ovatodiolide and Hepatitis--Autoimmune

ovatodiolide has been researched along with Hepatitis--Autoimmune* in 1 studies

Other Studies

1 other study(ies) available for ovatodiolide and Hepatitis--Autoimmune

Article	Year
Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile. Chemical communications (Cambridge, England), 2020, Sep-25, Volume: 56, Issue:75 Stepwise modification of ovatodiolide revealed a prodrug, NMP-diepoxyovatodiolide, which can provide sustained release of an active compound, substantial metabolic stability and a unique accumulation profile in the liver. Besides, NMP-diepoxyovatodiolide demonstrated therapeutic benefits in an acute autoimmune hepatitis mouse model and a broad safety window. Therefore, NMP-diepoxyovatodiolide is a very promising candidate for further development of liver-related drugs. Topics: Animals; Disease Models, Animal; Diterpenes; Hepatitis, Autoimmune; Mice; Mice, Inbred C57BL; Microsomes, Liver; Molecular Structure; Prodrugs; Rats; Rats, Sprague-Dawley	2020

Article

Year

Chemical modification of ovatodiolide revealed a promising amino-prodrug with improved pharmacokinetic profile.

Chemical communications (Cambridge, England), 2020, Sep-25, Volume: 56, Issue:75

Stepwise modification of ovatodiolide revealed a prodrug, NMP-diepoxyovatodiolide, which can provide sustained release of an active compound, substantial metabolic stability and a unique accumulation profile in the liver. Besides, NMP-diepoxyovatodiolide demonstrated therapeutic benefits in an acute autoimmune hepatitis mouse model and a broad safety window. Therefore, NMP-diepoxyovatodiolide is a very promising candidate for further development of liver-related drugs.

Topics: Animals; Disease Models, Animal; Diterpenes; Hepatitis, Autoimmune; Mice; Mice, Inbred C57BL; Microsomes, Liver; Molecular Structure; Prodrugs; Rats; Rats, Sprague-Dawley

2020