oxadiazoles and Intracranial-Aneurysm

Intracranial aneurysm (IA), common in the general public, causes lethal subarachnoid haemorrhage on rupture. It is, therefore, of utmost importance to prevent the IA from rupturing. However, there is currently no medical treatment. Recent studies suggest that IA is the result of chronic inflammation in the arterial wall caused by endothelial dysfunction and infiltrating macrophages. The sphingosine-1-phosphate receptor type 1 (S1P. The effects of a selective S1P. S1P. A selective S1P

Topics: Benzimidazoles; Capillary Permeability; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Intracranial Aneurysm; Macrophages; Oxadiazoles; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Structure-Activity Relationship; Transendothelial and Transepithelial Migration