oxalates and Aging--Premature

Oxidative stress, a well-known cause of stress-induced premature senescence (SIPS), is increased in patients with calcium oxalate (CaOx) kidney stones (KS). Oxalate and calcium oxalate monohydrate (COM) induce oxidative stress in renal tubular cells, but to our knowledge, their effect on SIPS has not yet been examined. Here, we examined whether oxalate, COM, or urine from patients with CaOx KS could induce SIPS and telomere shortening in human kidney (HK)-2 cells, a proximal tubular renal cell line. Urine from age- and sex-matched individuals without stones was used as a control. In sublethal amounts, H

Topics: Aged; Aging, Premature; Calcium Oxalate; Cell Line; Cyclin-Dependent Kinase Inhibitor p16; DNA Damage; Female; Humans; Hydrogen Peroxide; Male; Middle Aged; Nephrolithiasis; Oxalates; Oxidative Stress; Telomere Shortening; Telomeric Repeat Binding Protein 1