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oxalic acid and Hyperoxaluria, Primary

oxalic acid has been researched along with Hyperoxaluria, Primary in 29 studies

Oxalic Acid: A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.
oxalic acid : An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.

Hyperoxaluria, Primary: A genetic disorder characterized by excretion of large amounts of OXALATES in urine; NEPHROLITHIASIS; NEPHROCALCINOSIS; early onset of RENAL FAILURE; and often a generalized deposit of CALCIUM OXALATE. There are subtypes classified by the enzyme defects in glyoxylate metabolism.

Research Excerpts

ExcerptRelevanceReference
" B6 was administered orally starting at 5 mg/kg body weight per day and given in increments of 5 mg/kg every 6 weeks, up to a final dosage of 20 mg/kg per day at week 24."2.79Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. ( Beck, BB; Franklin, J; Hero, B; Hoppe, B; Hoyer-Kuhn, H; Kohbrok, S; Volland, R, 2014)
"Primary hyperoxaluria is a rare hereditary disease."2.39[Primary hyperoxaluria]. ( De Pauw, L; Toussaint, C, 1996)
"Patients with primary hyperoxaluria experience kidney stones from a young age and can develop progressive oxalate nephropathy."1.56End Points for Clinical Trials in Primary Hyperoxaluria. ( Allain, M; Blank, M; Dehmel, B; Fargue, S; Groothoff, J; Hollander, K; Knight, J; Lieske, JC; Lowther, WT; McGregor, TL; Milliner, DS; Rosskamp, R; Rumsby, G; Thompson, A; West, M; Yang, S, 2020)
"Stone formation and nephrocalcinosis are both very common features of primary hyperoxaluria, yet the extent of each disease varies markedly between patients."1.42Nephrocalcinosis is a risk factor for kidney failure in primary hyperoxaluria. ( Bergstralh, EJ; Lieske, JC; Mehta, RA; Milliner, DS; Tang, X; Vrtiska, TJ, 2015)
"Diagnosis of primary hyperoxaluria type I was made by measuring alanine/glyoxylate aminotransferase activity in a liver biopsy."1.30Late onset primary oxalosis type I: an uncommon presentation of a rare disease. ( Anthuber, M; Glück, T; Krämer, BK; Lang, B; Rogler, G; Rüschoff, J; Schölmerich, J; Schweda, F; Zülke, C, 1998)
"Primary oxalosis is a rare inborn error of oxalate metabolism."1.28Primary oxalosis mimicking hyperparathyroidism diagnosed after long-term hemodialysis. ( Cadario, A; Canavese, C; Marangella, M; Massara, C; Pavan, I; Petrarulo, M; Portigliatti Barbos, M; Rotolo, U; Salomone, M, 1990)
"Primary hyperoxaluria has not been reported as a spontaneous disease in the dog, although it is a well-known, but rare, inherited metabolic disease of man."1.28Oxalate nephropathy in a Tibetan spaniel litter. A probable case of primary hyperoxaluria. ( Arnesen, K; Jansen, JH, 1990)
"Most attempts to treat primary hyperoxaluria by renal transplantation have been unsuccessful because of rapid recurrence of nephrocalcinosis with uraemia and systemic oxalosis."1.27Renal transplantation in primary hyperoxaluria. ( Mansell, MA; Morgan, SH; Purkiss, P; Watts, RW, 1987)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19905 (17.24)18.7374
1990's15 (51.72)18.2507
2000's4 (13.79)29.6817
2010's3 (10.34)24.3611
2020's2 (6.90)2.80

Authors

AuthorsStudies
Milliner, DS3
McGregor, TL1
Thompson, A1
Dehmel, B1
Knight, J1
Rosskamp, R1
Blank, M1
Yang, S1
Fargue, S1
Rumsby, G1
Groothoff, J1
Allain, M1
West, M1
Hollander, K1
Lowther, WT1
Lieske, JC2
Letavernier, E1
Daudon, M1
Hoyer-Kuhn, H1
Kohbrok, S1
Volland, R1
Franklin, J1
Hero, B1
Beck, BB1
Hoppe, B1
Tang, X1
Bergstralh, EJ1
Mehta, RA1
Vrtiska, TJ1
Elgstoen, KB1
Belhaj, R1
Hayder, N1
Gargueh, T1
Zorguati, M1
Marrakchi, O1
Abdelhak, S1
Lakhoua, R1
Abdelmoula, J1
ZAREMBSKI, PM1
HODGKINSON, A1
Sugimoto, T1
Kamikawa, S1
Ishii, K1
Schulze, MR1
Wachter, R1
Schmeisser, A1
Fischer, R1
Strasser, RH1
Woolfson, RG1
Mansell, MA2
De Pauw, L2
Toussaint, C2
Cordonnier, C1
Noel, C1
Gosselin, B1
Watts, RW2
Ogawa, Y1
Hatano, T1
Glück, T1
Krämer, BK1
Zülke, C1
Rüschoff, J1
Rogler, G1
Schweda, F1
Anthuber, M1
Lang, B1
Schölmerich, J1
Cochat, P1
Monico, CG1
Petrarulo, M2
Marangella, M2
Cosseddu, D1
Linari, F1
Polinsky, MS1
Dunn, S1
Kaiser, BA1
Schulman, SL1
Wolfson, BJ1
Elfenbein, IB1
Baluarte, HJ1
Kasidas, GP1
Nemat, S1
Rose, GA2
Ruder, H1
Otto, G2
Schutgens, RB1
Querfeld, U1
Wanders, RJ1
Herzog, KH1
Wölfel, P1
Pomer, S1
Schärer, K2
Schürmann, G1
Wingen, AM1
Herfarth, C1
Gelin, M1
Danpure, CJ1
Vereerstraeten, P1
Adler, M1
Abramowicz, D1
Canavese, C1
Salomone, M1
Massara, C1
Portigliatti Barbos, M1
Cadario, A1
Pavan, I1
Rotolo, U1
Jansen, JH1
Arnesen, K1
Frosch, M1
Kuwertz-Bröking, E1
Bulla, M1
von Bassewitz, DB1
Leusmann, DB1
Suyama, I1
Isshiki, G1
Ono, K1
Ono, H1
Ono, T1
Kikawa, K1
Oh, Y1
Morgan, SH1
Purkiss, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
PILOTSTUDIE ZUR PYRIDOXALPHOSPHATTHERAPIE BEI PATIENTEN MIT PRIMÄRER HYPEROXALURIE TYP I (PHOX-B6-PILOT) Pilot Trial on Treatment of Patients With Primary Hyperoxaluria Type I With Pyridoxal-phosphate[NCT01281878]Phase 212 participants (Actual)Interventional2010-12-31Completed
Scientific Basis for a Newborn Screening for Cystinosis and Primary Hyperoxaluria[NCT05843851]200,000 participants (Anticipated)Interventional2022-03-15Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for oxalic acid and Hyperoxaluria, Primary

ArticleYear
Stiripentol identifies a therapeutic target to reduce oxaluria.
    Current opinion in nephrology and hypertension, 2020, Volume: 29, Issue:4

    Topics: Dioxolanes; Humans; Hyperoxaluria; Hyperoxaluria, Primary; L-Lactate Dehydrogenase; Oxalic Acid

2020
Hyperoxaluria and renal calculi.
    Postgraduate medical journal, 1994, Volume: 70, Issue:828

    Topics: Crystallization; Female; Humans; Hyperoxaluria; Hyperoxaluria, Primary; Kidney Calculi; Male; Oxalat

1994
[Primary hyperoxaluria].
    Revue medicale de Bruxelles, 1996, Volume: 17, Issue:2

    Topics: Biopsy; Diet; Glycolates; Glyoxylates; Humans; Hyperoxaluria, Primary; Ilium; Metabolism, Inborn Err

1996
[Oxalosis].
    Annales de pathologie, 1995, Volume: 15, Issue:6

    Topics: Calcinosis; Humans; Hyperoxaluria, Primary; Oxalates; Oxalic Acid

1995
Primary hyperoxaluria.
    Contributions to nephrology, 1997, Volume: 122

    Topics: Calcium Oxalate; Glyoxylates; Humans; Hyperoxaluria, Primary; Liver; Microbodies; Mutation; Oxalates

1997
[Primary hyperoxaluria type 1 (PH1)].
    Ryoikibetsu shokogun shirizu, 1998, Issue:19 Pt 2

    Topics: Biomarkers; Glycolates; Humans; Hyperoxaluria, Primary; Minisatellite Repeats; Mutation; Oxalates; O

1998
Primary hyperoxaluria type 1.
    Kidney international, 1999, Volume: 55, Issue:6

    Topics: Child; Female; Glycolates; Humans; Hyperoxaluria, Primary; Kidney Failure, Chronic; Kidney Transplan

1999

Trials

1 trial available for oxalic acid and Hyperoxaluria, Primary

ArticleYear
Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice.
    Clinical journal of the American Society of Nephrology : CJASN, 2014, Volume: 9, Issue:3

    Topics: Administration, Oral; Adolescent; Biomarkers; Child; Female; Genetic Predisposition to Disease; Germ

2014
Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice.
    Clinical journal of the American Society of Nephrology : CJASN, 2014, Volume: 9, Issue:3

    Topics: Administration, Oral; Adolescent; Biomarkers; Child; Female; Genetic Predisposition to Disease; Germ

2014
Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice.
    Clinical journal of the American Society of Nephrology : CJASN, 2014, Volume: 9, Issue:3

    Topics: Administration, Oral; Adolescent; Biomarkers; Child; Female; Genetic Predisposition to Disease; Germ

2014
Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice.
    Clinical journal of the American Society of Nephrology : CJASN, 2014, Volume: 9, Issue:3

    Topics: Administration, Oral; Adolescent; Biomarkers; Child; Female; Genetic Predisposition to Disease; Germ

2014

Other Studies

21 other studies available for oxalic acid and Hyperoxaluria, Primary

ArticleYear
End Points for Clinical Trials in Primary Hyperoxaluria.
    Clinical journal of the American Society of Nephrology : CJASN, 2020, 07-01, Volume: 15, Issue:7

    Topics: Biomarkers; Disease Progression; Endpoint Determination; Glomerular Filtration Rate; Humans; Hyperox

2020
Nephrocalcinosis is a risk factor for kidney failure in primary hyperoxaluria.
    Kidney international, 2015, Volume: 87, Issue:3

    Topics: Adolescent; Adult; Age of Onset; Child; Child, Preschool; Citric Acid; Female; Humans; Hyperoxaluria

2015
Liquid chromatography-tandem mass spectrometry method for routine measurement of oxalic acid in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Sep-15, Volume: 873, Issue:1

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Freezing; Humans; Hyperoxaluria, Primary; Oxal

2008
[Biochemical and molecular diagnosis of primary hyperoxaluria type 1: Tunisian study about 15 cases].
    Pathologie-biologie, 2011, Volume: 59, Issue:4

    Topics: Adolescent; Calcium; Calcium Oxalate; Child; Child, Preschool; Consanguinity; Crystallization; Femal

2011
THE RENAL CLEARANCE OF OXALIC ACID IN NORMAL SUBJECTS AND IN PATIENTS WITH PRIMARY HYPEROXALURIA.
    Investigative urology, 1963, Volume: 1

    Topics: Body Fluids; Humans; Hyperoxaluria, Primary; Metabolic Diseases; Oxalates; Oxalic Acid; Urine

1963
[Oxalate, oxalic acid].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 11

    Topics: Adult; Humans; Hyperoxaluria, Primary; Oxalates; Oxalic Acid

2004
Restrictive cardiomyopathy in a patient with primary hyperoxaluria type II.
    Clinical research in cardiology : official journal of the German Cardiac Society, 2006, Volume: 95, Issue:4

    Topics: Adult; Biomarkers; Cardiomyopathy, Restrictive; Humans; Hyperoxaluria, Primary; Hypertrophy, Left Ve

2006
Late onset primary oxalosis type I: an uncommon presentation of a rare disease.
    European journal of gastroenterology & hepatology, 1998, Volume: 10, Issue:9

    Topics: Female; Humans; Hyperoxaluria, Primary; Kidney Transplantation; Liver Transplantation; Middle Aged;

1998
Combined liver-kidney and kidney-alone transplantation in primary hyperoxaluria.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2001, Volume: 7, Issue:11

    Topics: Adolescent; Adult; Female; Graft Rejection; Humans; Hyperoxaluria, Primary; Kidney; Kidney Transplan

2001
High-performance liquid chromatographic assay for L-glyceric acid in body fluids. Application in primary hyperoxaluria type 2.
    Clinica chimica acta; international journal of clinical chemistry, 1992, Oct-30, Volume: 211, Issue:3

    Topics: Body Fluids; Chromatography, High Pressure Liquid; Glyceric Acids; Humans; Hydrogen-Ion Concentratio

1992
Combined liver-kidney transplantation in a child with primary hyperoxaluria.
    Pediatric nephrology (Berlin, Germany), 1991, Volume: 5, Issue:3

    Topics: Child, Preschool; Graft Rejection; Humans; Hyperoxaluria, Primary; Kidney Failure, Chronic; Kidney T

1991
Plasma oxalate and creatinine and oxalate/creatinine clearance ratios in normal subjects and in primary hyperoxaluria. Evidence for renal hyperoxaluria.
    Clinica chimica acta; international journal of clinical chemistry, 1990, Oct-31, Volume: 191, Issue:1-2

    Topics: Creatinine; Diuresis; Humans; Hyperoxaluria, Primary; Kidney; Metabolic Clearance Rate; Oxalates; Ox

1990
Excessive urinary oxalate excretion after combined renal and hepatic transplantation for correction of hyperoxaluria type 1.
    European journal of pediatrics, 1990, Volume: 150, Issue:1

    Topics: Child, Preschool; Creatinine; Humans; Hyperoxaluria, Primary; Kidney; Kidney Transplantation; Liver

1990
Early liver transplantation for primary hyperoxaluria type 1 in an infant with chronic renal failure.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1990, Volume: 5, Issue:9

    Topics: Acute Kidney Injury; Amino Acid Metabolism, Inborn Errors; Female; Humans; Hyperoxaluria, Primary; I

1990
Combined liver-kidney transplantation in primary hyperoxaluria type 1.
    Transplantation, 1990, Volume: 50, Issue:5

    Topics: Female; Humans; Hyperoxaluria, Primary; Infant; Kidney Transplantation; Liver Transplantation; Oxala

1990
Primary oxalosis mimicking hyperparathyroidism diagnosed after long-term hemodialysis.
    American journal of nephrology, 1990, Volume: 10, Issue:4

    Topics: Adult; Biopsy; Bone and Bones; Diagnosis, Differential; Glycolates; Humans; Hyperoxaluria, Primary;

1990
Oxalate nephropathy in a Tibetan spaniel litter. A probable case of primary hyperoxaluria.
    Journal of comparative pathology, 1990, Volume: 103, Issue:1

    Topics: Animals; Dog Diseases; Dogs; Female; Hyperoxaluria; Hyperoxaluria, Primary; Male; Oxalates; Oxalic A

1990
[Type I oxalosis in childhood--studies within the scope of terminal renal failure in the child].
    Klinische Wochenschrift, 1989, Nov-17, Volume: 67, Issue:22

    Topics: Adolescent; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Hyperoxaluria; Hyperoxaluria

1989
[Significance of oxalic acid analysis in clinical tests].
    Nihon rinsho. Japanese journal of clinical medicine, 1989, Volume: 48 Suppl

    Topics: Adult; Chromatography, Gas; Chromatography, High Pressure Liquid; Colorimetry; Humans; Hyperoxaluria

1989
Effect of vitamin C supplementation on renal oxalate deposits in five-sixths nephrectomized rats.
    Nephron, 1989, Volume: 51, Issue:4

    Topics: Animals; Ascorbic Acid; Hyperoxaluria, Primary; Kidney Failure, Chronic; Kidney Tubules; Male; Nephr

1989
Renal transplantation in primary hyperoxaluria.
    Annals of the Academy of Medicine, Singapore, 1987, Volume: 16, Issue:2

    Topics: Glomerular Filtration Rate; Humans; Hyperoxaluria; Hyperoxaluria, Primary; Kidney Transplantation; N

1987