oxazepam and Aging
oxazepam has been researched along with Aging in 13 studies
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this investigation was to examine the influence of increasing age on the pharmacokinetics and the time course of the anticonvulsant response of oxazepam in BN/BiRij rats as an animal model of aging." | 7.68 | Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats. ( Danhof, M; Hoogerkamp, A; Langemeijer, MW; Postel-Westra, I; Stijnen, AM; van Bezooijen, CF; Voskuyl, RA, 1992) |
| " Prenatal oxazepam (15 mg/kg, given per os twice daily on days 12-16 of pregnancy) did not influence hot-plate responding and morphine analgesia at any of the test ages." | 7.67 | Morphine effects on activity and pain reactivity of developing mice with or without late prenatal oxazepam exposure. ( Alleva, E; Bignami, G; Laviola, G, 1987) |
| " To test whether glucuronidation reactions supported by UDP-glucuronosyltransferases are differentially affected in such conditions, we investigated the in vitro glucuronidation of four selected drugs and xenobiotics (zidovudine, oxazepam, lamotrigine, and umbelliferone) by using microsomes from human healthy and unhealthy (cirrhosis, hepatitis) livers as enzyme sources." | 3.70 | Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers. ( Bourdon, O; Demirdjian, S; Furlan, V; Magdalou, J; Taburet, AM, 1999) |
| " The purpose of this investigation was to examine the influence of increasing age on the pharmacokinetics and the time course of the anticonvulsant response of oxazepam in BN/BiRij rats as an animal model of aging." | 3.68 | Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats. ( Danhof, M; Hoogerkamp, A; Langemeijer, MW; Postel-Westra, I; Stijnen, AM; van Bezooijen, CF; Voskuyl, RA, 1992) |
| " Prenatal oxazepam (15 mg/kg, given per os twice daily on days 12-16 of pregnancy) did not influence hot-plate responding and morphine analgesia at any of the test ages." | 3.67 | Morphine effects on activity and pain reactivity of developing mice with or without late prenatal oxazepam exposure. ( Alleva, E; Bignami, G; Laviola, G, 1987) |
| "The elimination half-life of chlordiazepoxide and diazepam increases with age, and this may cause prolongation of action after a single dose and delayed accumulation on multiple dosing in elderly patients." | 1.26 | [Pharmacokinetic of benzodiazepines in old age]. ( Vozeh, S, 1981) |
Research
Studies (13)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (69.23) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sacre, L | 1 |
| Ali, SM | 1 |
| Villa, A | 1 |
| Jouffroy, R | 1 |
| Raphalen, JH | 1 |
| Garnier, R | 1 |
| Baud, FJ | 1 |
| Vozeh, S | 1 |
| Ochs, HR | 1 |
| Greenblatt, DJ | 1 |
| Otten, H | 1 |
| Furlan, V | 1 |
| Demirdjian, S | 1 |
| Bourdon, O | 1 |
| Magdalou, J | 1 |
| Taburet, AM | 1 |
| Hoyumpa, AM | 1 |
| Schenker, S | 1 |
| Wilkinson, GR | 1 |
| Stone, BM | 1 |
| Kanto, J | 1 |
| Sellman, R | 1 |
| Haataja, M | 1 |
| Hurme, P | 1 |
| Stijnen, AM | 1 |
| Postel-Westra, I | 1 |
| Langemeijer, MW | 1 |
| Hoogerkamp, A | 1 |
| Voskuyl, RA | 1 |
| van Bezooijen, CF | 1 |
| Danhof, M | 1 |
| Sonne, J | 1 |
| Loft, S | 1 |
| Døssing, M | 1 |
| Boesgaard, S | 1 |
| Andreasen, F | 1 |
| Loew, F | 1 |
| Pawlak, C | 1 |
| Benaroyo, L | 1 |
| Junod, JP | 1 |
| Alleva, E | 1 |
| Laviola, G | 1 |
| Bignami, G | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Randomised Pilot Study Comparing the Efficacy, Safety and Tolerability of Raltegravir With Protease Inhibitor-based Therapy in Treatment-naïve, HIV/Hepatitis C Co-infected Injecting Drug Users Receiving Methadone[NCT01105611] | Phase 4 | 40 participants (Anticipated) | Interventional | 2010-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
2 trials available for oxazepam and Aging
| Article | Year |
|---|---|
Single dose pharmacokinetics and pharmacodynamics of oral oxazepam in very elderly institutionalised subjects.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Female; Half-Life; Humans; Institutiona | 1991 |
Comparison of midazolam and oxazepam as hypnotics in elderly hospitalized patients. A double-blind clinical trial.
Topics: Aged; Aged, 80 and over; Aging; Body Weight; Clinical Trials as Topic; Double-Blind Method; Dreams; | 1988 |
Other Studies
11 other studies available for oxazepam and Aging
| Article | Year |
|---|---|
Toxicodynetics in nordiazepam and oxazepam overdoses.
Topics: Adolescent; Adult; Aging; Central Nervous System Depressants; Child; Child, Preschool; Drug Overdose | 2017 |
[Pharmacokinetic of benzodiazepines in old age].
Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Half-Life; Humans; Lorazepam; M | 1981 |
Disposition of oxazepam in relation to age, sex, and cigarette smoking.
Topics: Adult; Aged; Aging; Female; Humans; Intestinal Absorption; Kinetics; Male; Metabolic Clearance Rate; | 1981 |
Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers.
Topics: Adolescent; Adult; Aging; Aryl Hydrocarbon Hydroxylases; Biotransformation; Child; Child, Preschool; | 1999 |
Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.
Topics: Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hepatitis; Humans; Liver Cirrhosis; Li | 1978 |
Effects of liver disease and of aging on the disposition and elimination of sedatives.
Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral, | 1978 |
The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man.
Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Female; H | 1978 |
Diazepam and its hydroxylated metabolites: studies on sleep in healthy man.
Topics: Adult; Aging; Diazepam; Humans; Hydroxylation; Male; Middle Aged; Oxazepam; Sleep; Sleep, REM; Temaz | 1979 |
Plasma and urine concentrations of diazepam and its metabolites in children, adults and in diazepam-intoxicated patients.
Topics: Adult; Aging; Biotransformation; Child; Creatinine; Diazepam; Female; Humans; Infant; Infant, Newbor | 1978 |
Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats.
Topics: Aging; Animals; Anticonvulsants; Drug Tolerance; Injections, Intravenous; Male; Oxazepam; Rats; Rece | 1992 |
Morphine effects on activity and pain reactivity of developing mice with or without late prenatal oxazepam exposure.
Topics: Aging; Animals; Female; Male; Mice; Mice, Inbred Strains; Models, Psychological; Morphine; Oxazepam; | 1987 |