oxalates and Growth-Disorders

Children with primary hyperoxaluria type 1 (PH1) often develop severe growth failure, which is related to metabolic and endocrine consequences of chronic renal failure, and/or oxalate deposition in bone and cartilage. Combined liver and kidney transplantation (LKT) corrects the underlying metabolic defect and restores renal function in these children.. We therefore analyzed longitudinal growth of 24 children with PH1 who underwent LKT at nine European centers. Mean age at LKT was 8.9 years, and mean duration of follow-up was 5.7 years.. After LKT mean standardized height tended to increase from -1.79 SD to -1.47 SD until last observation. Mean adult height amounted to 167 cm and 158 cm in boys and girls, respectively. At last observation, seven out of 24 patients were stunted. Within the whole study population, the degree of catch-up growth after LKT was positively associated with degree of stunting at the time of LKT and negatively associated with prednisolone dosage explaining together 39% of the overall variability.. Combined LKT does not induce true catch-up growth in the majority of children with PH1. Due to the preexisting growth retardation at the time of LKT, one third of patients end up with a reduced final height.

Topics: Body Height; Child; Female; Growth Disorders; Humans; Hyperoxaluria, Primary; Kidney Transplantation; Liver Transplantation; Male; Oxalates

We report a case of severe nephrocalcinosis related to hypercalcaemia in a newborn with glucose-galactose malabsorption. He presented with poor growth and was noted to have polyuria, which was later recognised to be severe watery diarrhoea. We discuss the possible aetiological factors for nephrocalcinosis in this condition.

Topics: Calcium; Diarrhea; Galactose; Glucose; Growth Disorders; Humans; Hypercalcemia; Infant, Newborn; Karyotyping; Kidney; Malabsorption Syndromes; Male; Nephrocalcinosis; Oxalates; Polyuria; Ultrasonography

The factors involved in choosing a treatment modality for the infant, child and adolescent with endstage renal disease (ESRD) are different than those utilized when counseling an adult patient. Age at the time ESRD develops, mental status, psychosocial status and the primary renal disease must be taken into consideration when contemplating the optimal therapeutic modality for the pediatric patient with ESRD.

Topics: Adolescent; Age Factors; Anorexia; Bone Diseases; Child; Child, Preschool; Cystinosis; Glomerulosclerosis, Focal Segmental; Growth Disorders; Humans; Infant; Kidney Failure, Chronic; Kidney Transplantation; Oxalates; Oxalic Acid; Peritoneal Dialysis; Peritoneal Dialysis, Continuous Ambulatory; Psychology; Wilms Tumor

Topics: Child, Preschool; Female; Fractures, Spontaneous; Growth Disorders; Humans; Hypercalcemia; Kidney Calculi; Kidney Failure, Chronic; Metabolism, Inborn Errors; Oxalates; Oxalic Acid

Topics: Animals; Calcium; Female; Growth Disorders; Hair; Kidney; Kidney Medulla; Liver; Magnesium; Magnesium Deficiency; Male; Oxalates; Phosphorus; Potassium; Rats; Skin Diseases; Sulfates; Vitamin B 6 Deficiency