oxamniquine has been researched along with Liver Diseases, Parasitic in 15 studies
Oxamniquine: An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)
oxamniquine : A racemate comprising equimolar amounts of (R)- and (S)-oxamniquine. An anthelmintic, it is administered orally for the treatment of schistomiasis caused by Schistosoma mansoni (but not by other Schistosoma species); intramuscular administration is no longer used as it causes severe pain at the injection site.
{2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol : A member of the class of quinolines that is 1,2,3,4-tetrahydroquinoline which is substituted at positions 2, 6, and 7 by (isopropylamino)methyl, hydroxymethyl, and nitro groups, respectively.
Liver Diseases, Parasitic: Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The introduction of oxamniquine and praziquantel constitutes a break through in the treatment of intestinal and urogenital schistosomiasis." | 4.76 | [Present status of the treatment of helminthiasis]. ( Coulaud, JP, 1984) |
| "Schistosomiasis mansoni affects the hepatic functional reserve." | 1.31 | Surgical hepatosplenic mansonic schistosomiasis in adolescents: repercussions of the post-treatment schistosomotic burden on the hepatic functional reserve. ( Brandt, CT; Carvalheira, R; da Mota Braga, MV; Melo, KL; Pinho Sá, H, 2001) |
| " There were no significant differences in oxamniquine mean area under the plasma concentration time curve (AUC), plasma half life (T1/2), or time to reach peak concentration (Tmax)." | 1.27 | Oxamniquine pharmacokinetics in hepatosplenic schistosomiasis in the Sudan. ( Daneshmend, TK; Homeida, MA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrade, ZA | 1 |
| Baptista, AP | 1 |
| Santana, TS | 1 |
| Coulaud, JP | 1 |
| Lambertucci, JR | 1 |
| Greco, DB | 1 |
| Pedroso, ER | 1 |
| da Costa Rocha, MO | 1 |
| Salazar, HM | 1 |
| de Lima, DP | 1 |
| García Goyco, C | 1 |
| Torres Borges, A | 1 |
| Kilpatrick, ME | 1 |
| El Masry, NA | 1 |
| Bassily, S | 3 |
| Farid, Z | 3 |
| Higashi, GI | 2 |
| Trabolsi, B | 1 |
| Watten, RH | 2 |
| Coelho, PM | 1 |
| Toppa, NH | 1 |
| Feldmann, JS | 1 |
| Gonçalves, R | 1 |
| Mello, RT | 1 |
| Brandt, CT | 1 |
| da Mota Braga, MV | 1 |
| Melo, KL | 1 |
| Pinho Sá, H | 1 |
| Carvalheira, R | 1 |
| Alves, JG | 1 |
| Ulisses Montenegro, FM | 1 |
| Guimarães, RX | 1 |
| Tchakerian, A | 1 |
| Dias, LC | 1 |
| de Almeida, FM | 1 |
| Vilela, MP | 1 |
| Cabeca, M | 1 |
| Takeda, AK | 1 |
| El-Hawey, AM | 1 |
| Gaber, A | 1 |
| Saber, MA | 1 |
| Abou-Taleb, S | 1 |
| Daneshmend, TK | 1 |
| Homeida, MA | 1 |
| Massoud, AM | 1 |
| Ghoneem, M | 1 |
| Massoud, M | 1 |
| el-Rooby, A | 1 |
2 reviews available for oxamniquine and Liver Diseases, Parasitic
| Article | Year |
|---|---|
[Present status of the treatment of helminthiasis].
Topics: Albendazole; Anthelmintics; Benzimidazoles; Cestode Infections; Echinococcosis; Helminthiasis; Human | 1984 |
Management of hepatic schistosomiasis.
Topics: Acute Disease; Animals; Central Nervous System; Child; Chronic Disease; Colon; Diagnosis, Differenti | 1985 |
2 trials available for oxamniquine and Liver Diseases, Parasitic
| Article | Year |
|---|---|
A double blind trial with oxamniquine in chronic schistosomiasis mansoni.
Topics: Adolescent; Child; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Feces; Female; Hu | 1982 |
Oxamniquine versus niridazole for treatment of uncomplicated Schistosoma mansoni infection.
Topics: Adolescent; Adult; Animals; Child; Humans; Liver Diseases, Parasitic; Liver Function Tests; Male; Mi | 1982 |
11 other studies available for oxamniquine and Liver Diseases, Parasitic
| Article | Year |
|---|---|
Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis.
Topics: Animals; Anthelmintics; Chronic Disease; Disease Models, Animal; Female; Granuloma; Humans; Liver Ci | 2006 |
[Schistosomiasis: clinical spectrum of the disease and response to oxamniquine treatment in chronic infections].
Topics: Adolescent; Adult; Child; Female; Humans; Intestinal Diseases, Parasitic; Liver Diseases, Parasitic; | 1982 |
Treatment of advanced hepatosplenic schistosomiasis with oxamniquine.
Topics: Adult; Child; Follow-Up Studies; Humans; Liver Diseases, Parasitic; Male; Middle Aged; Oxamniquine; | 1980 |
Schistosoma mansoni: permanence of modulation of the granulomatous inflammatory response in mice cured in the chronic phase.
Topics: Animals; Granuloma; Inflammation; Liver Diseases, Parasitic; Mice; Oxamniquine; Schistosomiasis mans | 1996 |
Surgical hepatosplenic mansonic schistosomiasis in adolescents: repercussions of the post-treatment schistosomotic burden on the hepatic functional reserve.
Topics: Adolescent; Animals; Child; Esophageal and Gastric Varices; Follow-Up Studies; Gastrointestinal Hemo | 2001 |
Portal hypertension due to schistosomiasis.
Topics: Child, Preschool; Female; Humans; Hypertension, Portal; Liver Diseases, Parasitic; Oxamniquine; Schi | 2001 |
[Resistance to hycanthone and oxamniquine in patients with a clinical hepato-intestinal form of schistosomiasis].
Topics: Adult; Animals; Drug Resistance; Female; Humans; Hycanthone; Intestinal Diseases, Parasitic; Liver D | 1979 |
Studies on portal hypertension and its relation to serum histamine level in patients with bilharzial hepatic fibrosis.
Topics: Antimony Potassium Tartrate; Histamine; Humans; Hypertension, Portal; Liver; Liver Diseases, Parasit | 1978 |
Treatment of complicated schistosomiasis mansoni with oxamniquine.
Topics: Adult; Child; Humans; Liver Diseases, Parasitic; Male; Middle Aged; Nitroquinolines; Oxamniquine; Sc | 1978 |
Oxamniquine pharmacokinetics in hepatosplenic schistosomiasis in the Sudan.
Topics: Adult; Female; Half-Life; Humans; Kinetics; Liver Diseases, Parasitic; Male; Middle Aged; Nitroquino | 1987 |
Effect of oxamniquine and praziquantel on intrasplenic pressure and portal vein diameter in hepatosplenic schistosomiasis.
Topics: Adult; Blood Pressure; Humans; Liver Diseases, Parasitic; Male; Nitroquinolines; Oxamniquine; Portal | 1986 |