oxazepam has been researched along with Cocaine-Related Disorders in 7 studies
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although cocaine dependence affects an estimated 1." | 2.77 | Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study. ( Casso, S; DeMuth, G; Fox, BS; Goeders, NE; Hefti, F; Kablinger, AS; Lindner, MA; McCarthy, BG; McNair, LA, 2012) |
| "Allopregnanolone and THDOC were measured using liquid chromatography-mass spectroscopy (LC-MS/MS) in the prefrontal cortex and amygdala in the brains from these rats." | 1.42 | A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats. ( Dhungana, S; Goeders, NE; Guerin, GF; Runyon, SP; Schmoutz, CD, 2015) |
| "Corticosterone levels were significantly different at the end of the 15-min session, but not following the 2-h session." | 1.39 | Combinations of oxazepam and metyrapone attenuate cocaine and methamphetamine cue reactivity. ( Cornett, EM; Goeders, NE; Guerin, GF; Keller, CM, 2013) |
| "Despite similar intensity of alcohol withdrawal symptoms, ALC/COC subjects received less oxazepam to treat alcohol withdrawal symptoms compared to ALC subjects." | 1.31 | Concurrent cocaine withdrawal alters alcohol withdrawal symptoms. ( Insua, A; Kaempf, G; Kampman, KM; Lipkin, C; O'Brien, CP; Pettinati, H; Sparkman, T; Turk, E; Volpicelli, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keller, CM | 2 |
| Goeders, NE | 6 |
| Cornett, EM | 1 |
| Guerin, GF | 4 |
| Schmoutz, CD | 2 |
| Runyon, SP | 1 |
| Dhungana, S | 1 |
| Kablinger, AS | 1 |
| Lindner, MA | 1 |
| Casso, S | 1 |
| Hefti, F | 1 |
| DeMuth, G | 1 |
| Fox, BS | 1 |
| McNair, LA | 1 |
| McCarthy, BG | 1 |
| Kampman, KM | 1 |
| Pettinati, H | 1 |
| Volpicelli, J | 1 |
| Kaempf, G | 1 |
| Turk, E | 1 |
| Insua, A | 1 |
| Lipkin, C | 1 |
| Sparkman, T | 1 |
| O'Brien, CP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1b, Randomized, Double-Blinded, Multiple-Dose, Placebo Controlled, Crossover Study To Evaluate The Safety, Tolerability And Pharmacokinetic Effects Of A Metyrapone And Oxazepam Combination (EMB-001) When Co-Administered With Cocaine[NCT02856854] | Phase 1 | 18 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study to Evaluate the Safety and Efficacy of EMB 001 in Subjects With Moderate-to-Severe Cocaine Use Disorder[NCT04501874] | Phase 2 | 82 participants (Actual) | Interventional | 2020-07-29 | Completed | ||
| Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment[NCT04933916] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2021-06-10 | Terminated (stopped due to Business decision) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for oxazepam and Cocaine-Related Disorders
| Article | Year |
|---|---|
The combination of metyrapone and oxazepam for the treatment of cocaine and other drug addictions.
Topics: Animals; Anti-Anxiety Agents; Cocaine-Related Disorders; Humans; Metyrapone; Oxazepam; Stress, Psych | 2014 |
1 trial available for oxazepam and Cocaine-Related Disorders
| Article | Year |
|---|---|
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study.
Topics: Adult; Cocaine; Cocaine-Related Disorders; Diagnostic and Statistical Manual of Mental Disorders; Do | 2012 |
5 other studies available for oxazepam and Cocaine-Related Disorders
| Article | Year |
|---|---|
Lack of effect of the combination of metyrapone and oxazepam on brain dopamine.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Corticosterone; Dopamine; Dopamine Uptake Inhibi | 2019 |
Combinations of oxazepam and metyrapone attenuate cocaine and methamphetamine cue reactivity.
Topics: Amphetamine-Related Disorders; Analysis of Variance; Animals; Central Nervous System Stimulants; Coc | 2013 |
A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Desoxycorticosterone; Disease Models, Animal; Do | 2015 |
Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats.
Topics: Animals; Cocaine-Related Disorders; Conditioning, Operant; Corticosterone; Dose-Response Relationshi | 2008 |
Concurrent cocaine withdrawal alters alcohol withdrawal symptoms.
Topics: Adolescent; Adult; Alcoholism; Anti-Anxiety Agents; Cocaine; Cocaine-Related Disorders; Ethanol; Fem | 2002 |