oxadiazoles and Arthritis--Juvenile

T-cell resilience is critical to the immune pathogenesis of human autoimmune arthritis. Autophagy is essential for memory T cell generation and associated with pathogenesis in rheumatoid arthritis (RA). Our aim here was to delineate the role and molecular mechanism of autophagy in resilience and persistence of pathogenic T cells from autoimmune arthritis. We demonstrated "Autophagic memory" as elevated autophagy levels in CD4

Topics: Adolescent; Adult; Animals; Arthritis, Juvenile; Arthritis, Rheumatoid; Autophagy; Case-Control Studies; CD4-Positive T-Lymphocytes; DNA Methylation; Female; Gene Expression Regulation; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Humans; Immunologic Memory; Jurkat Cells; Male; Mice; Mice, Inbred DBA; Oxadiazoles; Primary Cell Culture; Proto-Oncogene Proteins c-myc; T-Lymphocyte Subsets; Transcription Factors