oxadiazoles and Gastrointestinal-Hemorrhage

oxadiazoles has been researched along with Gastrointestinal-Hemorrhage* in 1 studies

Other Studies

1 other study(ies) available for oxadiazoles and Gastrointestinal-Hemorrhage

Article	Year
[Synthesis and anti-inflammatory analgesic activities of phenylfuroxan-coupled diclofenac]. Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:1 To search for new derivatives of diclofenac (DC) having higher potency than the parent drug and lacking its undesirable effects.. Coupling DC with NO donor 3-hydroxymethyl-4-phenylfuroxan and its isomer through esterification, evaluating anti-inflammatory and analgesic activities, observing side effects in the rat gastrointestinal (GI) tract and assessing NO releasing ability both in vitro and in vivo.. Fifteen new compounds including nine target ones (II1-9) were synthesized, and their structures were determined by IR, 1HNMR, MS and elemental analysis. Compounds II3 and II9 showed anti-inflammatory activity comparable to DC. Compound II2 showed stronger anti-inflammatory and analgesic activities and less GI side effect than DC, and released NO in vivo.. Compound II2 is worthy to be intensively studied. Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic N-Oxides; Diclofenac; Digestive System; Edema; Gastrointestinal Hemorrhage; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pain Threshold; Rats; Structure-Activity Relationship	2002

Article

Year

[Synthesis and anti-inflammatory analgesic activities of phenylfuroxan-coupled diclofenac].

Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:1

To search for new derivatives of diclofenac (DC) having higher potency than the parent drug and lacking its undesirable effects.. Coupling DC with NO donor 3-hydroxymethyl-4-phenylfuroxan and its isomer through esterification, evaluating anti-inflammatory and analgesic activities, observing side effects in the rat gastrointestinal (GI) tract and assessing NO releasing ability both in vitro and in vivo.. Fifteen new compounds including nine target ones (II1-9) were synthesized, and their structures were determined by IR, 1HNMR, MS and elemental analysis. Compounds II3 and II9 showed anti-inflammatory activity comparable to DC. Compound II2 showed stronger anti-inflammatory and analgesic activities and less GI side effect than DC, and released NO in vivo.. Compound II2 is worthy to be intensively studied.

Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic N-Oxides; Diclofenac; Digestive System; Edema; Gastrointestinal Hemorrhage; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pain Threshold; Rats; Structure-Activity Relationship

2002