oxazepam has been researched along with Alcoholism in 39 studies
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The progression in severity of withdrawal symptoms (increase in CIWA-Ar above baseline) was also significantly greater in the placebo group (p < 0." | 2.70 | Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial. ( Baer, JS; Malte, CA; Reoux, JP; Saxon, AJ; Sloan, KL, 2001) |
| "Among patients who had withdrawal symptoms at baseline, vital signs became normal more rapidly in the patients receiving atenolol, and their abnormal behavioral characteristics also resolved more rapidly." | 2.66 | The efficacy of atenolol in the outpatient management of the alcohol withdrawal syndrome. Results of a randomized clinical trial. ( Gottlieb, LD; Horwitz, RI; Kraus, ML, 1989) |
| " Recent research suggests that this is due to metabolic and pharmacokinetic differences rather than an intrinsically more favourable toxic-to-therapeutic dosage ratio." | 2.64 | The clinical activity of oxazepam. ( Cardon, A; Fouks, L; Pinalie, B; Porcheron, JB, 1978) |
| "Oxazepam is an anxiolytic with established clinical efficacy." | 2.38 | Oxazepam: update 1989. ( Ayd, FJ, 1990) |
| "According to the guidelines, benzodiazepines with a short half-life are the reference medication to treat alcohol withdrawal syndrome." | 1.43 | Population Pharmacokinetics of High-Dose Oxazepam in Alcohol-Dependent Patients: Is There a Risk of Accumulation? ( Imbert, B; Liachenko, N; Marsot, A; Simon, N, 2016) |
| "Oxazepam is a safe, efficient and cheap drug for the treatment of alcohol withdrawal symptoms, but controlled studies are needed to compare its effectiveness with that of clomethiazol." | 1.36 | Oxazepam versus clomethiazol in alcohol withdrawal treatment. ( de Millas, W; Ganzer, F; Haasen, C; Kuhn, S, 2010) |
| "Despite similar intensity of alcohol withdrawal symptoms, ALC/COC subjects received less oxazepam to treat alcohol withdrawal symptoms compared to ALC subjects." | 1.31 | Concurrent cocaine withdrawal alters alcohol withdrawal symptoms. ( Insua, A; Kaempf, G; Kampman, KM; Lipkin, C; O'Brien, CP; Pettinati, H; Sparkman, T; Turk, E; Volpicelli, J, 2002) |
| " Drug was most often given on a fixed dosing schedule with additional medication "as needed" (52% of the programs)." | 1.29 | Alcohol withdrawal: a nationwide survey of inpatient treatment practices. ( Friedman, LS; Mayo-Smith, MF; Saitz, R, 1995) |
| " We report five cases of high-dose triazolam abuse in which the daily dosage ranged from 5 to 15 mg (100-300 mg diazepam equivalent) and the duration of use ranged from 3 months to 5 years." | 1.28 | Detoxification for triazolam physical dependence. ( Sellers, EM; Sullivan, JT, 1992) |
| "Seizures and delirium tremens were recorded among 292 randomly selected patients admitted to an in-patient alcoholism program." | 1.27 | Should alcohol withdrawal seizures be treated with anti-epileptic drugs? ( Hillbom, ME; Hjelm-Jäger, M, 1984) |
| " These findings and other results of pharmacokinetic research have clinical implications in terms of dosage schedules, drug accumulation during long-term therapy, antianxiety therapy in the elderly, drug interactions, pharmacotherapy in specific disease states, and the influence of route of administration on drug action." | 1.26 | Clinical implications of benzodiazepine pharmacokinetics. ( Greenblatt, DJ; Shader, RI, 1977) |
| "Oxazepam has no important active metabolites and its net disposition is minimally altered by disulfiram." | 1.26 | Interaction of disulfiram with benzodiazepines. ( Billings, BJ; Giles, HG; Greenblatt, DJ; MacLeod, SM; Marshman, JA; Martin, PR; Sellers, EM, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (46.15) | 18.7374 |
| 1990's | 9 (23.08) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Verthein, U | 1 |
| Kuhn, S | 2 |
| Gabriel, K | 1 |
| Mautsch, U | 1 |
| Reimer, J | 1 |
| Behrendt, K | 1 |
| Martinez, L | 1 |
| Vorspan, F | 1 |
| Declèves, X | 1 |
| Azuar, J | 1 |
| Fortias, M | 1 |
| Questel, F | 1 |
| Dereux, A | 1 |
| Grichy, L | 1 |
| Barreteau, H | 1 |
| Bellivier, F | 1 |
| Lépine, JP | 1 |
| Bloch, V | 1 |
| Melby, K | 1 |
| Gråwe, RW | 1 |
| Aamo, TO | 1 |
| Salvesen, Ø | 1 |
| Spigset, O | 1 |
| Caputo, F | 1 |
| Skala, K | 1 |
| Mirijello, A | 1 |
| Ferrulli, A | 1 |
| Walter, H | 1 |
| Lesch, O | 1 |
| Addolorato, G | 1 |
| Bråtveit, A | 1 |
| Imbert, B | 1 |
| Marsot, A | 1 |
| Liachenko, N | 1 |
| Simon, N | 1 |
| Nüstedt, V | 1 |
| de Millas, W | 1 |
| Ganzer, F | 1 |
| Haasen, C | 1 |
| Kampman, KM | 1 |
| Pettinati, H | 1 |
| Volpicelli, J | 1 |
| Kaempf, G | 1 |
| Turk, E | 1 |
| Insua, A | 1 |
| Lipkin, C | 1 |
| Sparkman, T | 1 |
| O'Brien, CP | 1 |
| Pavlic, M | 1 |
| Libiseller, K | 1 |
| Hermann, M | 1 |
| Hengster, P | 1 |
| Margreiter, R | 1 |
| Wurm, M | 1 |
| Hillbom, ME | 1 |
| Hjelm-Jäger, M | 1 |
| Hicks, R | 1 |
| Dysken, MW | 1 |
| Davis, JM | 1 |
| Lesser, J | 1 |
| Ripeckyj, A | 1 |
| Lazarus, L | 1 |
| Solomon, JG | 1 |
| Mayo-Smith, MF | 2 |
| Bernard, D | 1 |
| Cohen, SI | 1 |
| Saitz, R | 1 |
| Friedman, LS | 1 |
| Wartenberg, AA | 1 |
| Goldstein, MZ | 1 |
| Pataki, A | 1 |
| Webb, MT | 1 |
| Reoux, JP | 2 |
| Miller, K | 1 |
| Saxon, AJ | 1 |
| Malte, CA | 1 |
| Baer, JS | 1 |
| Sloan, KL | 1 |
| Shader, RI | 1 |
| Greenblatt, DJ | 3 |
| MacLeod, SM | 1 |
| Sellers, EM | 2 |
| Giles, HG | 1 |
| Billings, BJ | 1 |
| Martin, PR | 1 |
| Marshman, JA | 1 |
| Baekeland, F | 1 |
| Lundwall, LK | 1 |
| Bliding, A | 2 |
| Fouks, L | 1 |
| Pinalie, B | 1 |
| Porcheron, JB | 1 |
| Cardon, A | 1 |
| Woo, E | 1 |
| Guthy, H | 1 |
| Sullivan, JT | 1 |
| Gallant, DM | 1 |
| Stuppaeck, CH | 1 |
| Pycha, R | 1 |
| Miller, C | 1 |
| Whitworth, AB | 1 |
| Oberbauer, H | 1 |
| Fleischhacker, WW | 1 |
| Ayd, FJ | 1 |
| Horwitz, RI | 1 |
| Gottlieb, LD | 1 |
| Kraus, ML | 1 |
| Gillmer, RE | 1 |
| Pernhaupt, G | 1 |
| Malm, U | 1 |
| Bonuzzi, L | 1 |
| Roncari, G | 1 |
| Zuanazzi, GF | 1 |
| Bowman, EH | 1 |
| Thimann, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute and Long-term Effects of Intranasal Oxytocin in Alcohol Withdrawal and Dependence: A Prospective Randomized Parallel Group Placebo-controlled Trial[NCT02903251] | Phase 3 | 40 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| The Gamma Hydroxybutyric Acid in Alcohol-dependence Treatment Efficacy (GATE) I Trial: a Comparative Study Versus Oxazepam in the Treatment of Alcohol Withdrawal Syndrome[NCT02090504] | Phase 4 | 127 participants (Actual) | Interventional | 2002-02-28 | Completed | ||
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| Placebo Controlled Trial of Depakote ER in Alcohol Dependent Patients With Mood and/or Anxiety Symptoms[NCT00202514] | Phase 2/Phase 3 | 40 participants | Interventional | 2004-09-30 | Completed | ||
| Prospective Assessment of Valproate on Ethanol Withdrawal[NCT03235531] | Phase 4 | 210 participants (Anticipated) | Interventional | 2017-07-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for oxazepam and Alcoholism
| Article | Year |
|---|---|
The pharmacokinetics of psychotropic medication in the elderly: a review.
Topics: Aged; Alcoholism; Analgesics; Antidepressive Agents, Tricyclic; Barbiturates; Biological Availabilit | 1981 |
Alcoholism among elderly persons.
Topics: Aged; Alcoholism; Benzodiazepines; Contraindications; Disulfiram; Humans; Incidence; Lorazepam; Ment | 1996 |
Oxazepam: update 1989.
Topics: Aged; Alcoholism; Alprazolam; Female; Humans; Oxazepam; Seizures; Substance Withdrawal Syndrome; Sub | 1990 |
12 trials available for oxazepam and Alcoholism
| Article | Year |
|---|---|
Effect of intranasal oxytocin on alcohol withdrawal syndrome: A randomized placebo-controlled double-blind clinical trial.
Topics: Administration, Intranasal; Adult; Alcoholism; Benzodiazepines; Double-Blind Method; Female; Humans; | 2019 |
Sodium oxybate in the treatment of alcohol withdrawal syndrome: a randomized double-blind comparative study versus oxazepam. The GATE 1 trial.
Topics: Adult; Alcoholism; Anxiety; Craving; Double-Blind Method; Female; Humans; Male; Oxazepam; Severity o | 2014 |
Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Alcoholism; Anticonvulsants; Anxiety; Depression; Double-Blind Method; Etha | 2001 |
Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Alcoholism; Anticonvulsants; Anxiety; Depression; Double-Blind Method; Etha | 2001 |
Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Alcoholism; Anticonvulsants; Anxiety; Depression; Double-Blind Method; Etha | 2001 |
Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial.
Topics: Adolescent; Adult; Aged; Alcoholism; Anticonvulsants; Anxiety; Depression; Double-Blind Method; Etha | 2001 |
Effects of discontinuity of medication on the results of a double-blind drug study in outpatient alcoholics.
Topics: Adult; Alcoholism; Ambulatory Care; Clinical Trials as Topic; Dibenzocycloheptenes; Drug Combination | 1975 |
The clinical activity of oxazepam.
Topics: Alcoholism; Anxiety Disorders; Clinical Trials as Topic; Depression; Drug Evaluation; Humans; Mental | 1978 |
[Therapy of inflammatory symptoms in chronic alcoholism with Adumbran].
Topics: Adult; Alcoholism; Clinical Trials as Topic; Humans; Inflammation; Male; Middle Aged; Oxazepam | 1976 |
One more look at carbamazepine in the treatment of alcohol withdrawal.
Topics: Adolescent; Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Carbamazepine; Double-Blind Method | 1992 |
Carbamazepine versus oxazepam in the treatment of alcohol withdrawal: a double-blind study.
Topics: Adult; Alcoholism; Carbamazepine; Double-Blind Method; Humans; Middle Aged; Oxazepam; Randomized Con | 1992 |
The efficacy of atenolol in the outpatient management of the alcohol withdrawal syndrome. Results of a randomized clinical trial.
Topics: Adult; Alcoholism; Atenolol; Double-Blind Method; Female; Humans; Male; Middle Aged; Oxazepam; Progn | 1989 |
Benzoctamine and oxazepam in the management of alcohol withdrawal states. Comparison by double-blind trial.
Topics: Adult; Aggression; Alcoholism; Anger; Anthracenes; Anxiety; Clinical Trials as Topic; Drive; Drug Ev | 1973 |
[Psychopharmacologic treatment of alcohol dependent postintoxication immobility. A double blind study of chlorprothixene--oxazepam--placebo].
Topics: Alcoholism; Chlorprothixene; Humans; Oxazepam; Placebos | 1970 |
Treatment of alcoholism in the subacute stage. (A study of three active agents).
Topics: Adult; Aged; Alcoholism; Antidepressive Agents; Chlordiazepoxide; Humans; Male; Middle Aged; Oxazepa | 1966 |
24 other studies available for oxazepam and Alcoholism
| Article | Year |
|---|---|
[Treatment of Alcohol Withdrawal Syndrome with Oxazepam or Clomethiazole - A Naturalistic Observational Study].
Topics: Alcoholism; Chlormethiazole; Female; Germany; Humans; Male; Middle Aged; Oxazepam; Substance Withdra | 2018 |
An observational study of benzodiazepine prescription during inpatient alcohol detoxification for patients with vs. without chronic pretreatment with high-dosage baclofen.
Topics: Administration, Oral; Adult; Alcohol Drinking; Alcoholism; Baclofen; Diazepam; Female; GABA Modulato | 2018 |
[Handwrestling or stethoscope?].
Topics: Alcoholism; Anti-Anxiety Agents; Humans; Life Style; Oxazepam; Physician-Patient Relations | 2014 |
Population Pharmacokinetics of High-Dose Oxazepam in Alcohol-Dependent Patients: Is There a Risk of Accumulation?
Topics: Administration, Oral; Adult; Aged; Alcoholism; Body Weight; Drug Monitoring; Ethanol; Female; Half-L | 2016 |
[Ambulant treatment of alcohol withdrawal].
Topics: Alcohol Withdrawal Delirium; Alcoholism; Ambulatory Care; Anticonvulsants; Chlormethiazole; Combined | 2016 |
Oxazepam versus clomethiazol in alcohol withdrawal treatment.
Topics: Adult; Alcoholism; Analysis of Variance; Chlormethiazole; Ethanol; Female; GABA Modulators; Humans; | 2010 |
Concurrent cocaine withdrawal alters alcohol withdrawal symptoms.
Topics: Adolescent; Adult; Alcoholism; Anti-Anxiety Agents; Cocaine; Cocaine-Related Disorders; Ethanol; Fem | 2002 |
Small human hepatocytes in rotary culture for treatment of alcohol addicts? A pilot study.
Topics: Alcoholism; Cell Count; Cell Culture Techniques; Cell Line; Culture Media; Cytochrome P-450 Enzyme S | 2007 |
[Therapeutic indications for high dosage of oxazepam].
Topics: Alcoholism; Amitriptyline; Dibenzazepines; Humans; Hypnotics and Sedatives; Mental Disorders; Methot | 1967 |
Should alcohol withdrawal seizures be treated with anti-epileptic drugs?
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Carbamazepine; Chlormethiazol | 1984 |
Drug interactions on an alcohol unit.
Topics: Adult; Alcoholism; Ataxia; Diagnosis, Differential; Drug Interactions; Epilepsy; Humans; Male; Oxaze | 1982 |
Late-onset seizures in alcohol withdrawal.
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Anti-Anxiety Agents; Diagnosis, Differential; | 1995 |
Alcohol and benzodiazepines generate anxiety, panic and phobias.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Anti-Anxiety Agents; Anxiety Disorders; Diazepam; Female; | 1995 |
Alcohol withdrawal: a nationwide survey of inpatient treatment practices.
Topics: Adrenergic beta-Antagonists; Alcoholism; Barbiturates; Benzodiazepines; Chlordiazepoxide; Clonidine; | 1995 |
Alcohol withdrawal treatment practices.
Topics: Alcoholism; Anti-Anxiety Agents; Ethanol; Humans; Oxazepam; Substance Withdrawal Syndrome; Treatment | 1996 |
Routine hospital alcohol detoxification practice compared to symptom triggered management with an Objective Withdrawal Scale (CIWA-Ar).
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Female; Hospitalization; Hos | 2000 |
Clinical implications of benzodiazepine pharmacokinetics.
Topics: Administration, Oral; Adult; Age Factors; Aged; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; C | 1977 |
Interaction of disulfiram with benzodiazepines.
Topics: Adult; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Disulfiram; Drug Interactions; H | 1978 |
The abuse potential of benzodiazepines with special reference to oxazepam.
Topics: Adult; Alcoholism; Anxiety; Benzodiazepines; Female; Humans; Male; Neurotic Disorders; Oxazepam; Sub | 1978 |
Massive benzodiazepine requirements during acute alcohol withdrawal.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Diazepam; Dose-Response Relationship, Drug; Half-Lif | 1979 |
Detoxification for triazolam physical dependence.
Topics: Adult; Alcoholism; Diazepam; Dose-Response Relationship, Drug; Female; Half-Life; Hospitalization; H | 1992 |
[Oxazepam in the treatment of neurotic disorders as well as in ambulatory detoxication treatment for alcoholics and polytoxicomaniacs].
Topics: Adult; Alcoholism; Ambulatory Care; Austria; Female; Humans; Male; Methods; Neurotic Disorders; Oxaz | 1972 |
[Oxazepam in alcoholism, depression and anxiety neuroses. A preliminary trial].
Topics: Absenteeism; Adolescent; Adult; Aged; Alcoholism; Anxiety Disorders; Depression; Humans; Male; Middl | 1968 |
[Preliminary note on a new antianxiety agent: oxazepam].
Topics: Alcoholism; Epilepsy; Humans; Intracranial Arteriosclerosis; Mental Disorders; Oxazepam; Tranquilizi | 1966 |