oxazepam has been researched along with Experimental Hepatoma in 7 studies
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oxazepam has been the subject of recent toxicological and carcinogenesis studies because it is a commonly prescribed tranquilizer and has been shown to cause tumors in rodents." | 5.29 | Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet. ( Anderson, MW; Bucher, JR; Devereux, TR; Maronpot, RR; Sills, RC; White, CM, 1994) |
| " PB produced a twofold increase in liver MF over controls after 27 weeks of treatment, but a similar increase was not observed with longer dosing times; at later time points, the MF in the PB groups was lower than that of the control group, suggesting that PB is not producing direct DNA damage in the liver." | 1.33 | Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice. ( de Boer, J; Fairchild, D; Glickman, B; Johnson, A; Kanazawa, N; Mirsalis, JC; Nguyen, T; Shimon, JA; Winegar, RA, 2005) |
| "Oxazepam is a benzodiazepine widely used as a sedative-hypnotic and antianxiety drug." | 1.29 | Carcinogenicity studies of oxazepam in mice. ( Bucher, JR; Haseman, JK; Johnson, JD; Kurtz, PJ; Persing, RL; Shackelford, CC, 1994) |
| "Oxazepam has been the subject of recent toxicological and carcinogenesis studies because it is a commonly prescribed tranquilizer and has been shown to cause tumors in rodents." | 1.29 | Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet. ( Anderson, MW; Bucher, JR; Devereux, TR; Maronpot, RR; Sills, RC; White, CM, 1994) |
| "Diazepam was more effective than oxazepam and its effect was proportionate to dose." | 1.27 | Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver. ( Diwan, BA; Rice, JM; Ward, JM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lahousse, SA | 1 |
| Hoenerhoff, M | 1 |
| Collins, J | 1 |
| Ton, TV | 1 |
| Masinde, T | 1 |
| Olson, D | 1 |
| Rebolloso, Y | 1 |
| Koujitani, T | 1 |
| Tomer, KB | 2 |
| Hong, HH | 1 |
| Bucher, J | 1 |
| Sills, RC | 3 |
| Iida, M | 2 |
| Anna, CH | 2 |
| Hartis, J | 1 |
| Bruno, M | 1 |
| Wetmore, B | 1 |
| Dubin, JR | 1 |
| Sieber, S | 1 |
| Bennett, L | 1 |
| Cunningham, ML | 1 |
| Paules, RS | 1 |
| Houle, CD | 1 |
| Merrick, AB | 1 |
| Devereux, TR | 3 |
| Mirsalis, JC | 1 |
| Shimon, JA | 1 |
| Johnson, A | 1 |
| Fairchild, D | 1 |
| Kanazawa, N | 1 |
| Nguyen, T | 1 |
| de Boer, J | 1 |
| Glickman, B | 1 |
| Winegar, RA | 1 |
| Gaskin, ND | 1 |
| Walker, NJ | 1 |
| Bucher, JR | 2 |
| Shackelford, CC | 1 |
| Haseman, JK | 1 |
| Johnson, JD | 1 |
| Kurtz, PJ | 1 |
| Persing, RL | 1 |
| White, CM | 1 |
| Maronpot, RR | 1 |
| Anderson, MW | 1 |
| Diwan, BA | 1 |
| Rice, JM | 1 |
| Ward, JM | 1 |
7 other studies available for oxazepam and Experimental Hepatoma
| Article | Year |
|---|---|
Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice.
Topics: Animals; Carcinogens; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome; L | 2011 |
Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.
Topics: Animals; Base Sequence; Carcinogens; DNA Primers; Gene Expression Regulation, Neoplastic; Liver Neop | 2003 |
Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.
Topics: Animals; Carcinogens; Clone Cells; Diethylnitrosamine; Female; Gene Frequency; Liver; Liver Neoplasm | 2005 |
The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b.
Topics: Animals; Antigens, Differentiation; Carcinogens; Cell Line, Tumor; Down-Regulation; Female; Gene Exp | 2007 |
Carcinogenicity studies of oxazepam in mice.
Topics: Animals; Behavior, Animal; Carcinogenicity Tests; Carcinogens; Female; Liver; Liver Neoplasms, Exper | 1994 |
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
Topics: Adenoma; Animals; Codon; Diet; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, | 1994 |
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cocarcinogenesis; Cytochrome P-450 Enzyme System; D | 1986 |