oxalates and Muscular-Atrophy

Topics: Adult; Humans; Hyperoxaluria; Hyperoxaluria, Primary; Kidney Failure, Chronic; Male; Muscles; Muscular Atrophy; Nerve Degeneration; Nerve Fibers, Myelinated; Neuromuscular Diseases; Oxalates; Polyneuropathies; Sural Nerve

A 7-month-old, male European cat was examined because of weakness and inappetence. The cat was dehydrated, polypnoeic and severely weak. Severe, generalised muscle atrophy was present. Spinal reflexes were all decreased to absent. Blood analysis and urinalysis showed several abnormalities, including intermittent hyperoxaluria. The L-gliceric acid concentration was remarkably increased. Electrodiagnostic tests of the peripheral nervous system were abnormal. At necropsy, generalised muscle atrophy was observed. Microscopically, both kidneys showed intraluminal birefringent oxalate crystals. Motor neuron degeneration and accumulation of neurofilaments were observed in the axons of the spinal motor neurons.

Topics: Acute Kidney Injury; Animals; Cat Diseases; Cats; Electromyography; Female; Hyperoxaluria, Primary; Muscle Weakness; Muscular Atrophy; Oxalates

Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood Chemical Analysis; Citrates; Clinical Enzyme Tests; Humans; Ketoglutaric Acids; Lactates; Metabolism; Muscular Atrophy; Muscular Diseases; Muscular Dystrophies; Oxalates; Pyruvates