oxazepam has been researched along with Cirrhosis, Liver in 7 studies
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oxazepam (Serax) is a tranquilizer-sedative of the benzodiazepine group that is predominantly metabolized to a pharmacologically inactive glucuronide and subsequently excreted by way of the kidneys." | 6.64 | Normal disposition of oxazepam in acute viral hepatitis and cirrhosis. ( Johnson, R; Schenker, S; Shull, HJ; Wilkinson, GR, 1976) |
| " To test whether glucuronidation reactions supported by UDP-glucuronosyltransferases are differentially affected in such conditions, we investigated the in vitro glucuronidation of four selected drugs and xenobiotics (zidovudine, oxazepam, lamotrigine, and umbelliferone) by using microsomes from human healthy and unhealthy (cirrhosis, hepatitis) livers as enzyme sources." | 3.70 | Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers. ( Bourdon, O; Demirdjian, S; Furlan, V; Magdalou, J; Taburet, AM, 1999) |
| "Oxazepam (Serax) is a tranquilizer-sedative of the benzodiazepine group that is predominantly metabolized to a pharmacologically inactive glucuronide and subsequently excreted by way of the kidneys." | 2.64 | Normal disposition of oxazepam in acute viral hepatitis and cirrhosis. ( Johnson, R; Schenker, S; Shull, HJ; Wilkinson, GR, 1976) |
| "Temazepam may prove to be a useful hypnotic sedative in patients with liver disease." | 1.27 | The effects of age and chronic liver disease on the elimination of temazepam. ( Breen, KJ; Desmond, PV; Ghabrial, H; Gijsbers, AJ; Harman, PJ; Mashford, ML; Watson, KJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perney, P | 1 |
| Butterworth, RF | 1 |
| Mousseau, DD | 1 |
| Lavoie, J | 1 |
| Fabbro-Peray, P | 1 |
| Blanc, F | 1 |
| Layrargues, GP | 1 |
| Furlan, V | 1 |
| Demirdjian, S | 1 |
| Bourdon, O | 1 |
| Magdalou, J | 1 |
| Taburet, AM | 1 |
| Hoyumpa, AM | 1 |
| Schenker, S | 2 |
| Shull, HJ | 1 |
| Wilkinson, GR | 1 |
| Johnson, R | 1 |
| Ghabrial, H | 1 |
| Desmond, PV | 1 |
| Watson, KJ | 1 |
| Gijsbers, AJ | 1 |
| Harman, PJ | 1 |
| Breen, KJ | 1 |
| Mashford, ML | 1 |
| Steidinger, J | 1 |
| Schmid, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Randomised Pilot Study Comparing the Efficacy, Safety and Tolerability of Raltegravir With Protease Inhibitor-based Therapy in Treatment-naïve, HIV/Hepatitis C Co-infected Injecting Drug Users Receiving Methadone[NCT01105611] | Phase 4 | 40 participants (Anticipated) | Interventional | 2010-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for oxazepam and Cirrhosis, Liver
| Article | Year |
|---|---|
Normal disposition of oxazepam in acute viral hepatitis and cirrhosis.
Topics: Acute Disease; Adolescent; Adult; Clinical Trials as Topic; Female; Half-Life; Hepatitis A; Humans; | 1976 |
6 other studies available for oxazepam and Cirrhosis, Liver
| Article | Year |
|---|---|
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clo | 1998 |
Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers.
Topics: Adolescent; Adult; Aging; Aryl Hydrocarbon Hydroxylases; Biotransformation; Child; Child, Preschool; | 1999 |
Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.
Topics: Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hepatitis; Humans; Liver Cirrhosis; Li | 1978 |
Effects of liver disease and of aging on the disposition and elimination of sedatives.
Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral, | 1978 |
The effects of age and chronic liver disease on the elimination of temazepam.
Topics: Adult; Age Factors; Aged; Anti-Anxiety Agents; Blood Proteins; Female; Half-Life; Humans; Kinetics; | 1986 |
[Studies of the metabolism of 7-chlor-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-on].
Topics: Adult; Aged; Chromatography, Thin Layer; Fluorescence; Glucuronates; Humans; Liver Cirrhosis; Middle | 1970 |