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oxaloacetic acid and Ataxia with Lactic Acidosis 2

oxaloacetic acid has been researched along with Ataxia with Lactic Acidosis 2 in 1 studies

Oxaloacetic Acid: A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.
oxaloacetic acid : An oxodicarboxylic acid that is succinic acid bearing a single oxo group.

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Marin-Valencia, I	1
Roe, CR	1
Pascual, JM	1

Clinical Trials (4)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Post Study Continuation of C7 for G1D[NCT02018302]		0 participants	Expanded Access		No longer available
Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526]	Phase 1/Phase 2	0 participants (Actual)	Interventional	2015-12-31	Withdrawn (stopped due to NIH funding resulted in new clinical trial)
The Glucose Transporter Type I Deficiency (G1D) Registry[NCT02013583]		750 participants (Anticipated)	Observational [Patient Registry]	2013-12-31	Recruiting
Clinical Trial of Citric Acid Cycle Stimulation in Energy-deficiency States: Treatment Development for Glucose Transporter Type I Deficiency Syndrome (G1D) (NMTUT 2010B)[NCT02018315]	Phase 1	14 participants (Actual)	Interventional	2012-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Change in Brain Metabolic Rate After 3 Months

Magnetic Resonance Imaging (MRI) used to calculate brain metabolic rate. Brain metabolic rate compared before oil ingestion (Baseline), 90 minutes after oil ingestion, and after 3 months of daily oil ingestion in each participant. Triheptanoin metabolism may lead to increased oxygen consumption only while the brain undergoes a reduction of ictogenesis. We hypothesize that when ictogenesis is abolished by triheptanoin or absent at baseline, triheptanoin exerts little or no effect on CMR02. (NCT02018315)
Timeframe: 3 months

Intervention	Participants (Count of Participants)
Experimental: Triheptanoin	5

Number of Participants With Reduction in Spike-wave Fraction of the EEG Recording Time

Visual analysis of EEG recording to determine the fraction of spike-range within the area of recording. (NCT02018315)
Timeframe: 1 day

Intervention	Participants (Count of Participants)
Experimental: Triheptanoin	13

Reviews

1 review available for oxaloacetic acid and Ataxia with Lactic Acidosis 2

Article	Year
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010
Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis. Molecular genetics and metabolism, 2010, Volume: 101, Issue:1 Topics: Animals; Carbon; Humans; Oxaloacetic Acid; Phenotype; Pyruvate Carboxylase; Pyruvate Carboxylase Def	2010