oxaloacetic acid has been researched along with Acute Confusional Senile Dementia in 3 studies
Oxaloacetic Acid: A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.
oxaloacetic acid : An oxodicarboxylic acid that is succinic acid bearing a single oxo group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both doses were safe and tolerated." | 3.01 | Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients. ( Anderson, H; Becker, A; Bothwell, R; Brooks, W; Burns, JM; Choi, IY; Clutton, J; Harris, RA; Lee, P; Mahnken, JD; Mosconi, L; Pleen, J; Reed, G; Sherry, E; Swerdlow, RH; Vidoni, ED; Wilkins, HM; Zhang, N, 2021) |
| "In the case of Alzheimer's disease (AD), amyloid β (Aβ)-mediated disruption of synaptic plasticity and memory can be alleviated by interventions that directly remove glutamate or block certain glutamate receptors." | 1.46 | Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus. ( Mably, AJ; Rowan, MJ; Walsh, DM; Zhang, D, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Vidoni, ED | 1 |
| Choi, IY | 1 |
| Lee, P | 1 |
| Reed, G | 1 |
| Zhang, N | 1 |
| Pleen, J | 1 |
| Mahnken, JD | 1 |
| Clutton, J | 1 |
| Becker, A | 1 |
| Sherry, E | 1 |
| Bothwell, R | 1 |
| Anderson, H | 1 |
| Harris, RA | 1 |
| Brooks, W | 1 |
| Wilkins, HM | 2 |
| Mosconi, L | 1 |
| Burns, JM | 1 |
| Swerdlow, RH | 2 |
| Zhang, D | 1 |
| Mably, AJ | 1 |
| Walsh, DM | 1 |
| Rowan, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anhydrous Enol-Oxaloacetate (AEO) on Improving Fatigue in Post-COVID-19 Survivors[NCT04592354] | 40 participants (Anticipated) | Interventional | 2020-10-15 | Recruiting | |||
| A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS[NCT05273372] | 80 participants (Anticipated) | Interventional | 2022-03-15 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for oxaloacetic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease.
Topics: Alzheimer Disease; DNA, Mitochondrial; Energy Metabolism; Exercise; Humans; Inflammation; Ketone Bod | 2016 |
1 trial available for oxaloacetic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cognition; Dose-Response Relationship, Drug; Ener | 2021 |
Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cognition; Dose-Response Relationship, Drug; Ener | 2021 |
Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cognition; Dose-Response Relationship, Drug; Ener | 2021 |
Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cognition; Dose-Response Relationship, Drug; Ener | 2021 |
1 other study available for oxaloacetic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus.
Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Aspartate Aminotransferase, Cy | 2017 |