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oxamniquine and Disease Models, Animal

oxamniquine has been researched along with Disease Models, Animal in 5 studies

Oxamniquine: An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)
oxamniquine : A racemate comprising equimolar amounts of (R)- and (S)-oxamniquine. An anthelmintic, it is administered orally for the treatment of schistomiasis caused by Schistosoma mansoni (but not by other Schistosoma species); intramuscular administration is no longer used as it causes severe pain at the injection site.
{2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl}methanol : A member of the class of quinolines that is 1,2,3,4-tetrahydroquinoline which is substituted at positions 2, 6, and 7 by (isopropylamino)methyl, hydroxymethyl, and nitro groups, respectively.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
"Praziquantel was the most effective drug; a dose of 100 mg/kg given orally for 5 days resulted in a 95% reduction in worm burdens."1.28Experimental chemotherapy of Schistosoma curassoni in mice. ( Hilderson, H; Rollinson, D; Southgate, VR; Vercruysse, J, 1989)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kinnamon, KE1
Steck, EA1
Hanson, WL1
Chapman, WL1
Hess, J1
Panic, G1
Patra, M1
Mastrobuoni, L1
Spingler, B1
Roy, S1
Keiser, J1
Gasser, G1
Yuen, T1
Iqbal, J1
Zhu, LL1
Sun, L1
Lin, A1
Zhao, H1
Liu, J1
Mistry, PK1
Zaidi, M1
Andrade, ZA1
Baptista, AP1
Santana, TS1
Vercruysse, J1
Southgate, VR1
Rollinson, D1
Hilderson, H1

Other Studies

5 other studies available for oxamniquine and Disease Models, Animal

ArticleYear
In search of anti-Trypanosoma cruzi drugs: new leads from a mouse model.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:6

    Topics: 5-Amino-3-((5-nitro-2-furyl)vinyl)-1,2,4-oxadiazole; Aminoquinolines; Animals; Chagas Disease; Disea

1977
Ferrocenyl, Ruthenocenyl, and Benzyl Oxamniquine Derivatives with Cross-Species Activity against Schistosoma mansoni and Schistosoma haematobium.
    ACS infectious diseases, 2017, 09-08, Volume: 3, Issue:9

    Topics: Animals; Anthelmintics; Chemistry, Pharmaceutical; Disease Models, Animal; Female; Male; Mice; Organ

2017
Disease-drug pairs revealed by computational genomic connectivity mapping on GBA1 deficient, Gaucher disease mice.
    Biochemical and biophysical research communications, 2012, Jun-15, Volume: 422, Issue:4

    Topics: Albendazole; Animals; Anthelmintics; Computational Biology; Disease Models, Animal; Drug Discovery;

2012
Remodeling of hepatic vascular changes after specific chemotherapy of schistosomal periportal fibrosis.
    Memorias do Instituto Oswaldo Cruz, 2006, Volume: 101 Suppl 1

    Topics: Animals; Anthelmintics; Chronic Disease; Disease Models, Animal; Female; Granuloma; Humans; Liver Ci

2006
Experimental chemotherapy of Schistosoma curassoni in mice.
    Parasitology research, 1989, Volume: 75, Issue:7

    Topics: Animals; Disease Models, Animal; Female; Hycanthone; Male; Mice; Nitroquinolines; Oxamniquine; Prazi

1989