oxatomide has been researched along with Asthma in 18 studies
oxatomide: structure; an anti-allergic & an anti-asthmatic
oxatomide : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty patients suffering from asthmatic conditions, often accompanied by emphysema, were treated either with an extempore combination of salbutamol syrup plus 30-mg oxatomide tablets or with 30-mg oxatomide tablets alone for purposes of comparison." | 9.06 | Treatment of asthma with an extempore combination of a bronchodilator, salbutamol, and a new antihistamine drug, oxatomide. ( Caprioglio, L; Scremin, S, 1986) |
| "Two groups of eight asthmatic children carried out serial treadmill exercise tests at 2-hourly intervals, after double-blind premedication with oxatomide (2 mg/kg by mouth), sodium cromoglycate powder (20 mg by inhalation) or matched placebo preparations." | 9.05 | Oxatomide and exercise-induced asthma in children: the value of serial exercise tests. ( Silverman, M; Tooley, M, 1981) |
| "A double-blind study comparing oxatomide, a new oral drug with anti-allergic properties, with placebo in the treatment of patients with asthma with or without perennial rhinitis has been undertaken." | 9.05 | A controlled trial of oxatomide in the treatment of asthma with or without perennial rhinitis. Brompton Hospital/Medical Research Council Collaborative Trial. ( , 1981) |
| "To determine whether oxatomide alone, or in combination with other interventions, results in better disease control in people with asthma." | 8.82 | Oxatomide for stable asthma in adults and children. ( Anami, K; Hayashi, K; Takamatsu, I; Wood-Baker, R; Yanagi, M, 2003) |
| "Oxatomide is a potent inhibitor of both the release and effects of allergic mediators and is similar to calcium antagonists in chemical structure." | 6.67 | Oxatomide modifies methacholine- and exercise-induced bronchoconstriction in asthmatic children. ( Iikura, Y; Kishida, M; Saito, S; Sasamoto, A, 1992) |
| "Oxatomide is an anti-allergic agent having an anti-histamine effect, and has been widely used for clinical purposes." | 5.29 | [Suppressive effect of oxatomide on the induction of IL2 responsiveness by DF-stimulated lymphocytes from patients with bronchial asthma]. ( Kawano, Y; Nakajima, T; Noma, T; Yoshizawa, I, 1994) |
| "Forty patients suffering from asthmatic conditions, often accompanied by emphysema, were treated either with an extempore combination of salbutamol syrup plus 30-mg oxatomide tablets or with 30-mg oxatomide tablets alone for purposes of comparison." | 5.06 | Treatment of asthma with an extempore combination of a bronchodilator, salbutamol, and a new antihistamine drug, oxatomide. ( Caprioglio, L; Scremin, S, 1986) |
| "Two groups of eight asthmatic children carried out serial treadmill exercise tests at 2-hourly intervals, after double-blind premedication with oxatomide (2 mg/kg by mouth), sodium cromoglycate powder (20 mg by inhalation) or matched placebo preparations." | 5.05 | Oxatomide and exercise-induced asthma in children: the value of serial exercise tests. ( Silverman, M; Tooley, M, 1981) |
| "A double-blind study comparing oxatomide, a new oral drug with anti-allergic properties, with placebo in the treatment of patients with asthma with or without perennial rhinitis has been undertaken." | 5.05 | A controlled trial of oxatomide in the treatment of asthma with or without perennial rhinitis. Brompton Hospital/Medical Research Council Collaborative Trial. ( , 1981) |
| "Forty asthmatic children were treated either with a combination of salbutamol plus oxatomide (20 cases) or with salbutamol alone (20 cases) for purposes of comparison." | 5.05 | Treatment of asthma syndromes in pediatric patients using a combination of a beta 2-stimulant drug and a histamine antagonist. ( Bianchi, G, 1985) |
| "To determine whether oxatomide alone, or in combination with other interventions, results in better disease control in people with asthma." | 4.82 | Oxatomide for stable asthma in adults and children. ( Anami, K; Hayashi, K; Takamatsu, I; Wood-Baker, R; Yanagi, M, 2003) |
| "Effect of oxatomide on release and production of platelet-activating factor (PAF) in neutrophils obtained from asthmatic and non-asthmatic patients was investigated." | 3.70 | Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. ( Fukumura, M; Shindo, K, 1998) |
| " When leukocytes from asthmatic patients sensitive to mite were stimulated with the allergen, epinastine inhibited histamine release with a concentration required for 50% inhibition (IC50) of 3 x 10(-5) mol/l and leukotriene C4 generation." | 3.69 | Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. ( Mita, H; Shida, T, 1995) |
| "Oxatomide is a potent inhibitor of both the release and effects of allergic mediators and is similar to calcium antagonists in chemical structure." | 2.67 | Oxatomide modifies methacholine- and exercise-induced bronchoconstriction in asthmatic children. ( Iikura, Y; Kishida, M; Saito, S; Sasamoto, A, 1992) |
| "Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation." | 2.37 | Oxatomide. A review of its pharmacodynamic properties and therapeutic efficacy. ( Avery, GS; Brogden, RN; Heel, RC; Richards, DM; Speight, TM, 1984) |
| "Oxatomide is an anti-allergic agent having an anti-histamine effect, and has been widely used for clinical purposes." | 1.29 | [Suppressive effect of oxatomide on the induction of IL2 responsiveness by DF-stimulated lymphocytes from patients with bronchial asthma]. ( Kawano, Y; Nakajima, T; Noma, T; Yoshizawa, I, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (61.11) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, K | 1 |
| Yanagi, M | 1 |
| Wood-Baker, R | 1 |
| Takamatsu, I | 1 |
| Anami, K | 1 |
| Silverman, M | 1 |
| Tooley, M | 1 |
| Ohmori, K | 1 |
| Ishii, H | 1 |
| Takei, Y | 1 |
| Shuto, K | 1 |
| Nakamizo, N | 1 |
| Furukawa, CT | 1 |
| Tschopp, JM | 1 |
| Turner-Warwick, M | 1 |
| Richards, DM | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| De Cree, J | 1 |
| Hörig, C | 1 |
| Verhaegen, H | 1 |
| Mita, H | 1 |
| Shida, T | 1 |
| Yoshizawa, I | 1 |
| Nakajima, T | 1 |
| Kawano, Y | 1 |
| Noma, T | 1 |
| Tanaka, Y | 1 |
| Masai, E | 1 |
| Yashima, T | 1 |
| Furukawa, M | 1 |
| Shindo, K | 1 |
| Fukumura, M | 1 |
| Kishida, M | 1 |
| Sasamoto, A | 1 |
| Saito, S | 1 |
| Iikura, Y | 1 |
| Antmann, I | 1 |
| Baba, M | 1 |
| Bianchi, G | 1 |
| Wüthrich, B | 1 |
| Radielovic, P | 1 |
| Scremin, S | 1 |
| Caprioglio, L | 1 |
2 reviews available for oxatomide and Asthma
| Article | Year |
|---|---|
Oxatomide for stable asthma in adults and children.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Child; Humans; Piperazines; Randomized Controlled Trials as To | 2003 |
Oxatomide. A review of its pharmacodynamic properties and therapeutic efficacy.
Topics: Animals; Asthma; Basophils; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; I | 1984 |
6 trials available for oxatomide and Asthma
| Article | Year |
|---|---|
Oxatomide and exercise-induced asthma in children: the value of serial exercise tests.
Topics: Asthma; Asthma, Exercise-Induced; Child; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Met | 1981 |
A controlled trial of oxatomide in the treatment of asthma with or without perennial rhinitis. Brompton Hospital/Medical Research Council Collaborative Trial.
Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Antag | 1981 |
Oxatomide modifies methacholine- and exercise-induced bronchoconstriction in asthmatic children.
Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchoconstriction; Chil | 1992 |
Observations with tinset tablet in allergic respiratory tract diseases.
Topics: Adolescent; Adult; Asthma; Child; Drug Evaluation; Histamine H1 Antagonists; Humans; Piperazines; Re | 1990 |
Treatment of asthma syndromes in pediatric patients using a combination of a beta 2-stimulant drug and a histamine antagonist.
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Auscultation; Child; Child, Preschool; Clinical Trials | 1985 |
Treatment of asthma with an extempore combination of a bronchodilator, salbutamol, and a new antihistamine drug, oxatomide.
Topics: Adrenal Cortex Hormones; Adult; Aged; Albuterol; Asthma; Clinical Trials as Topic; Drug Combinations | 1986 |
10 other studies available for oxatomide and Asthma
| Article | Year |
|---|---|
[Pharmacological actions of oxatomide (KW-4354). 3. Actions on experimental asthma and Schultz-Dale reaction].
Topics: Animals; Asthma; Bronchi; Bronchodilator Agents; Cromolyn Sodium; Guinea Pigs; Histamine H1 Antagoni | 1982 |
Other pharmacologic agents that may affect bronchial hyperreactivity.
Topics: Adrenergic alpha-Antagonists; Asthma; Asthma, Exercise-Induced; Benzothiazoles; Budesonide; Calcium | 1984 |
Persisting airflow limitation in asthmatics receiving routine self-adjusted medication.
Topics: Adult; Aerosols; Age Factors; Albuterol; Asthma; Beclomethasone; Female; Forced Expiratory Volume; H | 1984 |
Oxatomide in the treatment of various allergic diseases.
Topics: Adolescent; Adult; Aged; Asthma; Child; Child, Preschool; Female; Gastrointestinal Diseases; Humans; | 1980 |
Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes.
Topics: Asthma; Calcimycin; Dibenzazepines; Histamine H1 Antagonists; Humans; Hypersensitivity; Imidazoles; | 1995 |
[Suppressive effect of oxatomide on the induction of IL2 responsiveness by DF-stimulated lymphocytes from patients with bronchial asthma].
Topics: Animals; Antigens; Asthma; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; | 1994 |
[Antiallergic effects of a novel compound, SWR-00151].
Topics: Animals; Anti-Allergic Agents; Asthma; Bronchoconstriction; Cells, Cultured; Depression, Chemical; D | 1997 |
Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Asthmatic Agents; Asthma; Cell Extracts; Dose-Response Re | 1998 |
[Progress of therapeutic agents for asthma--2. Prophylactic anti-asthmatic agents].
Topics: Administration, Inhalation; Administration, Oral; Animals; Asthma; Child, Preschool; Cromolyn Sodium | 1987 |
[Preventive drug therapy in allergic bronchial asthma].
Topics: Asthma; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Ketotifen; Piperazines; Respiratory Hyper | 1986 |