oxatomide has been researched along with Allergic Reaction in 13 studies
oxatomide: structure; an anti-allergic & an anti-asthmatic
oxatomide : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The new antiallergic drug oxatomide was evaluated in 40 schoolchildren suffering from severe allergic seasonal rhinoconjunctivitis." | 9.05 | Oxatomide in seasonal rhinoconjunctivitis. ( Björkstén, B; Möller, C, 1980) |
| "This double-blind study suggests that oxatomide may be considered a first-line alternative in the treatment of allergic follicular conjunctivitis." | 9.05 | Oxatomide effects in follicular conjunctivitis of presumed allergic cause. A double-blind evaluation. ( Blockeel, J; Leuridan, O, 1980) |
| "The new antiallergic drug oxatomide was evaluated in 40 schoolchildren suffering from severe allergic seasonal rhinoconjunctivitis." | 5.05 | Oxatomide in seasonal rhinoconjunctivitis. ( Björkstén, B; Möller, C, 1980) |
| "This double-blind study suggests that oxatomide may be considered a first-line alternative in the treatment of allergic follicular conjunctivitis." | 5.05 | Oxatomide effects in follicular conjunctivitis of presumed allergic cause. A double-blind evaluation. ( Blockeel, J; Leuridan, O, 1980) |
| " When leukocytes from asthmatic patients sensitive to mite were stimulated with the allergen, epinastine inhibited histamine release with a concentration required for 50% inhibition (IC50) of 3 x 10(-5) mol/l and leukotriene C4 generation." | 3.69 | Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. ( Mita, H; Shida, T, 1995) |
| "Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation." | 2.37 | Oxatomide. A review of its pharmacodynamic properties and therapeutic efficacy. ( Avery, GS; Brogden, RN; Heel, RC; Richards, DM; Speight, TM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (84.62) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishikawa, Y | 1 |
| Shindo, T | 1 |
| Ishii, K | 1 |
| Nakamura, H | 1 |
| Kon, T | 1 |
| Uno, H | 1 |
| Walsh, DA | 1 |
| Franzyshen, SK | 1 |
| Yanni, JM | 1 |
| Ho, CY | 1 |
| Hageman, WE | 1 |
| Persico, FJ | 1 |
| Domae, M | 1 |
| Sagara, H | 1 |
| Sakaue, M | 1 |
| Fukuda, T | 1 |
| Kamikawa, Y | 1 |
| Davies, RJ | 1 |
| Moodley, I | 1 |
| Richards, DM | 1 |
| Brogden, RN | 1 |
| Heel, RC | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Möller, C | 1 |
| Björkstén, B | 1 |
| Blockeel, J | 1 |
| Leuridan, O | 1 |
| De Cree, J | 1 |
| Hörig, C | 1 |
| Verhaegen, H | 1 |
| Mita, H | 1 |
| Shida, T | 1 |
| Borgers, M | 1 |
| De Brabander, M | 1 |
| Van Reempts, J | 1 |
| Awouters, F | 1 |
| Janssen, PA | 1 |
| Bierman, CW | 1 |
| Assem, ES | 1 |
| Mongar, JL | 1 |
| Kovács, E | 1 |
2 reviews available for oxatomide and Allergic Reaction
| Article | Year |
|---|---|
Antiallergic compounds.
Topics: Adrenal Cortex Hormones; Allergens; Animals; Aspirin; Bronchodilator Agents; Cromolyn Sodium; Histam | 1982 |
Oxatomide. A review of its pharmacodynamic properties and therapeutic efficacy.
Topics: Animals; Asthma; Basophils; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; I | 1984 |
2 trials available for oxatomide and Allergic Reaction
| Article | Year |
|---|---|
Oxatomide in seasonal rhinoconjunctivitis.
Topics: Adolescent; Child; Child, Preschool; Cinnarizine; Clinical Trials as Topic; Conjunctivitis; Double-B | 1980 |
Oxatomide effects in follicular conjunctivitis of presumed allergic cause. A double-blind evaluation.
Topics: Adolescent; Adult; Cinnarizine; Clinical Trials as Topic; Conjunctivitis; Double-Blind Method; Femal | 1980 |
9 other studies available for oxatomide and Allergic Reaction
| Article | Year |
|---|---|
Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides.
Topics: Acrylamides; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine Antagonists; Histamine R | 1989 |
Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds.
Topics: Anaphylaxis; Animals; Benzhydryl Compounds; Chemical Phenomena; Chemistry; Drug Evaluation, Preclini | 1989 |
Indolo[2,1-c][1,4]benzodiazepines: a new class of antiallergic agents.
Topics: Anaphylaxis; Animals; Benzodiazepines; Cromolyn Sodium; Guinea Pigs; Histamine H1 Antagonists; Hyper | 1986 |
The antiallergic drug oxatomide promotes human eosinophil apoptosis and suppresses IL-5-induced eosinophil survival.
Topics: Anti-Allergic Agents; Apoptosis; Caspase 3; Caspases; Cell Survival; DNA Fragmentation; Eosinophils; | 2003 |
Oxatomide in the treatment of various allergic diseases.
Topics: Adolescent; Adult; Aged; Asthma; Child; Child, Preschool; Female; Gastrointestinal Diseases; Humans; | 1980 |
Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes.
Topics: Asthma; Calcimycin; Dibenzazepines; Histamine H1 Antagonists; Humans; Hypersensitivity; Imidazoles; | 1995 |
Morphological evaluation of oxatomide--a new anti-allergic drug in guinea pig anaphylaxis.
Topics: Anaphylaxis; Animals; Drug Evaluation; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity; Male | 1978 |
Inhibition and stimulation of histamine release by oxatomide.
Topics: Animals; Basophils; Histamine Release; Hypersensitivity; Immunoglobulin E; In Vitro Techniques; Lung | 1979 |
Use of oxatomide (Tinset) in allergic diseases.
Topics: Adolescent; Adult; Female; Humans; Hypersensitivity; Male; Middle Aged; Piperazines | 1987 |