syndrome; Obesity; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Yohimbine | 2003 |
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Collagen; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Lipopolysaccharides; Mice; Oxazoles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Structure-Activity Relationship; Thiazoles; Tumor Necrosis Factor-alpha | 2004 |
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Brain; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Interactions; Levodopa; Maze Learning; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; MPTP Poisoning; Nervous System Diseases; Nitrophenols; Oxazoles; Oxidopamine; Prefrontal Cortex; Quinolines; Rats; Rats, Sprague-Dawley; Serotonin; Stereotyped Behavior; Tolcapone; Tremor; Tyramine | 2004 |
In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599.
Topics: Animals; Butyrates; Ceftaroline; Cephalosporins; Disease Models, Animal; Enterococcus; Male; Methicillin Resistance; Mice; Mice, Inbred CBA; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxazoles; Pneumonia, Bacterial; Staphylococcal Infections; Staphylococcus | 2004 |
A selective estrogen receptor-beta agonist causes lesion regression in an experimentally induced model of endometriosis.
Topics: Adolescent; Adult; Animals; Biopsy; Disease Models, Animal; Endometriosis; Endometrium; Estrogen Receptor beta; Female; Humans; Mice; Mice, Nude; Middle Aged; Organ Culture Techniques; Ovariectomy; Oxazoles; RNA, Messenger | 2005 |
Activation of PPARgamma enhances myocardial glucose oxidation and improves contractile function in isolated working hearts of ZDF rats.
Topics: Adaptation, Physiological; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Metabolism; Gene Expression Regulation; Glucose; In Vitro Techniques; Insulin Resistance; Male; Myocardial Contraction; Myocardium; Oxazoles; PPAR gamma; Rats; Rats, Inbred Strains; Rats, Zucker; Signal Transduction; Transcriptional Activation; Triglycerides; Tyrosine | 2005 |
Hypoxia induces hypersensitivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Cells, Cultured; Disease Models, Animal; Heart Ventricles; Humans; Hypoxia; Infant, Newborn; Macrocyclic Compounds; Muscle Cells; Nifedipine; Organ Size; Oxazoles; Persistent Fetal Circulation Syndrome; Pulmonary Artery; Receptors, Thromboxane; Ryanodine; Swine; Vasoconstriction | 2006 |
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Cell Membrane; Cholesterol; Clonidine; Disease Models, Animal; Female; Guanabenz; Hyperlipidemias; Imidazoles; Imidazoline Receptors; Liver; Male; Metabolic Syndrome; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine; Triglycerides | 2006 |
Antitumor effect of kigamicin D on mouse tumor models.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Doxorubicin; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Oxazoles; Pancreatic Neoplasms; Xenograft Model Antitumor Assays | 2006 |
Characterization of ferric and ferrous iron transport systems in Vibrio cholerae.
Topics: Animals; Artificial Gene Fusion; Ascorbic Acid; ATP-Binding Cassette Transporters; Bacterial Proteins; beta-Galactosidase; Biological Transport; Catechols; Cholera; Disease Models, Animal; Escherichia coli; Escherichia coli Proteins; Ferric Compounds; Ferrous Compounds; Gene Deletion; Genes, Reporter; Genetic Complementation Test; Membrane Transport Proteins; Mice; Oxazoles; Oxidation-Reduction; Promoter Regions, Genetic; Shigella flexneri; Vibrio cholerae; Virulence; Virulence Factors | 2006 |
Improvement of cardiac diastolic function by long-term centrally mediated sympathetic inhibition in one-kidney, one-clip hypertensive rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cardiomyopathies; Diastole; Disease Models, Animal; Heart Rate; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Ligation; Male; Metoprolol; Myocardial Contraction; Nephrectomy; Oxazoles; Rabbits; Renal Artery; Rilmenidine; Sympathetic Nervous System; Systole; Time Factors; Ultrasonography; Ventricular Function; Ventricular Remodeling | 2008 |
Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by Nocardia brasiliensis.
Topics: Acetamides; Actinomycosis; Animals; Disease Models, Animal; Linezolid; Mice; Mice, Inbred BALB C; Mycetoma; Nocardia; Nocardia Infections; Organophosphates; Oxazoles; Oxazolidinones; Prodrugs; Tetrazoles; Treatment Outcome | 2008 |
Therapy for nonalcoholic fatty liver disease.
Topics: Animals; Antioxidants; Cholagogues and Choleretics; Disease Models, Animal; Fatty Liver; Glycine; Humans; Hypolipidemic Agents; Insulin Resistance; Liver; Mice; Oxazoles; Peroxisome Proliferator-Activated Receptors; Rats; Thiazolidinediones; Treatment Outcome; Ursodeoxycholic Acid; Vitamin E | 2008 |
Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dioxanes; Disease Models, Animal; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Lipoproteins; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred Strains; Molecular Structure; Oxazoles; PPAR alpha; Structure-Activity Relationship; Triglycerides | 2008 |
WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Body Temperature; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Receptor alpha; Estrogen Receptor beta; Hindlimb Suspension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Oxazoles; Phenols; Proto-Oncogene Proteins c-fyn; Psychomotor Performance; Time Factors | 2008 |
Comparison of the actions of trimethadione and chlordiazepoxide in animal models of anxiety and benzodiazepine receptor binding.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Conflict, Psychological; Discrimination Learning; Disease Models, Animal; Humans; Male; Oxazoles; Pentylenetetrazole; Rats; Receptors, Cell Surface; Receptors, GABA-A; Trimethadione | 1982 |
Laser-induced thrombi in rat mesenteric vessels and antithrombotic drugs.
Topics: Animals; Aspirin; Blood Platelets; Dipyridamole; Disease Models, Animal; Fibrinolytic Agents; Heparin; Lasers; Male; Mesenteric Arteries; Mesenteric Vascular Occlusion; Molsidomine; Oxazoles; Platelet Aggregation; Propionates; Pyrazoles; Pyrazolones; Rats; Rats, Inbred Strains; Sydnones; Thiophenes; Thrombosis; Ticlopidine | 1983 |
Superior activity of a thromboxane receptor antagonist as compared with aspirin in rat models of arterial and venous thrombosis.
Topics: Animals; Aspirin; Bleeding Time; Bridged Bicyclo Compounds, Heterocyclic; Carotid Artery Thrombosis; Disease Models, Animal; Epinephrine; Male; Mesenteric Arteries; Oxazoles; Platelet Aggregation Inhibitors; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane; Thrombosis; Venae Cavae | 1993 |
Thromboxane receptor antagonist BMS-180291, but not aspirin, reduces the severity of pacing-induced ischemia in dogs.
Topics: Angina Pectoris; Animals; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Cardiac Pacing, Artificial; Coronary Circulation; Disease Models, Animal; Dogs; Female; Hemodynamics; Injections, Intravenous; Male; Myocardial Ischemia; Oxazoles; Propionates; Radioligand Assay; Receptors, Thromboxane | 1994 |
Effect of long-acting thromboxane receptor antagonist (BMS 180,291) on experimental antiphospholipid syndrome.
Topics: Animals; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Embryo, Mammalian; Female; Fetal Resorption; Male; Mice; Mice, Inbred ICR; Organ Size; Oxazoles; Partial Thromboplastin Time; Placenta; Platelet Aggregation; Platelet Count; Pregnancy; Propionates; Receptors, Thromboxane | 1994 |
2-[3-[2-(4,5-diphenyl-2-oxazolyl) ethyl] phenoxy] acetic acid (BMY 42393): 2). Oral activity and efficacy in animal models of arterial thrombosis.
Topics: Administration, Oral; Animals; Chlorocebus aethiops; Coronary Thrombosis; Disease Models, Animal; Dogs; Humans; Macaca fascicularis; Male; Oxazoles; Phenoxyacetates; Rabbits; Rats; Rats, Sprague-Dawley; Renal Artery Obstruction | 1994 |
Carotid arterial changes produced by a centrally mediated antihypertensive agent in hypertensive rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Carotid Arteries; Disease Models, Animal; Heart Rate; Hypertension; Injections, Intravenous; Oxazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rilmenidine; Vascular Resistance | 1995 |
A ferret model of electrical-induction of arterial thrombosis that is sensitive to aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Carotid Arteries; Carotid Artery Injuries; Collagen; Disease Models, Animal; Electric Stimulation; Ferrets; Fibrin; Humans; In Vitro Techniques; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Oxazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prothrombin Time; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Species Specificity; Thrombosis; Thromboxane A2; Vasoconstrictor Agents | 1996 |
[Effects of rilmenidine on rats made insulin resistant and hypertensive by a high fructose diet].
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Disease Models, Animal; Fructose; Hypertension; Insulin; Insulin Resistance; Oxazoles; Rats; Rats, Wistar; Rilmenidine | 1996 |
Possible therapeutic effect of T-794, a novel reversible inhibitor of monoamine oxidase-A, on post-stroke emotional disturbances, assessed in animal models of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Depression; Disease Models, Animal; Emotions; Ischemic Attack, Transient; Male; Mice; Monoamine Oxidase Inhibitors; Motor Activity; Naphthalenes; Oxazoles; Oxazolidinones; Rats; Reserpine | 1997 |
Behavioural profiles of the reversible monoamine-oxidase-A inhibitors befloxatone and moclobemide in an experimental model for screening anxiolytic and anti-panic drugs.
Topics: Animals; Anxiety; Avoidance Learning; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Moclobemide; Monoamine Oxidase Inhibitors; Oxazoles; Panic Disorder; Rats | 1997 |
Pharmacological profile of JTE-522, a novel prostaglandin H synthase-2 inhibitor, in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzenesulfonates; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Indomethacin; Isoenzymes; Male; Membrane Proteins; Oxazoles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar | 1997 |
Cranial vascular effects of zolmitriptan, a centrally active 5-HT1B/1D receptor partial agonist for the acute treatment of migraine.
Topics: Animals; Arteriovenous Anastomosis; Blood Flow Velocity; Carotid Arteries; Cats; Cerebral Cortex; Disease Models, Animal; Dogs; Male; Migraine Disorders; Oxazoles; Oxazolidinones; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Serotonin Receptor Agonists; Tryptamines | 1998 |
Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
Topics: Animals; Benzenesulfonates; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Isoenzymes; Lung Neoplasms; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Oxazoles; Prostaglandin-Endoperoxide Synthases | 1999 |
Efficacy of linezolid in experimental otitis media.
Topics: Acetamides; Amoxicillin; Animals; Anti-Bacterial Agents; Chinchilla; Disease Models, Animal; Drug Resistance, Microbial; Drug Resistance, Multiple; Haemophilus Infections; Haemophilus influenzae; Humans; Linezolid; Otitis Media; Oxazoles; Oxazolidinones; Pneumococcal Infections; Streptococcus pneumoniae | 2000 |
Atorvastatin prevents glomerulosclerosis and renal endothelial dysfunction in hypercholesterolaemic rabbits.
Topics: Acetylcholine; Animals; Anticholesteremic Agents; Atorvastatin; Bridged Bicyclo Compounds, Heterocyclic; Cholesterol, Dietary; Disease Models, Animal; Endothelium, Vascular; Glomerulosclerosis, Focal Segmental; Heptanoic Acids; Hypercholesterolemia; Kidney; Male; Nitroprusside; Oxazoles; Phenylephrine; Platelet Aggregation Inhibitors; Pyrroles; Rabbits; Renal Circulation; Vasodilation | 2001 |
Silkworm larvae as an animal model of bacterial infection pathogenic to humans.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Bombyx; Disease Models, Animal; Drug Therapy, Combination; Humans; Inhibitory Concentration 50; Larva; Lethal Dose 50; Methicillin Resistance; Microbial Sensitivity Tests; Oxazoles; Pseudomonas aeruginosa; Staphylococcus aureus; Vancomycin; Vibrio cholerae | 2002 |
Antiviral effect of 3-[bis-(2-hydroxyethyl)-amino]-acetophenone-[4,5-diphenyl-oxyazolyl-(2)]hydrazone (IMET 98/69) in mice.
Topics: Administration, Oral; Animals; Antiviral Agents; Arbovirus Infections; Disease Models, Animal; Drug Evaluation, Preclinical; Encephalomyocarditis virus; Enterovirus Infections; Female; Injections, Subcutaneous; Male; Mice; Orthomyxoviridae Infections; Oxazoles; RNA Viruses; Semliki forest virus; Vaccinia; Virus Diseases | 1979 |
Experimental hyper-beta-lipoproteinemia and its amelioration by a novel hypolipidemic agent.
Topics: Animals; Cholesterol; Cholesterol, Dietary; Clofibrate; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins, LDL; Male; Oxazoles; Propylthiouracil; Rats; Triglycerides | 1978 |
Therapy for mouse tumors and human tumor xenografts with the antitumor antibiotic AT-125.
Topics: Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycine; Humans; Isoxazoles; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Oxazoles; Transplantation, Heterologous | 1979 |
Antibacterial activity of 3-(1-methyl-5-nitro-2-imidazolylmethylideneamino)-2-oxazolidinone.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Disease Models, Animal; Female; Furazolidone; Kidney Diseases; Male; Mice; Mice, Inbred Strains; Nitroimidazoles; Oxazoles; Rats; Rats, Inbred Strains | 1975 |
Immunological competence in Snell-Bagg pituitary dwarf mice: response to the contact-sensitizing agent oxazolone.
Topics: Animals; Disease Models, Animal; Dwarfism, Pituitary; Hypersensitivity, Delayed; Lymph Nodes; Lymphoid Tissue; Mice; Oxazoles; Oxazolone; Rodent Diseases; Skin; Skin Tests; Thymus Gland | 1976 |
Nucleus basalis lesions fail to induce senile plaques in the rat.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Basal Ganglia; Choline O-Acetyltransferase; Disease Models, Animal; Electroencephalography; Ibotenic Acid; Learning; Male; Oxazoles; Rats; Rats, Inbred F344 | 1990 |
Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril.
Topics: Animals; Antiviral Agents; Brain; Cyclophosphamide; Disease Models, Animal; Drug Resistance, Microbial; Enterovirus Infections; Immunosuppression Therapy; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Oxazoles; Poliomyelitis; Poliovirus | 1989 |
Remodelling of the heart in DOCA-salt hypertensive rats by propranolol and by an alpha-2 agonist, rilmenidine.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Disease Models, Animal; Heart; Heart Rate; Hypertension; Male; Oxazoles; Propranolol; Rats; Rats, Inbred Strains; Rilmenidine; Sodium Chloride | 1989 |
Mechanism of action and in vitro and in vivo activities of S-6123, a new oxazolidinone compound.
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Disease Models, Animal; Drug Resistance, Microbial; Escherichia coli; Male; Microbial Sensitivity Tests; Oxazoles; Peritonitis; Rats; Rats, Inbred Strains; Sulfonamides | 1988 |
Comparisons of ketoconazole, PR 969-566, PR 967-234, and PR 967-248 as antifungals in vitro and in the rat model of candidal vaginitis based on efficacy/safety profiles.
Topics: Animals; Antifungal Agents; Candida; Candidiasis, Vulvovaginal; Disease Models, Animal; Female; Fungi; Isoxazoles; Ketoconazole; Microbial Sensitivity Tests; Oxazoles; Rats | 1988 |
Effect of ACTH on enzymatic defect produced in vivo by a competitive inhibitor of 3-beta-hydroxysteroid dehydrogenase.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Androstanes; Animals; Carbon Isotopes; Cyanides; Disease Models, Animal; Female; Hydroxysteroid Dehydrogenases; Isomerases; Metabolism, Inborn Errors; Organ Size; Oxazoles; Pituitary-Adrenal System; Rats | 1970 |
[Pulmonary hypertension following chronic ingestion of aminorex in dogs. Preliminary communication].
Topics: Acid-Base Equilibrium; Amines; Animals; Appetite Depressants; Body Temperature; Body Weight; Disease Models, Animal; Dogs; Heart Ventricles; Hypertension, Pulmonary; Oxazoles; Placebos; Vascular Resistance; Water-Electrolyte Balance | 1973 |
Triton-induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs.
Topics: Animals; Carboxylic Acids; Cholesterol; Clofibrate; Disease Models, Animal; Fasting; Hyperlipidemias; Hypolipidemic Agents; Injections, Intraperitoneal; Injections, Intravenous; Kinetics; Male; Naphthalenes; Nicotinic Acids; Oxazoles; Phenols; Polysaccharides; Pyrrolidines; Rats; Surface-Active Agents; Thyroxine; Triglycerides; Triparanol | 1972 |
Carbohydrate metabolism in normal and hyperglycemic animals treated with 1-methyl-4-(3-methyl-5-isoxazolyl)pyridinium chloride and phenformin.
Topics: Animals; Blood Glucose; Carbamates; Carbohydrate Metabolism; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, Animal; Fasting; Glucosamine; Glycogen; Glycosuria; Guinea Pigs; Hyperglycemia; Hypoglycemia; Lactates; Liver Glycogen; Male; Mice; Nitroso Compounds; Obesity; Oxazoles; Phenformin; Pyridinium Compounds; Rats | 1971 |