oxadiazoles and Depressive-Disorder--Major

Positive allosteric modulation of mGlu2 has attracted much interest as an alternative approach to classical orthosteric receptor activation. Two mGlu2 PAMS have advanced into the clinic. The results obtained in schizophrenia and MDD phase 2 clinical trials have tempered the high expectations put on selective mGlu2 receptor activation for treating these conditions; nevertheless, the search for novel therapeutic indications and novel chemotypes continues to be an active field of research.. 2013-2018 patent literature on mGlu2 receptor PAMs.. After a decade of intensive research, the mGlu2 PAM field has seen a deceleration in the last five years. Negative phase 2 schizophrenia clinical trials with JNJ-40411813 and AZD8529 seem to have tempered the high expectations of the scientific community on the utility of mGlu2 PAMs for the treatment of schizophrenia. Nevertheless, novel therapeutic indications continue to be explored and AZD8529 is currently in a phase 2 study for smoking cessation. The advances in medicinal chemistry and in pharmacology, with novel indications such as epilepsy, have set the stage in the field of mGlu2 receptor PAMs. Ongoing preclinical and clinical studies will contribute to define their optimal therapeutic indication and potential to become novel therapeutic agents.

Topics: Allosteric Regulation; Animals; Depressive Disorder, Major; Humans; Indoles; Oxadiazoles; Patents as Topic; Piperidines; Pyridones; Receptors, Metabotropic Glutamate; Schizophrenia

Topics: Adjustment Disorders; Adolescent; Adult; Aged; Antidepressive Agents; Brain Diseases; Depression; Depressive Disorder, Major; Female; Humans; Hypothalamus; Male; Mental Disorders; Middle Aged; Neurasthenia; Oxadiazoles; Psychopharmacology; Sydnones; Tablets