oxalates and Coronary-Disease

The influence of nifedipine (20 nM) and mioflazine (300 nM), i.e. concentrations inducing a 60-70% recovery of cardiac function during reperfusion of globally ischaemic guinea-pig working hearts, on the mitochondrial calcium content was investigated in normoxic, globally ischaemic and reperfused globally ischaemic guinea-pig working hearts. Mitochondrial calcium was determined electronmicroscopically with oxalate-pyroantimonate method. In normoxic hearts both nifedipine and mioflazine reduced the mitochondrial calcium content. Global ischaemia for 45 min and subsequent reperfusion for 25 min resulted in a pronounced mitochondrial calcium overload and damage to the cellular structure. In ischaemic and in reperfusion hearts the drugs maintained mitochondrial calcium at pre-ischaemic levels and decreased the damage to the cellular structure.

Topics: Animals; Antimony; Calcium; Cardiovascular Agents; Coronary Disease; Guinea Pigs; Homeostasis; In Vitro Techniques; Mitochondria, Heart; Myocardial Reperfusion; Nifedipine; Oxalates; Piperazines

Topics: Adult; Aged; Anticoagulants; Blood Coagulation; Citrates; Coronary Disease; Female; Humans; Hypertension; Male; Middle Aged; Oxalates

Topics: Aged; Arteriosclerosis; Blood Coagulation; Coronary Disease; Female; Humans; Male; Middle Aged; Oxalates; Plasma; Thrombelastography

Topics: Ascorbic Acid; Aspirin; Asthma; Calcium; Citrates; Coronary Disease; Depression, Chemical; Diabetes Mellitus; Duodenal Ulcer; Dwarfism, Pituitary; Emphysema; Facial Paralysis; Gluconates; Histamine H1 Antagonists; Humans; Hypertension; Hyperthyroidism; Kidney Calculi; Liver Diseases, Parasitic; Magnesium; Oxalates; Phosphates; Pyridoxine; Schistosomiasis; Stimulation, Chemical; Terpenes; Tuberculosis, Pulmonary