Page last updated: 2024-11-02

oxazepam and Aging

oxazepam has been researched along with Aging in 13 studies

Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" The purpose of this investigation was to examine the influence of increasing age on the pharmacokinetics and the time course of the anticonvulsant response of oxazepam in BN/BiRij rats as an animal model of aging."7.68Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats. ( Danhof, M; Hoogerkamp, A; Langemeijer, MW; Postel-Westra, I; Stijnen, AM; van Bezooijen, CF; Voskuyl, RA, 1992)
" Prenatal oxazepam (15 mg/kg, given per os twice daily on days 12-16 of pregnancy) did not influence hot-plate responding and morphine analgesia at any of the test ages."7.67Morphine effects on activity and pain reactivity of developing mice with or without late prenatal oxazepam exposure. ( Alleva, E; Bignami, G; Laviola, G, 1987)
" To test whether glucuronidation reactions supported by UDP-glucuronosyltransferases are differentially affected in such conditions, we investigated the in vitro glucuronidation of four selected drugs and xenobiotics (zidovudine, oxazepam, lamotrigine, and umbelliferone) by using microsomes from human healthy and unhealthy (cirrhosis, hepatitis) livers as enzyme sources."3.70Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers. ( Bourdon, O; Demirdjian, S; Furlan, V; Magdalou, J; Taburet, AM, 1999)
" The purpose of this investigation was to examine the influence of increasing age on the pharmacokinetics and the time course of the anticonvulsant response of oxazepam in BN/BiRij rats as an animal model of aging."3.68Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats. ( Danhof, M; Hoogerkamp, A; Langemeijer, MW; Postel-Westra, I; Stijnen, AM; van Bezooijen, CF; Voskuyl, RA, 1992)
" Prenatal oxazepam (15 mg/kg, given per os twice daily on days 12-16 of pregnancy) did not influence hot-plate responding and morphine analgesia at any of the test ages."3.67Morphine effects on activity and pain reactivity of developing mice with or without late prenatal oxazepam exposure. ( Alleva, E; Bignami, G; Laviola, G, 1987)
"The elimination half-life of chlordiazepoxide and diazepam increases with age, and this may cause prolongation of action after a single dose and delayed accumulation on multiple dosing in elderly patients."1.26[Pharmacokinetic of benzodiazepines in old age]. ( Vozeh, S, 1981)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19909 (69.23)18.7374
1990's3 (23.08)18.2507
2000's0 (0.00)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sacre, L1
Ali, SM1
Villa, A1
Jouffroy, R1
Raphalen, JH1
Garnier, R1
Baud, FJ1
Vozeh, S1
Ochs, HR1
Greenblatt, DJ1
Otten, H1
Furlan, V1
Demirdjian, S1
Bourdon, O1
Magdalou, J1
Taburet, AM1
Hoyumpa, AM1
Schenker, S1
Wilkinson, GR1
Stone, BM1
Kanto, J1
Sellman, R1
Haataja, M1
Hurme, P1
Stijnen, AM1
Postel-Westra, I1
Langemeijer, MW1
Hoogerkamp, A1
Voskuyl, RA1
van Bezooijen, CF1
Danhof, M1
Sonne, J1
Loft, S1
Døssing, M1
Boesgaard, S1
Andreasen, F1
Loew, F1
Pawlak, C1
Benaroyo, L1
Junod, JP1
Alleva, E1
Laviola, G1
Bignami, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-label, Randomised Pilot Study Comparing the Efficacy, Safety and Tolerability of Raltegravir With Protease Inhibitor-based Therapy in Treatment-naïve, HIV/Hepatitis C Co-infected Injecting Drug Users Receiving Methadone[NCT01105611]Phase 440 participants (Anticipated)Interventional2010-08-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for oxazepam and Aging

ArticleYear
Single dose pharmacokinetics and pharmacodynamics of oral oxazepam in very elderly institutionalised subjects.
    British journal of clinical pharmacology, 1991, Volume: 31, Issue:6

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Female; Half-Life; Humans; Institutiona

1991
Comparison of midazolam and oxazepam as hypnotics in elderly hospitalized patients. A double-blind clinical trial.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Body Weight; Clinical Trials as Topic; Double-Blind Method; Dreams;

1988

Other Studies

11 other studies available for oxazepam and Aging

ArticleYear
Toxicodynetics in nordiazepam and oxazepam overdoses.
    Annales pharmaceutiques francaises, 2017, Volume: 75, Issue:3

    Topics: Adolescent; Adult; Aging; Central Nervous System Depressants; Child; Child, Preschool; Drug Overdose

2017
[Pharmacokinetic of benzodiazepines in old age].
    Schweizerische medizinische Wochenschrift, 1981, Nov-21, Volume: 111, Issue:47

    Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Half-Life; Humans; Lorazepam; M

1981
Disposition of oxazepam in relation to age, sex, and cigarette smoking.
    Klinische Wochenschrift, 1981, Aug-17, Volume: 59, Issue:16

    Topics: Adult; Aged; Aging; Female; Humans; Intestinal Absorption; Kinetics; Male; Metabolic Clearance Rate;

1981
Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Adolescent; Adult; Aging; Aryl Hydrocarbon Hydroxylases; Biotransformation; Child; Child, Preschool;

1999
Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.
    Southern medical journal, 1978, Volume: 71 Suppl 2

    Topics: Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hepatitis; Humans; Liver Cirrhosis; Li

1978
Effects of liver disease and of aging on the disposition and elimination of sedatives.
    Transactions of the American Clinical and Climatological Association, 1978, Volume: 89

    Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral,

1978
The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man.
    Acta psychiatrica Scandinavica. Supplementum, 1978, Issue:274

    Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Female; H

1978
Diazepam and its hydroxylated metabolites: studies on sleep in healthy man.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:1

    Topics: Adult; Aging; Diazepam; Humans; Hydroxylation; Male; Middle Aged; Oxazepam; Sleep; Sleep, REM; Temaz

1979
Plasma and urine concentrations of diazepam and its metabolites in children, adults and in diazepam-intoxicated patients.
    International journal of clinical pharmacology and biopharmacy, 1978, Volume: 16, Issue:6

    Topics: Adult; Aging; Biotransformation; Child; Creatinine; Diazepam; Female; Humans; Infant; Infant, Newbor

1978
Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats.
    British journal of pharmacology, 1992, Volume: 107, Issue:1

    Topics: Aging; Animals; Anticonvulsants; Drug Tolerance; Injections, Intravenous; Male; Oxazepam; Rats; Rece

1992
Morphine effects on activity and pain reactivity of developing mice with or without late prenatal oxazepam exposure.
    Psychopharmacology, 1987, Volume: 92, Issue:4

    Topics: Aging; Animals; Female; Male; Mice; Mice, Inbred Strains; Models, Psychological; Morphine; Oxazepam;

1987