oxadiazoles has been researched along with Extensively-Drug-Resistant-Tuberculosis* in 2 studies
2 other study(ies) available for oxadiazoles and Extensively-Drug-Resistant-Tuberculosis
| Article | Year |
|---|---|
Reversion of antibiotic resistance in
Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant Topics: Animals; Antitubercular Agents; DNA; Drug Resistance, Multiple, Bacterial; Ethionamide; Extensively Drug-Resistant Tuberculosis; Humans; Isoxazoles; Mice; Mutation; Mycobacterium tuberculosis; Oxadiazoles; Piperidines; Protein Binding; Repressor Proteins; Spiro Compounds | 2017 |
Identification and development of 2,5-disubstituted oxadiazole as potential candidate for treatment of XDR and MDR tuberculosis.
Tuberculosis, the infection on the verge of eradication once, is now a great threat to mankind. Emergence of MDR and XDR-TB synergised with HIV and other immune-compressive diseases have increased the life threatening capacities of the disease. A small molecule has been identified here, which showed potent anti-tubercular activity. The identified hit compound has also been proved active against nearly 25 clinical isolates comparable with isoniazid. Topics: Antitubercular Agents; Drug Discovery; Extensively Drug-Resistant Tuberculosis; Hep G2 Cells; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxadiazoles | 2012 |