oxaloacetic acid has been researched along with Seizures in 3 studies
Oxaloacetic Acid: A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.
oxaloacetic acid : An oxodicarboxylic acid that is succinic acid bearing a single oxo group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA (mtDNA) damage and seizures induced by kainic acid were examined both in vivo and in vitro." | 7.72 | Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice. ( Mohanan, PV; Yamamoto, HA, 2003) |
| "Limbic seizures were induced in rats by intraperitoneal injection of the glutamate receptor agonist kainic acid, followed, 24h later by injection of [1-13C]glucose and [1,2-13C]acetate." | 3.72 | Glial-neuronal interactions following kainate injection in rats. ( Aasly, J; Eloqayli, H; Müller, B; Qu, H; Sonnewald, U, 2003) |
| "The effects of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA (mtDNA) damage and seizures induced by kainic acid were examined both in vivo and in vitro." | 3.72 | Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice. ( Mohanan, PV; Yamamoto, HA, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruban, A | 1 |
| Biton, IE | 1 |
| Markovich, A | 1 |
| Mirelman, D | 1 |
| Qu, H | 1 |
| Eloqayli, H | 1 |
| Müller, B | 1 |
| Aasly, J | 1 |
| Sonnewald, U | 1 |
| Yamamoto, HA | 1 |
| Mohanan, PV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Glutamate-mediate Excitotoxicity in Invasion and Progression Processes of Glioblastoma Multiforme[NCT05775458] | 50 participants (Anticipated) | Observational | 2020-06-01 | Recruiting | |||
| Anhydrous Enol-Oxaloacetate (AEO) on Improving Fatigue in Post-COVID-19 Survivors[NCT04592354] | 40 participants (Anticipated) | Interventional | 2020-10-15 | Recruiting | |||
| A Phase 2, Randomized, Open-Label Study of Anhydrous Enol-Oxaloacetate in Subjects With Newly Diagnosed Glioblastoma Multiforme[NCT04450160] | Phase 2 | 80 participants (Anticipated) | Interventional | 2020-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for oxaloacetic acid and Seizures
| Article | Year |
|---|---|
MRS of brain metabolite levels demonstrates the ability of scavenging of excess brain glutamate to protect against nerve agent induced seizures.
Topics: Animals; Aspartate Aminotransferases; Brain; Glutamic Acid; Humans; Lactic Acid; Magnetic Resonance | 2015 |
Glial-neuronal interactions following kainate injection in rats.
Topics: Acetates; Acetyl Coenzyme A; Amino Acids; Animals; Astrocytes; Carbon Isotopes; Chromatography, High | 2003 |
Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice.
Topics: Animals; Brain; DNA Damage; DNA, Mitochondrial; Kainic Acid; Ketoglutaric Acids; Lipid Peroxidation; | 2003 |
Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice.
Topics: Animals; Brain; DNA Damage; DNA, Mitochondrial; Kainic Acid; Ketoglutaric Acids; Lipid Peroxidation; | 2003 |
Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice.
Topics: Animals; Brain; DNA Damage; DNA, Mitochondrial; Kainic Acid; Ketoglutaric Acids; Lipid Peroxidation; | 2003 |
Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice.
Topics: Animals; Brain; DNA Damage; DNA, Mitochondrial; Kainic Acid; Ketoglutaric Acids; Lipid Peroxidation; | 2003 |