oxamniquine has been researched along with Neglected Diseases in 4 studies
Oxamniquine: An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)
oxamniquine : A racemate comprising equimolar amounts of (R)- and (S)-oxamniquine. An anthelmintic, it is administered orally for the treatment of schistomiasis caused by Schistosoma mansoni (but not by other Schistosoma species); intramuscular administration is no longer used as it causes severe pain at the injection site.
{2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol : A member of the class of quinolines that is 1,2,3,4-tetrahydroquinoline which is substituted at positions 2, 6, and 7 by (isopropylamino)methyl, hydroxymethyl, and nitro groups, respectively.
Neglected Diseases: Diseases that are underfunded and have low name recognition but are major burdens in less developed countries. The World Health Organization has designated six tropical infectious diseases as being neglected in industrialized countries that are endemic in many developing countries (HELMINTHIASIS; LEPROSY; LYMPHATIC FILARIASIS; ONCHOCERCIASIS; SCHISTOSOMIASIS; and TRACHOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human schistosomiasis is a neglected tropical disease caused by Schistosoma mansoni, S." | 5.91 | Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis. ( Alwan, SN; LoVerde, PT; McHardy, SF; Rhodes, J; Taylor, AB; Tidwell, M, 2023) |
| "Currently, the main forms of treatment used for schistosomiasis are praziquantel (PZQ) and oxaminiquine (OXA)." | 2.55 | Schistosomiasis: Drugs used and treatment strategies. ( Aguilera, CSB; Ângelos, MA; da Silva, RMF; de Melo, CG; Fontes, DAF; Neto, PJR; Rolim, LA; Silva, LCPBB; Siqueira, LDP; Timóteo, TRR, 2017) |
| "Human schistosomiasis is a neglected tropical disease caused by Schistosoma mansoni, S." | 1.91 | Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis. ( Alwan, SN; LoVerde, PT; McHardy, SF; Rhodes, J; Taylor, AB; Tidwell, M, 2023) |
| "Schistosomiasis is a neglected tropical disease with more than 200 million new infections per year." | 1.72 | Disulfiram and dithiocarbamate analogues demonstrate promising antischistosomal effects. ( Gallinger, TL; Grevelding, CG; Grünweller, A; Haeberlein, S; Lange-Grünweller, K; Mäder, P; Rennar, GA; Schlitzer, M, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| da Silva, VBR | 1 |
| Campos, BRKL | 1 |
| de Oliveira, JF | 1 |
| Decout, JL | 1 |
| do Carmo Alves de Lima, M | 1 |
| Rennar, GA | 1 |
| Gallinger, TL | 1 |
| Mäder, P | 1 |
| Lange-Grünweller, K | 1 |
| Haeberlein, S | 1 |
| Grünweller, A | 1 |
| Grevelding, CG | 1 |
| Schlitzer, M | 1 |
| Alwan, SN | 1 |
| Taylor, AB | 1 |
| Rhodes, J | 1 |
| Tidwell, M | 1 |
| McHardy, SF | 1 |
| LoVerde, PT | 1 |
| Siqueira, LDP | 1 |
| Fontes, DAF | 1 |
| Aguilera, CSB | 1 |
| Timóteo, TRR | 1 |
| Ângelos, MA | 1 |
| Silva, LCPBB | 1 |
| de Melo, CG | 1 |
| Rolim, LA | 1 |
| da Silva, RMF | 1 |
| Neto, PJR | 1 |
2 reviews available for oxamniquine and Neglected Diseases
| Article | Year |
|---|---|
Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine.
Topics: Animals; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Humans; Molecular Structure; N | 2017 |
Schistosomiasis: Drugs used and treatment strategies.
Topics: Animals; Anthelmintics; Biomedical Research; Brazil; Child; Female; Humans; Neglected Diseases; Oxam | 2017 |
2 other studies available for oxamniquine and Neglected Diseases
| Article | Year |
|---|---|
Disulfiram and dithiocarbamate analogues demonstrate promising antischistosomal effects.
Topics: Adult; Aldehyde Dehydrogenase; Animals; Disulfiram; Humans; Neglected Diseases; Nitrogen; Oxamniquin | 2022 |
Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis.
Topics: Animals; Anthelmintics; Combined Modality Therapy; Humans; Neglected Diseases; Oxamniquine; Praziqua | 2023 |