oxalates and Hyperglycemia

Phytochemicals serve as potential therapeutic agents for the prevention and treatment of diseases. In this study, we elucidate the renoprotective activity of compounds isolated from Eucalyptus globulus and Melaleuca styphelioides extracts in glucose- and oxalate-challenged NRK-49F cell model. The antioxidant potential of isolated compounds was evaluated based on their effect on antioxidant enzyme activities and lipid peroxidation levels. The results demonstrated that exposure of NRK-49F cells to glucose and oxalate stress augmented cell damage and attenuated antioxidant enzyme activities. The phytochemicals 2,2,8-trimethyl-6-formyl-chrom-3-ene-7-O-β-D-glucopyranoside, Cornusiin B and tellimagrandin I treatment restored antioxidant enzyme activity, significantly lowered lipid peroxidation levels and effectively protected cells from glucose and oxalate stress equivalent to the known antioxidant, N-acetyl cysteine. Pterocarinin A significantly reversed cellular damage owing to glucose stress. In conclusion, the compounds isolated from E. globulus and M. styphelioides showed potential cytoprotective and anti-oxidative property against glucose- and oxalate-induced oxidative stress in NRK-49F cells.

Topics: Animals; Antioxidants; Cell Line; Enzymes; Eucalyptus; Gallic Acid; Glucose; Glucosides; Glycosides; Humans; Hydrolyzable Tannins; Hyperglycemia; Lipid Peroxidation; Melaleuca; Oxalates; Phenols; Plant Extracts; Protective Agents

The role of the vitamins of the B group in the therapy of metabolic diseases has been the theme of a recent symposium. All these vitamins exert essential functions in the balance of the intermediary metabolism and consequently in the treatment of their disorders. As far as metabolic diseases and the use of vitamins, i.e. of biological substances, are concerned, the boundaries between the fields of therapy and prophylaxis are difficult to settle strictly. The recent literature concerning these points is reviewed and some concepts discussed.

Topics: Acidosis; Homocystinuria; Humans; Hyperglycemia; Ketosis; Metabolic Diseases; Oxalates; Vitamin B Complex

Topics: Acidosis; Ascorbic Acid; Blood; Cholesterol; Gastrointestinal Diseases; Glycosuria; Humans; Hydrogen-Ion Concentration; Hyperglycemia; Kidney Calculi; Oxalates; Prothrombin; Vitamin B 12

Topics: Adult; Aged; Calcium; Cystinuria; Female; Humans; Hypercalcemia; Hyperglycemia; Male; Metabolic Diseases; Middle Aged; New Zealand; Oxalates; Phosphates; Prospective Studies; Radiography; Uric Acid; Urinary Calculi; Urinary Tract Infections

Topics: Alanine; Brain Diseases; Child; Humans; Hyperglycemia; Hyperoxaluria; Infant; Intellectual Disability; Metabolic Diseases; Oxalates; Urine