oxazepam has been researched along with Seizures in 25 studies
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this investigation was to examine the influence of increasing age on the pharmacokinetics and the time course of the anticonvulsant response of oxazepam in BN/BiRij rats as an animal model of aging." | 7.68 | Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats. ( Danhof, M; Hoogerkamp, A; Langemeijer, MW; Postel-Westra, I; Stijnen, AM; van Bezooijen, CF; Voskuyl, RA, 1992) |
| "Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 5.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
| " The purpose of this investigation was to examine the influence of increasing age on the pharmacokinetics and the time course of the anticonvulsant response of oxazepam in BN/BiRij rats as an animal model of aging." | 3.68 | Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats. ( Danhof, M; Hoogerkamp, A; Langemeijer, MW; Postel-Westra, I; Stijnen, AM; van Bezooijen, CF; Voskuyl, RA, 1992) |
| "Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic." | 3.66 | Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980) |
| "Oxazepam is an anxiolytic with established clinical efficacy." | 2.38 | Oxazepam: update 1989. ( Ayd, FJ, 1990) |
| " Bases for selection include: (1) availability of other than oral dosage forms; (2) differences in additive effect with alcohol in producing central nervous system depression; (3) differences in anticonvulsant effect; and (4) differences in duration of effect in the body (ie, half-life)." | 2.36 | Selection among benzodiazepines for alcohol withdrawal. ( Keeler, MH; Miller, WC, 1977) |
| "Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 1.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
| " Differential effects on the pharmacodynamic parameters were seen." | 1.29 | Characterization of the pharmacodynamics of several antiepileptic drugs in a direct cortical stimulation model of anticonvulsant effect in the rat. ( Danhof, M; Hoogerkamp, A; Vis, PW; Voskuyl, RA, 1994) |
| " for 14 days) the corresponding dose-response lines were shifted to the right suggesting tolerance development." | 1.27 | Subacute benzodiazepine treatment: observations on behavioural tolerance and withdrawal. ( Gonzalez, JP; McCulloch, AJ; Nicholls, PJ; Sewell, RD; Tekle, A, 1984) |
| "Seizures and delirium tremens were recorded among 292 randomly selected patients admitted to an in-patient alcoholism program." | 1.27 | Should alcohol withdrawal seizures be treated with anti-epileptic drugs? ( Hillbom, ME; Hjelm-Jäger, M, 1984) |
| "For each strain, when equivalent seizure thresholds were observed at different time points, equivalent receptor occupancies were also observed." | 1.27 | Evidence of strain differences in GABA-benzodiazepine coupling. ( File, SE; Martin, IL; Wilks, L, 1987) |
| " Flumazenil caused dose-related increases in the NPAS scores of both diazepam- and nordiazepam-dependent dogs; the slopes of the two dose-response lines were not different." | 1.27 | Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. ( Martin, WR; McNicholas, LF; Sloan, JW; Wala, E, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (84.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Klein, S | 1 |
| Bankstahl, M | 1 |
| Gramer, M | 1 |
| Hausknecht, M | 1 |
| Löscher, W | 1 |
| Gonzalez, JP | 1 |
| McCulloch, AJ | 1 |
| Nicholls, PJ | 1 |
| Sewell, RD | 1 |
| Tekle, A | 1 |
| Hillbom, ME | 1 |
| Hjelm-Jäger, M | 1 |
| Wynn, RL | 1 |
| McFarland, SA | 1 |
| Meyer, EA | 1 |
| Coffman, WB | 1 |
| Mumford, R | 1 |
| Hoogerkamp, A | 2 |
| Vis, PW | 1 |
| Danhof, M | 2 |
| Voskuyl, RA | 2 |
| Golovenko, NIa | 1 |
| Zin'kovskii, VG | 1 |
| Scrollini, F | 1 |
| Caliari, S | 1 |
| Romano, A | 1 |
| Torchio, P | 1 |
| Keeler, MH | 1 |
| Miller, WC | 1 |
| Stijnen, AM | 1 |
| Postel-Westra, I | 1 |
| Langemeijer, MW | 1 |
| van Bezooijen, CF | 1 |
| Ayd, FJ | 1 |
| File, SE | 3 |
| Wilks, LJ | 1 |
| Mabbutt, PS | 1 |
| Wilks, L | 1 |
| Martin, IL | 2 |
| Frey, HH | 1 |
| Scherkl, R | 1 |
| McNicholas, LF | 1 |
| Martin, WR | 1 |
| Sloan, JW | 1 |
| Wala, E | 1 |
| Greenblatt, DJ | 1 |
| Brown, C | 1 |
| Browne, TR | 1 |
| Penry, JK | 1 |
| Babbini, M | 1 |
| Torrielli, MV | 1 |
| Gluckman, MI | 1 |
| Marcucci, F | 2 |
| Guaitani, A | 1 |
| Fanelli, R | 1 |
| Mussini, E | 2 |
| Garattini, S | 2 |
| Christmas, AJ | 1 |
| Maxwell, DR | 1 |
| Coutinho, CB | 1 |
| Cheripko, JA | 1 |
| Carbone, JJ | 1 |
| Dolce, G | 1 |
| Kaemmerer, E | 1 |
| de Carolis, AS | 1 |
| Longo, VG | 1 |
| Lou, HO | 1 |
3 reviews available for oxazepam and Seizures
| Article | Year |
|---|---|
Selection among benzodiazepines for alcohol withdrawal.
Topics: Administration, Oral; Benzodiazepines; Central Nervous System; Chlordiazepoxide; Clorazepate Dipotas | 1977 |
Oxazepam: update 1989.
Topics: Aged; Alcoholism; Alprazolam; Female; Humans; Oxazepam; Seizures; Substance Withdrawal Syndrome; Sub | 1990 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
1 trial available for oxazepam and Seizures
| Article | Year |
|---|---|
Oxazepam in the treatment of psychomotor epilepsy.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Electroencephalography; Epilepsy, Temporal | 1968 |
21 other studies available for oxazepam and Seizures
| Article | Year |
|---|---|
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; | 2014 |
Subacute benzodiazepine treatment: observations on behavioural tolerance and withdrawal.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conditioning, Psychological; Diazepam; Drinking Beha | 1984 |
Should alcohol withdrawal seizures be treated with anti-epileptic drugs?
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Carbamazepine; Chlormethiazol | 1984 |
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacain | 1980 |
Characterization of the pharmacodynamics of several antiepileptic drugs in a direct cortical stimulation model of anticonvulsant effect in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Drug Evaluation, Preclinical; Female; Oxaz | 1994 |
[Analysis of the structure of the components of the convulsive action of corazole following administration of sulazepam and its metabolites to mice].
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C | 1976 |
Toxicological and pharmacological investigations of pinazepam (7-chloro-1-propargyl-5-phenyl-3H-1,4-benzodiazepin-2-one): a new psychotherapeutic agent.
Topics: Abnormalities, Drug-Induced; Aggression; Analgesia; Animals; Anti-Anxiety Agents; Blood Pressure; Ca | 1975 |
Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats.
Topics: Aging; Animals; Anticonvulsants; Drug Tolerance; Injections, Intravenous; Male; Oxazepam; Rats; Rece | 1992 |
The role of the benzodiazepine receptor in mediating long-lasting anticonvulsant effects and the late-appearing reductions in motor activity and exploration.
Topics: Animals; Anticonvulsants; Exploratory Behavior; Lorazepam; Male; Mice; Motor Activity; Oxazepam; Pen | 1989 |
Evidence of strain differences in GABA-benzodiazepine coupling.
Topics: Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepa | 1987 |
Clorazepate, correlation between metabolism and anticonvulsant activity.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Clorazepate Dipotassium; Half-Life; Male; Mice | 1988 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures | 1988 |
Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy.
Topics: Animals; Anticonvulsants; Brain Chemistry; Diazepam; Mice; Mice, Inbred C3H; Nordazepam; Oxazepam; P | 1985 |
Investigation on pharmacological properties of hexadiphane, oxazepam hemisuccinate and of their combination.
Topics: Animals; Azepines; Benzene Derivatives; Diphenylacetic Acids; Drug Synergism; Female; Gallbladder; G | 1972 |
Pharmacology of 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one (lorazepam; Wy 4036).
Topics: Animals; Behavior, Animal; Benzazepines; Blood Pressure; Cats; Chemical Phenomena; Chemistry; Diazep | 1971 |
Metabolism and anticonvulsant activity of diazepam in guinea pigs.
Topics: Adipose Tissue; Animals; Anticonvulsants; Brain; Chromatography, Gas; Diazepam; Drug Antagonism; Gui | 1971 |
Studies on the anticonvulsant action of diazepam.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Chromatography, Gas; Diazepam; Mice; Oxazepam; Pen | 1970 |
A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats.
Topics: Aggression; Animals; Chlordiazepoxide; Diazepam; Electroshock; Exploratory Behavior; Humans; Locomot | 1970 |
Correlation between the duration of the anticonvulsant activity of diazepam and its physiological disposition in mice.
Topics: Adipose Tissue; Animals; Anticonvulsants; Benzazepines; Brain; Brain Chemistry; Chemical Phenomena; | 1970 |
[Neurophysiological studies with 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-on in animal experiments].
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Depression, Chemical; Drug Synergism; Electric Stim | 1967 |
Studies on the anticonvulsant properties of some benzodiazepines. (Chlordiazepoxide, diazepam, oxazepam).
Topics: Action Potentials; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Electroencephalography; Fem | 1967 |