oxamniquine has been researched along with Enlarged Spleen in 8 studies
Oxamniquine: An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)
oxamniquine : A racemate comprising equimolar amounts of (R)- and (S)-oxamniquine. An anthelmintic, it is administered orally for the treatment of schistomiasis caused by Schistosoma mansoni (but not by other Schistosoma species); intramuscular administration is no longer used as it causes severe pain at the injection site.
{2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol : A member of the class of quinolines that is 1,2,3,4-tetrahydroquinoline which is substituted at positions 2, 6, and 7 by (isopropylamino)methyl, hydroxymethyl, and nitro groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The course of hepatosplenic schistosomiasis after mass chemotherapy with oxamniquine has been rarely reported." | 7.73 | Ultrasound and clinical investigation of hepatosplenic schistosomiasis: evaluation of splenomegaly and liver fibrosis four years after mass chemotherapy with oxamniquine. ( Antunes, CM; Cota, GF; Lambertucci, JR; Pinto-Silva, RA, 2006) |
| "The course of hepatosplenic schistosomiasis after mass chemotherapy with oxamniquine has been rarely reported." | 3.73 | Ultrasound and clinical investigation of hepatosplenic schistosomiasis: evaluation of splenomegaly and liver fibrosis four years after mass chemotherapy with oxamniquine. ( Antunes, CM; Cota, GF; Lambertucci, JR; Pinto-Silva, RA, 2006) |
| "Schistosomiasis mansoni is a tropical parasitic disease caused by a blood fluke which inhabits the portal system of humans." | 1.29 | Scintigraphic findings in schistosomiasis. ( Orduña, E; Silva, F, 1995) |
| "The high prevalence of hepatomegaly (over 80%) and of splenomegaly (over 15%) contrasted with rates of 10% and 1%, respectively, in a non-endemic area." | 1.27 | Three-year prospective study of the evolution of Manson's schistosomiasis in north-east Brazil. ( Barreto, ML; Hoff, R; Maguire, JH; Mota, EA; Mott, KE; Sherlock, I; Sleigh, AC; Weller, TH, 1985) |
| "Oxamniquine was given in single daily doses of 20 mg/kg of body weight for either two or three days and cured 50% and 85%, respectively, of subjects treated; ova excretion was reduced by 86%-93% for up to 12 months." | 1.26 | Clinical characteristics and response to therapy in Egyptian children heavily infected with Schistosoma mansoni. ( Abdel-Wahab, F; El-Sahly, A; Merritt, W; Strickland, GT, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cota, GF | 1 |
| Pinto-Silva, RA | 1 |
| Antunes, CM | 1 |
| Lambertucci, JR | 1 |
| Strickland, GT | 1 |
| Merritt, W | 1 |
| El-Sahly, A | 1 |
| Abdel-Wahab, F | 1 |
| Farid, Z | 1 |
| Higashi, GI | 1 |
| Bassily, S | 1 |
| Trabolsi, B | 1 |
| Watten, RH | 1 |
| Orduña, E | 1 |
| Silva, F | 1 |
| Bina, JC | 1 |
| Sleigh, AC | 1 |
| Mott, KE | 1 |
| Hoff, R | 1 |
| Barreto, ML | 1 |
| Mota, EA | 1 |
| Maguire, JH | 1 |
| Sherlock, I | 1 |
| Weller, TH | 1 |
| Kloetzel, K | 1 |
| Schuster, NH | 1 |
| Coutinho, A | 1 |
| Domingues, AL | 1 |
1 review available for oxamniquine and Enlarged Spleen
| Article | Year |
|---|---|
[Specific treatment as a weapon for controlling schistosomiasis].
Topics: Adolescent; Brazil; Child; Child, Preschool; Clinical Trials as Topic; Female; Follow-Up Studies; He | 1992 |
7 other studies available for oxamniquine and Enlarged Spleen
| Article | Year |
|---|---|
Ultrasound and clinical investigation of hepatosplenic schistosomiasis: evaluation of splenomegaly and liver fibrosis four years after mass chemotherapy with oxamniquine.
Topics: Adolescent; Adult; Alcoholism; Female; Humans; Liver Cirrhosis; Logistic Models; Male; Multivariate | 2006 |
Clinical characteristics and response to therapy in Egyptian children heavily infected with Schistosoma mansoni.
Topics: Adolescent; Anemia; Child; Egypt; Female; Hepatomegaly; Humans; Male; Nitroquinolines; Oxamniquine; | 1982 |
Treatment of advanced hepatosplenic schistosomiasis with oxamniquine.
Topics: Adult; Child; Follow-Up Studies; Humans; Liver Diseases, Parasitic; Male; Middle Aged; Oxamniquine; | 1980 |
Scintigraphic findings in schistosomiasis.
Topics: Acute Disease; Adolescent; Child; Follow-Up Studies; Hepatomegaly; Humans; Liver Function Tests; Mal | 1995 |
Three-year prospective study of the evolution of Manson's schistosomiasis in north-east Brazil.
Topics: Adolescent; Adult; Brazil; Child; Child, Preschool; Cross-Sectional Studies; Hepatomegaly; Humans; O | 1985 |
Repeated mass treatment of schistosomiasis mansoni: experience in hyperendemic areas of Brazil. I. Parasitological effects and morbidity.
Topics: Adolescent; Adult; Age Factors; Brazil; Humans; Hypertension, Portal; Middle Aged; Nitroquinolines; | 1987 |
Specific treatment of advanced schistosomiasis liver disease in man: favourable results.
Topics: Adolescent; Adult; Aged; Child; Drug Evaluation; Female; Hepatitis, Chronic; Hepatomegaly; Humans; L | 1987 |